DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HERC2 and herc-1

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:NP_490834.1 Gene:herc-1 / 171700 WormBaseID:WBGene00021685 Length:1019 Species:Caenorhabditis elegans


Alignment Length:1134 Identity:260/1134 - (22%)
Similarity:402/1134 - (35%) Gaps:355/1134 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly  3965 GCQSPGASMLNSTTSLSSSTVSNVSPPPGITGEQPDLHCHAHQLESTSTLLHEDHTLFQAPHDAQ 4029
            ||...|...|.  ..||.||   :..|..|.|...|:...|    .||....|.||:|       
 Worm     7 GCGHTGEGQLG--VRLSEST---IQVPERIIGAPNDMDGTA----VTSVTCGEQHTVF------- 55

  Fly  4030 LLQWLNRRPDDWALSWGGASTIYGWGHNHRGQLGGLEGSRIK---TPTPCEALSLLRPVQLAGGE 4091
                |.:....|::           |.|..||||  .|||.:   :..|....|..:.:|::.|.
 Worm    56 ----LTKDGKMWSV-----------GSNMDGQLG--RGSRTEGSFSIYPVSWTSSAKIIQISAGR 103

  Fly  4092 QSLFAVTPDGKLFATGYGSGGRLGVGGSDSW-AIPTLLGSLQHVFVKKVAVNSGGKHCLALTTEG 4155
            ....:||.||::||.|....|:||:....:| ..|..:..:..:    |.|.||..||:||...|
 Worm   104 SHTVSVTDDGRVFAWGSNEHGQLGMESKFTWQGTPRRVQEINDI----VQVASGSNHCIALDEGG 164

  Fly  4156 EVYAWGEGEDGKLGHGNRMSYDRPKLVEHLNGMSVADIACGSAHSAAITASGHVLTWGKGRYGRL 4220
            .|:.|||..||:..|       ||:.||.|:|:.:..:..|:.|..|::|||.|.|||:...|.|
 Worm   165 RVFVWGEQADGRCIH-------RPEPVEQLSGVPIVRVLAGARHCLALSASGAVFTWGQNNSGEL 222

  Fly  4221 GHGDSEDQLRPKLVEALLGYRAIDIACGSGDAQTLCITDDDNVWSWGDGDYGKLGRGGSDGCKLP 4285
            |    .|.|||                     ||..                             
 Worm   223 G----IDDLRP---------------------QTSV----------------------------- 233

  Fly  4286 YKIESLAGLGVVKVECGSQFSVALTKSGAVYTWGKGDFHRLGHG-SVDHVRRPKKVAALQGKKII 4349
            ..:..:.|||||:..||...:|.||..|..:::|.....:.|.| .|:....|..|:.|.|..:.
 Worm   234 QHVHQMDGLGVVEAACGDNHTVLLTHCGRTFSFGSDALGQCGFGKKVEKRTNPTAVSDLIGSHVT 298

  Fly  4350 SIATGSLHCVA-CSDSGEVYTWGDNDEGQLGDGTVTAIQRPRLVAALQGKHIVKVTCGSAHTLAL 4413
            .||.|:.|.:| |  .|..|.:|.|..||||:|.:.....||....|.  |:..|..|...|..:
 Worm   299 RIAAGACHTIAIC--KGAPYPFGLNSSGQLGNGKIMTQSTPRKTDELD--HVTGVFAGYHQTFFV 359

  Fly  4414 STSQLSERLRPL-PNPPLEYDL------VRDLAPE--ALHARLILLHHFSELV------------ 4457
            .:|...|:...: |:.|::|.:      ::.|..|  ||....::...||.|.            
 Worm   360 RSSGTIEQNEIVGPSCPMQYPIKLDHESLKKLLDEGDALEVMSLIESVFSSLASMNMSFLYKDER 424

  Fly  4458 ------C--------------------------------------------------PC---LAM 4463
                  |                                                  .|   |.|
 Worm   425 RYNVGFCFERSHGIDMDQVMEAFMLFDEYPMKRQYMELIVDSLKIAFQEWSENLKGIECLRVLLM 489

  Fly  4464 LP----ISGDLSLGALKDV---------LVYNIKEAA------------FRKVIQT------TMV 4497
            ||    .:.::::..:|:|         |:.....||            ||:::..      .|:
 Worm   490 LPWLPIFTENVNVQTIKNVHTPFVDAMCLITGDLRAALEKWWTQLSTRHFRRMVTVFKTAIKAML 554

  Fly  4498 RDKQHGP-------------------------------------------VIELNRIQVKRSRNR 4519
            :.|: ||                                           |:||.|    :..|:
 Worm   555 KAKK-GPRDCHKFILIMQKLSLINKTYHIIPLETFYIDELNTSVDLKLEYVLELTR----QDPNK 614

  Fly  4520 CN---------GLAGIDGMKSVFGQMVQKLPLLTQEAL----------ALPHRVWKVK--FVGES 4563
            ..         .|.|:...:.:|.:......|..|.:|          .|||....|:  |:...
 Worm   615 TELDYWTHFPFLLNGVAKGELIFVEAWLMQTLRRQSSLFNTAHGTIIFELPHLELTVRREFIVSD 679

  Fly  4564 VDDCGGGYSESIAEMCDELQNGSVPLLINTPNGRGE-----AGANRDCFLLDPTLSSVLQMN--- 4620
            ..:...|.|||      :||.   ||.:|.   .||     .|..::.|:|  .:..:||.:   
 Worm   680 TMNQMAGLSES------DLQK---PLKVNI---AGEDADDAGGVRKEFFIL--VMRKILQSDYGM 730

  Fly  4621 -----------------------MFRFLGVLMGIAVRTGS--PLSINLAEPVWRQLTGEVLRPTD 4660
                                   .|..||.|:|:::...|  |....||  :::.|........|
 Worm   731 FSEDEESHLVWFSGLPSEFCDREQFHQLGRLVGLSIYNHSIVPFPFPLA--LYKYLLDTPPDLED 793

  Fly  4661 LTEVDRDYVAGLLCIRNMDDDPKLFTALELPFSTS---SARGHEVPLSTRYTH--ISPRNRAEYV 4720
            |.|:......||..:.:.::| .:.....|.|..|   ....|...|.:..|.  ::..||.|||
 Worm   794 LCELSPSEGKGLKMLLSYEED-DVEDVFGLNFCISFNILGETHTTELLSGGTEKPVTNANRDEYV 857

  Fly  4721 RLALGFRLH-----EFDEQVKAVRDGMSKVIPVPLLSLFSAAELQAMVCGSPDIPLGLLKSVATY 4780
            ||.:..||.     |..:|....|.|.|:.:....|..|...||:.|:.|:.:......:.:..|
 Worm   858 RLYVHHRLELGYNGEIAQQALLFRKGFSESLHSRTLRFFQPCELKEMIVGNENYDWNEFRDILMY 922

  Fly  4781 KG-FDPSSALVTWFWEVMEEFTNQERSLFLRFVWGRTRLPRTIADFRGRDFVLQVLEKNPPDHFL 4844
            :| :..|...:..||:.....|:.||..||:|:.|.||:|     ..|.:.:...::.:.|:. |
 Worm   923 RGEYSSSHPTIQAFWKAFFALTDDERRKFLQFLTGSTRIP-----VSGWEELHAAIQPSAPES-L 981

  Fly  4845 PESYTCFFLLKMPRYSCKAVLLEKLKYAI 4873
            |.::|||.||.:|..:....||.:|:.:|
 Worm   982 PVAHTCFNLLDLPNIADDVELLRRLRISI 1010

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826
RCC1 3091..3140 CDD:278826
RCC1 3144..3194 CDD:278826
RCC1 3197..3246 CDD:278826
RCC1 3250..3298 CDD:278826
RCC1 3302..3350 CDD:278826
RCC1_2 4136..4166 CDD:290274 13/29 (45%)
RCC1 4154..4203 CDD:278826 16/48 (33%)
RCC1 4206..4257 CDD:278826 15/50 (30%)
RCC1 4260..4309 CDD:278826 8/48 (17%)
RCC1 4312..4360 CDD:278826 13/48 (27%)
RCC1 4364..4413 CDD:278826 16/48 (33%)
HECTc 4509..4880 CDD:238033 100/430 (23%)
HECTc 4553..4878 CDD:214523 89/367 (24%)
herc-1NP_490834.1 ATS1 2..359 CDD:227511 128/453 (28%)
HECTc 667..1016 CDD:238033 89/367 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1062377at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

Return to query results.
Submit another query.