DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HERC2 and Itch

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:NP_001230641.1 Gene:Itch / 16396 MGIID:1202301 Length:864 Species:Mus musculus


Alignment Length:903 Identity:191/903 - (21%)
Similarity:329/903 - (36%) Gaps:211/903 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly  4097 VTPDGKLFATGYG-----SGGRLGVGG--------SDSWAIPTLLGSLQHVFVKKVAVNSGG-KH 4147
            |||..||....:.     |...||..|        |::..:..::.:||.|..|:.....|. ..
Mouse    73 VTPTSKLCFRVWSHQTLKSDVLLGTAGLDIYETLKSNNMKLEEVVMTLQLVGDKEPTETMGDLSV 137

  Fly  4148 CL-ALTTEGEVYAWGE---------GEDG-KLGHGNRMSYDRPKLVEHLNGMSVADIACGSAHSA 4201
            || .|..|.||...||         .:|| :.....|:|         .||....::|....:..
Mouse   138 CLDGLQVEAEVVTNGETSCSESTTQNDDGCRTRDDTRVS---------TNGSEDPEVAASGENKR 193

  Fly  4202 AITASGHVLTWG---KGRYGRLGHGDSEDQLRPKLVEALLGYRAIDIACGSGDAQTLCITDDDNV 4263
            |...:...|:.|   ..|..|..........||..|              :|...|...:|..:.
Mouse   194 ANGNNSPSLSNGGFKPSRPPRPSRPPPPTPRRPASV--------------NGSPSTNSDSDGSST 244

  Fly  4264 WSWGDGDYG---KLGRGGSDGCKLPYKIESLAGLGVVKVECGSQ------FSVALTKSGAVYTWG 4319
            .|....:..   ....|.:.|..:|..|.  .|.|...:...||      :...:.:.|.||   
Mouse   245 GSLPPTNTNVNTSTSEGATSGLIIPLTIS--GGSGPRPLNTVSQAPLPPGWEQRVDQHGRVY--- 304

  Fly  4320 KGDFHRLGHGSVDHVR------RPKKVAALQGKKIISIATGSLHCVACSDSGEVY---------T 4369
                      .||||.      ||:.:.....:::             .:.|.:|         |
Mouse   305 ----------YVDHVEKRTTWDRPEPLPPGWERRV-------------DNMGRIYYVDHFTRTTT 346

  Fly  4370 WGDNDEGQLGDGTVTAIQRPRLVAALQGKHIVKVTCGSAHTLALSTSQLSERLRPLP-------- 4426
            |.......:.:.....:||.:|..|:| :...:...|:....|.|.::..:.|.|||        
Mouse   347 WQRPTLESVRNYEQWQLQRSQLQGAMQ-QFNQRFIYGNQDLFATSQNKEFDPLGPLPPGWEKRTD 410

  Fly  4427 ------------------NPPLEYDLVRDLAPEALHARLIL--LHHF-------SELVCPCLAML 4464
                              :|..:..|.....||....|..:  :.:|       :..:.|.....
Mouse   411 SNGRVYFVNHNTRITQWEDPRSQGQLNEKPLPEGWEMRFTVDGIPYFVDHNRRATTYIDPRTGKS 475

  Fly  4465 PISGDLSLGALKDVLVYNIKEAAFRKVIQTTMVRDKQHGPVIELNRIQVKRSRNRCNGLAGIDGM 4529
            .:.....:..::|   :..|...||...|...:  .||        |::..:|            
Mouse   476 ALDNGPQIAYVRD---FKAKVQYFRFWCQQLAM--PQH--------IKITVTR------------ 515

  Fly  4530 KSVFGQMVQKLPLLTQEALALPHRVWKVKFVGESVDDCGGGYSESIAEMCDELQNGSVPLLINTP 4594
            |::|....|::...:.:.|.  .|:| |.|.||...|.||...|....:..|:.|....|.    
Mouse   516 KTLFEDSFQQIMSFSPQDLR--RRLW-VIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLF---- 573

  Fly  4595 NGRGEAGANRDCFLLDPTLSSVL---QMNMFRFLGVLMGIAVRTGSPLSINLAEPVWRQLTGEVL 4656
               ..||.:..|..::|  :|.:   .:..|||:|..:.:|:..|..:....:.|.::::..:.:
Mouse   574 ---EYAGKDNYCLQINP--ASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFYKRILNKPV 633

  Fly  4657 RPTDLTEVDRDYVAGLLCIR--NMDDDPKLFTALELPFST-----SSARGHEVPLSTRYTHISPR 4714
            ...||..:|.::...|:.::  |:::     ..||:.||.     ...:.|::..:.....::..
Mouse   634 GLKDLESIDPEFYNSLIWVKENNIEE-----CGLEMYFSVDKEILGEIKSHDLKPNGGNILVTEE 693

  Fly  4715 NRAEYVRLALGFRLHE-FDEQVKAVRDGMSKVIPVPLLSLFSAAELQAMVCGSPDIPLGLLKSVA 4778
            |:.||:|:...:||.. .:||.:|..:|.::::|...|..|.|.||:.::||..:|.|...:..|
Mouse   694 NKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHA 758

  Fly  4779 TYKGFDPSSALVTWFWEVMEEFTNQERSLFLRFVWGRTRLP-RTIADFRGRDFVLQ-VLEKNPPD 4841
            .|:.:..:|..:.|||:.::|..|::|...|:||.|..||| ...||..|.:...: .:||...:
Mouse   759 IYRHYTRTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKE 823

  Fly  4842 HFLPESYTCFFLLKMPRYSCKAVLLEKLKYAIHFCKSIDTDEYARVAMGEPTEATGSE 4899
            ::||.|:|||..|.:|.|.....|.|||.:||                 |.||..|.|
Mouse   824 NWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAI-----------------EETEGFGQE 864

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826
RCC1 3091..3140 CDD:278826
RCC1 3144..3194 CDD:278826
RCC1 3197..3246 CDD:278826
RCC1 3250..3298 CDD:278826
RCC1 3302..3350 CDD:278826
RCC1_2 4136..4166 CDD:290274 10/40 (25%)
RCC1 4154..4203 CDD:278826 12/58 (21%)
RCC1 4206..4257 CDD:278826 9/53 (17%)
RCC1 4260..4309 CDD:278826 9/57 (16%)
RCC1 4312..4360 CDD:278826 9/53 (17%)
RCC1 4364..4413 CDD:278826 10/57 (18%)
HECTc 4509..4880 CDD:238033 97/383 (25%)
HECTc 4553..4878 CDD:214523 91/337 (27%)
ItchNP_001230641.1 C2_E3_ubiquitin_ligase 17..140 CDD:175988 16/66 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 151..294 29/167 (17%)
WW 289..318 CDD:278809 7/41 (17%)
WW 321..350 CDD:278809 4/41 (10%)
Required for interaction with FYN. /evidence=ECO:0000250 356..432 13/76 (17%)
WW 401..430 CDD:278809 2/28 (7%)
WW 440..471 CDD:197736 4/30 (13%)
HECTc 509..862 CDD:238033 100/398 (25%)
HECTc 533..861 CDD:214523 95/361 (26%)
MAP kinase docking site 535..544 4/11 (36%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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