Sequence 1: | NP_608388.2 | Gene: | HERC2 / 33035 | FlyBaseID: | FBgn0031107 | Length: | 4912 | Species: | Drosophila melanogaster |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_001347009.1 | Gene: | Herc2 / 15204 | MGIID: | 103234 | Length: | 4836 | Species: | Mus musculus |
Alignment Length: | 5181 | Identity: | 2235/5181 - (43%) |
---|---|---|---|
Similarity: | 2980/5181 - (57%) | Gaps: | 718/5181 - (13%) |
- Green bases have known domain annotations that are detailed below.
Fly 79 LDAKWLRADL-IASLRNAADGAVLWNHLIQDCELVSSPTAPLLNARGQLSYLGDDGKHYCGAQQL 142
Fly 143 KCSCCQPEYCGPLSACNCDGCRPLDSDTAIKKLTTQAAAQQAAHLSQATDMVLSGWLWSQPPSQQ 207
Fly 208 ARLDCQRSMISELQELALRAAGNCLSAQHLRQQLFIYERYFVALKRERERERKSTTSAQAVASVT 272
Fly 273 TANTTIAATTANAAVESQPAEQQAE----HGALGLARVATHAALNFSFAFLRRAWRSGEDTEMCS 333
Fly 334 ELLSEALASLQELPEATLFEAAVVSSLWLEVMERSIKFLRLVALGDPMGNRCT-----APLNDRH 393
Fly 394 TALCLLLELGVQKGTLAATLECVVLLLLLWEKDRAGNDNRDMPRKTGAPLQRILLRYQKI----- 453
Fly 454 -GATAKGGGIAGGEPAPVASATETFLRFLSLPKSSAAIVDLRRAAVVIISHLDRMVQPLMPRCLL 517
Fly 518 RGGQATAASSSSAPQQRIYALGWPSLSKDQQGFSAEPTLSWSGESAGVPTLSCR----FQIKQVA 578
Fly 579 CCETQMLILSQEGKLYTWRLAKPEAEPLPMEEVAHDVFISIAGHCEGRHFLAIDSNHNAYSWGTG 643
Fly 644 EDHRLGHGDTHARAVPTKIAALE-----QHCVQSVYCGCSYSAAITCGGNLLTWGRGTYARLGHG 703
Fly 704 NSDDRSLPTLVVALSDHMVVDVALGSGDAHSLALTSEGLVFAWGDGDYGKLGNGNCNGSLQPILV 768
Fly 769 ESLP--RVQRVFAGSQFSVALSSEGQLYTWGKA--TCLGHQLVERSVQGCSVPRLVSSLQHKRIV 829
Fly 830 DVAVSVAHCLALSSSGEVFGWGRNDSQQICPASVSSEPLLRTPILVSLPTFPASGIACTSAQSLV 894
Fly 895 WTQSSHQGVPRRAPFVVDLGEPTFRLLDQLL-----GMCSSQDNRQTPNQESECIAVACLNLFRL 954
Fly 955 QLLALIANGVEPRQVGLASGSRLLCSLKTRILGLAGGSQVLRTIQVAAQQALQDGWSVLLPTAAE 1019
Fly 1020 RAQTLTSLLP---SEPGQASSAGHRFMTDLLVSSLMAEGGLESALQHAIRLESSSCSAD------ 1075
Fly 1076 ------------------------CGDGVH-------LPLLQLITRLLSNNAALSQTRLSPTLGK 1109
Fly 1110 QQEKEEEER-------EQQHQEPSTSPSLSLLHRFQRLLLSHIHQAQ---PEEETTGAEALLLQY 1164
Fly 1165 MHALIPACVATLQKAHELALQCREPGE---------NSFGQMVGHLGRVLQADISDALLNELLVG 1220
Fly 1221 LLLLKRDRPQ---------CLGGLRWARLFLPLLRVLDRLNRALGEGELRDGDDMGWPGII---- 1272
Fly 1273 ----CRGGPKGGPPPADPETHYVRRADMENLLLDGSRCIILAGYVCDLSGYNCESETLRSVLDSG 1333
Fly 1334 LGKDLTAEMSSQVHRTAMEHILEHHKLGKYMVQASTEEKSSAPGPSRLTH--FSSECALAQLLGL 1396
Fly 1397 VANLMCSGPALQPAELQCRQLDKSSLLSGGLQLLQPSNPFDEEKGEARSSHSCHSTAGNTPTELP 1461
Fly 1462 PPLPMQQQLAPGRGKSQLQLRADAFISGLAEARVSEPPVAAWLALTERYCKAHNLMWHQEFATEH 1526
Fly 1527 PVQELERLLSAVLIRHQYLGGLVLNALETEV---------PPPRQLGEIIRLVHQAKWSVVRTRQ 1582
Fly 1583 QLNRSYKEVCAPILERLRFLLYEVRPAISPQQRGLRRLPILQRPPRFKMLVRRLLQELRSSRQPA 1647
Fly 1648 KPE-------------DLLNASIQQEQ----EKKPQSM--PKQELEEQEEEETLLRRLN--ERQI 1691
Fly 1692 HGEGELDP--ALMQDIVDFAL-QDSCDVETARRAMYCQMQRYQLRLAGLQIVQQLLELHGLLDAA 1753
Fly 1754 QYSLLNGFLGLHLKSTSSGGGSTGSGSSLHVLGQLNMISAYQKARLLLAQSRVLDWAVRELRRLV 1818
Fly 1819 NQEQQGHARGKD-----------------STNLGTYVLLKRLPRARFLLSVFGLLAKELGPNELG 1866
Fly 1867 FLINSGLLG---TVLGLLAQT--GGEGATGGQVHGELSILYEDSVLKQKSSKAQL--SGPDLAKL 1924
Fly 1925 MKIGTRIVRGADWKWGDQDGNPPGEGRIISEVGEDGWVRVEWYTGATNSYRMGKEGQYDLQLADS 1989
Fly 1990 ALNVASPTEPEREDVSGSEASPTSDS----HPSKLLRHCAAKLLQILAVGTGLHGAQLDKDALRG 2050
Fly 2051 MTSMFRTII----YPKPSMSNISYA----LGWLNLGFIRAISGDCPRLCLELSTPGWLSHYLSLL 2107
Fly 2108 EQPAG-NEAGVYRQLHCLRLLQLILAQWGAEEEPR-MPALVHQLFATLGRIALHCPGDASLLPTA 2170
Fly 2171 -----EGKARVLLTASHSGSVAEELVALLRRLHTLPSWNPVINSFLAQKLCVAAELLAEQSHSTA 2230
Fly 2231 L------DSEQVFV---LGVLGAMGGHDLRPRVGLHCFH----EGSHMVIASFTPKGRCLLAPGG 2282
Fly 2283 VGSGVGFVKVQLPAVMP-----HLDHTVFSLSRLPMNEMLLNAWTVL--LYGPAPELRELPSSAD 2340
Fly 2341 ----GRLDLALLRAQQLQMAVLHTNGVLYRHQVALRRILKQRA---PGSIY------ASPDEPDR 2392
Fly 2393 SDAESQQPGEQDQQLSSGSGQEPQLLIQCILLRATQASPVKACYSYMDLATAALNCIQSLATQAH 2457
Fly 2458 QELSEGGGVPPNGRALSSPPQPTMVHGVPVYNVARKEQKPSEQVEQKSKWPAAATDAQLIGQIME 2522
Fly 2523 MGFTRRTVELALKQL---SLQAEIMPTPEQIVQWILEHPDVCANTIEEDTLPLASSASSHDPEAD 2584
Fly 2585 SDNECPSSNSTTSSSTSSDTVEGQPMAVSGPAPPVKFESRKDFQTADLYALYVRGLVRPGMTVRC 2649
Fly 2650 CRDFEEIKQGDMGTVLIVDTEGLHDLNVQVDWRNHGSTYWVCFVHIELVEAAQTHHQPRPPP--- 2711
Fly 2712 --IAVGARVRLRTSSLRYGMLCPLRLGRSQGSSAIGVVS--SVRSKQLTVDFPDQPAWQGHINEV 2772
Fly 2773 ELVASQPTSATLPSLGDSCSQMP------------------------------------------ 2795
Fly 2796 -----------------PSDLIEDWSRCIRSLTVSSNEAAAKHLLNGSNQPWQSCSSGPCRHWIR 2843
Fly 2844 LELHDRILVHSLTLKVSPEDHSHMPSLLEIRVGDCVDSLKEYTWIPVPAGASRVLLMQQVPTYYP 2908
Fly 2909 WVEVVVKQCQNNGIQCKIHGIKFVG--RRQQPDLQHILANAQFLASEYSAGV-GPGSTAGAGAVS 2970
Fly 2971 TSHEEAAAAPEQDLPCTVMVWGLNDKEQLGGLKGSKVKVPTFSQTISRLRPIHIAGGSKSLFIVS 3035
Fly 3036 QDGKVYACGEGTNGRLGLGVTH-NVPLPHQLPVLRQYVVKKVAVHSGGKHALALTLDGKVFSWGE 3099
Fly 3100 GEDGKLGHGNRTTLDKPRLVEALRAKKIRDVACGSSHSAAISSQGELYTWGLGEYGRLGHGDNTT 3164
Fly 3165 QLKPKLVTALAGRRVVQVACGSRDAQTLALTEDGAVFSWGDGDFGKLGRGGSEGSDTPHEIERLS 3229
Fly 3230 GIGVVQIECGAQFSLALTRAGEVWTWGKGDYYRLGHGGDQHVRKPQPIGGLRGRRVIHVAVGALH 3294
Fly 3295 CLAVTDAGQVYAWGDNDHGQQGSGNTFVNKKPALVIGLDAVFVNRVACGSSHSIAWGLPNASSDE 3359
Fly 3360 EKRGPVPFSSTRDPLGGSSLGI-YEAETMQTLKQ-----EAKPLNQSSLSE-SLALETPAARQAA 3417
Fly 3418 LGHVLRAMSILQARQLIVAALTSHSKVNFKERGAVGGEEDHLIGGPIMGAPLQLAETIAQGGGEA 3482
Fly 3483 PADATDAGLQEHSPEAAVDALTGGMSGGANTLPPLSAGPLS--AFQSLTGSLSMSGSLSSSALPQ 3545
Fly 3546 HKHSRMS---------ASAMSVMAATMTQQEEMLSHISHCHG-----LDDFGGLLGEPEAKSLVE 3596
Fly 3597 LLKLAVCGRCGPPSTSQTIADTLISLGAGTPAVAAMLLETCITELEDLCTSRHCLGKL-PKPVMQ 3660
Fly 3661 ESSHPYVDNVNVTGVVRIPGAEMLRLEFDSQCSTEKRNDPLVIMDGTGRVLAMRSGREFAHWAPE 3725
Fly 3726 IRVLGDELRWKFSSDSSVNGWGWRFWVHAIMPAATLGESGSDRAVLSQPSMALVMSLLDSRL-AP 3789
Fly 3790 RQPSVLLRLASALAACSQLGALTTAQRIWSLRKLHAVLLLE------------------QAPRPQ 3836
Fly 3837 DPSLSTLLQPLIPELLRQYEYEEPQVRGGIHLMHSDYFKTLAALACDMQLDAALPATSSSSSSSA 3901
Fly 3902 APGAISSTGDVHKWAWFKRYCIAVRVAQSLIRRTELPRAFCLEVRKKFAEMLPSSSSNSNANPGC 3966
Fly 3967 QSPGASMLNSTTSLSSSTVSNVSPPPGITGEQPDLHCHAHQLESTSTLLHEDHTLFQAPHDAQLL 4031
Fly 4032 QWLNRRPDDWALSWGGASTIYGWGHNHRGQLGGLEGSRIKTPTPCEALSLLRPVQLAGGEQSLFA 4096
Fly 4097 VTPDGKLFATGYGSGGRLGVGGSDSWAIPTLLGSLQHVFVKKVAVNSGGKHCLALTTEGEVYAWG 4161
Fly 4162 EGEDGKLGHGNRMSYDRPKLVEHLNGMSVADIACGSAHSAAITASGHVLTWGKGRYGRLGHGDSE 4226
Fly 4227 DQLRPKLVEALLGYRAIDIACGSGDAQTLCITDDDNVWSWGDGDYGKLGRGGSDGCKLPYKIESL 4291
Fly 4292 AGLGVVKVECGSQFSVALTKSGAVYTWGKGDFHRLGHGSVDHVRRPKKVAALQGKKIISIATGSL 4356
Fly 4357 HCVACSDSGEVYTWGDNDEGQLGDGTVTAIQRPRLVAALQGKHIVKVTCGSAHTLALSTSQLSER 4421
Fly 4422 LRPLPNPPLEYDLVRDLAPEALHARLILLHHFSELVCPCLAMLPISGDL-------SLG--ALKD 4477
Fly 4478 VLVYNIKEAAFRKVIQTTMVRDKQHGPVIELNRIQVKRSRNRCNGLAGIDGMKSVFGQMVQKLPL 4542
Fly 4543 LTQEALALPHRVWKVKFVGESVDDCGGGYSESIAEMCDELQNGSVPLLINTPNGRGEAGANRDCF 4607
Fly 4608 LLDPTLSSVLQMNMFRFLGVLMGIAVRTGSPLSINLAEPVWRQLTGEVLRPTDLTEVDRDYVAGL 4672
Fly 4673 LCIRNMDDDPKLFTALELPFSTSSARGHEVPLSTRYTHISPRNRAEYVRLALGFRLHEFDEQVKA 4737
Fly 4738 VRDGMSKVIPVPLLSLFSAAELQAMVCGSPDIPLGLLKSVATYKGFDPSSALVTWFWEVMEEFTN 4802
Fly 4803 QERSLFLRFVWGRTRLPRTIADFRGRDFVLQVLEK-NPPDHFLPESYTCFFLLKMPRYSCKAVLL 4866
Fly 4867 EKLKYAIHFCKSIDTDEYARVAM-GEPTEATGSE--DNSDLESVAS 4909 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
HERC2 | NP_608388.2 | RCC1 | 638..683 | CDD:278826 | 22/49 (45%) |
RCC1 | 687..737 | CDD:278826 | 29/49 (59%) | ||
RCC1 | 740..787 | CDD:278826 | 25/48 (52%) | ||
RCC1 | 790..841 | CDD:278826 | 21/52 (40%) | ||
RCC1_2 | 828..857 | CDD:290274 | 14/28 (50%) | ||
Cyt-b5 | 1290..1363 | CDD:278597 | 16/72 (22%) | ||
MIB_HERC2 | 1928..1987 | CDD:284184 | 44/58 (76%) | ||
UBA_HERC2 | 2515..2559 | CDD:270585 | 20/46 (43%) | ||
Cul7 | 2624..2699 | CDD:288381 | 42/74 (57%) | ||
APC10-HERC2 | 2762..2932 | CDD:176485 | 66/228 (29%) | ||
RCC1 | 3037..3088 | CDD:278826 | 34/51 (67%) | ||
RCC1 | 3091..3140 | CDD:278826 | 37/48 (77%) | ||
RCC1 | 3144..3194 | CDD:278826 | 43/49 (88%) | ||
RCC1 | 3197..3246 | CDD:278826 | 38/48 (79%) | ||
RCC1 | 3250..3298 | CDD:278826 | 36/47 (77%) | ||
RCC1 | 3302..3350 | CDD:278826 | 34/47 (72%) | ||
RCC1_2 | 4136..4166 | CDD:290274 | 24/29 (83%) | ||
RCC1 | 4154..4203 | CDD:278826 | 32/48 (67%) | ||
RCC1 | 4206..4257 | CDD:278826 | 41/50 (82%) | ||
RCC1 | 4260..4309 | CDD:278826 | 43/48 (90%) | ||
RCC1 | 4312..4360 | CDD:278826 | 39/47 (83%) | ||
RCC1 | 4364..4413 | CDD:278826 | 40/48 (83%) | ||
HECTc | 4509..4880 | CDD:238033 | 266/371 (72%) | ||
HECTc | 4553..4878 | CDD:214523 | 237/325 (73%) | ||
Herc2 | NP_001347009.1 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 58..90 | 10/54 (19%) | |
RCC1 1-1 | 416..462 | 10/60 (17%) | |||
RCC1 1-2 | 463..513 | 16/49 (33%) | |||
ATS1 | <494..787 | CDD:227511 | 132/299 (44%) | ||
RCC1 1-3 | 514..569 | 24/55 (44%) | |||
RCC1 1-4 | 570..621 | 29/50 (58%) | |||
RCC1 1-5 | 624..675 | 27/50 (54%) | |||
RCC1 1-6 | 676..727 | 23/54 (43%) | |||
RCC1 1-7 | 729..779 | 18/51 (35%) | |||
Cyt-b5 | 1212..1283 | CDD:365921 | 16/70 (23%) | ||
MIB_HERC2 | 1871..1930 | CDD:369043 | 44/58 (76%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 2351..2376 | 8/25 (32%) | |||
UBA_HERC2 | 2461..2508 | CDD:270585 | 20/46 (43%) | ||
Cul7 | 2555..2632 | CDD:371573 | 42/84 (50%) | ||
SH3_15 | 2640..2697 | CDD:375773 | 18/61 (30%) | ||
ZZ_HERC2 | 2707..2751 | CDD:239084 | 4/47 (9%) | ||
APC10-HERC2 | 2766..2911 | CDD:176485 | 54/145 (37%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 2928..2947 | 5/18 (28%) | |||
ATS1 | 2957..3323 | CDD:227511 | 270/369 (73%) | ||
RCC1 2-1 | 2959..3010 | 34/50 (68%) | |||
RCC1 2-2 | 3011..3065 | 36/53 (68%) | |||
RCC1 2-3 | 3066..3117 | 38/50 (76%) | |||
RCC1 2-4 | 3119..3169 | 43/49 (88%) | |||
RCC1 2-5 | 3172..3223 | 40/50 (80%) | |||
RCC1 2-6 | 3225..3275 | 38/49 (78%) | |||
RCC1 2-7 | 3276..3327 | 36/50 (72%) | |||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 3479..3499 | 4/19 (21%) | |||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 3517..3537 | 2/19 (11%) | |||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 3604..3632 | 12/28 (43%) | |||
RCC1 3-1 | 3953..4004 | 39/50 (78%) | |||
RCC1 3-2 | 4006..4058 | 40/51 (78%) | |||
ATS1 | 4025..4330 | CDD:227511 | 235/304 (77%) | ||
RCC1 3-3 | 4060..4110 | 31/49 (63%) | |||
RCC1 3-4 | 4112..4164 | 42/51 (82%) | |||
RCC1 3-5 | 4166..4216 | 44/49 (90%) | |||
RCC1 3-6 | 4218..4268 | 40/49 (82%) | |||
RCC1 3-7 | 4270..4320 | 41/49 (84%) | |||
HECTc | 4423..4794 | CDD:238033 | 266/371 (72%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 4806..4836 | 10/21 (48%) |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 1 | 0.930 | - | - | C167849542 | |
Domainoid | 1 | 1.000 | 475 | 1.000 | Domainoid score | I439 |
eggNOG | 1 | 0.900 | - | - | E1_COG5184 | |
Hieranoid | 1 | 1.000 | - | - | ||
Homologene | 1 | 1.000 | - | - | H3430 | |
Inparanoid | 1 | 1.050 | 3580 | 1.000 | Inparanoid score | I10 |
Isobase | 0 | 0.000 | Not matched by this tool. | |||
OMA | 1 | 1.010 | - | - | QHG50139 | |
OrthoDB | 1 | 1.010 | - | - | D1062377at2759 | |
OrthoFinder | 1 | 1.000 | - | - | FOG0007465 | |
OrthoInspector | 1 | 1.000 | - | - | oto93928 | |
orthoMCL | 1 | 0.900 | - | - | OOG6_102650 | |
Panther | 1 | 1.100 | - | - | LDO | PTHR22870 |
Phylome | 1 | 0.910 | - | - | ||
RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R4599 |
SonicParanoid | 1 | 1.000 | - | - | X6340 | |
SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
TreeFam | 1 | 0.960 | - | - | ||
16 | 15.800 |