DRSC/TRiP Functional Genomics Resources

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Protein Alignment HERC2 and Herc2

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:NP_001347009.1 Gene:Herc2 / 15204 MGIID:103234 Length:4836 Species:Mus musculus


Alignment Length:5181 Identity:2235/5181 - (43%)
Similarity:2980/5181 - (57%) Gaps:718/5181 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    79 LDAKWLRADL-IASLRNAADGAVLWNHLIQDCELVSSPTAPLLNARGQLSYLGDDGKHYCGAQQL 142
            ||:|||:.|: :|..|:...|  |||.:::|.|:|.:.|.  |....:|....|||   ..||  
Mouse    14 LDSKWLKTDIQLAFTRDGLCG--LWNEMVKDGEIVYTGTE--LAQNRELPLRKDDG---VDAQ-- 69

  Fly   143 KCSCCQPEYCGPLSACNCDGCRPLDSDTAIKKLTTQAAAQQAAHLSQATDMVLSGWLWSQPPSQQ 207
                              .|.:..|.:...||...:..|......|     :|..|:|.:.|...
Mouse    70 ------------------SGTKKEDLNDKEKKEEEETPAPVYRAKS-----ILESWVWGRQPDVN 111

  Fly   208 ARLDCQRSMISELQELALRAAGNCLSAQHLRQQLFIYERYFVALKRERERERKSTTSAQAVASVT 272
            ...:|...::.|.|.||:::|...|||..|:|:|.|.||||:||.|                  |
Mouse   112 ELKECLSVLVKEQQALAVQSATTTLSALRLKQRLVILERYFIALNR------------------T 158

  Fly   273 TANTTIAATTANAAVESQPAEQQAE----HGALGLARVATHAALNFSFAFLRRAWRSGEDTEMCS 333
            .....:.....::::...|.|:::.    .|..|||||.:.|||:|:|||||||||||||.::||
Mouse   159 VFQENVKVKWKSSSISVPPTEKKSARPTGRGVEGLARVGSRAALSFAFAFLRRAWRSGEDADLCS 223

  Fly   334 ELLSEALASLQELPEATLFEAAVVSSLWLEVMERSIKFLRLVALGDPMGNRCT-----APLNDRH 393
            |||.|:|.:|:.||||:||:.:.|||:||||:||:.:|||.|..||..|...|     .||.|:|
Mouse   224 ELLQESLDALRALPEASLFDESTVSSVWLEVVERATRFLRSVVTGDVHGTPGTKGPGGVPLQDQH 288

  Fly   394 TALCLLLELGVQKGTLAATLECVVLLLLLWEKDRAGNDNRDMPRKTGAPLQRILLRYQKI----- 453
            .||.:||||.||:|||:..|..::|||.||:......||....:.|.|||..:|.|:|.|     
Mouse   289 LALAILLELAVQRGTLSQMLSAILLLLQLWDSGAQETDNERSAQGTSAPLLPLLQRFQSIICSKD 353

  Fly   454 -GATAKGGGIAGGEPAPVASATETFLRFLSLPKSSAAIVDLRRAAVVIISHLDRMVQPLMPRCLL 517
             ..|.....:..|..:|    .|:|||:|:||:.:...:|||:.|||:::||||:..|.||..  
Mouse   354 VPHTESDMHLLSGPLSP----NESFLRYLTLPQDNELAIDLRQTAVVVMAHLDRLATPCMPPL-- 412

  Fly   518 RGGQATAASSSSAPQQRIYALGWPSLSKDQQGFSAEPTLSWSGESAGVPTLSCR----FQIKQVA 578
                .::.:|.....|.:  :||             ..:.|...:..:..:.|.    ..:.|||
Mouse   413 ----CSSPTSHKGSLQEV--IGW-------------GLIGWKYYANVIGPIQCEGLASLGVMQVA 458

  Fly   579 CCETQMLILSQEGKLYTWRLAKPEAEPLPMEEVAHDVFISIAGHCEGRHFLAIDSNHNAYSWGTG 643
            |.|.:.||||:.|::||.........|..::.:|....:.||.|.:|.|:||:.:....||||.|
Mouse   459 CAEKRFLILSRNGRVYTQAYNSDMLAPQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCG 523

  Fly   644 EDHRLGHGDTHARAVPTKIAALE-----QHCVQSVYCGCSYSAAITCGGNLLTWGRGTYARLGHG 703
            :..|||||||.....|..|:|..     :|.|. :.||.:||||||..|.|.|||||.|.|||||
Mouse   524 DGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVH-IACGSTYSAAITAEGELYTWGRGNYGRLGHG 587

  Fly   704 NSDDRSLPTLVVALSDHMVVDVALGSGDAHSLALTSEGLVFAWGDGDYGKLGNGNCNGSLQPILV 768
            :|:|.::|.||..|....|:|||.|||||.:||:|..|.|::||||||||||.|..:|...|.|:
Mouse   588 SSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLI 652

  Fly   769 ESLP--RVQRVFAGSQFSVALSSEGQLYTWGKA--TCLGHQLVERSVQGCSVPRLVSSLQHKRIV 829
            |.|.  .|.:|..|||||:||:.:||:|:|||.  ..|||...|.    ...|:|:..||.|:::
Mouse   653 EKLQDLDVIKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEH----VRYPKLLEGLQGKKVI 713

  Fly   830 DVAVSVAHCLALSSSGEVFGWGRNDSQQICPASVSSEPLLRTPILVSLPTFPASGIACTSAQSLV 894
            |||....|||||:...||..||.||..|.......::|  ....|..|.:....||||..|||..
Mouse   714 DVAAGSTHCLALTEDSEVHSWGSNDQCQHFDTLRVTKP--EPTALPGLDSKHIVGIACGPAQSFA 776

  Fly   895 WTQSSHQGVPRRAPFVVDLGEPTFRLLDQLL-----GMCSSQDNRQTPNQESECIAVACLNLFRL 954
            |:..|...:..|.|||||:...||..||.||     ||..:.|  ..|.||.||:|||.|||.||
Mouse   777 WSSCSEWSIGLRVPFVVDICSMTFEQLDLLLRQVSEGMDGTAD--WPPPQEKECMAVATLNLLRL 839

  Fly   955 QLLALIANGVEPRQVGLASGSRLLCSLKTRILGLAGGSQVLRTIQVAAQQALQDGWSVLLPTAAE 1019
            ||.|.|::.|:|..:||..||.||.|||..::.||..:.||.|:|.|||..||.|||||||||.|
Mouse   840 QLHAAISHQVDPEFLGLGLGSVLLNSLKQTVVTLASSAGVLSTVQSAAQAVLQSGWSVLLPTAEE 904

  Fly  1020 RAQTLTSLLP---SEPGQASSAGHRFMTDLLVSSLMAEGGLESALQHAIRLESSSCSAD------ 1075
            ||:.|::|||   |......|.|.|||.||||.||||:|||||||..||..|.....|.      
Mouse   905 RARALSALLPCTVSGNEVNISPGRRFMIDLLVGSLMADGGLESALNAAITAEIQDIEAKKEAQKE 969

  Fly  1076 ------------------------CGDGVH-------LPLLQLITRLLSNNAALSQTRLSPTLGK 1109
                                    ...|::       |||:|||.:||.|.|:.:..||      
Mouse   970 KEIDEQEASASTFHRSRTPLDKDLINTGIYESSGKQCLPLVQLIQQLLRNIASQTVARL------ 1028

  Fly  1110 QQEKEEEER-------EQQHQEPSTSPSLSLLHRFQRLLLSHIHQAQ---PEEETTGAEALLLQY 1164
               |:...|       |||..|  .|.||.||.||||||:|.::..:   |..:|:..|.:    
Mouse  1029 ---KDVARRISSCLDFEQQSCE--RSASLDLLLRFQRLLISKLYPGEKIGPISDTSSPELM---- 1084

  Fly  1165 MHALIPACVATLQKAHELALQCREPGE---------NSFGQMVGHLGRVLQADISDALLNELLVG 1220
                   .|.:|.|.: .||.|...|:         :|..|....:..|::.|.:..||.||:|.
Mouse  1085 -------GVGSLLKKY-TALVCTHIGDILPVAASIASSSWQHFAEVACVMEGDFTGVLLPELVVS 1141

  Fly  1221 LLLLKRDRPQ---------CLGGLRWARLFLPLLRVLDRLNRALGEGELRDGDDMGWPGII---- 1272
            ::||......         .|||         ||..|||.|......|..|.:::.||||:    
Mouse  1142 IVLLLSKNASLMQEAGAIPLLGG---------LLEHLDRFNHLAPGKERDDHEELAWPGIMESFF 1197

  Fly  1273 ----CRGGPKGGPPPADPETHYVRRADMENLLLDGSRCIILAGYVCDLSGYNCESETLRSVLDSG 1333
                ||.         :.|...:|:||:||...||....::.|.|..:..:..:|.|..|:|...
Mouse  1198 TGQNCRN---------NEEVTLIRKADLENHNKDGGFWTVIDGKVYGIKDFQTQSLTGNSILAQF 1253

  Fly  1334 LGKDLTAEMSSQVHRTAMEHILEHHKLGKYMVQASTEEKSSAPGPSRLTH--FSSECALAQLLGL 1396
            .|:|....:.:.:.....:..:....:|:|:  ...:|..:.|....|:.  ..:|..|..||||
Mouse  1254 AGEDPVVALEAALQFEDTQESMHAFCVGQYL--EPDQEVVTIPDLGSLSSPLIDTERNLGLLLGL 1316

  Fly  1397 VANLMCSGPALQPAELQCRQLDKSSLLSGGLQLLQPSNPFDEEKGEARSSHSCHSTAGNTPTELP 1461
            .|:.:.....|.|.|::|.:..:||:.|||||..|....::|||.|   .| | |:.|.||..  
Mouse  1317 HASYLAMSTPLSPVEVECAKWLQSSIFSGGLQTSQIHYSYNEEKDE---DH-C-SSPGGTPIS-- 1374

  Fly  1462 PPLPMQQQLAPGRGKSQLQLRADAFISGLAEARVSEPPVAAWLALTERYCKAHNLMWHQEFATEH 1526
                 :.:|...|.  .|...:.||:..:|:..:.:..|..:|...||||:..:|.....|..||
Mouse  1375 -----KSRLCSHRW--ALGDHSQAFLQAIADNNIQDYNVKDFLCQIERYCRQCHLTTPITFPPEH 1432

  Fly  1527 PVQELERLLSAVLIRHQYLGGLVLNALETEV---------PPPRQLGEIIRLVHQAKWSVVRTRQ 1582
            ||:|:.|||...|::|:.||.:.|:.:....         ..|:.:.::.|:|:|||.|:::|.|
Mouse  1433 PVEEVGRLLLCCLLKHEDLGHVALSLVHVGTLGIEQVKHRTLPKSVVDVCRVVYQAKCSLIKTHQ 1497

  Fly  1583 QLNRSYKEVCAPILERLRFLLYEVRPAISPQQRGLRRLPILQRPPRFKMLVRRLLQELRSSRQPA 1647
            :..|||||||||::||||||..|:|||:......:.:..:|...||::.:.:::::|.|..|.|.
Mouse  1498 EQGRSYKEVCAPVIERLRFLFNELRPAVCSDLSIMSKFKLLGSLPRWRRIAQKIIRERRKKRVPK 1562

  Fly  1648 KPE-------------DLLNASIQQEQ----EKKPQSM--PKQELEEQEEEETLLRRLN--ERQI 1691
            |||             ||..|.:....    :|:|.||  ||.:.:......|.:.:..  ::.:
Mouse  1563 KPESIDSEEKIGNEESDLEEACVLPHSPINVDKRPISMKSPKDKWQPLLNTVTGVHKYKWLKQNV 1627

  Fly  1692 HGEGELDP--ALMQDIVDFAL-QDSCDVETARRAMYCQMQRYQLRLAGLQIVQQLLELHGLLDAA 1753
            .|   |.|  ||:..||:||| ::..|||..|:.:..|::|.::||.|:..:.:|.....||.:.
Mouse  1628 QG---LYPQSALLNTIVEFALKEEPVDVEKMRKCLLKQLERAEVRLEGIDTILKLAAKSFLLPSV 1689

  Fly  1754 QYSLLNGFLGLHLKSTSSGGGSTGSGSSLHVLGQLNMISAYQKARLLLAQSRVLDWAVRELRRLV 1818
            ||::..|:..|..:....|...|      ..|..:::|..:.:..|.:...::..|||:.:|.::
Mouse  1690 QYAMFCGWQRLIPEGIDIGEPLT------DCLRDVDLIPPFNRMLLEVTFGKLYAWAVQNIRSVL 1748

  Fly  1819 NQEQQGHARGKD-----------------STNLGTYVLLKRLPRARFLLSVFGLLAKELGPNELG 1866
               ....||.|:                 ..:|||      :|:|||||.:..:|..:.|.|.|.
Mouse  1749 ---MDASARFKELGIQPVPLQTITNENPAGPSLGT------IPQARFLLVMLSMLTLQHGANNLD 1804

  Fly  1867 FLINSGLLG---TVLGLLAQT--GGEGATGGQVHGELSILYEDSVLKQKSSKAQL--SGPDLAKL 1924
            .|:|||.|.   |.|.|:..|  ..|........|..:.:.|::  :::::..||  |||:||.:
Mouse  1805 LLLNSGTLALTQTALRLIGPTCDSVEDDMNASARGASATVLEET--RKETAPVQLPVSGPELAAM 1867

  Fly  1925 MKIGTRIVRGADWKWGDQDGNPPGEGRIISEVGEDGWVRVEWYTGATNSYRMGKEGQYDLQLADS 1989
            ||||||::||.|||||||||.|||.||:|.|:|||||:||:|.||:||||||||||:|||:|.: 
Mouse  1868 MKIGTRVMRGVDWKWGDQDGPPPGLGRVIGELGEDGWIRVQWDTGSTNSYRMGKEGKYDLKLVE- 1931

  Fly  1990 ALNVASPTEPEREDVSGSEASPTSDS----HPSKLLRHCAAKLLQILAVGTGLHGAQLDKDALRG 2050
             |.|:|  :|..||....:.|.....    ||:.::......|||.|.:..|:|...:..:|.:.
Mouse  1932 -LPVSS--QPSAEDSDTEDDSEAEQGERNIHPTAMMLTSVINLLQTLCLSVGVHADIMQSEATKT 1993

  Fly  2051 MTSMFRTII----YPKPSMSNISYA----LGWLNLGFIRAISGDCPRLCLELSTPGWLSHYLSLL 2107
            :..:.|.::    ..||:..:...|    ..|..|||:|:|: ..|:.|..||:|.|::..:.::
Mouse  1994 LCGLLRMLVESGTTDKPAPPDRLVAREQHRSWCTLGFVRSIA-LTPQACGALSSPRWITLLMKVV 2057

  Fly  2108 EQPAG-NEAGVYRQLHCLRLLQLILAQWGAEEEPR-MPALVHQLFATLGRIALHCPGDASLLPTA 2170
            |..|. ..|.:.||:..:.|||.:|..|...|..| |..||.:||..||.:...|..|..||..:
Mouse  2058 EGHAPFTAASLQRQILAVHLLQAVLPSWDKTERARDMKCLVEKLFGFLGSLLTTCSSDVPLLRES 2122

  Fly  2171 -----EGKARVLLTASHSGSVAEELVALLRRLHTLPSWNPVINSFLAQKLCVAAELLAEQSHSTA 2230
                 ..:.:..|||:||.::|||:|.|||.||:|..||.:||.::..:||...:..|.::...|
Mouse  2123 TLRKRRARPQASLTATHSSTLAEEVVGLLRTLHSLTQWNGLINKYINSQLCSVTQSYAGKTSERA 2187

  Fly  2231 L------DSEQVFV---LGVLGAMGGHDLRPRVGLHCFH----EGSHMVIASFTPKGRCLLAPGG 2282
            .      |||.:.|   :.||..:||.|.|.|:|....|    ||:   :...|||||..     
Mouse  2188 QLEDYFPDSENLEVGGLMAVLAVIGGIDGRLRLGGQVMHDEFGEGT---VTRITPKGRIT----- 2244

  Fly  2283 VGSGVGFVKVQLPAVMP-----HLDHTVFSLSRLPMNEMLLNAWTVL--LYGPAPELRELPSSAD 2340
                |.|..:::..|.|     .|....||::.||..|.:|:.|..|  |.|...|..:...||.
Mouse  2245 ----VQFCDMRMCRVCPLNQLKPLPAVAFSVNNLPFTEPMLSVWAELVNLAGSKLEKHKTKKSAK 2305

  Fly  2341 ----GRLDLALLRAQQLQMAVLHTNGVLYRHQVALRRILKQRA---PGSIY------ASPDEPDR 2392
                |::||.|||:|||::.:|.....|..||..||:||.|.|   .|::.      ||||..|.
Mouse  2306 PAFAGQVDLDLLRSQQLKLYILKAGRALLSHQDKLRQILSQPAVQGTGTLQTDDGAAASPDLGDM 2370

  Fly  2393 SDAESQQPGEQDQQLSSGSGQEPQLLIQCILLRATQASPVKACYSYMDLATAALNCIQSLATQAH 2457
            | .|..||              |.:|:|.:|..|||.|||||.:...:|..|||...|.||.::.
Mouse  2371 S-PEGPQP--------------PMILLQQLLSSATQPSPVKAIFDKQELEAAALALCQCLAVEST 2420

  Fly  2458 QELSEGGGVPPNGRALSSPPQPTMVHGVPVYNVARKEQKPSEQVEQKSKWPAAATDAQLIGQIME 2522
            ...|.|    ....:.|....|..|..:.:....::.|.|:         ||    ..::.|:||
Mouse  2421 HPSSPG----CEDCSSSEATTPVSVQHIHLARAKKRRQSPA---------PA----LPIVVQLME 2468

  Fly  2523 MGFTRRTVELALKQL---SLQAEIMPTPEQIVQWILEHPDVCANTIEEDTLPLASSASSHDPEAD 2584
            |||.|:.:|.|||.|   |..|..:|..|.:|.|:|:|.||.. |...|...|:...|..:...|
Mouse  2469 MGFPRKNIEFALKSLTGTSGNASGLPGVEALVGWLLDHSDVQV-TEFSDAETLSDEYSDEEVVED 2532

  Fly  2585 SDNECPSSNSTTSSSTSSDTVEGQPMAVSGPAPPVKFESRKDFQTADLYALYVRGLVRPGMTVRC 2649
            .| :.|...:..:..|.|.|                ::.|.||.:.|.||:|||..|:.||.|||
Mouse  2533 VD-DTPYPVAAGAVVTESQT----------------YKKRADFLSNDDYAVYVRENVQVGMMVRC 2580

  Fly  2650 CRDFEEIKQGDMGTVLIVDTEGLHDLNVQVDWRNHGSTYWVCFVHIELVEAAQTHHQPRPPP--- 2711
            ||.:||:.:||:|.|:.:|.:||||||||.||:..|.||||.::|:||:        ..|||   
Mouse  2581 CRTYEEVCEGDVGKVIKLDRDGLHDLNVQCDWQQKGGTYWVRYIHVELI--------GYPPPSSS 2637

  Fly  2712 --IAVGARVRLRTSSLRYGMLCPLRLGRSQGSSAIGVVS--SVRSKQLTVDFPDQPAWQGHINEV 2772
              |.:|.:||::.|     :..|.....|....::|:|.  |...|.:.||||.|..|.|.::|:
Mouse  2638 SHIKIGDKVRVKAS-----VTTPKYKWGSVTHQSVGLVKAFSANGKDIIVDFPQQSHWTGLLSEM 2697

  Fly  2773 ELVASQPTSATLPSLGDSCSQMP------------------------------------------ 2795
            |||.|.....|.    |.|...|                                          
Mouse  2698 ELVPSIHPGVTC----DGCQTFPINGSRFKCRNCDDFDFCETCFKTKKHNTRHTFGRINEPGQSA 2758

  Fly  2796 -----------------PSDLIEDWSRCIRSLTVSSNEAAAKHLLNGSNQPWQSCSSGPCRHWIR 2843
                             |..|::.|||.::||.|||:...|..|::||...||| |....:||||
Mouse  2759 VFCGRSGKQLKRCHSSQPGMLLDSWSRMVKSLNVSSSVNQASRLIDGSEPCWQS-SGSQGKHWIR 2822

  Fly  2844 LELHDRILVHSLTLKVSPEDHSHMPSLLEIRVGDCVDSLKEYTWIPVPAGASRVLLMQQVPTYYP 2908
            ||:...:|||.|.:.|.|.|.|:||||:.:..|:.:::|.|...|.:....:.|.|:.....|:.
Mouse  2823 LEIFPDVLVHRLKMIVDPADSSYMPSLVVVSGGNSLNNLIELKTININQTDTTVPLLSDCAEYHR 2887

  Fly  2909 WVEVVVKQCQNNGIQCKIHGIKFVG--RRQQPDLQHILANAQFLASEYSAGV-GPGSTAGAGAVS 2970
            ::|:.:|||:::||.|||||:..:|  |.::.|    ||...||||:..... ..|||.......
Mouse  2888 YIEIAIKQCRSSGIDCKIHGLILLGRIRAEEED----LAAVPFLASDNEEEEDDKGSTGSLIRKK 2948

  Fly  2971 TSHEEAAAAPEQDLPCTVMVWGLNDKEQLGGLKGSKVKVPTFSQTISRLRPIHIAGGSKSLFIVS 3035
            |...|:.|.    :...|.|||||||:|||||||||:|||:||:|:|.|..:.:||||||||.|:
Mouse  2949 TPGLESTAT----IRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVT 3009

  Fly  3036 QDGKVYACGEGTNGRLGLGVTH-NVPLPHQLPVLRQYVVKKVAVHSGGKHALALTLDGKVFSWGE 3099
            .:||||:|||.||||||||::. .||:|.|:..|..||||||||||||:||.|||:|||||||||
Mouse  3010 VEGKVYSCGEATNGRLGLGMSSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGE 3074

  Fly  3100 GEDGKLGHGNRTTLDKPRLVEALRAKKIRDVACGSSHSAAISSQGELYTWGLGEYGRLGHGDNTT 3164
            |:||||||.:|...|||||:|||:.|:|||:|||||||||::|.|||||||||||||||||||||
Mouse  3075 GDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTT 3139

  Fly  3165 QLKPKLVTALAGRRVVQVACGSRDAQTLALTEDGAVFSWGDGDFGKLGRGGSEGSDTPHEIERLS 3229
            |||||:|..|.|.||:|||||||||||||||::|.|||||||||||||||||||.:.|..||||:
Mouse  3140 QLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLN 3204

  Fly  3230 GIGVVQIECGAQFSLALTRAGEVWTWGKGDYYRLGHGGDQHVRKPQPIGGLRGRRVIHVAVGALH 3294
            |.||.|||||||||||||::|.|||||||||:|||||.|.||||||.:.||||::::||||||||
Mouse  3205 GQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALH 3269

  Fly  3295 CLAVTDAGQVYAWGDNDHGQQGSGNTFVNKKPALVIGLDAVFVNRVACGSSHSIAWGLPNASSDE 3359
            ||||||:|||||||||||||||:|.|.||:||.||.||:...:.|||||||||:||...:.::..
Mouse  3270 CLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHSVAWTTVDVATPS 3334

  Fly  3360 EKRGPVPFSSTRDPLGGSSLGI-YEAETMQTLKQ-----EAKPLNQSSLSE-SLALETPAARQAA 3417
            ... ||.|.:.|||||.|.||: .:|::..:..:     ..|| |:.||:: .|:||...|:|.|
Mouse  3335 VHE-PVLFQTARDPLGASYLGVPSDADSSSSSNKISGANNCKP-NRPSLAKILLSLEGNLAKQQA 3397

  Fly  3418 LGHVLRAMSILQARQLIVAALTSHSKVNFKERGAVGGEEDHLIGGPIMGAPLQLAETIAQGGGEA 3482
            |.|:|.|:.|:.||..:|.||....                      |.||:           |.
Mouse  3398 LSHILTALQIMYARDAVVGALMPAG----------------------MLAPV-----------EC 3429

  Fly  3483 PADATDAGLQEHSPEAAVDALTGGMSGGANTLPPLSAGPLS--AFQSLTGSLSMSGSLSSSALPQ 3545
            |:.::.|      |.:.|.|:...|....:||.......||  .:|.....:|...:::.||:..
Mouse  3430 PSFSSSA------PASDVSAMASPMHMEDSTLAADLEDRLSPNLWQEKREIVSSEDAVTPSAVTP 3488

  Fly  3546 HKHSRMS---------ASAMSVMAATMTQQEEMLSHISHCHG-----LDDFGGLLGEPEAKSLVE 3596
            ...|..|         ..|.|::|.|||:.:|.:...:...|     ||:|..||...:.:.:||
Mouse  3489 SAPSASSRPFIPVTDDPGAASIIAETMTKTKEDVESQNKTSGPEPQSLDEFTSLLIPDDTRVVVE 3553

  Fly  3597 LLKLAVCGRCGPPSTSQTIADTLISLGAGTPAVAAMLLETCITELEDLCTSRHCLGKL-PKPVMQ 3660
            ||||:||.|.|... .:.::..|..:|...|.||.||||.|:|||||:.|.... |:| .:||:.
Mouse  3554 LLKLSVCSRAGDKG-REVLSAVLSGMGTAYPQVADMLLELCVTELEDVATDSQS-GRLSSQPVVV 3616

  Fly  3661 ESSHPYVDNVNVTGVVRIPGAEMLRLEFDSQCSTEKRNDPLVIMDGTGRVLAMRSGREFAHWAPE 3725
            ||||||.|:.:.:|.|:|||||.||:|||.|||||:|:|||.:|||..|::::|||||::.|:.|
Mouse  3617 ESSHPYTDDTSTSGTVKIPGAEGLRVEFDRQCSTERRHDPLTVMDGVNRIVSVRSGREWSDWSSE 3681

  Fly  3726 IRVLGDELRWKFSSDSSVNGWGWRFWVHAIMPAATLGESGSDRAVLSQPSMALVMSLLDSRL-AP 3789
            :|:.||||:|||.||.|||||||||.|:.|||||...:..|||.|||.|||.||..|||.|| ..
Mouse  3682 LRIPGDELKWKFISDGSVNGWGWRFTVYPIMPAAGPKDLLSDRCVLSCPSMDLVTCLLDFRLNLT 3746

  Fly  3790 RQPSVLLRLASALAACSQLGALTTAQRIWSLRKLHAVLLLE------------------QAPRPQ 3836
            ...|::.|||::||||:||.||..:.|:|:|::|..:|..|                  :|....
Mouse  3747 SNRSIVPRLAASLAACAQLSALAASHRMWALQRLRRLLTTEFGQSININRLLGENDGESRALSFT 3811

  Fly  3837 DPSLSTLLQPLIPELLRQYEYEEPQVRGGIHLMHSDYFKTLAALACDMQLDAALPATSSSSSSSA 3901
            ..:|:.|::.|...|.||:|||:|.||||..|:||.:||.|.|||||::|| .||..:       
Mouse  3812 GSALAALVKGLPEALQRQFEYEDPIVRGGKQLLHSPFFKVLVALACDLELD-TLPCCA------- 3868

  Fly  3902 APGAISSTGDVHKWAWFKRYCIAVRVAQSLIRRTELPRAFCLEVRKKFAEMLPSSSSNSNANPGC 3966
                     :.||||||:|||:|.|||.:|.:||.|||.|..||.||..|::..|.|        
Mouse  3869 ---------ETHKWAWFRRYCMASRVAVALDKRTPLPRLFLDEVAKKIRELMADSES-------- 3916

  Fly  3967 QSPGASMLNSTTSLSSSTVSNVSPPPGITGEQPDLHCHAHQLESTSTLLHEDHTLFQAPHDAQLL 4031
                                                         ..:|||.|::|:...|.||:
Mouse  3917 ---------------------------------------------MDVLHESHSIFKREQDEQLV 3936

  Fly  4032 QWLNRRPDDWALSWGGASTIYGWGHNHRGQLGGLEGSRIKTPTPCEALSLLRPVQLAGGEQSLFA 4096
            ||:|||||||.||.||:.|||||||||||||||:||:::|.|||||||:.||||||.||||:|||
Mouse  3937 QWMNRRPDDWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFA 4001

  Fly  4097 VTPDGKLFATGYGSGGRLGVGGSDSWAIPTLLGSLQHVFVKKVAVNSGGKHCLALTTEGEVYAWG 4161
            ||.||||:|||||:|||||:||::|.:.||||.|:||||:|||||||||||||||::|||||:||
Mouse  4002 VTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWG 4066

  Fly  4162 EGEDGKLGHGNRMSYDRPKLVEHLNGMSVADIACGSAHSAAITASGHVLTWGKGRYGRLGHGDSE 4226
            |.||||||||||...|||:::|.|.|:.|.|:|.|.||||.:||:|.:.||||||||||||.|||
Mouse  4067 EAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSE 4131

  Fly  4227 DQLRPKLVEALLGYRAIDIACGSGDAQTLCITDDDNVWSWGDGDYGKLGRGGSDGCKLPYKIESL 4291
            |||:|||||||.|:|.||||||||||||||:||||.|||||||||||||||||||||:|.||:||
Mouse  4132 DQLKPKLVEALQGHRVIDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSL 4196

  Fly  4292 AGLGVVKVECGSQFSVALTKSGAVYTWGKGDFHRLGHGSVDHVRRPKKVAALQGKKIISIATGSL 4356
            .||||||||||||||||||||||||||||||:|||||||.||||||::|..|||||:|:||||||
Mouse  4197 TGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSL 4261

  Fly  4357 HCVACSDSGEVYTWGDNDEGQLGDGTVTAIQRPRLVAALQGKHIVKVTCGSAHTLALSTSQLSER 4421
            |||.|::.||||||||||||||||||..||||||||||||||.:.:|.||||||||.|||:.:..
Mouse  4262 HCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWSTSKPASA 4326

  Fly  4422 LRPLPNPPLEYDLVRDLAPEALHARLILLHHFSELVCPCLAMLPISGDL-------SLG--ALKD 4477
            .:.....|:||:.::::...||..||:||||.|||.|||:.|..:.|.|       |:|  .|:.
Mouse  4327 GKLPAQVPMEYNHLQEIPIIALRNRLLLLHHISELFCPCIPMFDLEGSLDETGLGPSVGFDTLRG 4391

  Fly  4478 VLVYNIKEAAFRKVIQTTMVRDKQHGPVIELNRIQVKRSRNRCNGLAGIDGMKSVFGQMVQKLPL 4542
            :|:...||||||||:|.|||||:|||||:|||||||||||:: .||||.||.|||||||..|:..
Mouse  4392 ILISQGKEAAFRKVVQATMVRDRQHGPVVELNRIQVKRSRSK-GGLAGPDGTKSVFGQMCAKMSS 4455

  Fly  4543 LTQEALALPHRVWKVKFVGESVDDCGGGYSESIAEMCDELQNGSVPLLINTPNGRGEAGANRDCF 4607
            .:.::|.||||||||||||||||||||||||||||:|:|||||..||||.|||||.|:||||||:
Mouse  4456 FSPDSLLLPHRVWKVKFVGESVDDCGGGYSESIAEICEELQNGLTPLLIVTPNGRDESGANRDCY 4520

  Fly  4608 LLDPTLSSVLQMNMFRFLGVLMGIAVRTGSPLSINLAEPVWRQLTGEVLRPTDLTEVDRDYVAGL 4672
            ||:|...:.:..:||||||||:|||:|||||||:|||||||:||.|..|...||:|||:|::.||
Mouse  4521 LLNPATRAPVHCSMFRFLGVLLGIAIRTGSPLSLNLAEPVWKQLAGMSLTIADLSEVDKDFIPGL 4585

  Fly  4673 LCIRNMDDDPKLFTALELPFSTSSARGHEVPLSTRYTHISPRNRAEYVRLALGFRLHEFDEQVKA 4737
            :.||:.:...:.|.|:.|||:..||.|.::.||:::|||:..|||||||||:.:|||||||||.|
Mouse  4586 MYIRDNEATSEEFEAMSLPFTVPSASGQDIQLSSKHTHITLDNRAEYVRLAINYRLHEFDEQVAA 4650

  Fly  4738 VRDGMSKVIPVPLLSLFSAAELQAMVCGSPDIPLGLLKSVATYKGFDPSSALVTWFWEVMEEFTN 4802
            ||:||::|:||||||||:..||:.||||||||||.||||||||||.:||::||.|||||||.|:|
Mouse  4651 VREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKGIEPSASLVQWFWEVMESFSN 4715

  Fly  4803 QERSLFLRFVWGRTRLPRTIADFRGRDFVLQVLEK-NPPDHFLPESYTCFFLLKMPRYSCKAVLL 4866
            .||||||||||||||||||||||||||||:|||:| ||||||||||||||||||:||||||.||.
Mouse  4716 TERSLFLRFVWGRTRLPRTIADFRGRDFVIQVLDKYNPPDHFLPESYTCFFLLKLPRYSCKQVLE 4780

  Fly  4867 EKLKYAIHFCKSIDTDEYARVAM-GEPTEATGSE--DNSDLESVAS 4909
            ||||||||||||||||:|||:|: |||.....||  ||.|.:|.||
Mouse  4781 EKLKYAIHFCKSIDTDDYARIALTGEPAADDSSEDSDNEDADSFAS 4826

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826 22/49 (45%)
RCC1 687..737 CDD:278826 29/49 (59%)
RCC1 740..787 CDD:278826 25/48 (52%)
RCC1 790..841 CDD:278826 21/52 (40%)
RCC1_2 828..857 CDD:290274 14/28 (50%)
Cyt-b5 1290..1363 CDD:278597 16/72 (22%)
MIB_HERC2 1928..1987 CDD:284184 44/58 (76%)
UBA_HERC2 2515..2559 CDD:270585 20/46 (43%)
Cul7 2624..2699 CDD:288381 42/74 (57%)
APC10-HERC2 2762..2932 CDD:176485 66/228 (29%)
RCC1 3037..3088 CDD:278826 34/51 (67%)
RCC1 3091..3140 CDD:278826 37/48 (77%)
RCC1 3144..3194 CDD:278826 43/49 (88%)
RCC1 3197..3246 CDD:278826 38/48 (79%)
RCC1 3250..3298 CDD:278826 36/47 (77%)
RCC1 3302..3350 CDD:278826 34/47 (72%)
RCC1_2 4136..4166 CDD:290274 24/29 (83%)
RCC1 4154..4203 CDD:278826 32/48 (67%)
RCC1 4206..4257 CDD:278826 41/50 (82%)
RCC1 4260..4309 CDD:278826 43/48 (90%)
RCC1 4312..4360 CDD:278826 39/47 (83%)
RCC1 4364..4413 CDD:278826 40/48 (83%)
HECTc 4509..4880 CDD:238033 266/371 (72%)
HECTc 4553..4878 CDD:214523 237/325 (73%)
Herc2NP_001347009.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 58..90 10/54 (19%)
RCC1 1-1 416..462 10/60 (17%)
RCC1 1-2 463..513 16/49 (33%)
ATS1 <494..787 CDD:227511 132/299 (44%)
RCC1 1-3 514..569 24/55 (44%)
RCC1 1-4 570..621 29/50 (58%)
RCC1 1-5 624..675 27/50 (54%)
RCC1 1-6 676..727 23/54 (43%)
RCC1 1-7 729..779 18/51 (35%)
Cyt-b5 1212..1283 CDD:365921 16/70 (23%)
MIB_HERC2 1871..1930 CDD:369043 44/58 (76%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2351..2376 8/25 (32%)
UBA_HERC2 2461..2508 CDD:270585 20/46 (43%)
Cul7 2555..2632 CDD:371573 42/84 (50%)
SH3_15 2640..2697 CDD:375773 18/61 (30%)
ZZ_HERC2 2707..2751 CDD:239084 4/47 (9%)
APC10-HERC2 2766..2911 CDD:176485 54/145 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2928..2947 5/18 (28%)
ATS1 2957..3323 CDD:227511 270/369 (73%)
RCC1 2-1 2959..3010 34/50 (68%)
RCC1 2-2 3011..3065 36/53 (68%)
RCC1 2-3 3066..3117 38/50 (76%)
RCC1 2-4 3119..3169 43/49 (88%)
RCC1 2-5 3172..3223 40/50 (80%)
RCC1 2-6 3225..3275 38/49 (78%)
RCC1 2-7 3276..3327 36/50 (72%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3479..3499 4/19 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3517..3537 2/19 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3604..3632 12/28 (43%)
RCC1 3-1 3953..4004 39/50 (78%)
RCC1 3-2 4006..4058 40/51 (78%)
ATS1 4025..4330 CDD:227511 235/304 (77%)
RCC1 3-3 4060..4110 31/49 (63%)
RCC1 3-4 4112..4164 42/51 (82%)
RCC1 3-5 4166..4216 44/49 (90%)
RCC1 3-6 4218..4268 40/49 (82%)
RCC1 3-7 4270..4320 41/49 (84%)
HECTc 4423..4794 CDD:238033 266/371 (72%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4806..4836 10/21 (48%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167849542
Domainoid 1 1.000 475 1.000 Domainoid score I439
eggNOG 1 0.900 - - E1_COG5184
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H3430
Inparanoid 1 1.050 3580 1.000 Inparanoid score I10
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG50139
OrthoDB 1 1.010 - - D1062377at2759
OrthoFinder 1 1.000 - - FOG0007465
OrthoInspector 1 1.000 - - oto93928
orthoMCL 1 0.900 - - OOG6_102650
Panther 1 1.100 - - LDO PTHR22870
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4599
SonicParanoid 1 1.000 - - X6340
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1615.800

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