DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HERC2 and Trip12

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:XP_011236956.1 Gene:Trip12 / 14897 MGIID:1309481 Length:2074 Species:Mus musculus


Alignment Length:2369 Identity:472/2369 - (19%)
Similarity:731/2369 - (30%) Gaps:766/2369 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly  2960 PGSTAGAGAVSTSHEEAAAAPEQDLPCTVMVWGLNDKEQLGGLK----------GSKVKVPTF-S 3013
            |.:..|.....:....|.|.|:.|        .:..:..||..|          .|..|.|.. |
Mouse     5 PNNNPGGSLRRSQRNTAGAQPQDD--------SIGGRSHLGQAKRKGYIPPESRKSNFKAPKVQS 61

  Fly  3014 QTISRLRPIHIAG---GSKSLFIVSQDGKVYACGEGTNGRLGLGVTHNVPLPHQLPVLRQYVVKK 3075
            .|.|.|...|::.   .|.|..||.|.............:.|           |:|       ||
Mouse    62 NTTSELSRGHLSKRSCSSSSAVIVPQPEDPDRANTSERQKTG-----------QVP-------KK 108

  Fly  3076 VAVHSGGKHALALTLDGKVFSWGEGEDGKLGHGNRTTLDKPRLVEALRAKKIRDVACGSSHSAAI 3140
                                      |...|.....:.|..|......|||.|    ...|..:.
Mouse   109 --------------------------DNSRGVKRSASPDYNRTNSPSSAKKPR----AFQHIESF 143

  Fly  3141 SSQGELYTWGLGEYGRLGHGDNTTQLKPKLV--TALAGRRVVQVACGSRDAQTLALTEDGAVFSW 3203
            |...:.::     ..:..|.|...|||...:  |:.|..| ..||.||...|....||...|.|.
Mouse   144 SETNKPHS-----KSKKRHLDQEQQLKSAQLPSTSKAHTR-KSVAAGSSRNQKRKRTESSCVKSG 202

  Fly  3204 GDGDFGKLGRGGSEGSDTPHEIERLS------GIGVVQIECGA----QFSLALTRAGEVWTWGKG 3258
            .    |....|..|.|..|.::...|      |...:.....|    ..|.|:..|......|. 
Mouse   203 S----GSESTGAEERSAKPIKLASKSATSAKAGCSTITDSSSAASTSSSSSAIASASSTVPAGA- 262

  Fly  3259 DYYRLGHGGDQH-------VRKPQPIGGLRGRRVIHVAVGALHCLAVTDAGQVYAWG-------- 3308
               |:..|.||:       ...|.|....|.:.           .:.|.....:.|.        
Mouse   263 ---RVKQGKDQNKARRSRSASSPSPRRSSREKE-----------QSKTGGSSKFDWAARFSPKVS 313

  Fly  3309 --DNDHGQQGSGNTFVNKK-PALVIGLDA--VFVNRVACGSSHSIAWGLPN--ASSDEEKRGPVP 3366
              .......||..:..:|. |:   ||.|  ..:.:.....|.|....||:  .|:.::..|...
Mouse   314 LPKTKLSLPGSSKSETSKPGPS---GLQAKLASLRKSTKKRSESPPAELPSLRRSTRQKTTGSCA 375

  Fly  3367 FSSTRDPLGGSSLGIYEAETMQTLKQEAKPLNQSSLSESLALETPAARQAALGHVLRAMSILQAR 3431
            .:|.|    ||.||...|...:..::.|.|.:......|.|..|..|.|.|..    :.|:..| 
Mouse   376 STSRR----GSGLGKRGAAEARRQEKMADPESNQETVNSSAARTDEAPQGAAA----SSSVAGA- 431

  Fly  3432 QLIVAALTS-HSKVNFKERGAV------GGEEDHLIG--GPIMGAPLQLAETIAQGGGEAPADAT 3487
               |...|| .|:.:..|.|.:      .|...||.|  ||.|.   ||.......|..:.|...
Mouse   432 ---VGMTTSGESESDDSEMGRLQALLEARGLPPHLFGPLGPRMS---QLFHRTIGSGASSKAQQL 490

  Fly  3488 DAGLQ----EHSPEAAVDALTGGMSGGANTL---PPLSAGPL---------------SAFQSLT- 3529
            ..|||    ....:|.::.....:.|...||   |..|..|.               .|.::|| 
Mouse   491 LQGLQASDESQQLQAVIEMCQLLVMGNEETLGGFPVKSVVPALITLLQMEHNFDIMNHACRALTY 555

  Fly  3530 --GSLSMSGSLSSSALPQHKHSRMSASAMSVMAATMTQQEEMLSHISHCHGLDDFGGLLGEPEAK 3592
              .:|..|.::...|:|...........:.|....:|.. ||||. .|...:...|||     |.
Mouse   556 MMEALPRSSAVVVDAIPVFLEKLQVIQCIDVAEQALTAL-EMLSR-RHSKAILQAGGL-----AD 613

  Fly  3593 SLVEL---------LKLAVCGRCG---PPSTSQTIADTLISLGAGTPAVAAMLLETCITELEDLC 3645
            .|:.|         ..||:...|.   .|.....:||:|       |.:...|.......:|..|
Mouse   614 CLLYLEFFSINAQRNALAIAANCCQSITPDEFHFVADSL-------PLLTQRLTHQDKKSVESTC 671

  Fly  3646 TSRHCLGKL-------PKPVMQESSHPYVDNVNVTGVVRIP-------------------GAEML 3684
            .   |..:|       ...:.|.:|...:.||....||..|                   ....|
Mouse   672 L---CFARLVDNFQHEENLLQQVASKDLLTNVQQLLVVTPPILSSGMFIMVVRMFSLMCSNCPTL 733

  Fly  3685 RLEFDSQCSTEKRNDPLVIMDGTGR-------VLAMRSGREFAHWA----------PEIRVLGDE 3732
            .::...|..|:.......::.|...       .|..||.:|.....          |:..:...:
Mouse   734 AVQLMKQSFTDIAETLHFLLCGASNGSCQEQIDLVPRSPQELYELTSLICELMPCLPKEGIFAVD 798

  Fly  3733 LRWKFSSDSSVNG--WGWRFWVHAIMPAATLGESGSDRAVLSQPSMALVMSLLDSRLAPRQPSVL 3795
            ...|..:..:.:|  |.||                .||. |..|     .:.:|||:..      
Mouse   799 TMLKKGNAQNTDGAIWQWR----------------DDRG-LWHP-----YNRIDSRIIE------ 835

  Fly  3796 LRLASALAACSQLG----ALTTAQRIW-----SLRKLH----AVLLLEQAPRPQDPSLSTLLQPL 3847
                   .|..|:|    :|:|..|::     |:::::    ....:::.|.|...|.::....|
Mouse   836 -------VAAHQVGEDEISLSTLGRVYTIDFNSMQQINEDTGTARAIQRKPNPLANSNTSGYSEL 893

  Fly  3848 IPELLR-QYEYEEPQVRGGIHLMHSDYFKTLAALACDMQLDAALPAT------------------ 3893
            ..:..| |...|:|:       :...:.|||..:..::...:|.||.                  
Mouse   894 KKDDARAQLMKEDPE-------LAKSFIKTLFGVLYEVYSSSAGPAVRHKCLRAILRIIYFADAE 951

  Fly  3894 ------SSSSSSSAAPGAISSTGDVHKWAWFKRYCIAVRVAQSLIRRTELPRAFCLEVRKK---- 3948
                  .:.:.||.....:||..       .|....|:::|:.|:::  ||..|.:..|::    
Mouse   952 LLKDVLKNHAVSSHIASMLSSQD-------LKIVVGALQMAEILMQK--LPDIFSVYFRREGVMH 1007

  Fly  3949 FAEMLPSSSSNSNANPGCQSPGASMLNSTTSLSSSTVSNVSPPPGITGEQPDLHCHAHQLESTST 4013
            ..:.|..|.|...:.|...:.|:..|.|||..||.|.:      ..|....||        .:.:
Mouse  1008 QVKHLAESESLLTSPPKACTNGSGSLGSTTPASSGTAT------AATNASADL--------GSPS 1058

  Fly  4014 LLH-EDHTLFQAPHDAQLLQWLN---------RRP-----------DDWALS------------- 4044
            |.| .|.:|..:| ..:|...|.         |||           |:.|.|             
Mouse  1059 LQHSRDDSLDLSP-QGRLSDVLKRKRLPKRGPRRPKYSPPRDDDKVDNQAKSPTTTQSPKSSFLA 1122

  Fly  4045 ------WGGAST--------------IYGWGH--------NHRGQLGG----------------- 4064
                  ||..|.              :.|...        |:|.::.|                 
Mouse  1123 SLNPKTWGRLSAQSNSNNIEPARTAGVSGLARAASKDTISNNREKIKGWIKEQAHKFVERYFSSE 1187

  Fly  4065 -LEGSRIKTPTPCEALSLLR---------PVQLAGGEQSLFAVTPDGKLFATGYGSGGRLGVGGS 4119
             ::||.       .||::|:         .:|:.||.:.|..:               |..|..|
Mouse  1188 NMDGSN-------PALNVLQRLCAATEQLNLQVDGGAECLVEI---------------RSIVSES 1230

  Fly  4120 DSWAIPTLLGSLQHV-FVKKVAVNSGGKHCLALTTEGEVYAWGE-----------------GED- 4165
            |..:.     .:||. |||::        .|.||::.|..|.|.                 ||: 
Mouse  1231 DVSSF-----EIQHSGFVKQL--------LLYLTSKNEKDAVGREIRLKRFLHVFFSSPLPGEEP 1282

  Fly  4166 -GK---LGHGNRMSYDRPKLVEHLNG---------MSVADIACGSAHSAAITASGHVLTWGKGRY 4217
             |:   :||...::     ||..:|.         :.|.|...|:               |.|..
Mouse  1283 VGRVEPVGHAPLLA-----LVHKMNNCLSQMEQFPVKVHDFPSGN---------------GAGGS 1327

  Fly  4218 GRLGHGDSEDQLRPKLVEALLGYRAIDIACGSGDAQTLCITDDDNVWSWGDGDYGKLGRGGSDGC 4282
            ..|..|.          :||..:....:.|     |.....|..||..|         :||    
Mouse  1328 FSLNRGS----------QALKFFNTHQLKC-----QLQRHPDCANVKQW---------KGG---- 1364

  Fly  4283 KLPYKIESLAGLGVVK---------------------------VECGSQFSVALTKSGAVYTWGK 4320
              |.||:.||.:..::                           .|.....:.....||.|.    
Mouse  1365 --PVKIDPLALVQAIERYLVVRGIFRYGRVREDDEDSDDDGSDEEIDESLAAQFLNSGNVR---- 1423

  Fly  4321 GDFHRLGHGSVDHVRRPKKVAALQGKKIISIATGSLHCVACSDSGEVYTWGDNDEGQLG--DGTV 4383
               |||.....:|: .|..:...|..:..|        |...|..|......|..|:.|  ..|.
Mouse  1424 ---HRLQFYIGEHL-LPYNMTVYQAVRQFS--------VQAEDERESTDDESNPLGRAGIWTKTH 1476

  Fly  4384 TAIQRPRLVAALQGKHIVKVTCGSAHTLALSTSQLSER---------LRPLPNPPLEYDLVRDLA 4439
            |...:|........|..|....|.|.|....||..:.:         :.|....|||..|: ...
Mouse  1477 TIWYKPVREDEESTKDCVGGKRGRAQTAPTKTSPRNAKKHDELWHDGVCPSVANPLEVYLI-PTP 1540

  Fly  4440 PE-------ALHARLIL--LHHFSEL------VCPCLAMLP----ISGDLSLGA---LKDVLVY- 4481
            ||       :|...|:|  ||..|..      ...|..::|    |:..|:..|   |:|.||. 
Mouse  1541 PENITFEDPSLDVILLLRVLHAISRYWYYLYDNAMCKEIIPTSEFINSKLTAKANRQLQDPLVIM 1605

  Fly  4482 --NI------------------------------KEAAFRKVIQT------TMVRDKQHGPVIE- 4507
              ||                              ::.|.::::.|      :..:|.:..|.:: 
Mouse  1606 TGNIPTWLTELGKTCPFFFPFDTRQMLFYVTAFDRDRAMQRLLDTNPEINQSDSQDSRVAPRLDR 1670

  Fly  4508 ----LNRIQ-VKRSRNRCNGLAGIDGMKSV---------FGQMVQKLPLLTQEALALPHRVWKVK 4558
                :||.: :|::.:....|.....|..:         .|..::...|::||.......:|:  
Mouse  1671 KKRTVNREELLKQAESVMQDLGSSRAMLEIQYENEVGTGLGPTLEFYALVSQELQRADLCLWR-- 1733

  Fly  4559 FVGESVDDCGGGYSESIAEMCDELQNGSVPLLINTPNGRGEAGANRDCFLLDPTLSSVLQMNM-F 4622
              ||.|.......|:...:....||.     |...|.||....|:            :.::.| |
Mouse  1734 --GEEVTLSNPKGSQEGTKYIQNLQG-----LFALPFGRTAKPAH------------IAKVKMKF 1779

  Fly  4623 RFLGVLMGIAVR----TGSPLSINLAEPVWRQLTGEVLRPTDLTEVDRDYVAGLLCIRNM----- 4678
            ||||.||..|:.    ...||.:...:.:.||.|.  |...||.::|......:..:.::     
Mouse  1780 RFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETS--LTSHDLFDIDPVVARSVYHLEDIVRQKK 1842

  Fly  4679 ---DDDPKLFTALELPFSTSSARGHEV-PLSTRYT----------------HISPRNRAEYVRLA 4723
               .|..:...:|:....|.:..|..| .|...:|                .::..|..||:||.
Mouse  1843 RLEQDKSQTKESLQYALETLTMNGCSVEDLGLDFTLPGFPNIELKKGGKDIPVTIHNLEEYLRLV 1907

  Fly  4724 LGFRLHE-FDEQVKAVRDGMSKVIPVPLLSLFSAAELQAMVCGSP----DIPLGLLKSVATYKGF 4783
            :.:.|:| ...|..:.|||...|.|:..|..|...||..::|||.    |... |::......|:
Mouse  1908 IFWALNEGVCRQFDSFRDGFESVFPLCHLQYFYPEELDQLLCGSKADTWDAKT-LMECCRPDHGY 1971

  Fly  4784 DPSSALVTWFWEVMEEFTNQERSLFLRFVWGRTRLPRTIADFRGRDFVLQVLEK-----NPPDHF 4843
            ...|..|.:.:|::..|.|:::.|||:||.|..|||  :..||..:..|.::.|     ..||.|
Mouse  1972 THDSRAVKFLFEILSSFDNEQQRLFLQFVTGSPRLP--VGGFRSLNPPLTIVRKTFESTENPDDF 2034

  Fly  4844 LPESYTCFFLLKMPRYSCKAVLLEKLKYA 4872
            ||...||...||:|.||...::.:||..|
Mouse  2035 LPSVMTCVNYLKLPDYSSIDIMRDKLLIA 2063

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826 5/50 (10%)
RCC1 3091..3140 CDD:278826 9/48 (19%)
RCC1 3144..3194 CDD:278826 13/51 (25%)
RCC1 3197..3246 CDD:278826 11/58 (19%)
RCC1 3250..3298 CDD:278826 8/54 (15%)
RCC1 3302..3350 CDD:278826 10/60 (17%)
RCC1_2 4136..4166 CDD:290274 10/48 (21%)
RCC1 4154..4203 CDD:278826 14/79 (18%)
RCC1 4206..4257 CDD:278826 8/50 (16%)
RCC1 4260..4309 CDD:278826 11/75 (15%)
RCC1 4312..4360 CDD:278826 10/47 (21%)
RCC1 4364..4413 CDD:278826 12/50 (24%)
HECTc 4509..4880 CDD:238033 102/414 (25%)
HECTc 4553..4878 CDD:214523 93/360 (26%)
Trip12XP_011236956.1 SRP1 489..>714 CDD:227396 50/241 (21%)
WWE 814..876 CDD:397111 17/96 (18%)
HECTc 1672..2072 CDD:238033 102/418 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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