DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HERC2 and Gas7

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:XP_006532265.1 Gene:Gas7 / 14457 MGIID:1202388 Length:476 Species:Mus musculus


Alignment Length:598 Identity:112/598 - (18%)
Similarity:180/598 - (30%) Gaps:270/598 - (45%)


- Green bases have known domain annotations that are detailed below.


  Fly  1234 GLRW-ARLFLPLLRVLDRLNRALGEGELRDGDDMGW-----------PGIICRGGPKGGPPPADP 1286
            |||: |...|.||:|.|   ....|||..|| ..||           ||::       .|||.: 
Mouse    20 GLRFSAGELLTLLQVPD---GGWWEGEKDDG-LRGWFPASYVQLLEKPGMV-------PPPPGE- 72

  Fly  1287 ETHYVRRADMENLLLDGSRCIILAGYVCDLSGYNCESETLRSVLDSGLGKDLTAEMSSQVHRTAM 1351
                                               ||:|:  :|..|    ..:.:|.|..|   
Mouse    73 -----------------------------------ESQTV--ILPPG----WHSYLSPQGRR--- 93

  Fly  1352 EHILEHHKLGKYMVQASTEEK-----------SSAPGPSRLTHFSSECALAQLLGLVANLMCSGP 1405
                       |.|..:|.|.           |::|||.|          :.|...|.....||.
Mouse    94 -----------YYVNTTTNETTWERPSSSPGISASPGPHR----------SSLPTTVNGYHASGT 137

  Fly  1406 ALQPAELQCRQLDKSSLLSGGLQLLQPSNPFDEEKGEARSSHSC----HSTAGNTPTELPPPLPM 1466
            ...|.|.....|.||   :|..|.|..|:|..::..|...:.:|    |          |..:|.
Mouse   138 PAHPPETAHMSLRKS---TGDSQNLGSSSPGRKQSKENTITINCVTFPH----------PDTMPE 189

  Fly  1467 QQQLAP-----------------GRGK--------------SQLQLRADAFISGLAE-------- 1492
            ||.|.|                 |.|.              .|:|.....||....:        
Mouse   190 QQLLKPTEWSYCDYFWADKKDPQGNGTVAGFELLLQKQLKGKQMQKEMSEFIRERIKIEEEYAKN 254

  Fly  1493 -ARVSEPPVA---------AWLALTERY-----------CKAHN------LMWHQEF-----ATE 1525
             |::|:..:|         ||..:.:..           .|.|:      :.:.:.|     ..:
Mouse   255 LAKLSQNSLAAQEEGSLGEAWAQVKKSLADEAEVHLKFSAKLHSEVEKPLMNFRENFKKDMKKCD 319

  Fly  1526 HPVQELERLLSA------------------VLIRHQYLGGLVLNALETEVPPPR----QLG-EII 1567
            |.:.:|.:.|::                  :.::.|.|...:.|..|.::...|    |.| :::
Mouse   320 HHIADLRKQLASRYASVEKARKALTERQKDLEMKTQQLEIKLSNKTEEDIKKARRKSTQAGDDLM 384

  Fly  1568 RLVH-----QAKWSVVRTRQQLNRSYKEVCAPILERLRFLLYEVRPAISPQQRGLRRLPILQRPP 1627
            |.|.     |:||            ::|:....||                   |.||.:    .
Mouse   385 RCVDLYNQAQSKW------------FEEMVTTTLE-------------------LERLEV----E 414

  Fly  1628 RFKMLVRRLLQ--ELRSSRQPAKPEDLLNASIQQEQEKKPQSMPKQELEEQEEEETLLRRLNERQ 1690
            |.:|:.:.|.|  :||..      .|:.|.|..:     |.....::::..::.|..:|.     
Mouse   415 RVEMIRQHLCQYTQLRHE------TDMFNQSTVE-----PVDQLLRKVDPAKDRELWVRE----- 463

  Fly  1691 IHGEGELDPALMQ 1703
             |..|.:.|..|:
Mouse   464 -HKTGNIRPVDME 475

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597 8/72 (11%)
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826
RCC1 3091..3140 CDD:278826
RCC1 3144..3194 CDD:278826
RCC1 3197..3246 CDD:278826
RCC1 3250..3298 CDD:278826
RCC1 3302..3350 CDD:278826
RCC1_2 4136..4166 CDD:290274
RCC1 4154..4203 CDD:278826
RCC1 4206..4257 CDD:278826
RCC1 4260..4309 CDD:278826
RCC1 4312..4360 CDD:278826
RCC1 4364..4413 CDD:278826
HECTc 4509..4880 CDD:238033
HECTc 4553..4878 CDD:214523
Gas7XP_006532265.1 SH3_GAS7 5..57 CDD:212763 16/40 (40%)
WW_FCH_linker 109..201 CDD:374680 28/114 (25%)
F-BAR_GAS7 214..446 CDD:153333 44/277 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.