DRSC/TRiP Functional Genomics Resources

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Protein Alignment HERC2 and Ube3b

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:NP_473434.2 Gene:Ube3b / 117146 MGIID:1891295 Length:1070 Species:Mus musculus


Alignment Length:507 Identity:129/507 - (25%)
Similarity:211/507 - (41%) Gaps:121/507 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly  4429 PLEYDLVRDLAPEAL---------HARLILLHHFSELVCPCLAMLPISGDLSLGALKDVLVYNIK 4484
            |.::.|.|||.|..|         .|:|:|.|                       :..|:.:..:
Mouse   614 PEDHWLRRDLKPGVLFQELDKDRRRAQLVLQH-----------------------IPHVVPHKNR 655

  Fly  4485 EAAFRKVIQTTMVRDKQHGPVIE-------LNRIQVKRSRNRCNGLAGIDGMKSVFGQMVQKLPL 4542
            ...||.::    :::|:...::|       :..|.::|||...:|              .::|..
Mouse   656 VLLFRNMV----IKEKEKLGLVETSSASPHVTHITIRRSRMLEDG--------------YEQLRQ 702

  Fly  4543 LTQEALALPHRVWKVKFVGE-SVDDCG----GGYSESIAEMCDELQNGSVPLLINTPNGRGEAGA 4602
            |:|.|:   ..|.:||||.: .||:.|    |.:.|.:.|:...:.:.::.|...|      :|.
Mouse   703 LSQHAM---KGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTT------SGD 758

  Fly  4603 NRDCFLLDPTLSSVLQMN---MFRFLGVLMGIAVRTGSPLSINLAEPVWRQLTGE-----VLRPT 4659
            .|    |.|:.:|.:..|   :|.|:|.::|.||..|..:.:..|.....|:.|.     .....
Mouse   759 ER----LYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQMLGHHHSVFYSSVD 819

  Fly  4660 DLTEVDRDYVAGLLCIRNMDDDPKLFTALELPFS-TSSARG----HEVPLSTRYTHISPRNRAEY 4719
            :|..:|.::...|..|:..|.|   ...|.|..| .....|    ||:....:...::..|:..|
Mouse   820 ELPSLDSEFYKNLTSIKRYDGD---IADLGLTLSYDEDVMGQLVCHELVPGGKTIPVTDENKISY 881

  Fly  4720 VRLALGFRLH-EFDEQVKAVRDGMSKVIPVPLLSLFSAAELQAMVCG-SPDIPL-GLLKSVATYK 4781
            :.|...||:| :...|..|:..|...:|....:.:||..|||.::.| :.:|.| .|.|....|.
Mouse   882 IHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYG 946

  Fly  4782 GFDPSSALVTWFWEVM-EEFTNQERSLFLRFVWGRTRLP---------------------RTIAD 4824
            ||..|..::.|.|::: .:||.:||::||:||...:|.|                     :...|
Mouse   947 GFHGSHRVIIWLWDILASDFTPEERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGD 1011

  Fly  4825 FRG---RDFVLQVLEKNPPDHFLPESYTCFFLLKMPRYSCKAVLLEKLKYAI 4873
            ..|   |.|.  .:.|..|...||.|.|||.|||:|.||.|:||.|||:|||
Mouse  1012 TLGSVLRGFF--TIRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAI 1061

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826
RCC1 3091..3140 CDD:278826
RCC1 3144..3194 CDD:278826
RCC1 3197..3246 CDD:278826
RCC1 3250..3298 CDD:278826
RCC1 3302..3350 CDD:278826
RCC1_2 4136..4166 CDD:290274
RCC1 4154..4203 CDD:278826
RCC1 4206..4257 CDD:278826
RCC1 4260..4309 CDD:278826
RCC1 4312..4360 CDD:278826
RCC1 4364..4413 CDD:278826
HECTc 4509..4880 CDD:238033 113/411 (27%)
HECTc 4553..4878 CDD:214523 104/367 (28%)
Ube3bNP_473434.2 HECTc 684..1068 CDD:238033 113/410 (28%)
HECTc 709..1067 CDD:214523 104/368 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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