DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HERC2 and Magi2

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:NP_446073.2 Gene:Magi2 / 113970 RGDID:621855 Length:1277 Species:Rattus norvegicus


Alignment Length:1094 Identity:220/1094 - (20%)
Similarity:323/1094 - (29%) Gaps:444/1094 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly  2298 MPHLDHTVFSLSRLPMNEMLLNAWTVLLYGPAPELRELPSSADGRLDLALLRAQQLQMAVLHTNG 2362
            |||.:     |...|:.              ||..||.|        |....|.||:...|.|. 
  Rat   392 MPHTE-----LGTKPLQ--------------APGFREKP--------LFTRDASQLKGTFLSTT- 428

  Fly  2363 VLYRHQVALRRILKQRAPGSIYA--SPDEPDR----SDAESQQPGEQDQQLSSGSGQEPQLLI-- 2419
                        ||:...|..:.  ..||||.    .......|..||.::.:|     .:::  
  Rat   429 ------------LKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETG-----DVIVYI 476

  Fly  2420 -QCILLRATQASPVKACYSYMDLATAALNCIQSLATQAHQELSEGGGVPPNGRALSSPPQPTMVH 2483
             :..:|..|.|..||...|.....:..|...:........|......|||  .|:...|.|.||:
  Rat   477 NEVCVLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPP--LAIMERPPPVMVN 539

  Fly  2484 GVPVYN-----VARKEQKPSEQVEQK----SKWPAAATDAQLIG-----------QIMEMGFTRR 2528
            |...|.     ::|..|...:..::.    ...||   |.||.|           .:...|.|  
  Rat   540 GRHNYETYLEYISRTSQSVPDITDRPPHSLHSMPA---DGQLDGTYPPPVHDDNVSVASSGAT-- 599

  Fly  2529 TVELALKQLSLQAEIM------------------PTPEQIVQWILEHPDV--CANTIEEDTLPLA 2573
                       |||:|                  ||.:::.|.:    |:  |....|.|.:...
  Rat   600 -----------QAELMTLTIVKGAQGFGFTIADSPTGQRVKQIL----DIQGCPGLCEGDLIVEI 649

  Fly  2574 SSAS----SHDPEADSDNECPSSNST----------TSSSTSSDTV-----EGQPM-AVSGPA-- 2616
            :..:    ||....|...:||..:.|          :...|....|     :|.|. ::|.||  
  Rat   650 NQQNVQNLSHTEVVDILKDCPVGSETSLIIHRGGFFSPWKTPKPMVDRWENQGSPQTSLSAPAVP 714

  Fly  2617 -----PPV-----------KFESRKDFQTADLYALY--------VRGLVRPGMTVRCCR---DFE 2654
                 ||.           .|:.||    .|.|.||        .|..|.|..:.|...   |::
  Rat   715 QSLPFPPALHRSSFPDSTEAFDPRK----PDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPDYK 775

  Fly  2655 E---------------IKQGD-------MGTVLIV---DTEG-LH--DLNVQVD-----WRNHGS 2686
            |               |..||       :|.|:.:   |.:| ||  |..|.||     .:.|..
  Rat   776 ELDVHLRRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRY 840

  Fly  2687 TYWVCFVHIELVEAAQTHHQPRPPPIAVGARVRLRTSSLRYGMLCPLRLGRSQGSSAIGVVSSVR 2751
            .       |:|:     ||..|...:    .:.:|...|..|..|| ..|||.||.:.. .||.|
  Rat   841 V-------IDLM-----HHAARNGQV----NLTVRRKVLCGGEPCP-ENGRSPGSVSTH-HSSPR 887

  Fly  2752 SKQLTVDFPDQPAWQGHINEVELVASQPTSATLPSLGDSCSQMPPSDLIEDWSRCIRSLTVSSNE 2816
            |...|.      |...|        :.|:|...|..|.:...:..||:|         :....||
  Rat   888 SDYATY------ANSNH--------AAPSSNASPPEGFASHSLQTSDVI---------IHRKENE 929

  Fly  2817 AAAKHLLNGSNQPWQSCS------------SGPCRHWIRLELHDRILVHSLTLKVSPEDHSHMPS 2869
            .....:::..|:|....:            ..|.....:|::.||||.      |:.:...:||.
  Rat   930 GFGFVIISSLNRPESGATITVPHKIGRIIDGSPADRCAKLKVGDRILA------VNGQSIINMPH 988

  Fly  2870 LLEIRVGDCVDSLKEYTWIPVPAGAS---RVLLMQQV--PTYYPWVEVVVKQCQNNGIQCKIHGI 2929
                  .|.|..:|:       ||.|   |::..:::  ||..|..|                  
  Rat   989 ------ADIVKLIKD-------AGLSVTLRIIPQEELNSPTSAPSSE------------------ 1022

  Fly  2930 KFVGRRQQPDLQHILANAQFLASEYSAGVGPGSTAGAGAVSTSHEEAAAAPEQDLPCTVMVWGLN 2994
                 :|.|..|    ....||.::|....|........|      |..||.|.|          
  Rat  1023 -----KQSPMAQ----QHSPLAQQHSPLAQPSPATPNSPV------AQPAPPQPL---------- 1062

  Fly  2995 DKEQLGGLKGS-------------KVKVPTFSQTISRLRPIHIAGGSKSLFIVSQDGKVYACGEG 3046
               ||.|.:.|             .::.|.|  |..|..|:                        
  Rat  1063 ---QLQGHENSYRSEVKARQDVKPDIRQPPF--TDYRQPPL------------------------ 1098

  Fly  3047 TNGRLGLGVTHNVPLP----HQLPVLRQYVVK-----------KVAVHSGGK------------- 3083
             :.|...|..::.|.|    ...|..|||.:.           .|.:..|.|             
  Rat  1099 -DYRQPPGGDYSQPSPLDYRQHSPDTRQYPLSDYRQPQDFDYFTVDMEKGAKGFGFSIRGGREYK 1162

  Fly  3084 ---HALALTLDGKVFSWGEGEDGKLGHGNRTTLDKPRLVEALRAKKIRDVACGSSHSAA---ISS 3142
               :.|.|..||...     .:|::..|:       :::| :..:..||:    :|:.|   |.|
  Rat  1163 MDLYVLRLAEDGPAI-----RNGRMRVGD-------QIIE-INGESTRDM----THARAIELIKS 1210

  Fly  3143 QGE----LYTWGLG---EYGR---------------------LGHGDNTTQLKP 3168
            .|.    |...|.|   |||.                     |||..:||...|
  Rat  1211 GGRRVRLLLKRGTGQVPEYGMVPSSLSMCMKSDKHGSPYFYLLGHPKDTTNPTP 1264

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585 12/72 (17%)
Cul7 2624..2699 CDD:288381 28/118 (24%)
APC10-HERC2 2762..2932 CDD:176485 33/186 (18%)
RCC1 3037..3088 CDD:278826 12/81 (15%)
RCC1 3091..3140 CDD:278826 9/51 (18%)
RCC1 3144..3194 CDD:278826 13/53 (25%)
RCC1 3197..3246 CDD:278826
RCC1 3250..3298 CDD:278826
RCC1 3302..3350 CDD:278826
RCC1_2 4136..4166 CDD:290274
RCC1 4154..4203 CDD:278826
RCC1 4206..4257 CDD:278826
RCC1 4260..4309 CDD:278826
RCC1 4312..4360 CDD:278826
RCC1 4364..4413 CDD:278826
HECTc 4509..4880 CDD:238033
HECTc 4553..4878 CDD:214523
Magi2NP_446073.2 PDZ_signaling 22..96 CDD:238492
GuKc 118..291 CDD:214504
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 205..308
Interaction with DDN. /evidence=ECO:0000250 302..381
WW 304..333 CDD:395320
WW 350..381 CDD:197736
PDZ 428..509 CDD:214570 18/98 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 556..575 3/21 (14%)
PDZ 602..683 CDD:214570 15/84 (18%)
MAGI_u5 687..758 CDD:406953 17/74 (23%)
PDZ 775..861 CDD:214570 21/101 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 869..913 18/59 (31%)
PDZ_signaling 920..1007 CDD:238492 22/114 (19%)
PRK10263 <1007..>1135 CDD:236669 34/200 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1011..1130 34/191 (18%)
PDZ_signaling 1140..1220 CDD:238492 18/96 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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