DRSC/TRiP Functional Genomics Resources

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Protein Alignment HERC2 and WWP1

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:NP_008944.1 Gene:WWP1 / 11059 HGNCID:17004 Length:922 Species:Homo sapiens


Alignment Length:437 Identity:114/437 - (26%)
Similarity:188/437 - (43%) Gaps:64/437 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly  4493 QTTMVRDKQH--------GPVIELN---RIQVKRSRNRCNGLAGIDGMK------SVFGQMVQKL 4540
            :||..:|.::        ||.|...   |.::...|..|...|....:|      ::|....|::
Human   520 RTTTFKDPRNGKSSVTKGGPQIAYERGFRWKLAHFRYLCQSNALPSHVKINVSRQTLFEDSFQQI 584

  Fly  4541 PLLTQEALALPHRVWKVKFVGESVDDCGGGYSESIAEMCDELQNGSVPLLINTPNGRGEAGANRD 4605
            ..|  :...|..|:: |.|.||...|.||...|....:..|:.|....|.       ..||.|..
Human   585 MAL--KPYDLRRRLY-VIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLF-------EYAGKNNY 639

  Fly  4606 CFLLDPTLSSVL---QMNMFRFLGVLMGIAVRTGSPLSINLAEPVWRQLTGEVLRPTDLTEVDRD 4667
            |..::|  :|.:   .::.|.|:|..:.:|:..|..:....:.|.::::..:.|...||..:|.:
Human   640 CLQINP--ASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTE 702

  Fly  4668 YVAGLLCIR--NMDDDPKLFTALELPFST-----SSARGHEVPLSTRYTHISPRNRAEYVRLALG 4725
            :...|:.||  |:::     ..||:.||.     .....|::.|......::..|:.||:.|...
Human   703 FYNSLIWIRDNNIEE-----CGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTE 762

  Fly  4726 FRLHE-FDEQVKAVRDGMSKVIPVPLLSLFSAAELQAMVCGSPDIPLGLLKSVATYKGFDPSSAL 4789
            :|... ..||.||..||.::|:|:..|..|...||:.|:||..::.|...:....|:.:..:|..
Human   763 WRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRHYTRNSKQ 827

  Fly  4790 VTWFWEVMEEFTNQERSLFLRFVWGRTRLP-RTIADFRGRDFVLQ-VLEKNPPDHFLPESYTCFF 4852
            :.|||:.::|..|:.|...|:||.|..||| ...|:..|.:...: .:||...|.:||.|:|||.
Human   828 IIWFWQFVKETDNEVRMRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFN 892

  Fly  4853 LLKMPRYSCKAVLLEKLKYAIHFCKSIDTDEYARVAMGEPTEATGSE 4899
            .|.:|.|.....|.|||.:||                 |.||..|.|
Human   893 RLDLPPYKSYEQLKEKLLFAI-----------------EETEGFGQE 922

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826
RCC1 3091..3140 CDD:278826
RCC1 3144..3194 CDD:278826
RCC1 3197..3246 CDD:278826
RCC1 3250..3298 CDD:278826
RCC1 3302..3350 CDD:278826
RCC1_2 4136..4166 CDD:290274
RCC1 4154..4203 CDD:278826
RCC1 4206..4257 CDD:278826
RCC1 4260..4309 CDD:278826
RCC1 4312..4360 CDD:278826
RCC1 4364..4413 CDD:278826
HECTc 4509..4880 CDD:238033 103/392 (26%)
HECTc 4553..4878 CDD:214523 94/337 (28%)
WWP1NP_008944.1 C2_E3_ubiquitin_ligase 17..140 CDD:175988
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 210..388
HUL4 <307..922 CDD:227354 113/435 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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