DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HERC2 and Plekha5

DIOPT Version :9

Sequence 1:	NP_608388.2	Gene:	HERC2 / 33035	FlyBaseID:	FBgn0031107	Length:	4912	Species:	Drosophila melanogaster
Sequence 2:	XP_006506926.1	Gene:	Plekha5 / 109135	MGIID:	1923802	Length:	1270	Species:	Mus musculus

Alignment Length:	897	Identity:	164/897 - (18%)
Similarity:	269/897 - (29%)	Gaps:	309/897 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   876 SLPTFPASGIACTSAQSLVWTQSSHQGV-PRR-------APFVVDLGEPTFRLLDQLLGMCSSQD 932
            |:||.|:.|.|           :::||. |:|       :|  :..|:.|.             |
Mouse   546 SIPTSPSHGSA-----------AAYQGFSPQRTYRSEVTSP--IQRGDVTI-------------D 584

  Fly   933 NRQTPNQESECIAVACLNLFRLQLLALIANGVEPRQVGLASGSRLLCSLKTRILGLAGGSQVLRT 997
            .|..|:                          .|:.|.:|....:...|               |
Mouse   585 RRHRPH--------------------------HPKHVYVADRRSMPAGL---------------T 608

  Fly   998 IQVAAQQALQDGWSVLLPTAAERAQTLTSLLPSEPGQASSAGHRFMTDLLVSSLMAEGGLESALQ 1062
            :|..:.|:||.       ...|....|...|..:..:.||.....:..|:...|.|.......|.
Mouse   609 LQAVSPQSLQG-------RTPEELTLLLIKLRRQQAELSSVREHTLAQLMQLKLEAHSPKNEILS 666

  Fly  1063 HAIRLESSSCSADCGDGVHLPLLQLITRLLSNNA-------------------ALSQTRLSPTLG 1108
            |  .|:.::...|.....:.|::.::..::.|:|                   .|||.....||.
Mouse   667 H--HLQRNTIYLDHQMKENEPIITMVHTMIENSALRPQLYQQFLRQKNKISLYCLSQDECRGTLY 729

  Fly  1109 KQQEKE--------------------EEEREQQHQEPSTSPSLSLLHRFQRLLLSHIHQAQPEEE 1153
            |.:.:|                    ||:.:|.|:|..|         .::.|||...:.:...:
Mouse   730 KYRPEEAGIDAKLSRLCEQDKVVRALEEKLQQLHKEKYT---------LEQALLSASQEIEMNAD 785

  Fly  1154 TTGA-EALLLQ---YMHALIPACVATLQKAHELALQCREPGENSF------GQMVGHLGRVLQAD 1208
            ...| :.::||   ..:.|:..|....:...||....||..:..:      .||.|.|.|:.:..
Mouse   786 NPAAIQTVVLQRDDLQNGLLSTCRELSRATAELERAWREYDKLEYDVTVTRDQMQGQLDRLGEVQ 850

  Fly  1209 ISDALLNELLVGLLLLKRDRPQCLGGLRWARLFLPLLRVLDRLNRALGEGELRDGDDMGWPGIIC 1273
            ...|                     |::.|::...|.|:.|                      :.
Mouse   851 SESA---------------------GIQRAQIQKELWRIQD----------------------VM 872

  Fly  1274 RGGPKGGPPPADPETHYVRRADMENLLLDGSRCIILAGYVCDLSGYNCESETLRSVLDSGLGKDL 1338
            .|..|          |..:|...|.:.|.||:                   ...||
Mouse   873 EGLSK----------HKQQRGSSETVGLAGSK-------------------PFSSV--------- 899

  Fly  1339 TAEMSSQVHRTAMEHILEHHKLGKYMVQASTEEKSSAPGP--SRLTHFSSE-CALAQLLGLVANL 1400
                                   ||   .|.||:...|.|  .|...|:.: ..:..|....::|
Mouse   900 -----------------------KY---KSEEEEVVPPRPPLPRSYDFTEQPPIIPPLPSDSSSL 938

  Fly  1401 MC--SGPALQPAELQCRQLD---KSSLLSGGLQLLQPSNP-------FDEEKGEARSS------- 1446
            :|  .||...|.:.:..|:.   ::....|....|..|.|       .||..||.:|.
Mouse   939 LCYSRGPVHLPEDKKIHQVQGYPRNGSHCGPDYRLYKSEPELTTVAEVDESNGEEKSEPVSETEA 1003

  Fly  1447 ---HSCHSTAGNTPTELPPPLPMQQQLAPGRGKSQLQLRADAFISGLAEARVSEPPVAAWLALTE 1508
               ...|...| .|.....|.|....:|     |.:.||.   ...:.|.|...|..|     .|
Mouse  1004 PVVKGSHFPVG-VPLRTKSPTPESSTIA-----SYVTLRK---TKKMVELRTERPRSA-----VE 1054

  Fly  1509 RYCKAHNLMWHQEFATEHPVQELERLLSAVLIRHQYLGGLVLNALE-TEV-PPPRQLGEIIRLVH 1571
            :.|.|.:.  ......|..::.:.|...|.| |.:..|..||.|.: ::| ..|.:|.:.:|...
Mouse  1055 QLCLAESA--RPRMTVEEQLERIRRHQQACL-REKKKGLSVLGASDPSDVRDSPLRLTQTLRRDD 1116

  Fly  1572 QAK-WSVVRTRQQLNRSYKEVCAPILERLRFLLYEVRPAISPQQRGLRRLPILQRPPRFKMLVRR 1635
            ..| ...|.....:...|:...|....     |.:..|..:...|.|:|..:|..|....|....
Mouse  1117 NVKELDTVHRENDVKPDYETPAAQCAH-----LEDAEPQNADIGRKLKRSEMLYTPEPNGMASEE 1176

  Fly  1636 LLQELRSSRQ-----PAKPEDLLNASIQQEQEKKPQSMPKQELEEQEEEETL 1682
            :.::.|...|     ...|::  ..::.:.|.:.|   |::.....||||||
Mouse  1177 VTEKERQKEQVHADGSCSPQE--ETAMTEHQMEGP---PEEAESLHEEEETL 1223

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826
		RCC1	687..737	CDD:278826
		RCC1	740..787	CDD:278826
		RCC1	790..841	CDD:278826
		RCC1_2	828..857	CDD:290274
		Cyt-b5	1290..1363	CDD:278597	7/72 (10%)
		MIB_HERC2	1928..1987	CDD:284184
		UBA_HERC2	2515..2559	CDD:270585
		Cul7	2624..2699	CDD:288381
		APC10-HERC2	2762..2932	CDD:176485
		RCC1	3037..3088	CDD:278826
		RCC1	3091..3140	CDD:278826
		RCC1	3144..3194	CDD:278826
		RCC1	3197..3246	CDD:278826
		RCC1	3250..3298	CDD:278826
		RCC1	3302..3350	CDD:278826
		RCC1_2	4136..4166	CDD:290274
		RCC1	4154..4203	CDD:278826
		RCC1	4206..4257	CDD:278826
		RCC1	4260..4309	CDD:278826
		RCC1	4312..4360	CDD:278826
		RCC1	4364..4413	CDD:278826
		HECTc	4509..4880	CDD:238033
		HECTc	4553..4878	CDD:214523
Plekha5	XP_006506926.1	WW	13..42	CDD:366073
		WW	59..88	CDD:366073
		PH_PEPP1_2_3	165..268	CDD:270068
		Smc	<623..>864	CDD:224117	48/272 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900