DRSC/TRiP Functional Genomics Resources

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Protein Alignment HERC2 and Rcc2

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:NP_776292.1 Gene:Rcc2 / 108911 MGIID:1919784 Length:520 Species:Mus musculus


Alignment Length:452 Identity:119/452 - (26%)
Similarity:194/452 - (42%) Gaps:58/452 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly  2961 GSTAGAGAVSTSHEEAAAAPE-QDLPC--TVMVWGLNDKEQLGGLK-----------GSKVKVPT 3011
            |..|||.|:.|..|......: :...|  .::::|..:.:.:|..:           |..:..|.
Mouse    74 GKAAGAAAIITEPEHTKERVKLEGSKCKGQLLIFGATNWDLIGRKEVPKQQAAYRNLGQNLWGPH 138

  Fly  3012 FSQTISRLRPIHIAGGSKSL--FIVSQDGKVYACGEGTNGRLGLGVTHNVPLPHQLPVLRQYVVK 3074
            ....:|.:|...:..||.:.  .:::.:||:::.|....|:||.|.|..|..|..:..|....: 
Mouse   139 RYGCLSGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEALSHEAI- 202

  Fly  3075 KVAVHSGGKHALALTLDGKVFSWGEGEDGKLGHGNRT-TLDKPRLVEALRAKKIRDVACGSSHSA 3138
             |....|..|.||||..|.||::||.:.|:||.||:| .:..|..: ....:.|..:|||:..|.
Mouse   203 -VLAACGRNHTLALTDTGSVFAFGENKMGQLGLGNQTDAVPSPAQI-MYNGQPITKMACGAEFSM 265

  Fly  3139 AISSQGELYTWGLGEYGRLGHGDN------------TTQLKPKLVTALAGRR------------V 3179
            .:..:|.||::|..|||:|||..:            ..:|.|:.|.....:.            |
Mouse   266 LMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVV 330

  Fly  3180 VQVACGSRDAQTLALTEDGAVFSWGDGDFGKLGRGGSEGSDTPHEIERLS--GIGVVQIECGAQF 3242
            ..||||:.  .||.|.....|||||.|.:|:||....:....|..::...  |.|..||..|...
Mouse   331 RDVACGAN--HTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGATQIYAGYTC 393

  Fly  3243 SLALTRAGEVWTWGKGDYYRLGHGGDQHVRKPQPIGGLRGRRVIHVAVGALHCLAVTDAGQVYAW 3307
            |.|::..|.::.||..:..|      :....|:.:..|.|.|:..:|.|....:...|...: :|
Mouse   394 SFAVSEVGGLFFWGATNTSR------ESTMYPKAVQDLCGWRIRSLACGKSSIIVAADESTI-SW 451

  Fly  3308 GDN-DHGQQGSGNTFVNKKPAL--VIGLDAVFVNRVACGSSHSIAWGLPNASSDEEKRGPVP 3366
            |.: ..|:.|.|:.......|.  |..||.:|..:||.|.|||:......:.:::||...:|
Mouse   452 GPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIARDESEAEKEKLQRLP 513

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826 15/50 (30%)
RCC1 3091..3140 CDD:278826 17/49 (35%)
RCC1 3144..3194 CDD:278826 20/73 (27%)
RCC1 3197..3246 CDD:278826 16/50 (32%)
RCC1 3250..3298 CDD:278826 10/47 (21%)
RCC1 3302..3350 CDD:278826 16/50 (32%)
RCC1_2 4136..4166 CDD:290274
RCC1 4154..4203 CDD:278826
RCC1 4206..4257 CDD:278826
RCC1 4260..4309 CDD:278826
RCC1 4312..4360 CDD:278826
RCC1 4364..4413 CDD:278826
HECTc 4509..4880 CDD:238033
HECTc 4553..4878 CDD:214523
Rcc2NP_776292.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..78 1/3 (33%)
RCC1 1 101..163 8/61 (13%)
ATS1 129..479 CDD:227511 97/361 (27%)
RCC1 2 166..217 17/52 (33%)
RCC1 3 219..269 17/50 (34%)
RCC1 4 271..345 21/75 (28%)
Required for interaction with RAC1. /evidence=ECO:0000250|UniProtKB:Q9P258 316..323 0/6 (0%)
RCC1 5 346..399 17/52 (33%)
RCC1 6 401..445 10/49 (20%)
RCC1 7 446..499 16/53 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5184
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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