DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HERC2 and Ibtk

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:NP_001074751.1 Gene:Ibtk / 108837 MGIID:1918677 Length:1352 Species:Mus musculus


Alignment Length:821 Identity:170/821 - (20%)
Similarity:279/821 - (33%) Gaps:266/821 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly  4152 TTEGEVYAWGEGEDGKLGHGNRMSYDRPKLVE--HLNGMSVADIACGSAHSAAITASGHVLTWGK 4214
            |...|||.||:..:..||||::.|...|:|::  ..:|:.|..:.....||..::..|.|.|.|.
Mouse   139 TDPTEVYTWGDNTNFTLGHGSQNSKHHPELLDLFSRSGVYVKQVVLCKFHSVFLSQKGQVYTCGH 203

  Fly  4215 GRYGRLGHGDSEDQLRPKLVEALLGYRAIDIACGSGDAQTLCITDDDNVWSWGDGDYGKLGRGGS 4279
            ||.|||||||.:..|.|:|||.|.|:....:|....  .|:.:|||                   
Mouse   204 GRGGRLGHGDEQTCLVPRLVEGLSGHNCSQVAAAKD--HTVVLTDD------------------- 247

  Fly  4280 DGCKLPYKIESLAGLGVVKVECGSQFSVALTKSGAVYTWGKGDFHRLG---HGSVDHVRRPKKVA 4341
                                             |.|||:|...||:||   ..:..:|.|..:..
Mouse   248 ---------------------------------GCVYTFGLNMFHQLGIIPPPASCNVPRQIQAK 279

  Fly  4342 ALQGKKIISIATGSLHCVACSDSGEVYTWGDNDEGQLG-----DGTVTAIQRPR----------- 4390
            .|:|:.||.:|.|..|.|..:... |||.|.|. ||||     :|. ..:..||           
Mouse   280 YLKGRTIIGVAAGRFHTVLWTREA-VYTLGLNG-GQLGHLLDPNGE-KCVTTPRQVSALHHKDIA 341

  Fly  4391 --LVAALQGKHIVKVTCGSAHTLA------LSTSQLSERLRPLPNPPLEYDLVRDLAPEALHARL 4447
              ||||..|..:...|.|..:.||      ::|.||:.:...:....:||    .:.||      
Mouse   342 VSLVAASDGATVCVTTRGDIYLLADYQCKKMATKQLNLKKVLVSGGCMEY----KVDPE------ 396

  Fly  4448 ILLHHFSELVCPCLAMLPISGDLSLGALKDVLVYNIKEAAFRKVIQTTMVRDKQHGPVIELNRIQ 4512
                |.:|.....:.:|.:.|...:...:.: ..::|:..:....|.: :.|      |.|||.:
Mouse   397 ----HLTENGGQKICVLAMDGAGRVFCWRSI-SSSLKQCRWAYPRQVS-ISD------IALNRNE 449

  Fly  4513 V-------------------KRSRNRCNGLAG----------IDGMKSVFGQM-VQKLPLLTQEA 4547
            :                   |.|..:.:.|..          :....||:.:: ::|||      
Mouse   450 ILFVTQDGEGFKGKWFEDKRKNSEKKADILPNLHHSSSDVSCVPDTNSVYERIRLEKLP------ 508

  Fly  4548 LALPHRVWKVKFVGESVDDCGGGYSESIAEMCDELQNGSVPLLINTPNGRGEAGANRDCFLLDPT 4612
              ..||.     |..|.|..|..:  :|.:...:.....:| ::::.:...|.|         ..
Mouse   509 --FAHRA-----VSVSTDPSGCNF--AILQSDPKTSLYEIP-VVSSSSFFEEFG---------KL 554

  Fly  4613 LSSVLQMNMFRFLGVLMG----------IAVRTGSPLSINLAEPVWRQLTGEVLRPTDLTEVDRD 4667
            |....:|:.|..:...:|          :|||:.....:.|::       |..|..||:.:.|.|
Mouse   555 LRETDEMDSFHDVTFQVGNRHFPAHKYILAVRSDFFQKLFLSD-------GSSLELTDVYQKDED 612

  Fly  4668 YVAG--LLCIRNMDDD----------------------PKLFTALELPFSTSSARGHEVPLSTRY 4708
             .||  |..:..:..|                      |::....:......|...|   |.|..
Mouse   613 -AAGCHLFVVEKVHPDLFEYLLQFMYTDTCDLLTHGFKPRMIVKRKAEDCEGSPDSH---LHTVN 673

  Fly  4709 THISPRNRAEYVRLALGFRLHEFDEQVKAVRDGMSKVIPVPLLSLFSAAELQAMVCGSPDIPLGL 4773
            .|:..:.::.: .:....:.|...|:.|:......|...|                 ..|.|:.:
Mouse   674 CHVDDKQKSAF-EVYRSNQAHTLSERQKSKPKSSKKGKGV-----------------GDDDPVRM 720

  Fly  4774 LKSVATYKGFDPSSALVTWFWEVMEEFTNQERSLFLRFVWGRTRLPRTIADFRGRDFVLQVLEKN 4838
            |:|||  |.|                              |.:.|...:...|..:..:.|:.|.
Mouse   721 LQSVA--KKF------------------------------GLSNLSSRLEGVRLENEKINVIAKK 753

  Fly  4839 PPDHFLPESYTCFFLLKM-------PRYSC-KAVLLEKLKY 4871
            ..:........|.||..:       ..:|| |.||..:|:|
Mouse   754 TGNKLKLSQKKCSFLYDVTMKSVDGKEFSCHKCVLCARLEY 794

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826
RCC1 3091..3140 CDD:278826
RCC1 3144..3194 CDD:278826
RCC1 3197..3246 CDD:278826
RCC1 3250..3298 CDD:278826
RCC1 3302..3350 CDD:278826
RCC1_2 4136..4166 CDD:290274 6/13 (46%)
RCC1 4154..4203 CDD:278826 16/50 (32%)
RCC1 4206..4257 CDD:278826 22/50 (44%)
RCC1 4260..4309 CDD:278826 1/48 (2%)
RCC1 4312..4360 CDD:278826 18/50 (36%)
RCC1 4364..4413 CDD:278826 21/72 (29%)
HECTc 4509..4880 CDD:238033 72/435 (17%)
HECTc 4553..4878 CDD:214523 61/361 (17%)
IbtkNP_001074751.1 Ank_2 25..116 CDD:289560
ANK <47..135 CDD:238125
ANK repeat 51..82 CDD:293786
ANK 1 51..80
ANK repeat 84..116 CDD:293786
ANK 2 85..114
RCC1 1 141..194 16/52 (31%)
RCC1 143..192 CDD:278826 16/48 (33%)
RCC1 2 195..246 22/52 (42%)
RCC1_2 232..260 CDD:290274 11/81 (14%)
RCC1 247..299 CDD:278826 20/103 (19%)
RCC1 3 248..301 19/52 (37%)
BTB 562..>643 CDD:279045 16/88 (18%)
BTB 566..>643 CDD:197585 15/84 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 692..716 5/40 (13%)
BTB 762..868 CDD:279045 10/33 (30%)
BTB 770..872 CDD:197585 7/25 (28%)
SPOP_C_like 872..>919 CDD:269810
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 976..1002
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1032..1094
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5184
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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