Sequence 1: | NP_608388.2 | Gene: | HERC2 / 33035 | FlyBaseID: | FBgn0031107 | Length: | 4912 | Species: | Drosophila melanogaster |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | XP_016884680.1 | Gene: | HUWE1 / 10075 | HGNCID: | 30892 | Length: | 4501 | Species: | Homo sapiens |
Alignment Length: | 5473 | Identity: | 993/5473 - (18%) |
---|---|---|---|
Similarity: | 1639/5473 - (29%) | Gaps: | 2144/5473 - (39%) |
- Green bases have known domain annotations that are detailed below.
Fly 5 QASGGAGSSGQGAGSSQTASAAPVSAGVGVGGGGGASGAAAGAGSAAGSGSGSGSGSAAPPSHSP 69
Fly 70 DLYLRPLPFLDAKWLRADLIASLRNAADGAVLWNHLIQDCELVSSPTAPLLNARGQLSYLGDDG- 133
Fly 134 KHYCGAQ---QLKCSCCQPEYCGPLSACNCDGCRPLDSDTAIKKLTTQAAA----QQAAHLSQ-- 189
Fly 190 ---ATDMVLSGWLWSQPPSQQARLDCQRSMISELQELALRAAGNCLSAQHLRQQLFI----YER- 246
Fly 247 --------YFVALKRERERERKSTTSA---QAVASVTTANTTIAATTANAAVE------------ 288
Fly 289 ----SQPAEQQAEHGALGLARVATHAALNFSFAFLRRAWRSGEDTEMCSELLSEALASLQELPEA 349
Fly 350 TLFEA----AVVSS---LWLEVME---RSIKFLRLVALGDPMGNRCTAPLNDRHTALCLLLELGV 404
Fly 405 QKGTLAATLECVVLLLLLWEKDRAGNDNRDMPRKTGAPLQRILLRYQKIGATAKGGGIAGGEP-A 468
Fly 469 PVASATETFLRFLSLPKSSA--AIVDLRRAAVVIISHLDRMVQPLMPRCLLRGGQATAASSSSAP 531
Fly 532 QQRIYALGWPSLSKDQQGFSAEPTLSWSGESAGVPTLSCRFQIKQVACCETQMLILSQEGKLYTW 596
Fly 597 RLAKPEAEPLPMEEVAHDVFISI------AGHCEGRHFLAIDSNHNAYSWGTGEDHRLGHGDTHA 655
Fly 656 RAVPTKIAALEQHCVQSVYCGCSYSAAI---TCGGNLLTWGRGTYARLGHGN------SDDRSLP 711
Fly 712 TLVVALSDHMVVDVALGSGDAHSLALTSEGLVFAWG-DGDYGKLGNGNCNGSLQPILVESLPRVQ 775
Fly 776 RVFAGSQFSVALSSEGQLYTWGKATCLGHQLVERSVQGCSVPRLVSSL-QHKRIVDVAVSVAHCL 839
Fly 840 ALSSSGEVFGWGRNDSQQIC------------PASVSSEPLLRTPILVSLPTFPASGIACTSAQS 892
Fly 893 LVWTQSSHQGVPRRAPFVVDLGEPTFRLLDQL--LGMCSSQ--DNRQTPNQESECIAVACLNLFR 953
Fly 954 LQLLALIANGVEPRQVGLASGSRLLCSLKTRILGLAGGSQVLRTIQVAAQQALQDGWSVLLPTAA 1018
Fly 1019 ERAQTLTSLLPSEPGQASSAGHRFMTDLLVSSLMAEGGLESALQHAIRLESSSCSADCGDGVHLP 1083
Fly 1084 L---LQLITRLLSNNAALSQTRLSPTLGKQQEKEEEEREQQHQEPSTSP-SLSLLHRFQRLLLSH 1144
Fly 1145 IHQAQPEEETTGAEALLLQYMHALIPACVATLQKAHELALQC------REPGENSFGQMVGHLGR 1203
Fly 1204 VLQADISDALLNELLVGLLLLKRDRPQCLGGLRWARLFLPLLRVLDRLNRALGEGELRDGDDMGW 1268
Fly 1269 PGIICRGGPKGGPPPADPETHYVRRADMENLLLDGSRCIILAGYVCDLSGYNCESETLRSVLDSG 1333
Fly 1334 LGKD--LTAEMSSQVHRTAMEHILEHHK--LGKYMVQASTEEKSSAPGPSRLTHFSSECALAQLL 1394
Fly 1395 GLVANLMCSGPALQPAELQCRQLDKSSLL--------SGGLQLLQPSNPFDEEKGEARSSHSCHS 1451
Fly 1452 TAGNTPTELPPPLPMQQQL--------------APGRGKSQLQLRADAFISGLAEARVSEPPVAA 1502
Fly 1503 WLALTERYCKAHNLMWHQEFATEHPVQELERLLSAVLIRHQYLGGLVLNALETEVP------PPR 1561
Fly 1562 QLGEIIRLVHQAKWSVVRTRQQLNRSYKEV-----CAPILERLRFLLYEVRPAISPQQR------ 1615
Fly 1616 --------------------------------------------GLRRLPIL------------- 1623
Fly 1624 QRPPRFKML-VRRLL--------QELRSSRQPAKPEDLLNASIQQEQEKKPQSMPKQELEEQEEE 1679
Fly 1680 ETLLR--RLNERQIHGEGELDPALMQDIVDFALQDSC--------DVETARRAMYCQMQ-----R 1729
Fly 1730 YQLRLAGLQIVQQLLELHGLLDAAQYSLLNGFLGL------HL----------------KSTSSG 1772
Fly 1773 GGSTGSGSSLHVLGQLNMISAYQKARLLLAQSRVLDWAVRELRRLVNQEQQGHA--RGKD-STNL 1834
Fly 1835 GTYVLLKRLPRARFLLSVFGLLAKE-------LGPNELGFLINSGLLGTVLGLLAQTGGEGATGG 1892
Fly 1893 QVHGELSILYEDSVLKQKSSKAQLSGPDLAKLMKIGTRIVRGADWKWGDQDGNPPG-----EGRI 1952
Fly 1953 ISEVGEDGWVRVEWYTGATNSYRMGKEGQYDLQ----------LADSALNVASPTEPEREDVSGS 2007
Fly 2008 EASPTSDSHPSKLLRHCAAKLLQILAVGTGLHGAQLDKDALRGMTSMFRTIIYPKPSMSNISYAL 2072
Fly 2073 GWLNLGFIRAISGDCPRLCLELSTPGWLSHYLSLLEQPAGNEAGVYRQLHCLRLLQLILAQWGAE 2137
Fly 2138 EEPRMPALVHQLFATLGRIALHCPGDASLLPTAEGKARVLLTASHSGSVAEELVALLRRLHTLPS 2202
Fly 2203 WNPVINSFLAQKLCVAAELLAEQSHSTALDSEQVFVLGVLGAMGGHDLRPRVGLHCFHEGSHMVI 2267
Fly 2268 ASFTPKGRCLLAPGGVGSGVGFVKVQLPAVMPHLDHTVFSLSRLPMNEMLLNAWTVLLYGPAPEL 2332
Fly 2333 RELPSSADGRLDLALLRAQQLQMAVLHTNGVLYRHQVALRRILKQRAPGSIYASPDEPDRSDAES 2397
Fly 2398 QQPGEQD----QQLSSGSGQEPQLLIQCILLRATQASPVKACYSYMDLATAALNCIQSLATQAHQ 2458
Fly 2459 ----ELSEG----GGVPPNGRALSSPPQPTMVHGVPVYNVARKEQKPSEQVEQKSKWPAAATDAQ 2515
Fly 2516 LIGQIMEM--GFTRRTV----------------ELALKQLSLQAEIMPTPEQIVQWILEHPDVCA 2562
Fly 2563 NTIEEDTLPLASSASSHD--------PEADSDNECPSSNSTTSSSTSSDTVEGQPMAVS------ 2613
Fly 2614 GPAPPVKFE--SRKD---------FQTA-DL----------YALYVRGLVRPGMTVRCCRDFEEI 2656
Fly 2657 KQGDMGTVLIVDTEGLHDLNVQVDWRNHGSTYWVCFVHIELVEAAQTHHQPRPPPI-------AV 2714
Fly 2715 GARVRLRTSSLRYGMLCPLR-LGRSQ---GSSAIGVVSSVRSKQLTVDFPDQPAWQGHINEVELV 2775
Fly 2776 ASQPTSATLPSLGDSCSQMPPSDLIEDWSRCIRSLTVSSNEAAAKHLLNGSNQPWQSCSSGPCRH 2840
Fly 2841 WIRLELHDRILVHSLTLKVSPEDHSHMPSLLEIRVGDCVDSLKEYTWIPVPAGASRVLLMQQVPT 2905
Fly 2906 YYPWVEVVV-------KQCQNNGIQCKIHGIKFVGRRQQPDLQHILANAQFLASEYSAGVGPGST 2963
Fly 2964 AGAGAVSTSHEEAAAAPEQDLPCTVMVWGLNDKEQLGGLKGSKVKVPTFSQTISRLRPIHIAGGS 3028
Fly 3029 KSLFIVSQDGKVYACGEGTNGRLGLGVTHNVPLPHQLPVLRQYVVKKVAVHSGGKHALALTLDGK 3093
Fly 3094 VFSWGEGEDGKLGHGNRTTLDKPRLVEALRAKKIRDVACGSSHSAAISSQGELYTWGLGEYGRLG 3158
Fly 3159 HGDNTTQLKPK------LVTALAGRRVVQVACGSRDAQTLA-LTEDGAVFSWGDGDFGKLGRGGS 3216
Fly 3217 E----GSDTPHEIERLSGIGVVQIECGAQFSLALTRAGEVWTWGKGDYYRLGHGGDQHVRKPQPI 3277
Fly 3278 GGLRGRRVIHVAVGALHCLAVTDAGQVYAWGDNDHGQQGSGNTFVNKKPALVIGLDAVFVNRVAC 3342
Fly 3343 GSSHSIAWGLPNASSDEEKRGPVPFSSTRDPL----GGSSLGIYEAETMQTLKQEAKPLNQSSLS 3403
Fly 3404 ESLALETPAARQAALGHVLRAMSILQARQLIVAALTSHSKVNFKERGAVGGEEDHLIGGPIMGAP 3468
Fly 3469 LQLAETIAQGGGEAPADATDAGLQEHSPE--AAV--------------DALTGGMSGGANTLPPL 3517
Fly 3518 SAGPLSAFQSLTGSL------SMSGSLSSSALPQHKHSRMSASAMSVMAATMTQQEEMLSHISHC 3576
Fly 3577 H-GLDDFGGLLGEPEAKSL------VELLKLAVCGRCGP-----------PSTSQTIADTLISLG 3623
Fly 3624 A----GTPAVAAMLLETCITE-----------LEDLC---TSRHCLGKLPKPVMQESSHPYVDNV 3670
Fly 3671 NVTGVVRIPGAEMLRLEFDSQCSTEKRNDPLVIMDGTGRVLAMRSGREFAHWAPEIRVLGDELRW 3735
Fly 3736 KFSSDSSVNGWGWRFWVHAIMPAATLG---------------------ESGSDRAVLSQPSMALV 3779
Fly 3780 MSLLDSRLAPRQPSVLLRLASALAACSQLGALTTAQRIWSLRKLHAVLLLEQAPRPQDPSLSTLL 3844
Fly 3845 QPLIPELLRQYEYEEPQVRGGIHLMHSDYFKTLAALACD-----MQLDAALPATSSSSSSSAAPG 3904
Fly 3905 AISSTGDVHKWAWFKRYCIAV--------RVAQSLIRRTELPRAFCLEVRKKFAEMLPSSS-SNS 3960
Fly 3961 NANPGCQSPGASMLNSTTSLSSSTVSNVSPPPGITGEQPDLHCHA-HQLESTSTLLHEDHTLFQA 4024
Fly 4025 PHDAQLLQWL------NRRPDDWALSWGGASTIYGWGHNHRGQLGGLEGSRIK------TPTPC- 4076
Fly 4077 -----EALSLLRPVQLAGGEQSLFAVTPDG--KLFATGYGSGGRLGVGGSDSWAIPTLLGSLQHV 4134
Fly 4135 FVKKVAVNSGGKHCLALTTEGEVYAWGEGEDGKLGHGNRMSYDRPKLVEHLNG--MSVADIACGS 4197
Fly 4198 AHSAAITASGHVLTWGKGRYGRLGHGDSEDQLRPKLVEALLGYRAIDIACGS------------- 4249
Fly 4250 GDAQTLCITDDDNVWSWGDGDYGKLGRGGSDGCKLPYKIESLAGLGVVKVECGSQFSVALTKSGA 4314
Fly 4315 VYTWGKGDFHRLGHGSVDHVRRPKKVA---ALQGKKIISIATGSLHCVACSDSGEVYTWGDNDEG 4376
Fly 4377 QLGDGTVTAIQRPRLVAALQGKHIVKVTCGSAHTLALSTSQLSERLRPLP--NPPLEYDLVRDLA 4439
Fly 4440 PEAL---------HARLIL--------LHHFSELVC-------------------PCLAMLP--- 4465
Fly 4466 ------------------ISGDLSLGALKDVLVYNIKEAAFRKVIQ--TTMVRDKQHGPVIELNR 4510
Fly 4511 I---QVKRSRNRCNGLAGID-GMKS-----------VFGQMVQKLPLLTQEALALPHRVWKVKFV 4560
Fly 4561 GESVDDCGGGYSESIAEMCDELQNGSVPLLINTPNGRGEAGANRDCFLLDPTL-SSVLQMNMFRF 4624
Fly 4625 LGVLMGIAVRTGSPLSINLAEPVWRQLTGEVLRPTDLTEVDRDYVAGLLCIRNMDDDPKLFTALE 4689
Fly 4690 LPFSTSSARGHEVPLSTRYTH-----------------ISPRNRAEYVRLALGFRL-HEFDEQVK 4736
Fly 4737 AVRDGMSKVIPVPLLSLFSAAELQAMVCGSPDIPLGLLKSVATYKGFDPSSALVTWFWEVMEEFT 4801
Fly 4802 NQERSLFLRFVWGRTRLP-RTIADFRGRDFV--LQVLEKNPPDHFLPESYTCFFLLKMPRYSCKA 4863
Fly 4864 VLLEKLKYAIHFC 4876 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
HERC2 | NP_608388.2 | RCC1 | 638..683 | CDD:278826 | 9/44 (20%) |
RCC1 | 687..737 | CDD:278826 | 14/55 (25%) | ||
RCC1 | 740..787 | CDD:278826 | 8/47 (17%) | ||
RCC1 | 790..841 | CDD:278826 | 7/51 (14%) | ||
RCC1_2 | 828..857 | CDD:290274 | 5/28 (18%) | ||
Cyt-b5 | 1290..1363 | CDD:278597 | 12/76 (16%) | ||
MIB_HERC2 | 1928..1987 | CDD:284184 | 10/73 (14%) | ||
UBA_HERC2 | 2515..2559 | CDD:270585 | 12/61 (20%) | ||
Cul7 | 2624..2699 | CDD:288381 | 18/94 (19%) | ||
APC10-HERC2 | 2762..2932 | CDD:176485 | 24/176 (14%) | ||
RCC1 | 3037..3088 | CDD:278826 | 7/50 (14%) | ||
RCC1 | 3091..3140 | CDD:278826 | 9/48 (19%) | ||
RCC1 | 3144..3194 | CDD:278826 | 13/56 (23%) | ||
RCC1 | 3197..3246 | CDD:278826 | 11/52 (21%) | ||
RCC1 | 3250..3298 | CDD:278826 | 5/47 (11%) | ||
RCC1 | 3302..3350 | CDD:278826 | 4/47 (9%) | ||
RCC1_2 | 4136..4166 | CDD:290274 | 3/29 (10%) | ||
RCC1 | 4154..4203 | CDD:278826 | 7/50 (14%) | ||
RCC1 | 4206..4257 | CDD:278826 | 9/63 (14%) | ||
RCC1 | 4260..4309 | CDD:278826 | 10/48 (21%) | ||
RCC1 | 4312..4360 | CDD:278826 | 5/50 (10%) | ||
RCC1 | 4364..4413 | CDD:278826 | 6/48 (13%) | ||
HECTc | 4509..4880 | CDD:238033 | 95/405 (23%) | ||
HECTc | 4553..4878 | CDD:214523 | 83/346 (24%) | ||
HUWE1 | XP_016884680.1 | None |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 0 | 0.000 | Not matched by this tool. | |||
Domainoid | 0 | 0.000 | Not matched by this tool. | |||
eggNOG | 1 | 0.900 | - | - | E1_COG5021 | |
Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
Homologene | 0 | 0.000 | Not matched by this tool. | |||
Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
Isobase | 0 | 0.000 | Not matched by this tool. | |||
OMA | 0 | 0.000 | Not matched by this tool. | |||
OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
Panther | 0 | 0.000 | Not matched by this tool. | |||
Phylome | 1 | 0.910 | - | - | ||
RoundUp | 0 | 0.000 | Not matched by this tool. | |||
SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
TreeFam | 0 | 0.000 | Not matched by this tool. | |||
User_Submission | 0 | 0.000 | Not matched by this tool. | |||
2 | 1.810 |