DRSC/TRiP Functional Genomics Resources

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Protein Alignment HERC2 and HUWE1

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:XP_016884680.1 Gene:HUWE1 / 10075 HGNCID:30892 Length:4501 Species:Homo sapiens


Alignment Length:5473 Identity:993/5473 - (18%)
Similarity:1639/5473 - (29%) Gaps:2144/5473 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 QASGGAGSSGQGAGSSQTASAAPVSAGVGVGGGGGASGAAAGAGSAAGSGSGSGSGSAAPPSHSP 69
            :|||.:.|:...:|.|...|..|     |.|.|.| .|...|.|...|.|.|.|.|....|...|
Human   565 RASGSSSSTNISSGPSPGPSPGP-----GTGPGPG-PGPGPGPGPGPGPGPGPGPGPGPGPGPRP 623

  Fly    70 DLYLRPLPFLDAKWLRADLIASLRNAADGAVLWNHLIQDCELVSSPTAPLLNARGQLSYLGDDG- 133
            .:...|        .||.|:.|:.|....|      |||         |..:          || 
Human   624 GVQCIP--------QRAALLKSMLNFLKKA------IQD---------PAFS----------DGI 655

  Fly   134 KHYCGAQ---QLKCSCCQPEYCGPLSACNCDGCRPLDSDTAIKKLTTQAAA----QQAAHLSQ-- 189
            :|.....   .||......||.||                ::..|.|:...    |:.:.||.  
Human   656 RHVMDGSLPTSLKHIISNAEYYGP----------------SLFLLATEVVTVFVFQEPSLLSSLQ 704

  Fly   190 ---ATDMVLSGWLWSQPPSQQARLDCQRSMISELQELALRAAGNCLSAQHLRQQLFI----YER- 246
               .||::|...|....|:.:..|....::.|.|          ||:|:.|  |.|:    :|| 
Human   705 DNGLTDVMLHALLIKDVPATREVLGSLPNVFSAL----------CLNARGL--QSFVQCQPFERL 757

  Fly   247 --------YFVALKRERERERKSTTSA---QAVASVTTANTTIAATTANAAVE------------ 288
                    |..|::|.|..:....|::   .||..:.....|:......|.::            
Human   758 FKVLLSPDYLPAMRRRRSSDPLGDTASNLGSAVDELMRHQPTLKTDATTAIIKLLEEICNLGRDP 822

  Fly   289 ----SQPAEQQAEHGALGLARVATHAALNFSFAFLRRAWRSGEDTEMCSELLSEALASLQELPEA 349
                .:|:.|:|:..|......:.|||..          .|.||.|      .|.:.::|.....
Human   823 KYICQKPSIQKADGTATAPPPRSNHAAEE----------ASSEDEE------EEEVQAMQSFNST 871

  Fly   350 TLFEA----AVVSS---LWLEVME---RSIKFLRLVALGDPMGNRCTAPLNDRHTALCLLLELGV 404
            ...|.    .||.:   :.:.:|:   ..:||:..:...:...:.|...:|              
Human   872 QQNETEPNQQVVGTEERIPIPLMDYILNVMKFVESILSNNTTDDHCQEFVN-------------- 922

  Fly   405 QKGTLAATLECVVLLLLLWEKDRAGNDNRDMPRKTGAPLQRILLRYQKIGATAKGGGIAGGEP-A 468
            |||.|                                ||..||                 |.| .
Human   923 QKGLL--------------------------------PLVTIL-----------------GLPNL 938

  Fly   469 PVASATETFLRFLSLPKSSA--AIVDLRRAAVVIISHLDRMVQPLMPRCLLRGGQATAASSSSAP 531
            |:           ..|.|:|  |:..:.: :::.:||..:::|    ..||   |..:..||..|
Human   939 PI-----------DFPTSAACQAVAGVCK-SILTLSHEPKVLQ----EGLL---QLDSILSSLEP 984

  Fly   532 QQRIYALGWPSLSKDQQGFSAEPTLSWSGESAGVPTLSCRFQIKQVACCETQMLILSQEGKLYTW 596
            ..|                   |.     ||.|...|     ::::||.          |.:...
Human   985 LHR-------------------PI-----ESPGGSVL-----LRELACA----------GNVADA 1010

  Fly   597 RLAKPEAEPLPMEEVAHDVFISI------AGHCEGRHFLAIDSNHNAYSWGTGEDHRLGHGDTHA 655
            .|: .:|.||.....|...:|.:      .|..|.|   :|..|    .||:    :||      
Human  1011 TLS-AQATPLLHALTAAHAYIMMFVHTCRVGQSEIR---SISVN----QWGS----QLG------ 1057

  Fly   656 RAVPTKIAALEQHCVQSVYCGCSYSAAI---TCGGNLLTWGRGTYARLGHGN------SDDRSLP 711
            .:|.:|::.|        ||...:.:.:   .|..|.|..|    ...|..:      .|:::..
Human  1058 LSVLSKLSQL--------YCSLVWESTVLLSLCTPNSLPSG----CEFGQADMQKLVPKDEKAGT 1110

  Fly   712 TLVVALSDHMVVDVALGSGDAHSLALTSEGLVFAWG-DGDYGKLGNGNCNGSLQPILVESLPRVQ 775
            |.....||. ..|.|.||.||     :::||:...| |||           :|.|:..:.     
Human  1111 TQGGKRSDG-EQDGAAGSMDA-----STQGLLEGIGLDGD-----------TLAPMETDE----- 1153

  Fly   776 RVFAGSQFSVALSSEGQLYTWGKATCLGHQLVERSVQGCSVPRLVSSL-QHKRIVDVAVSVAHCL 839
                    ..|..|:|:    .|.|                |.:.:.: |.|.::..:..:...|
Human  1154 --------PTASDSKGK----SKIT----------------PAMAARIKQIKPLLSASSRLGRAL 1190

  Fly   840 ALSSSGEVFGWGRNDSQQIC------------PASVSSEPLLRTPILVSLPTFPASGIACTSAQS 892
            |     |:||.    ..::|            .||.::.|   ||...|    .||.:.....:.
Human  1191 A-----ELFGL----LVKLCVGSPVRQRRSHHAASTTTAP---TPAARS----TASALTKLLTKG 1239

  Fly   893 LVWTQSSHQGVPRRAPFVVDLGEPTFRLLDQL--LGMCSSQ--DNRQTPNQESECIAVACLNLFR 953
            |.|....:...||            |||...:  :|..|..  |.|:.|              :.
Human  1240 LSWQPPPYTPTPR------------FRLTFFICSVGFTSPMLFDERKYP--------------YH 1278

  Fly   954 LQLLALIANGVEPRQVGLASGSRLLCSLKTRILGLAGGSQVLRTIQVAAQQALQDGWSVLLPTAA 1018
            |.|                  .:.|||        .|.:.:..|.          .|        
Human  1279 LML------------------QKFLCS--------GGHNALFETF----------NW-------- 1299

  Fly  1019 ERAQTLTSLLPSEPGQASSAGHRFMTDLLVSSLMAEGGLESALQHAIRLESSSCSADCGDGVHLP 1083
              |.::...:|                      ::||     |:|          :|..||....
Human  1300 --ALSMGGKVP----------------------VSEG-----LEH----------SDLPDGTGEF 1325

  Fly  1084 L---LQLITRLLSNNAALSQTRLSPTLGKQQEKEEEEREQQHQEPSTSP-SLSLLHRFQRLLLSH 1144
            |   |.|:.::::....|                    |..|..|:..| .:....:|..|..  
Human  1326 LDAWLMLVEKMVNPTTVL--------------------ESPHSLPAKLPGGVQNFPQFSALRF-- 1368

  Fly  1145 IHQAQPEEETTGAEALLLQYMHALIPACVATLQKAHELALQC------REPGENSFGQMVGHLGR 1203
                                        :...|||   |..|      |:|.:...|:|      
Human  1369 ----------------------------LVVTQKA---AFTCIKNLWNRKPLKVYGGRM------ 1396

  Fly  1204 VLQADISDALLNELLVGLLLLKRDRPQCLGGLRWARLFLPLLRVLDRLNRALGEGELRDGDDMGW 1268
               |:...|:|..:|.|                     .|::|  :||::. .||...:.|    
Human  1397 ---AESMLAILCHILRG---------------------EPVIR--ERLSKE-KEGSRGEED---- 1430

  Fly  1269 PGIICRGGPKGGPPPADPETHYVRRADMENLLLDGSRCIILAGYVCDLSGYNCESETLRSVLDSG 1333
                 .|..:||.          ||....|                        .:.|:.::|.|
Human  1431 -----TGQEEGGS----------RREPQVN------------------------QQQLQQLMDMG 1456

  Fly  1334 LGKD--LTAEMSSQVHRTAMEHILEHHK--LGKYMVQASTEEKSSAPGPSRLTHFSSECALAQLL 1394
            ..::  :.|.:::.....|.|::|.|..  :|..:...|..|:.....           |:|..|
Human  1457 FTREHAMEALLNTSTMEQATEYLLTHPPPIMGGVVRDLSMSEEDQMMR-----------AIAMSL 1510

  Fly  1395 GLVANLMCSGPALQPAELQCRQLDKSSLL--------SGGLQLLQPSNPFDEEKGEARSSHSCHS 1451
            |  .::.....|..|.|:.||:.::....        :..|:..|.::|.::::        .|:
Human  1511 G--QDIPMDQRAESPEEVACRKEEEERKAREKQEEEEAKCLEKFQDADPLEQDE--------LHT 1565

  Fly  1452 TAGNTPTELPPPLPMQQQL--------------APGRGKSQLQLRADAFISGLAEARVSEPPVAA 1502
            .   |.|.||....:..:|              ....|.....:.....::.:.||  ::..:.|
Human  1566 F---TDTMLPGCFHLLDELPDTVYRVCDLIMTAIKRNGADYRDMILKQVVNQVWEA--ADVLIKA 1625

  Fly  1503 WLALTERYCKAHNLMWHQEFATEHPVQELERLLSAVLIRHQYLGGLVLNALETEVP------PPR 1561
            .|.||....|..: .|..:.||   :.:...|.:.:|:       |.|...|.::|      ...
Human  1626 ALPLTTSDTKTVS-EWISQMAT---LPQASNLATRILL-------LTLLFEELKLPCAWVVESSG 1679

  Fly  1562 QLGEIIRLVHQAKWSVVRTRQQLNRSYKEV-----CAPILERLRFLLYEVRPAISPQQR------ 1615
            .|..:|:|:     .||:...|..:..|||     ..|:|..:.|  || :.|||.::|      
Human  1680 ILNVLIKLL-----EVVQPCLQAAKEQKEVQTPKWITPVLLLIDF--YE-KTAISSKRRAQMTKY 1736

  Fly  1616 --------------------------------------------GLRRLPIL------------- 1623
                                                        |.||..:.             
Human  1737 LQSNSNNWRWFDDRSGRWCSYSASNNSTIDSAWKSGETSVRFTAGRRRYTVQFTTMVQVNEETGN 1801

  Fly  1624 QRPPRFKML-VRRLL--------QELRSSRQPAKPEDLLNASIQQEQEKKPQSMPKQELEEQEEE 1679
            :||....:| |.||.        |||..:.:.:|..|:      :.:|.|....|........|:
Human  1802 RRPVMLTLLRVPRLNKNSKNSNGQELEKTLEESKEMDI------KRKENKGNDTPLALESTNTEK 1860

  Fly  1680 ETLLR--RLNERQIHGEGELDPALMQDIVDFALQDSC--------DVETARRAMYCQMQ-----R 1729
            ||.|.  ::.|..|.|       |.:|:|...:: :|        |.:|....:...::     :
Human  1861 ETSLEETKIGEILIQG-------LTEDMVTVLIR-ACVSMLGVPVDPDTLHATLRLCLRLTRDHK 1917

  Fly  1730 YQLRLAGLQIVQQLLELHGLLDAAQYSLLNGFLGL------HL----------------KSTSSG 1772
            |.:..|.|:..:.:|.|      .|.|..|||..|      |:                .:.:||
Human  1918 YAMMFAELKSTRMILNL------TQSSGFNGFTPLVTLLLRHIIEDPCTLRHTMEKVVRSAATSG 1976

  Fly  1773 GGSTGSGSSLHVLGQLNMISAYQKARLLLAQSRVLDWAVRELRRLVNQEQQGHA--RGKD-STNL 1834
            .|||.||.   |.|.|.              ||.:::.:|.|         |.|  |..| .|.:
Human  1977 AGSTTSGV---VSGSLG--------------SREINYILRVL---------GPAACRNPDIFTEV 2015

  Fly  1835 GTYVLLKRLPRARFLLSVFGLLAKE-------LGPNELGFLINSGLLGTVLGLLAQTGGEGATGG 1892
            ....:...||..|    ..|..:.:       .|||.:..:..:.|..:.|.::..|..|     
Human  2016 ANCCIRIALPAPR----GSGTASDDEFENLRIKGPNAVQLVKTTPLKPSPLPVIPDTIKE----- 2071

  Fly  1893 QVHGELSILYEDSVLKQKSSKAQLSGPDLAKLMKIGTRIVRGADWKWGDQDGNPPG-----EGRI 1952
                   ::|:     ..::.|....|:.|                  |:....||     .|::
Human  2072 -------VIYD-----MLNALAAYHAPEEA------------------DKSDPKPGVMTQEVGQL 2106

  Fly  1953 ISEVGEDGWVRVEWYTGATNSYRMGKEGQYDLQ----------LADSALNVASPTEPEREDVSGS 2007
            :.::|:|.:   :.|...|.     :...:|.|          .||.|     .||......|..
Human  2107 LQDMGDDVY---QQYRSLTR-----QSSDFDTQSGFSINSQVFAADGA-----STETSASGTSQG 2158

  Fly  2008 EASPTSDSHPSKLLRHCAAKLLQILAVGTGLHGAQLDKDALRGMTSMFRTIIYPKPSMSNISYAL 2072
            |||...:|...|..:.......:....|.|..........||.:..:.|:.:.....::|.||.:
Human  2159 EASTPEESRDGKKDKEGDRASEEGKQKGKGSKPLMPTSTILRLLAELVRSYVGIATLIANYSYTV 2223

  Fly  2073 GWLNLGFIRAISGDCPRLCLELSTPGWLSHYLSLLEQPAGNEAGVYRQLHCLRLLQLILAQWGAE 2137
            |...|     |..||..|...      |.|.|...:.....:.....:|.   |..|..|..|.:
Human  2224 GQSEL-----IKEDCSVLAFV------LDHLLPHTQNAEDKDTPALARLF---LASLAAAGSGTD 2274

  Fly  2138 EEPRMPALVHQLFATLGRIALHCPGDASLLPTAEGKARVLLTASHSGSVAEELVALLRRLHTLPS 2202
            .:   .|||:::.|.|||          .|..||.      |..|:     .|.|::..:.|:..
Human  2275 AQ---VALVNEVKAALGR----------ALAMAES------TEKHA-----RLQAVMCIISTIME 2315

  Fly  2203 WNPVINSFLAQKLCVAAELLAEQSHSTALDSEQVFVLGVLGAMGGHDLRPRVGLHCFHEGSHMVI 2267
            ..|..:||                :|:|....|                        |.|.:.:|
Human  2316 SCPSTSSF----------------YSSATAKTQ------------------------HNGMNNII 2340

  Fly  2268 ASFTPKGRCLLAPGGVGSGVGFVKVQLPAVMPHLDHTVFSLSRLPMNEMLLNAWTVLLYGPAPEL 2332
            ..|..||                                          |:|           :|
Human  2341 RLFLKKG------------------------------------------LVN-----------DL 2352

  Fly  2333 RELPSSADGRLDLALLRAQQLQMAVLHTNGVLYRHQVALRRILKQRAPGSIYASPDEPDRSDAES 2397
            ..:|.|    |||:     ...||  :|.....:....|.||:.|  |.|::.|      ..|.|
Human  2353 ARVPHS----LDLS-----SPNMA--NTVNAALKPLETLSRIVNQ--PSSLFGS------KSASS 2398

  Fly  2398 QQPGEQD----QQLSSGSGQEPQLLIQCILLRATQASPVKACYSYMDLATAALNCIQSLATQAHQ 2458
            :...|||    .|.||.:.|:|             ..|.:|                .:..:.|.
Human  2399 KNKSEQDAQGASQDSSSNQQDP-------------GEPGEA----------------EVQEEDHD 2434

  Fly  2459 ----ELSEG----GGVPPNGRALSSPPQPTMVHGVPVYNVARKEQKPSEQVEQKSKWPAAATDAQ 2515
                |:::|    |....:...::..|:.          ::.:|.:...::|            .
Human  2435 VTQTEVADGDIMDGEAETDSVVIAGQPEV----------LSSQEMQVENELE------------D 2477

  Fly  2516 LIGQIMEM--GFTRRTV----------------ELALKQLSLQAEIMPTPEQIVQWILEHPDVCA 2562
            ||.:::|.  |....|:                :.|...|| ||..:....:....||:..|...
Human  2478 LIDELLERDGGSGNSTIIVSRSGEDESQEDVLMDEAPSNLS-QASTLQANREDSMNILDPEDEEE 2541

  Fly  2563 NTIEEDTLPLASSASSHD--------PEADSDNECPSSNSTTSSSTSSDTVEGQPMAVS------ 2613
            :|.|||     ||.|:.|        .|.:.|.|....:.........|..:|..|.:.      
Human  2542 HTQEED-----SSGSNEDEDDSQDEEEEEEEDEEDDQEDDEGEEGDEDDDDDGSEMELDEDYPDM 2601

  Fly  2614 GPAPPVKFE--SRKD---------FQTA-DL----------YALYVRGLVRPGMTVRCCRDFEEI 2656
            ..:|.|:||  .|:|         |.:| |:          :.|.||......:|:........:
Human  2602 NASPLVRFERFDREDDLIIEFDNMFSSATDIPPSPGNIPTTHPLMVRHADHSSLTLGSGSSTTRL 2666

  Fly  2657 KQGDMGTVLIVDTEGLHDLNVQVDWRNHGSTYWVCFVHIELVEAAQTHHQPRPPPI-------AV 2714
            .|| :|.    ....|..|..     |.|.|     :|:..    ..:.||.||.|       :.
Human  2667 TQG-IGR----SQRTLRQLTA-----NTGHT-----IHVHY----PGNRQPNPPLILQRLLGPSA 2712

  Fly  2715 GARVRLRTSSLRYGMLCPLR-LGRSQ---GSSAIGVVSSVRSKQLTVDFPDQPAWQGHINEVELV 2775
            .|.:...:|||      ||: .||::   |:..:.:::....:.|...|.||             
Human  2713 AADILQLSSSL------PLQSRGRARLLVGNDDVHIIARSDDELLDDFFHDQ------------- 2758

  Fly  2776 ASQPTSATLPSLGDSCSQMPPSDLIEDWSRCIRSLTVSSNEAAAKHLLNGSNQPWQSCSSGPCRH 2840
                  :|..|...:.|.:|.:  :..|:...:.|...|                          
Human  2759 ------STATSQAGTLSSIPTA--LTRWTEECKVLDAES-------------------------- 2789

  Fly  2841 WIRLELHDRILVHSLTLKVSPEDHSHMPSLLEIRVGDCVDSLKEYTWIPVPAGASRVLLMQQVPT 2905
                 :||.:.|    :|||..:|      ||....:.::..:|         ..|..|.::   
Human  2790 -----MHDCVSV----VKVSIVNH------LEFLRDEELEERRE---------KRRKQLAEE--- 2827

  Fly  2906 YYPWVEVVV-------KQCQNNGIQCKIHGIKFVGRRQQPDLQHILANAQFLASEYSAGVGPGST 2963
                 |..:       |:.::...||       ...:.....:..|::...:...|.  ..|.||
Human  2828 -----ETKITDKGKEDKENRDQSAQC-------TASKSNDSTEQNLSDGTPMPDSYP--TTPSST 2878

  Fly  2964 AGAGAVSTSHEEAAAAPEQDLPCTVMVWGLNDKEQLGGLKGSKVKVPTFSQTISRLRPIHIAGGS 3028
            ..|.:.|                         ||.||.|:.|: :.||..               
Human  2879 DAATSES-------------------------KETLGTLQSSQ-QQPTLP--------------- 2902

  Fly  3029 KSLFIVSQDGKVYACGEGTNGRLGLGVTHNVPLPHQLPVLRQYVVKKVAVHSGGKHALALTLDGK 3093
                              |...||     .||...|.|.                          
Human  2903 ------------------TPPALG-----EVPQELQSPA-------------------------- 2918

  Fly  3094 VFSWGEGEDGKLGHGNRTTLDKPRLVEALRAKKIRDVACGSSHSAAISSQGELYTWGLGEYGRLG 3158
                |||       |:.|.|..|...|.|...:               ..||..|..:    .|.
Human  2919 ----GEG-------GSSTQLLMPVEPEELGPTR---------------PSGEAETTQM----ELS 2953

  Fly  3159 HGDNTTQLKPK------LVTALAGRRVVQVACGSRDAQTLA-LTEDGAVFSWGDGDFGKLGRGGS 3216
            .....|.|.|:      .:||::.    |:.....|..:|| .|.:.||     ||..  ..|.|
Human  2954 PAPTITSLSPERAEDSDALTAVSS----QLEGSPMDTSSLASCTLEEAV-----GDTS--AAGSS 3007

  Fly  3217 E----GSDTPHEIERLSGIGVVQIECGAQFSLALTRAGEVWTWGKGDYYRLGHGGDQHVRKPQPI 3277
            |    ||.||                                            ||    .|..:
Human  3008 EQPRAGSSTP--------------------------------------------GD----APPAV 3024

  Fly  3278 GGLRGRRVIHVAVGALHCLAVTDAGQVYAWGDNDHGQQGSGNTFVNKKPALVIGLDAVFVNRVAC 3342
            ..::||                              ..|||.                       
Human  3025 AEVQGR------------------------------SDGSGE----------------------- 3036

  Fly  3343 GSSHSIAWGLPNASSDEEKRGPVPFSSTRDPL----GGSSLGIYEAETMQTLKQEAKPLNQSSLS 3403
             |:.......|.|||:.        |||||..    |..|.||.|.....|..:|..||...||.
Human  3037 -SAQPPEDSSPPASSES--------SSTRDSAVAISGADSRGILEEPLPSTSSEEEDPLAGISLP 3092

  Fly  3404 ESLALETPAARQAALGHVLRAMSILQARQLIVAALTSHSKVNFKERGAVGGEEDHLIGGPIMGAP 3468
            |.:    ..:..|||...:| ..:|| .||.:...|                             
Human  3093 EGV----DPSFLAALPDDIR-REVLQ-NQLGIRPPT----------------------------- 3122

  Fly  3469 LQLAETIAQGGGEAPADATDAGLQEHSPE--AAV--------------DALTGGMSGGANTLPPL 3517
                .|.......|||...:.|:.|.|||  ||:              :.....::..|::..|:
Human  3123 ----RTAPSTNSSAPAVVGNPGVTEVSPEFLAALPPAIQEEVLAQQRAEQQRRELAQNASSDTPM 3183

  Fly  3518 SAGPLSAFQSLTGSL------SMSGSLSSSALPQHKHSRMSASAMSVMAATMTQQEEMLSHISHC 3576
            .  |::..|:|...|      .|..|:.:...|.     ::|.|.::......:|.:::......
Human  3184 D--PVTFIQTLPSDLRRSVLEDMEDSVLAVMPPD-----IAAEAQALRREQEARQRQLMHERLFG 3241

  Fly  3577 H-GLDDFGGLLGEPEAKSL------VELLKLAVCGRCGP-----------PSTSQTIADTLISLG 3623
            | .......:|..|...|.      |:..:||| .|.|.           ||.|.  .|||:.|.
Human  3242 HSSTSALSAILRSPAFTSRLSGNRGVQYTRLAV-QRGGTFQMGGSSSHNRPSGSN--VDTLLRLR 3303

  Fly  3624 A----GTPAVAAMLLETCITE-----------LEDLC---TSRHCLGKLPKPVMQESSHPYVDNV 3670
            .    ...|::.:|:...:.|           |.:||   .:||.:.:....::|.||.      
Human  3304 GRLLLDHEALSCLLVLLFVDEPKLNTSRLHRVLRNLCYHAQTRHWVIRSLLSILQRSSE------ 3362

  Fly  3671 NVTGVVRIPGAEMLRLEFDSQCSTEKRNDPLVIMDGTGRVLAMRSGREFAHWAPEIRVLGDELRW 3735
                       ..|.:|.....::|::              ..:|.:.....:.|.|.|  :|..
Human  3363 -----------SELCIETPKLTTSEEK--------------GKKSSKSCGSSSHENRPL--DLLH 3400

  Fly  3736 KFSSDSSVNGWGWRFWVHAIMPAATLG---------------------ESGSDRAVLSQPSMALV 3779
            |..|.||    ....|:...|.|| ||                     ..||...:..|.:..:.
Human  3401 KMESKSS----NQLSWLSVSMDAA-LGCRTNIFQIQRSGGRKHTEKHASGGSTVHIHPQAAPVVC 3460

  Fly  3780 MSLLDSRLAPRQPSVLLRLASALAACSQLGALTTAQRIWSLRKLHAVLLLEQAPRPQDPSLSTLL 3844
            ..:||:         |::||...                                   ||..|  
Human  3461 RHVLDT---------LIQLAKVF-----------------------------------PSHFT-- 3479

  Fly  3845 QPLIPELLRQYEYEEPQVRGGIHLMHSDYFKTLAALACD-----MQLDAALPATSSSSSSSAAPG 3904
                .:..::...|..:.||...........:.:.:..|     ::||....:....:|..:.|.
Human  3480 ----QQRTKETNCESDRERGNKACSPCSSQSSSSGICTDFWDLLVKLDNMNVSRKGKNSVKSVPV 3540

  Fly  3905 AISSTGDVHKWAWFKRYCIAV--------RVAQSLIRRTELPRAFCLEVRKKFAEMLPSSS-SNS 3960
            :....|:.      ..|.:..        .::..:|||:.|.....|.:....:..||.:. |.:
Human  3541 SAGGEGET------SPYSLEASPLGQLMNMLSHPVIRRSSLLTEKLLRLLSLISIALPENKVSEA 3599

  Fly  3961 NANPGCQSPGASMLNSTTSLSSSTVSNVSPPPGITGEQPDLHCHA-HQLESTSTLLHEDHTLFQA 4024
            .||.|..:...:...||||.:::|.::.:|.|. |...|.....| ....:.||::....|....
Human  3600 QANSGSGASSTTTATSTTSTTTTTAASTTPTPP-TAPTPVTSAPALVAATAISTIVVAASTTVTT 3663

  Fly  4025 PHDAQLLQWL------NRRPDDWALSWGGASTIYGWGHNHRGQLGGLEGSRIK------TPTPC- 4076
            |..|.....:      ::.|.  .:|.||:|:.     :.:....||..::::      |...| 
Human  3664 PTTATTTVSISPTTKGSKSPA--KVSDGGSSST-----DFKMVSSGLTENQLQLSVEVLTSHSCS 3721

  Fly  4077 -----EALSLLRPVQLAGGEQSLFAVTPDG--KLFATGYGSGGRLGVGGSDSWAIPTLLGSLQHV 4134
                 :|.::|  :||:.|:..    |.|.  ||..     .|...:|.:....|.|||..|:..
Human  3722 EEGLEDAANVL--LQLSRGDSG----TRDTVLKLLL-----NGARHLGYTLCKQIGTLLAELREY 3775

  Fly  4135 FVKKVAVNSGGKHCLALTTEGEVYAWGEGEDGKLGHGNRMSYDRPKLVEHLNG--MSVADIACGS 4197
            .:::    .....|..|:.:|                  :..::|:..: |.|  .|..|:    
Human  3776 NLEQ----QRRAQCETLSPDG------------------LPEEQPQTTK-LKGKMQSRFDM---- 3813

  Fly  4198 AHSAAITASGHVLTWGKGRYGRLGHGDSEDQLRPKLVEALLGYRAIDIACGS------------- 4249
            |.:..|.||                     |.||      ||.|.:.:...|             
Human  3814 AENVVIVAS---------------------QKRP------LGGRELQLPSMSMLTSKTSTQKFFL 3851

  Fly  4250 GDAQTLCITDDDNVWSWGDGDYGKLGRGGSDGCKLPYKIESLAGLGVVKVECGSQFSVALTKSGA 4314
            ...|.:....||.  ...:....:.||.||.|......|::    .|.::|..:...:.:.:.| 
Human  3852 RVLQVIIQLRDDT--RRANKKAKQTGRLGSSGLGSASSIQA----AVRQLEAEADAIIQMVREG- 3909

  Fly  4315 VYTWGKGDFHRLGHGSVDHVRRPKKVA---ALQGKKIISIATGSLHCVACSDSGEVYTWGDNDEG 4376
                             ...||.::.|   :.|.:..:......:.....|.|.:      :.:.
Human  3910 -----------------QRARRQQQAATSESSQSEASVRREESPMDVDQPSPSAQ------DTQS 3951

  Fly  4377 QLGDGTVTAIQRPRLVAALQGKHIVKVTCGSAHTLALSTSQLSERLRPLP--NPPLEYDLVRDLA 4439
            ...|||.            ||:                 .:..||...||  :..|..|.:.|:.
Human  3952 IASDGTP------------QGE-----------------KEKEERPPELPLLSEQLSLDELWDML 3987

  Fly  4440 PEAL---------HARLIL--------LHHFSELVC-------------------PCLAMLP--- 4465
            .|.|         ||.|:|        |.|.:|...                   |.|:..|   
Human  3988 GECLKELEESHDQHAVLVLQPAVEAFFLVHATERESKPPVRDTRESQLAHIKDEPPPLSPAPLTP 4052

  Fly  4466 ------------------ISGDLSLGALKDVLVYNIKEAAFRKVIQ--TTMVRDKQHGPVIELNR 4510
                              ||..|.....|.:...........::::  ||.:.|.....:::..|
Human  4053 ATPSSLDPFFSREPSSMHISSSLPPDTQKFLRFAETHRTVLNQILRQSTTHLADGPFAVLVDYIR 4117

  Fly  4511 I---QVKRSRNRCNGLAGID-GMKS-----------VFGQMVQKLPLLTQEALALPHRVWKVKFV 4560
            :   .|||...| ..|..:| |::.           ||....::|...:.|  .:.:|:: :.|.
Human  4118 VLDFDVKRKYFR-QELERLDEGLRKEDMAVHVRRDHVFEDSYRELHRKSPE--EMKNRLY-IVFE 4178

  Fly  4561 GESVDDCGGGYSESIAEMCDELQNGSVPLLINTPNGRGEAGANRDCFLLDPTL-SSVLQMNMFRF 4624
            ||...|.||...|....:..|:.|....|...:|       .:|..:.::|:. .:...::.|:|
Human  4179 GEEGQDAGGLLREWYMIISREMFNPMYALFRTSP-------GDRVTYTINPSSHCNPNHLSYFKF 4236

  Fly  4625 LGVLMGIAVRTGSPLSINLAEPVWRQLTGEVLRPTDLTEVDRDYVAGLLCIRNMDDDPKLFTALE 4689
            :|.::..||.....|........::.:.|:.:|.||:...|..:..||:.:...|          
Human  4237 VGRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLEND---------- 4291

  Fly  4690 LPFSTSSARGHEVPLSTRYTH-----------------ISPRNRAEYVRLALGFRL-HEFDEQVK 4736
                 .|..|:::..||....                 ::..|:.|||.|....|: ....:|:.
Human  4292 -----VSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLA 4351

  Fly  4737 AVRDGMSKVIPVPLLSLFSAAELQAMVCGSPDIPLGLLKSVATYKGFDPSSALVTWFWEVMEEFT 4801
            |..:|..::||..|:|:|:..||:.::.|.|.|.:..|||...|..:..:|..:.|||..:..|.
Human  4352 AFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEYHKYQSNSIQIQWFWRALRSFD 4416

  Fly  4802 NQERSLFLRFVWGRTRLP-RTIADFRGRDFV--LQVLEKNPPDHFLPESYTCFFLLKMPRYSCKA 4863
            ..:|:.||:||.|.:::| :..|...|.:.:  .|:...:.....||.::|||..|.:|.|....
Human  4417 QADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFE 4481

  Fly  4864 VLLEKLKYAIHFC 4876
            .|...|..||..|
Human  4482 KLRHMLLLAIQEC 4494

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826 9/44 (20%)
RCC1 687..737 CDD:278826 14/55 (25%)
RCC1 740..787 CDD:278826 8/47 (17%)
RCC1 790..841 CDD:278826 7/51 (14%)
RCC1_2 828..857 CDD:290274 5/28 (18%)
Cyt-b5 1290..1363 CDD:278597 12/76 (16%)
MIB_HERC2 1928..1987 CDD:284184 10/73 (14%)
UBA_HERC2 2515..2559 CDD:270585 12/61 (20%)
Cul7 2624..2699 CDD:288381 18/94 (19%)
APC10-HERC2 2762..2932 CDD:176485 24/176 (14%)
RCC1 3037..3088 CDD:278826 7/50 (14%)
RCC1 3091..3140 CDD:278826 9/48 (19%)
RCC1 3144..3194 CDD:278826 13/56 (23%)
RCC1 3197..3246 CDD:278826 11/52 (21%)
RCC1 3250..3298 CDD:278826 5/47 (11%)
RCC1 3302..3350 CDD:278826 4/47 (9%)
RCC1_2 4136..4166 CDD:290274 3/29 (10%)
RCC1 4154..4203 CDD:278826 7/50 (14%)
RCC1 4206..4257 CDD:278826 9/63 (14%)
RCC1 4260..4309 CDD:278826 10/48 (21%)
RCC1 4312..4360 CDD:278826 5/50 (10%)
RCC1 4364..4413 CDD:278826 6/48 (13%)
HECTc 4509..4880 CDD:238033 95/405 (23%)
HECTc 4553..4878 CDD:214523 83/346 (24%)
HUWE1XP_016884680.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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