Protein Alignment HERC2 and herc1

DIOPT Version :9

• Sequence 1: NP_608388.2
• Gene: HERC2 / 33035
• FlyBaseID: FBgn0031107
• Length: 4912
• Species: Drosophila melanogaster
• Sequence 2: XP_017947876.1
• Gene: herc1 / 100493988
• XenbaseID: XB-GENE-1002062
• Length: 4854
• Species: Xenopus tropicalis
• Alignment Length: 5678
• Identity: 1317/5678 - (23%)
• Similarity: 2054/5678 - (36%)
• Gaps: 1707/5678 - (30%)

  Fly    69 PDLYLRPLPFLDAKWLRADLIASLRNAADGAVLWNHLIQDCELVSSPTAPLLNARGQLSYLGDDG 133
            |.:.|:.|..|::.|:..| ..|:......::|:..||.:.|:|..|
 Frog     6 PPVKLKWLEHLNSSWITED-SESIATREGVSLLYAKLISNKEVVPLP------------------ 51

  Fly   134 KHYCGAQQLKCSCCQPEYCGP------LSACNCDGCRPLDSDTAIKKLTTQAAAQQAAHLSQATD 192
                  ||:.|      ..||      ..:.:||                    :|..:|    |
 Frog    52 ------QQVLC------LKGPQLPDFERESLSCD--------------------EQDHYL----D 80

  Fly   193 MVLSGWLWSQPPSQQARLDCQRSMISELQELALRAAGNCLSAQHLRQQLFIYERYFVAL------ 251
            .:||..|      ..|::.|..|..                |..||::|.:.:|.|.||
 Frog    81 ALLSSQL------ALAKVVCSDSPF----------------AGALRKRLLVLQRVFYALSNKYHD 123

  Fly   252 KRERERERKSTTSAQAVASVTTANTTIAATTANAAVESQPAEQQAEHGALGLARVATHAALNFSF 316
            |.:.::::.|..::..     :|:|.:.:....::.::             |..:.....|:..|
 Frog   124 KGKVKQQQHSPENSSG-----SADTLLISERPRSSTDA-------------LIEMGVRTGLSLLF 170

  Fly   317 AFLRRAW---RSGEDTEMCSELLSEALASLQELPEATLFEAAVVSSLWLEVMERSIKFLRLVAL- 377
            |.||::|   .:|....:|::::..|:..:..||..:|...:.:..:.|:.:.:...||:.|.:
 Frog   171 ALLRQSWMMPAAGPGLSLCNDVIQTAIDVVNSLPPLSLANESKIPPMGLDCLSQVTSFLKGVTVL 235

  Fly   378 ---GDPMGNRCTAPLNDRHTALCLLLELGVQKGTLAATLECVVLLL----LLWEKDRAGNDNRDM 435
               .|.:|.|..:.         |||.|..|:|:|...||.:.:.|    |:.|.|:    |:.:
 Frog   236 NSGADILGRRLASE---------LLLGLASQRGSLRYLLEWIEMALAASALVGETDK----NKML 287

  Fly   436 PRKTG--------APLQRILLRYQKIGATAKGGGIAGGEPAPVASATETFLRFLSLPKSSAAIVD 492
            ..:.|        :.||::   .:.:|::|...  ...||.                ::|..:..
 Frog   288 TAQEGMISCDCFMSILQQM---RRSLGSSADRS--QWREPT----------------RTSDGLCS 331

  Fly   493 LRRAAVVIISHLDRMVQPLMPRCL----LRGGQATAASSSSAPQQRIYALGWPSLSKDQ-----Q 548
            |..||:.:...:.:|.......|.    ::.|:....|.:.    .:|.  |.|.|..|     |
 Frog   332 LYEAALCLFEEVCQMASDYSRTCASPDSIQSGENPVVSETC----EVYV--WGSNSSHQLVEGTQ 390

  Fly   549 GFSAEPTLSWSGESAGVPTLS----------CRFQIK---QVACCETQMLILSQEGKLYTWRLAK 600
            ....:|.|:        |..|          |.|.|.   .|..|          ||....||..
 Frog   391 EKILQPKLA--------PCFSDAQTIEAGQYCTFVISTDGSVRAC----------GKGSYGRLGL 437

  Fly   601 PEA------EPLPMEEVAHDVFISIAGHCEGRHFLAIDSNHNAYSWGTGEDHRLGHGDTHARAVP 659
            .::      :.|..|.......:|.:...:| |.||..:....:|||.|:..:||||::..:..|
 Frog   438 GDSNNQSTLKKLTFEPHRSIKKVSSSKGSDG-HTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYP 501

  Fly   660 TKI-AALEQHCVQSVYCGCSYSAAITCGGNLLTWGRGTYARLGHGNSDDRSLPTLVVALSDHMVV 723
            ..| ..|:...|..|..|..:|||:|..|.|.|||.|.:.|||||:|:.|::||||..:|:  |.
 Frog   502 KLIQGTLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISN--VG 564

  Fly   724 DVALGSGDAHSLALTSEG-LVFAWGDGDYGKLGNGNCNGSLQPILVESLPRV--QRVFAGSQFSV 785
            :|:.||  :|::||:.:| .|:::|.||.||||:|:.|...:|.:||:|..:  ::|.||||.|:
 Frog   565 EVSCGS--SHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVVEALQGMFTRKVCAGSQSSL 627

  Fly   786 ALSSEGQLYTWGKATCLGHQLVERSVQGCSVPRLVSSLQHKRIVDVAVSVAHCLALSSSGEVFGW 850
            ||:|.||:|.||...|||....|.:...   |:|:..|...||||:::..:||||||...||:.|
 Frog   628 ALTSTGQVYAWGCGACLGCGSSEATALR---PKLIEELAATRIVDISIGDSHCLALSHDNEVYAW 689

  Fly   851 GRNDSQQICPASVSSEPLLRTPILVSLPTFPASGIACTSAQSLVWT--QSSHQGVPRRAPFVVDL 913
            |.|...| |....|:.|:.:...:..|.......|:..::.||.||  ....|.|....|:.|||
 Frog   690 GNNSMGQ-CGQGNSTGPITKPKKVSGLDGVAIQQISAGTSHSLAWTALPRDRQVVAWHRPYCVDL 753

  Fly   914 GEPTFRLLDQLLGMCSSQDNRQTP------NQESECIAVACLNLFRLQLLALIANGVEPRQVGLA 972
            .|.||..|...|.....:.|.:.|      :::.......||.:....|...:|.||....:|..
 Frog   754 EESTFFHLRSFLERYCEKINSEIPPPPFPSSRDHHGFLKLCLKMLSNHLALALAGGVATSILGRQ 818

  Fly   973 SGSRLLCSLKTRILGLAGGSQVLRTIQVAAQQALQDGWSVLLPTAAERAQTLTSLLPSEPG--QA 1035
            :|.  |.:|..|::    .:.|...||....:.|..|.::|||...||.:.|.||||..|.  ::
 Frog   819 AGP--LRNLLFRLM----DASVPDEIQEVVIETLSVGATMLLPPLRERMELLHSLLPQGPDRWES 877

  Fly  1036 SSAGHRFMTDLLVSSLMAEGGLESALQHAIRLESSSCSADCGDGVHLP----------------- 1083
            .|.|.|...|::::||...       .|...|...|..:|..|...||
 Frog   878 LSKGQRMQLDIILTSLQDH-------THVASLLGYSTPSDSSDVTSLPMTSDPSYSSQGSHPDTH 935

  Fly  1084 LLQLITRLLSNNAALSQTRLSPTLGKQQEK------EEEEREQQHQEPSTSPSLSLLHRFQRLLL 1142
            |.:::.:.|..|......:....|.|..:|      ..|..:..|..       .||...|:.||
 Frog   936 LAEILMKTLLRNLGFYTDQAFGELEKNSDKFIVGASSSENSQPAHLH-------ELLCSLQKQLL 993

  Fly  1143 SHIHQAQPEEETTGAEALLLQYMHALIPACVATLQKAHELALQCREPGENSFGQMVGHLGRVLQA 1207
            ::.|.....|.::.. |||.:::..|:|.  ||...:....|....|...|.|:   .|..|:..
 Frog   994 AYCHTNHISENSSSV-ALLHKHLQLLLPH--ATDIYSRSATLLEESPWNGSVGE---KLRDVIYV 1052

  Fly  1208 DISDALLNELLVGLLLLKRD--RPQCLGGLRWARLFLPLLRVLDRLNRALGEGELRDGDDMGWPG 1270
            ..:.::|.:|:..||||...  ||       .....|.||..||||||.|....|.:..::.||
 Frog  1053 SAAGSMLCQLVNALLLLPASVARP-------LLSYLLDLLPPLDRLNRLLPAAALLEDQELQWP- 1109

  Fly  1271 IICRGGPK----GGPPPADPETHYVRRADMEN--LLLDGSRCIILAGYVCDLSGYNCESETLRSV 1329
              ..|||:    ||.....|...:|...|:|.  .||.| ||         |.|
 Frog  1110 --LHGGPEHIDPGGVSLPAPAQSWVWLVDLERTVALLIG-RC---------LGG----------- 1151

  Fly  1330 LDSGLGKDLTAEMSSQVHRTAMEHILEHHKLGKYMVQ---ASTEEKSSAPGPSRLTHFSSECALA 1391
                                              |:|   ||.||:.        |::
 Frog  1152 ----------------------------------MLQGSPASPEEQD--------TNY------- 1167

  Fly  1392 QLLGLVANLMCSGPALQPAELQCRQLDK--SSLLSGGLQLLQPSNPFDEEKGEARSSHSCHSTAG 1454
               .|...|..:|     .:::..||||  |:||...|...:....||
 Frog  1168 ---WLKTPLFGNG-----IDMEVPQLDKCMSALLEVSLSGNEEQKTFD----------------- 1207

  Fly  1455 NTPTELPPPLPMQQQLAPGRGKSQLQLRADAFISGLAEARVSEPPVAAWLALTERYCKAHNLMWH 1519
               .:|.|.:.:...||.|..|                    ||....|:::.: |..:.:  |.
 Frog  1208 ---YKLRPEVSLLVDLAVGSTK--------------------EPAQNLWISMQD-YAISKD--WD 1246

  Fly  1520 Q-EFATEHPVQELERLLSAVLIRHQYLGGLVLNA-LETEVPPPRQLGEIIRLVHQAKWSVVRTRQ 1582
            . ..:.|..:..:.|.:.|.|::|.   ||:..| :::...|.:.|.|:.|.|::.:..::..:
 Frog  1247 SATVSNESLLDTVSRFVLAALLKHT---GLLSQATVDSRYQPEKSLAEVYRNVYKVRSRLLACK- 1307

  Fly  1583 QLNRSYKEVCAPILERLRFLLYEVRPAISPQQRGLRRLPILQRPPRFKMLVRRLLQELRSSRQPA 1647
              |....:.|:...|                                     |.:.|.:.|....
 Frog  1308 --NMELIQTCSSSRE-------------------------------------RWVSENQESGDLG 1333

  Fly  1648 KPEDLLNASIQQEQEKKPQSMPKQE---LEEQEEEETLLRRLNERQIHGEGELDPALM--QDIVD 1707
            ..|:....:|.:|.|.:.|:...:|   .|::||:|.     .|.:|...|::....:  :|:..
 Frog  1334 SQENSFTRTIDEEAEMEEQADRDREEGHTEQEEEDEE-----REHEILTAGKIFQCFLSARDVAR 1393

  Fly  1708 FALQDSCDVETARRA---MYCQMQRYQLRLAGLQIVQQLLELHGLLDAAQYSLLNG----FLGL- 1764
            ...:|.....:|..:   :....|..|| :.|.:..:.|.|...|...|..|:::.    .||:
 Frog  1394 NRERDRMSTSSAADSGPGLRADEQPQQL-IQGRRDSRHLAEGQDLYTGACNSVIHRCALLLLGVS 1457

  Fly  1765 ----HLKSTSS--------GGGSTGSGS------------SLHVLGQLNMISAYQKARLLLAQSR 1805
                ||::||.        |....|:.:            |:||.....:|.:..::.|...:|.
 Frog  1458 PVIYHLENTSEDSHEQTVPGCSQEGTAAMTRSESLTAERRSVHVHPSYRLIKSRSESDLSQPESD 1522

  Fly  1806 VLDWAVRELRRLVNQEQQGHARGKDSTNLGTYVLLKRLPRAR----FLLSVF--------GLLAK 1858
            ...:.: ..|:..:.:...|.:....|:..|.....||..||    ...|||        .|...
 Frog  1523 EEGYLL-SARQNTDFDLTSHRKRGSPTDPPTSDSWSRLKHAREWPSSSASVFDSDVEYGKSLSVH 1586

  Fly  1859 ELGPNELGFLINSGLLGTVLGLLAQTGGEGATGG-----------QVHGELSI--LYEDSVL--- 1907
            .|..|.|.|:  ||.:|:..|.  :...||.:..           |:..||.:  |::..||
 Frog  1587 TLVDNVLSFV--SGDIGSSPGF--KEPEEGMSSSPQACIVAMEQQQLRAELRLEALHQILVLLSG 1647

  Fly  1908 ------KQKSSKAQLSGP-------------------DLAKLMKIGTRIVRGADWKWGD------ 1941
                  .|.....|...|                   .|..:..:||:         ||
 Frog  1648 MEEKENMQSLGNRQAPAPFQSSSLLTSVRLQFLAGCFGLGTVGHVGTK---------GDSVHLHH 1703

  Fly  1942 -QDGNPPGEGRIISEVGEDGWVRVEWYTGAT-------NSYRMGKEGQYDL------------QL 1986
             |||....:..|..|: :....::.....||       |.:.:  |.|..|            |.
 Frog  1704 YQDGIRASKNSIQKEI-QKAVHKIYQQLSATLDRALQANKHHV--EAQQRLLLVTVFALSVRYQP 1765

  Fly  1987 ADSALNVASPTEPEREDVSGSEAS--------PTSD-SHPSKLLRHCAAKLLQILAVGTGLHGAQ 2042
            .|.:|.:::........:.|::..        |.|. |..|..|:..:.:||||||:.||.:..:
 Frog  1766 VDVSLAISTGLLSVLSQLCGTDTMLGQPLQLLPKSGVSQLSTALKVASTRLLQILAITTGTYADK 1830

  Fly  2043 LDKDALR-----------------GMTSM-----------------------FRTIIYPKPSMSN 2067
            |....::                 |:|.|                       ||..:..:.:..
 Frog  1831 LSPKVVQSLLDLLCSQLKNLLAQAGVTLMSSCNAEEEGDRKADLTGEIDRKDFRASLRKQRTAE- 1894

  Fly  2068 ISYALGWLNLG----FIRAISGDCPRLCLELSTPGWLSHYLSLLEQP-------AGNEAGVYRQL 2121
                   |:||    |:|.:... ..:..::::|.|....|::..|.       .||   :..:|
 Frog  1895 -------LHLGDFLVFLRRVVSS-KAIQSKMASPKWTEVLLNIASQKCSSGLPLVGN---LRTRL 1948

  Fly  2122 HCLRLLQLILAQWGAE-EEPRMPALVHQLFATLGRIALHCPGDASLLPTAEGKARVLL------- 2178
            ..|.:|:.:|....|. |:.:|..:|.:||:.|.    .|..||   |.|:.|..:.:
 Frog  1949 LALHVLEAVLPACEANVEDDQMAQVVERLFSLLS----DCMWDA---PIAQAKHSIQIREKEQET 2006

  Fly  2179 TASHSGSVAEELVALLRRLHTLP----SWNPVINSFLAQKLCVAAELLAEQSHSTALDSEQVFVL 2239
            ..:.:|.|.||       ...||    |::|                  |:.....:::.|:...
 Frog  2007 KLNKTGEVEEE-------EEDLPIQEVSFDP------------------EKVQCCVVENGQILTH 2046

  Fly  2240 GVLGAMGGHDLRPRVGLHCFHEGSHMVIASFTPKGRCLLAPGGVGSGVGFVKVQLPAVMPHLDHT 2304
            |..|...|                              ||..||.||....|..:.......:.|
 Frog  2047 GSGGKGYG------------------------------LASTGVTSGCYQWKFYIVKENRGNEGT 2081

  Fly  2305 VFSLSRLPMNEM---------LLNAWTVLLYGPAPELRELPSSADGRLDLALL------------ 2348
            ...:||.|:::.         |..|::..||....:...|||...|.....:|
 Frog  2082 CVGVSRWPVHDFNHRTTSDMWLYRAYSGNLYHNGEQTLTLPSFTQGDFITCVLDMEARTVSFGKN 2146

  Fly  2349 --------------------------RAQQLQMAVLHTNG-----------------VLYRHQVA 2370
                                      ..:::::..:...|                 ||....|.
 Frog  2147 GEEPKLAFEDVDAGELYPCVMFYSSNPGEKVKICDMQMRGTPRDLLPGDPICSPVATVLAESSVQ 2211

  Fly  2371 LRRILKQ-----------------------RAPGS-IYASPDEPDRSDAESQQPGEQDQQLSSGS 2411
            |.|||.:                       |..|| :..|.....|.:.|::...|:|:......
 Frog  2212 LLRILHRTERWTYCINKKMIERLQKIKGCLREAGSKLKKSRSVQSREENETRDDREEDKGKHGRH 2276

  Fly  2412 G----QEPQLLIQCILLRATQASPVKACYSYMDLA-TAALNCIQSLATQAHQELSEGGGVPPNGR 2471
            |    .||||...|:     :..||.|....:|.. .....|:.. .|..|..|.   ||...|.
 Frog  2277 GLADLGEPQLRTLCV-----EVWPVLAVIGGVDTGLRVGGRCVHK-QTGRHATLL---GVVKEGS 2332

  Fly  2472 ------------ALSSP----PQPTMVHGVPVYNVARKEQKPSEQVEQKSKWPAAATDAQLIGQI 2520
                        .:|.|    |..|     |:||:...:..|.:....:....:|..|...:..|
 Frog  2333 TSAKVQWDEAEITISFPTFWSPSDT-----PLYNLEPCDPPPFDVTRFRGLTASALLDLTYLTGI 2392

  Fly  2521 ME----MGFTRRTVELALKQLSLQAEIMP-------TPEQIVQWILEHPDVCANTI-----EEDT 2569
            .|    :| .:|..:....:...:.:|.|       |..||.:      |..:|.|     .|..
 Frog  2393 HEEPGKVG-AKRHEKKHRHESEEKGDIEPRGDADIATEVQITE------DAKSNNIVPKLENESG 2450

  Fly  2570 LPLASSAS------SHDPEADSDNECPSSNSTTSSSTSSDTVEGQPMAVSGPAPPVKFESRKDFQ 2628
            .||..:|.      |.|.:..|.:..|.|:         |..:.:..||.
 Frog  2451 PPLGETAQVDIQHHSTDGKRKSHDHIPRSH---------DVAQSEIRAVQ--------------- 2491

  Fly  2629 TADLYALYVR-GLVRPGMTVRCCRDFEEIKQGDMGTVLIVDTEGLHDLNVQVDWRNHGSTYWVC- 2691
                 ..|:. |.::...|:..|..:.|         |::..:.|.|       ..|.|.   |
 Frog  2492 -----LSYINLGAMKSLGTLLSCSKYAE---------LLLIPKVLAD-------NGHNSD---CA 2532

  Fly  2692 ---FVH--IELVEAAQ---THHQPR-----PPPIAVGARVRLRTSSLRY-----GML-------- 2730
               .||  :|:..|.|   .|...|     |...|:|.....|..::.|     |:|
 Frog  2533 SSPVVHEDVEMRAALQFLMRHMVKRAVMRSPIKRALGLADLERAQAMIYKLVVHGLLEEQFGSRL 2597

  Fly  2731 ------------------CPLRLGRSQGSSAIGVVSSVRSKQL---------TVDFPDQPAWQGH 2768
                              .|:....|..|:...:.||:.....         ||...:.|.....
 Frog  2598 RQELEQQAEETDQAQQAQTPVTTSPSASSTTSFMSSSLEDTTTATTPVTDTETVPASESPGVMPL 2662

  Fly  2769 INEVELVASQPTSATLPSLGDSCSQMPPSDLIEDWSRCIRSLTVSSNEAAAKHLLNGSNQPWQSC 2833
            ....::.:|.||:..||:   ..:|.||          |.||..|..:..      |..|...|.
 Frog  2663 SLLRQMFSSYPTTTILPT---RRAQTPP----------ITSLPTSPTDEV------GRRQSLTSP 2708

  Fly  2834 SSGPCRHWIRLELHDRILVHSLTLKVSPEDHSHMPSLLEIRVGDCVDSLKEYTWIPVPAGASRVL 2898
            .|.|.||..|..|.|    .|..|..||...:.:..|||  :|..:..:|:    .:.|..:|..
 Frog  2709 DSQPTRHTNRAALSD----PSSRLSTSPPPPAVVVPLLE--MGFSIRQIKK----AMEATGAREA 2763

  Fly  2899 LMQQVPTYYPWVEVVVKQCQNNGIQCKIHGIKFVGRRQQPDLQHILANAQFLASEYSAGVGPGST 2963
            ..|.:.....|:           |:......:|.||..:        ..|
 Frog  2764 DPQNITVLAMWM-----------IEHPDDEERFSGRTTE--------QCQ--------------- 2794

  Fly  2964 AGAGAVSTSHEEAAAAPEQDLPCTVMVWGLNDKEQLGGLKGSKVKVPTFSQTISRLRPIHI---- 3024
               |||||:|                              |.|.....::..||...|..:
 Frog  2795 ---GAVSTAH------------------------------GGKSSDTAYTGDISSSDPAEMEECF 2826

  Fly  3025 AGGSKSLFIVSQDGKVYACGEGTNGRLGLGVTHNVPLPHQLPVLRQYVVKKVAVHSGGKHALALT 3089
            .|...||......|.  :.|:.:.||..:.......|..:..:.|..:|.|.....|..:   ||
 Frog  2827 CGSPDSLEHTENAGA--SSGQQSRGRSTVTRRQKFDLAARTLLARAEIVLKWMSQLGPNN---LT 2886

  Fly  3090 LDGKVFSWGEGEDGKLGHGNRTTLDKPRLVEALRAKKIRDVACGSSHSAAISSQ---GELYTWGL 3151
            ::..::                     |.|:|.|.:..|:         .:|.|   |.||...|
 Frog  2887 VNAGLY---------------------RTVQAHRNQGRRE---------GVSLQQDPGALYDLNL 2921

  Fly  3152 GEYGRLGHGDNTTQLKPKLVTALAGRRVVQVACGSRDAQTLALTEDGAVFSWGDGDFGKLGRGGS 3216
            .|       :....|..:.:.|:.|             |.||          .|.|.  ||....
 Frog  2922 DE-------ELEIDLDEEAMEAMFG-------------QDLA----------SDNDI--LGIWIP 2954

  Fly  3217 EGSDTP--HEIERLSGIGVVQIE-CGAQFSLALTRAGEVWTWGKGDYYRLGHGGDQHVRKPQPIG 3278
            |..|.|  |..|......||..| |.|          .|.::            :||:::..|..
 Frog  2955 EVLDWPTWHVCETDDREEVVICELCEA----------SVLSF------------NQHMKRYHPGC 2997

  Fly  3279 GLRGRRVIHVAVGALHCLAVTDAGQVYAWGDNDHGQQGSGNTF---------------------V 3322
            |....|..:.:.|:          .|..|..   |:.||||.:                     .
 Frog  2998 GHSANRQGYRSNGS----------YVDGWFG---GECGSGNPYYLLCSSCREKYLSLRSKRKATA 3049

  Fly  3323 NKK-----PALVIGLDAVFVNRVACGSSHSIAWGLPNASSDEEKRG------------------- 3363
            ::|     |.|:...|:|:..          .|.:.:...||:..|
 Frog  3050 SEKYKGHAPDLIGKQDSVYEE----------DWDMMDVDEDEKLTGEEEFELLAGPLGLNERRMV 3104

  Fly  3364 --PVPFSSTRDPLGGSSLGIYEAETM-QTLKQ-------EAKPLNQSSLSE-SLALETPAARQAA 3417
              ||.|..: ||||.|...:....:| :||.|       |.....:.:|.| :.||..|..|..|
 Frog  3105 PEPVQFPDS-DPLGASVAMVTATNSMEETLMQIGCQGTLEKSSSGRITLGEQAAALVNPHDRVMA 3168

  Fly  3418 LGHVLRAMSILQARQLIVAALTSHSKVNFKERGAVGGEEDHLIGGPIMGAPLQLAETIAQGGGEA 3482
            |..|:.|..:|.||.:::.||:..|         |.|....|..| :....|....|:.:  ...
 Frog  3169 LRRVIAAAQVLLARTMVMRALSLLS---------VSGSSCSLAAG-LESLGLTDIRTLVR--LMC 3221

  Fly  3483 PADATDAGLQEHSPEAAVDALTGGMSG-GANTLPPLSAGPLSAFQSLTGSLSMSGSLSSSALPQH 3546
            .|.|..|||.. ||...:.:.:....| .:.|..|:|.  |:...:..|.|:.|...::..|.|.
 Frog  3222 LAAAGRAGLST-SPSTTLPSSSERSRGLHSKTSKPISC--LAYLSTAVGCLASSTPSAARLLVQL 3283

  Fly  3547 KHSRMSASAMSVMAATMTQQEEMLSHISHCHGLDDFGGLLGEPE---AKSLVELL---------- 3598
            ....:.::|..|...|:....:.....|...|:.:...|:..|.   .::||.||
 Frog  3284 CTQNLISAATGVNLTTVDDPVQRKFLPSFLRGIAEENKLVTSPNFVVTQALVALLADKGAKLRPN 3348

  Fly  3599 ----------------KLAVCGRCGPPSTS------------------------QTIAD------ 3617
                            .||.|......|:.                        ||:||
 Frog  3349 YDKAEMEKRGPLELANALAACCLSSRLSSQHRQWAAQQLVRTLAAHDRDNQTAPQTLADMAGDLR 3413

  Fly  3618 --TLISLGAGTPAVAA-----------------------------MLLETCI-------TELED- 3643
              :...|.|....|.|                             .|.:||:       ||..|
 Frog  3414 KCSFTKLEAHQNRVTASVWCSKKDLLATSGSDGTVRVWNVSRTQYSLQQTCVFHKMEGSTEETDP 3478

  Fly  3644 ----LCTS---RHCLGKLPKPV----------MQESSHPYV-------DNVNVT----------- 3673
                :|.|   |:..|.|.|.:          :.::...:|       :|....
 Frog  3479 SLSLICWSVSGRYLAGALEKTINIWQVNGGKGLVDAQPHWVSALTWPEENSGAAWTSDAPESLLV 3543

  Fly  3674 -------GVVRIPGA-EMLRLEFDSQC------------STEKRNDPLVIMDGT----GRVLAMR 3714
                   |::.:..| .|.|:|.: .|            .:|.|:..:...||.    .|.:|.:
 Frog  3544 GRMDGSLGLIEVTDASSMQRMELE-HCYRKEVAVTCIAWYSEDRSFAVGYSDGKLLIGNRDIAEK 3607

  Fly  3715 SGREF--AH--------WAP------------EIRVLGDE-LRWK----FSSDSSVNGWGW---- 3748
            :|...  ||        |.|            .:::.|.. |.||    .|..|.||...|
 Frog  3608 AGIVIIDAHKDMIVSMKWDPTGQMLLTCAKEETVKLWGKSGLSWKTLYCLSHPSLVNTAAWCSLV 3672

  Fly  3749 -------------------RFWV------HAIMPAATLGESGSDRAV------------------ 3770
                               ..|:      ..:.|.::..:...::|:
 Frog  3673 GNGERPQLMLGTGCQSGLVCVWIIPQIPQEGVQPKSSASDDWKEQAISKEMFRKVEYVRCVFKLR 3737

  Fly  3771 ----------LSQPSMALVMSLLDSRL---APRQPSVLLRLASALAACSQLGALTTAQRIWS--- 3819
                      .|...:|||...|...:   :.:..|||..:.:.      .||:||.  :|.
 Frog  3738 GHITPVRTVAFSHDGLALVSGGLGGLMNIWSLKDGSVLQSVVTG------SGAVTTT--VWIPDV 3794

  Fly  3820 ---------------------LRKLHAVLLLEQAPRPQD-------PSLSTLLQPLIPELLRQYE 3856
                                 |...|.:.....|.:.|.       |.:.|.|:.|...|..||.
 Frog  3795 GVAACSNRSKDVLVVNFTPEWLSSNHVLATCRTALKQQGIVGLNMAPCMQTFLERLPVMLQEQYA 3859

  Fly  3857 YEEPQVRGGIHLMHSDYFKTLAALACDMQLDAAL---PATSSSSSSSAAPGAISSTGDVHKWAWF 3918
            ||:|.|..|..|:||.|.:.||:||..:.||..|   |.......|...|.:.:.|    :|.|.
 Frog  3860 YEKPHVVCGDQLVHSPYMQCLASLAVGLNLDRLLCNPPVPPHHYPSPPDPASWNPT----EWVWL 3920

  Fly  3919 KRYCIAVRVAQSLIRRTELPRAFCLEVRKKFAEMLPSSSSNSNANPGCQSPGASMLNSTTSLSSS 3983
            :.:...::.|::|.|.::.|..|
 Frog  3921 ECFSTTIKAAEALARGSQFPECF------------------------------------------ 3943

  Fly  3984 TVSNVSPPPGITGEQPDLHCHAHQLESTSTLLHEDHTLFQAPHDAQLLQWLNRRPDDWALSWGGA 4048
            ||.::.|.|            ..:|:     |..|::.:....|.|::.|...:|:||.|  ||.
 Frog  3944 TVPDLEPVP------------EEELK-----LVMDNSKWNNGTDEQIMSWATSKPEDWHL--GGK 3989

  Fly  4049 STIYGWGHNHRGQLGGLEGSRIKTPTPCEALSLLRPVQLAGGEQSLFAVTPDGKLFATGYGSGGR 4113
            ..::.||....|||.  |..| ....|..|.|..:..|:..|:...|.:..:|.:.|.|.||.||
 Frog  3990 CDVFLWGAGRHGQLA--EAGR-NVMIPSGAGSFSQAQQVICGQNCTFVIQANGTVLACGEGSYGR 4051

  Fly  4114 LGVGGSDSWAIPTLLGSLQHVFVKKVAVNSGGK-HCLALTTEGEVYAWGEGEDGKLGHGNRMSYD 4177
            ||.|.||...:.|::.:||...|.::..:.|.. |.:|||..|||::||:|:.|||||||.....
 Frog  4052 LGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQR 4116

  Fly  4178 RPKLVEHLNGMSVADIACGSAHSAAITASGHVLTWGKGRYGRLGHGDSEDQLRPKLVEALLGYRA 4242
            ||:.:|.|.|..|..::||..|||.:||.|.:.|:|.|.|||||.|::.::..|:.|.||.|...
 Frog  4117 RPRQIEALQGEEVVQMSCGFKHSAVVTADGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGLHI 4181

  Fly  4243 IDIACGSGDAQTLCITDDDN-VWSWGDGDYGKLGRGGSDGCKLPYKIESLAGLGVVKVECGSQFS 4306
            ..:|||..  .||.::.|.: ||::|||||||||.|.|.....|.|::.|.|:|:.||.||:|||
 Frog  4182 GQVACGLN--HTLAVSADGSLVWAFGDGDYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFS 4244

  Fly  4307 VALTKSGAVYTWGKGDFHRLGHGSVDHVRRPKKVAALQGKKIISIATGSLHCVACSDSGEVYTWG 4371
            |||||.|.|||:|:.....|..|...:..||:.|..|.|..|..||.|:.|.:|.|.|||||.||
 Frog  4245 VALTKDGHVYTFGQDRLIGLPEGRARNHNRPQLVPVLLGIFIDDIAVGAEHTLALSASGEVYAWG 4309

  Fly  4372 DNDEGQLGDGTVTAIQRPRLVAALQGKHIVKVTCGSAHTLALSTSQLSERLRPLPNP-------- 4428
            .|.|||||.|....::.|.||.|||||:|.:::.|..|:.|.:.:.:..|...:..|
 Frog  4310 SNSEGQLGLGHTNHVREPTLVTALQGKNIRQISAGRCHSAAWTAAPVPPRAPGVAVPLQLGLPDV 4374

  Fly  4429 -PLEYDLVRDLAPEALHARLILLHHFSELVCPCLAMLPISGD--------------LSLGALKDV 4478
             |.:|..::|:....:.|||.||:|||:|:.....:|.:|.:              :..|.|:.:
 Frog  4375 IPPQYSCLKDICLHTVRARLRLLYHFSDLMYSSWRLLNLSPNNQSSASHYNAGTWGIVQGQLRPL 4439

  Fly  4479 LVYNIKEAAFRKVIQTTMVRDKQHGPVIELNRIQVKRSRNRCNGLAGIDGMKSVFGQMVQKLPLL 4543
            |...:......:.|..|||:.|.:||.|.:.||.. |.| :|         |.:|.|:.:::..|
 Frog  4440 LAPRVYTLPMVRSIGKTMVQGKNYGPQITVKRIST-RGR-KC---------KPIFVQIARQVVKL 4493

  Fly  4544 TQEALALPHRVWKVKFVGESVDDCGGGYSESIAEMCDELQNGSVPLLINTPNGRGEAGANRDCFL 4608
            ....|.||.|.||||.|||..||.||.:.::|.|||.||:.|.|.|||.:||...|.|.|||.||
 Frog  4494 NASDLRLPSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGVVDLLIPSPNATAEVGYNRDRFL 4558

  Fly  4609 LDPTLSSVLQMNMFRFLGVLMGIAVRTGSPLSINLAEPVWRQLTGEVLRPTDLTEVDRDYVAGLL 4673
            |:|:......:..|:|||:|||:|:||..||.::||..||:||....|...||.|||..||..|.
 Frog  4559 LNPSSGLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCIPLTLEDLEEVDLLYVQTLN 4623

  Fly  4674 CIRNMDD----DPKLFTALEL-PFSTSSARGHEVPL--STRYTHISPRNRAEYVRLALGFRLHEF 4731
            .|.:::|    :......:.| .|...||.|..||:  ......::..||.|||..|:.:||||.
 Frog  4624 SILHIEDSGITEENFHEMIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVDRAIDYRLHEM 4688

  Fly  4732 DEQVKAVRDGMSKVIPVPLLSLFSAAELQAMVCGSPDIPLGLLKSVATYKGFDPSSALVTWFWEV 4796
            |.||.|||:|||.:||||||||.:|.:|:.||||.|:|.:.:||.|..|:..|....||.|||:.
 Frog  4689 DRQVAAVREGMSWIIPVPLLSLLTARQLEQMVCGMPEISVDVLKKVVRYREVDEQHQLVQWFWQT 4753

  Fly  4797 MEEFTNQERSLFLRFVWGRTRLPRTIADFRGRDFVLQVLEKNPPDHFLPESYTCFFLLKMPRYSC 4861
            :|||:|:||.||:|||.||:|||...||...|   .|:::.:.|...||.|.||||.|::|.||.
 Frog  4754 LEEFSNEERVLFMRFVSGRSRLPANTADISQR---FQIMKVDRPHDSLPTSQTCFFQLRLPPYSS 4815

  Fly  4862 KAVLLEKLKYAIHFCKSIDTDEY 4884
            :.|:.|:|:|||:.|:|||.|.|
 Frog  4816 QPVMAERLRYAINNCRSIDMDNY 4838

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826	16/45 (36%)
		RCC1	687..737	CDD:278826	23/49 (47%)
		RCC1	740..787	CDD:278826	21/49 (43%)
		RCC1	790..841	CDD:278826	19/50 (38%)
		RCC1_2	828..857	CDD:290274	14/28 (50%)
		Cyt-b5	1290..1363	CDD:278597	10/74 (14%)
		MIB_HERC2	1928..1987	CDD:284184	16/84 (19%)
		UBA_HERC2	2515..2559	CDD:270585	9/54 (17%)
		Cul7	2624..2699	CDD:288381	14/81 (17%)
		APC10-HERC2	2762..2932	CDD:176485	37/169 (22%)
		RCC1	3037..3088	CDD:278826	9/50 (18%)
		RCC1	3091..3140	CDD:278826	5/48 (10%)
		RCC1	3144..3194	CDD:278826	10/49 (20%)
		RCC1	3197..3246	CDD:278826	14/51 (27%)
		RCC1	3250..3298	CDD:278826	7/47 (15%)
		RCC1	3302..3350	CDD:278826	12/73 (16%)
		RCC1_2	4136..4166	CDD:290274	12/30 (40%)
		RCC1	4154..4203	CDD:278826	24/48 (50%)
		RCC1	4206..4257	CDD:278826	20/50 (40%)
		RCC1	4260..4309	CDD:278826	27/49 (55%)
		RCC1	4312..4360	CDD:278826	17/47 (36%)
		RCC1	4364..4413	CDD:278826	25/48 (52%)
		HECTc	4509..4880	CDD:238033	167/377 (44%)
		HECTc	4553..4878	CDD:214523	154/331 (47%)
herc1	XP_017947876.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920