DRSC/TRiP Functional Genomics Resources

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Protein Alignment HERC2 and herc3

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:XP_002938676.3 Gene:herc3 / 100488790 XenbaseID:XB-GENE-968537 Length:1050 Species:Xenopus tropicalis


Alignment Length:1090 Identity:246/1090 - (22%)
Similarity:420/1090 - (38%) Gaps:317/1090 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly  4054 WGHNHRGQLG---GLEGSRIKTPTPCEALSLLRPVQ--LAGGEQSLFAVTPDGKLFATGYGSGGR 4113
            |||:..||||   ..:|| :..|..|. .||...|:  ..||:.:|| :..||::::.|:...|:
 Frog     4 WGHSTFGQLGNGHSFQGS-VSDPCVCR-FSLAACVKEVACGGKHTLF-LLEDGQVYSCGWNGEGQ 65

  Fly  4114 LGVG--GSDSWAIPTLLGSLQHVFVKKVAVNSGGKHCLALTTEGEVYAWGEGEDGKLGHGNRMSY 4176
            ||..  |:|...:.||  :.:|:    ..:..|..|.|||:.:|::|:||.|.||:|||......
 Frog    66 LGHDHEGTDPVQVTTL--TEEHI----THIACGQSHNLALSYQGQLYSWGSGNDGQLGHATVEHS 124

  Fly  4177 DR-PKLVEHLNGMSVADIACGSAHSAAITASGHVLTWGKGRYGRLGHGDS-EDQLRPKLVEALLG 4239
            .| |::::.||...:..::||:.|..|:...|.:.|||:..:|:||.|:. ..|..|:.|::|.|
 Frog   125 SRIPRIIKKLNQQKIQQVSCGNDHCMALGDDGQLFTWGQNLHGQLGLGNGFLSQSSPQRVKSLEG 189

  Fly  4240 YRAIDIACGSGDAQTLCITDDDNVWSWGDGDYGKLGRGGSDGCKLPYKIESLAGLGVVKVECGSQ 4304
            .....:..|...:..|.::  ..|:.||:...|:||.......:.|..::.|....|:.:.||.:
 Frog   190 IPLAQVTAGGSHSFALSLS--GAVFGWGNNSAGQLGLNDEKVRETPCHVKPLRTHKVIYISCGEE 252

  Fly  4305 FSVALTKSGAVYTWGKGDFHRLGHGSVDHVRRPKKVAALQGKKIISIATGSLHCVA-CSDSGEVY 4368
            .:..|||:|.::|:|.|...:|||.|:::...|::|..|.|.::..||.|..|.:| ...||.:|
 Frog   253 HTAILTKAGGLFTFGAGGSGQLGHDSLNNEINPRRVLELMGSEVSQIACGRQHTLAFVPSSGTLY 317

  Fly  4369 TWGDNDEGQLGDGTVTAIQRPRLV----AALQGK----------HIVK----------VTCGSA- 4408
            .:|..|.||||.|....::.|.:|    ||..|:          :|||          |.|... 
 Frog   318 AFGCGDLGQLGTGHKNNVKCPAVVKGKWAAHSGQISMHADRAAYNIVKQIFSGGNKTFVLCSKLE 382

  Fly  4409 ---------------HTLALSTSQL--------------------------------------SE 4420
                           ||..::...:                                      .|
 Frog   383 SSQPADDFRFCSQRNHTSVINEETIDVWRQKVLENSNTNSMNGIVQTLSSLACWNGSFLEKRNDE 447

  Fly  4421 RLRPLPN-PPLEYDLVRDLAPEAL---HARLI--LLHHFSELVCPCLAMLP-------------- 4465
            ..|..|. |.:....::.|..:.:   |:||:  :|..|...:.|.|:..|              
 Frog   448 HFRTSPKIPGINMCSIKVLFEKLMNVHHSRLLEQILKGFESFLIPQLSSSPPDVEAMRIYIILPE 512

  Fly  4466 ----------------------------------------------------------ISGDLSL 4472
                                                                      ::|..:|
 Frog   513 FPLLQDSKYYITLTLPLAMAILRLDTNPSKVLDNWWAQVCPKYFLKLISLYKEAVVYLLNGRKTL 577

  Fly  4473 -----------GALK---------------------------------DVLVYNIKEAAFRKVIQ 4493
                       .|||                                 |.|::.:.||..:  ::
 Frog   578 LIPVLFTSYITAALKLLEKLHKVNGKAQHVEHDTFYIPEISSLVDIQEDYLMWFLNEAGLK--LR 640

  Fly  4494 TTMVRD-------------KQHGPVIELN-RIQVKRSRNRCNGLAGIDGMKSVFGQMVQKL-PLL 4543
            .|:::|             :....:::.: .:|::.:.|..|       :::||  |:..| |:|
 Frog   641 PTIMQDSITLCSYPFVFDAQAKTKMLQTDAELQMQVAINGAN-------LQNVF--MLLTLDPML 696

  Fly  4544 TQEALALPH-----------------------RVWKVKFVGESVDDCGGGYSESIAEMCDELQNG 4585
            .:....:.|                       :..||.|.||...|.||...|....:..||.| 
 Frog   697 VKNPFLVLHVRRTSLVADALRELSIYSDIDLKKPLKVIFDGEEAVDDGGVTKEFFLLLLKELLN- 760

  Fly  4586 SVPLLINTPNGRGEAGANRDCFLLDPTLSSVLQMNMFRFLGVLMGIAVRTGSPLSINLAEPVWRQ 4650
              |:.       |.....:|..||..:....::.|.|..:|::.|:|:...:.:.:.....::::
 Frog   761 --PIY-------GMFTVYQDSNLLWFSDICFVEHNWFHLIGIMCGLAIYNFTVVDLYFPLALYKK 816

  Fly  4651 LTG--------EVLRPT------DLTEVDRDYVAGLLCIRNMDDDPKLFTALELPFSTSSARGHE 4701
            |..        :.|.||      :|.:...|.|..:.|:.        ||.....:..:..|   
 Frog   817 LLNVQPTLEDLKELSPTEGRSLQELLDYPEDDVDDVFCLN--------FTICRESYGLAERR--- 870

  Fly  4702 VPLSTRYTHI--SPRNRAEYVRLALGFRLHE-FDEQVKAVRDGMSKVIPVPLLSLFSAAELQAMV 4763
             ||.....||  :..||.::|...:.:..:: ..|..:|...|..||....:|.||..:||::||
 Frog   871 -PLVAGGDHITVTKDNRQQFVDAYVNYVFNQSVQEWYEAFSTGFLKVCGGKILELFQPSELRSMV 934

  Fly  4764 CGSPDIPLGLLKSVATYKGFDPSSA--LVTWFWEVMEEFTNQERSLFLRFVWGRTRLPRTIADFR 4826
            .||.:.....|:..|.||| |.|:|  .|..|||...:|..:::..||.|:.|..|:|  |....
 Frog   935 VGSNNYNWQELEENAIYKG-DYSTAHPTVRMFWETFHDFPLEKKKKFLLFLTGSDRIP--IYGMS 996

  Fly  4827 GRDFVLQVLEKNPPDHFLPESYTCFFLLKMPRYSCKAVLLEKLKYAI-HF 4875
            ....::|.:... .|| ||.::||:.||.:|:||.|..|..:|..|| |:
 Frog   997 SLRIIIQSISSG-EDH-LPVAHTCYNLLDLPKYSSKETLRRRLTQAIDHY 1044

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826
RCC1 3091..3140 CDD:278826
RCC1 3144..3194 CDD:278826
RCC1 3197..3246 CDD:278826
RCC1 3250..3298 CDD:278826
RCC1 3302..3350 CDD:278826
RCC1_2 4136..4166 CDD:290274 10/29 (34%)
RCC1 4154..4203 CDD:278826 17/49 (35%)
RCC1 4206..4257 CDD:278826 15/51 (29%)
RCC1 4260..4309 CDD:278826 11/48 (23%)
RCC1 4312..4360 CDD:278826 16/47 (34%)
RCC1 4364..4413 CDD:278826 22/88 (25%)
HECTc 4509..4880 CDD:238033 102/412 (25%)
HECTc 4553..4878 CDD:214523 92/343 (27%)
herc3XP_002938676.3 RCC1 3..49 CDD:395335 18/47 (38%)
ATS1 44..353 CDD:227511 97/317 (31%)
HECTc 702..1048 CDD:238033 93/370 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1062377at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.920

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