Protein Alignment HERC2 and herc2

DIOPT Version :9

• Sequence 1: NP_608388.2
• Gene: HERC2 / 33035
• FlyBaseID: FBgn0031107
• Length: 4912
• Species: Drosophila melanogaster
• Sequence 2: XP_012813154.2
• Gene: herc2 / 100487407
• XenbaseID: XB-GENE-1012659
• Length: 4848
• Species: Xenopus tropicalis
• Alignment Length: 5194
• Identity: 2239/5194 - (43%)
• Similarity: 2972/5194 - (57%)
• Gaps: 734/5194 - (14%)

  Fly    80 DAKWLRADLIASLRNAADG-AVLWNHLIQDCELVSSPTAPLLNARGQLSYLGDDGKHYCGAQQLK 143
            |:|||:.||  .|....|| ..|||.:::|               |::.|.|.|..........|
 Frog    15 DSKWLKTDL--QLAFTRDGFCSLWNEMVKD---------------GEIVYTGTDATQTGDLPSRK 62

  Fly   144 CSCCQPEYCGPLSACNCDGCRPLDSDTAIKKLTTQAAAQQAAHLSQATDMVLSGWLWSQPPSQQA 208
            ....:.:          ...:..|.:...||...:..|.     :.....::..|:|.:.|....
 Frog    63 DEINEAQ----------SSSKKEDQNDKEKKEDDEILAP-----NYKAKTIMESWVWGRQPDVNE 112

  Fly   209 RLDCQRSMISELQELALRAAGNCLSAQHLRQQLFIYERYFVALKRERERERKSTTSAQAVASVTT 273
            ..:|..:::.|.|.||.:.|...|||..::|:|.|.||||:||.|                  |.
 Frog   113 LKECLYTLVKEQQLLAAQTAKTTLSAMRMKQRLVILERYFIALNR------------------TV 159

  Fly   274 ANTTIAATTANAAVESQPAEQQAE------------HGALGLARVATHAALNFSFAFLRRAWRSG 326
            ...|:.....:::|....||:::|            .|..|||||.:.|||:|:|||||||||||
 Frog   160 FQDTVKVKWKSSSVPQPSAEKKSEDMFHVHSSRPVGQGVEGLARVGSRAALSFAFAFLRRAWRSG 224

  Fly   327 EDTEMCSELLSEALASLQELPEATLFEAAVVSSLWLEVMERSIKFLRLVALGD--------PMGN 383
            ||.::|||||.|:|.:|:.|||||||:...|||:||||:||:.||||.|. ||        ..||
 Frog   225 EDADLCSELLQESLDALRALPEATLFDEGTVSSVWLEVVERATKFLRSVT-GDVHSTQSPRSPGN 288

  Fly   384 RCTAPLNDRHTALCLLLELGVQKGTLAATLECVVLLLLLWEKDRAGNDNRDMPRKTGAPLQRILL 448
               .||.|:|.||.:||||.||:|||:..|..|:|||.|||......||....:.|.|||..:|.
 Frog   289 ---IPLQDQHLALAILLELAVQRGTLSQMLSAVMLLLQLWESGTKETDNERSAQGTSAPLLPLLQ 350

  Fly   449 RYQKIGAT------AKGGGIAGGEPAPVASATETFLRFLSLPKSSAAIVDLRRAAVVIISHLDRM 507
            |:|.|...      .|...|...:.:|    .|.|||:|.||:.:...:|||:.||||::||||:
 Frog   351 RFQSIVCNKEIHNMEKEMQILSCQLSP----NENFLRYLILPQDNELAIDLRQTAVVIMAHLDRL 411

  Fly   508 VQPLMPRCLLRGGQATAASSSSAPQQRIYA---LGWPSLSKDQQGFSAEPTLSWSGESAGVPTLS 569
            ..|.||      .|.::.:|.....|.:.:   |||...:........|..
 Frog   412 AAPCMP------PQCSSPTSHKGALQEVISWGLLGWKYYANVSGPIQCEAL-------------- 456

  Fly   570 CRFQIKQVACCETQMLILSQEGKLYTWRLAKPEAEPLPMEEVAHDVFISIAGHCEGRHFLAIDSN 634
            ....:.||||.|...||||:.|||||.........|..::.:|....:.||.|.:|:|:||:.:.
 Frog   457 ANLGVTQVACAEKCFLILSRNGKLYTQAYNNNTLGPQLVQGLASRNIVKIAAHPDGQHYLALSAT 521

  Fly   635 HNAYSWGTGEDHRLGHGDTHARAVPTKIAAL--EQHCVQSVY--CGCSYSAAITCGGNLLTWGRG 695
            ...:|||.|:..|||||||.:...|..::||  :|...|.::  ||.:||||||..|.|.|||||
 Frog   522 SELFSWGCGDGGRLGHGDTVSLEEPKLVSALSGKQTGKQVIHIACGSTYSAAITADGELYTWGRG 586

  Fly   696 TYARLGHGNSDDRSLPTLVVALSDHMVVDVALGSGDAHSLALTSEGLVFAWGDGDYGKLGNGNCN 760
            .|.|||||:|:|:::|.||..|....||||:.|||||.:|::|..|.|::||||||||||.|..:
 Frog   587 NYGRLGHGSSEDQTVPMLVTGLKGLKVVDVSCGSGDAQTLSVTENGQVWSWGDGDYGKLGRGGSD 651

  Fly   761 GSLQPILVESLP--RVQRVFAGSQFSVALSSEGQLYTWGKA--TCLGHQLVERSVQGCSVPRLVS 821
            |...|.|:|.|.  .:.:|..|||||:|::.:||:|:|||.  ..|||...|.    ...|::::
 Frog   652 GCKTPKLIEKLQDLDIVKVRCGSQFSIAITKDGQVYSWGKGDNQRLGHGTEEH----VRYPKIMN 712

  Fly   822 SLQHKRIVDVAVSVAHCLALSSSGEVFGWGRNDSQQICPASVSSEPLLRTPILVSLPTFPASGIA 886
            .||.|::|||||...|||||:.||||:.||.||..|.......::|:  ..:|..|.:....||:
 Frog   713 GLQGKKVVDVAVGSTHCLALTESGEVYSWGSNDQCQHFDTLRIAKPV--PSVLPGLDSKHIVGIS 775

  Fly   887 CTSAQSLVWTQSSHQGVPRRAPFVVDLGEPTFRLLDQLL-----GMCSSQDNRQTPNQESECIAV 946
            |..|||..|:..|...:..|.|||||:...||..||.||     ||..:.|  ..|.||.||:||
 Frog   776 CGPAQSFAWSSCSEWSIGLRVPFVVDVCPMTFEQLDLLLRQVSEGMDGTSD--WPPPQEKECMAV 838

  Fly   947 ACLNLFRLQLLALIANGVEPRQVGLASGSRLLCSLKTRILGLAGGSQVLRTIQVAAQQALQDGWS 1011
            |.|||.||||.|.|::..:|..:||..||.||.|||..::.||..:.||.|:|.|||..||.|||
 Frog   839 AMLNLLRLQLHAAISHQADPECLGLGLGSVLLNSLKQTVVTLASNAGVLNTVQSAAQAVLQSGWS 903

  Fly  1012 VLLPTAAERAQTLTSLLPSEPG---QASSAGHRFMTDLLVSSLMAEGGLESALQHAI-------- 1065
            ||||||.|||:.|::|||:...   ...|.|.|||.|||||||||:||||.||..||
 Frog   904 VLLPTAEERARALSALLPNAASGNEMTISPGRRFMIDLLVSSLMADGGLECALNTAITAEIQDIE 968

  Fly  1066 -------------------RLESSSCSAD---CGDGVH-------LPLLQLITRLLSNNAALSQT 1101
                               .|..||...|   ...|::       |||:|||.:||.|.|  |||
 Frog   969 AKKEAQKEKEIDEQEANASSLHMSSTPLDKDLINAGIYESAGKQTLPLVQLIQQLLRNIA--SQT 1031

  Fly  1102 ---------RLSPTLGKQQEKEEEEREQQHQEPSTSPSLSLLHRFQRLLLSHIHQAQPEEETTGA 1157
                     |:|..|           ||:|.....|.|:.||.||||||:|.::.....::|...
 Frog  1032 IAKLKDMARRISSCL-----------EQEHYSKERSASMDLLLRFQRLLISKLYPGNDVDQTANT 1085

  Fly  1158 EALLLQYMHALIPACVATLQKAHELALQCREPGE------NSFGQMVGH---LGRVLQADISDAL 1213
                    ||.....|.:|.|.: :||.|...|:      |.....:.|   :.|::..|::..:
 Frog  1086 --------HAPEHLGVGSLLKKY-IALLCTHIGDILPVATNIASVSLRHFAEVSRIVAGDLTGVI 1141

  Fly  1214 LNELLVG--LLLLKRDRPQCLGGLRWAR-------LFLPLLRVLDRLNRALGEGELRDGDDMGWP 1269
            |.||:|.  |||.|.         .|..       |...||..||:.|......|..|.:|:.||
 Frog  1142 LPELVVSTVLLLCKN---------AWLMQESGAIPLLASLLEPLDKFNHLAPGKERDDNEDLAWP 1197

  Fly  1270 GIICRGGP--KGGPPPADPETHYVRRADMENLLLDGSRCIILAGYVCDLSGYNCESETLRSVLDS 1332
            ||:   |.  .|.....:.|...:|:||:||...||....::.|.|.|:..:..:|....::|..
 Frog  1198 GIL---GSFYNGQNSRNNEEVTLIRKADLENHNKDGGFWTVIDGKVYDIKDFQAQSLQANTILAH 1259

  Fly  1333 GLGKD----LTAEMSSQVHRTAMEHILEHHKLGKYMVQASTEEKSSAPGPSRLTH--FSSECALA 1391
            ..|:|    |.|.:..:..|.:|:...    :|.||  ...:|..:||..|.|:.  ..:|..|.
 Frog  1260 FAGEDPVVALEAALQFEDTRESMQAFC----VGHYM--EPDQEVIAAPDLSSLSSPLIDTERNLG 1318

  Fly  1392 QLLGLVANLMCSGPALQPAELQCRQLDKSSLLSGGLQLLQPSNPFDEEKGEARSSHSCHSTAGNT 1456
            .||||.|:.:.....|.|.|::|.:..:||:.|||||..|....::|||.|.. |:|..:||.|.
 Frog  1319 LLLGLHASYLSLSTPLAPVEVECAKWLRSSIFSGGLQTSQIHYSYNEEKDEDH-SNSPGNTASNK 1382

  Fly  1457 PTELPPPLPMQQQLAPGRGKSQLQLRADAFISGLAEARVSEPPVAAWLALTERYCKAHNLMWHQE 1521
            .......|.|.....|             |:..:|:....:..|..:|...:||||..:|.....
 Frog  1383 AKLYAHKLSMSDHSQP-------------FLQAIADNNTQDHNVKEFLCQIDRYCKQCHLTTPIT 1434

  Fly  1522 FATEHPVQELERLLSAVLIRHQYLGGLVLN-----ALETEVPP----PRQLGEIIRLVHQAKWSV 1577
            |..||||:|:.|||...|::|:.||.:.|:     ||..|...    |:.:.::.|:|:|||.|:
 Frog  1435 FPPEHPVEEVGRLLLCCLLKHEDLGNIALSLVHHGALSVEQVKHKTLPKSVVDVCRVVYQAKCSL 1499

  Fly  1578 VRTRQQLNRSYKEVCAPILERLRFLLYEVRPAISPQQRGLRRLPILQRPPRFKMLVRRLLQELRS 1642
            ::|.|:..|||||||||::||||||..|:|||:......:.:|.:|...||:|.:|:::::|.|.
 Frog  1500 IKTHQEQGRSYKEVCAPVIERLRFLFNELRPAVCNDLSIVSKLKLLSSVPRWKRIVQKIIREKRK 1564

  Fly  1643 SRQPAKPE--DLLNASIQQEQ---------EKKPQSMPKQEL---EEQEEEETLLRRLN------ 1687
            .:.|.|.|  |:.:..:..|:         ...|.|:.|:.:   ..:::.:.||..:.
 Frog  1565 KKVPKKSESADVDDTKLGNEEGEMEESCVVPSSPVSVDKKTVPIKSPKDKWQPLLSTVAGVHKYK 1629

  Fly  1688 --ERQIHGEGELDPALMQDIVDFAL-QDSCDVETARRAMYCQMQRYQLRLAGLQIVQQLLELHGL 1749
              :..:.|... ..||:..||:|.| ::..|||..|:.:..|::|.::||.|:..:.:|.....|
 Frog  1630 WLKHNVQGTYP-QSALLGTIVEFVLKEEPVDVEKMRKCLLKQLERAEVRLEGIDTMLKLAAKTFL 1693

  Fly  1750 LDAAQYSLLNGFLGLHLKSTSSGGGSTGSGSSLHVLGQLNMISAYQKARLLLAQSRVLDWAVREL 1814
            |.:.||::..|:..|..:.|:.....|      ..|..:::|..:.:..|.:...::..|||:.:
 Frog  1694 LPSVQYAMFCGWQRLAPEGTNISEPLT------DCLKDVDLIPPFNRMLLEVTFGKLYAWAVQNI 1752

  Fly  1815 RR---------------------LVNQEQQGHARGKDSTNLGTYVLLKRLPRARFLLSVFGLLAK 1858
            |.                     :.|:...|       .:|||      :|:|||:|.:..:|..
 Frog  1753 RNTLMDASSCFKEMGIQPVPLQTITNENPSG-------PSLGT------IPQARFMLVMVNMLTC 1804

  Fly  1859 ELGPNELGFLINSGLLG---TVLGLLAQT--GGEGATGGQVHGELSILYEDSVLKQKSSKAQL-- 1916
            :.|...|..|:|||:|.   |:|.|:..:  ..|..:...|.|..:.:.|:|  :::::..||
 Frog  1805 QHGAKSLNLLLNSGMLALTQTILRLIGPSCENSEDDSSVCVMGASATVLEES--RKETTPVQLPA 1867

  Fly  1917 SGPDLAKLMKIGTRIVRGADWKWGDQDGNPPGEGRIISEVGEDGWVRVEWYTGATNSYRMGKEGQ 1981
            |||:||.:||||||::||.|||||||||.|||.||:|.|:|||||:||:|.||:||||||||||:
 Frog  1868 SGPELAAMMKIGTRVMRGVDWKWGDQDGPPPGLGRVIGELGEDGWIRVQWDTGSTNSYRMGKEGK 1932

  Fly  1982 YDLQLADSALNVASPTEPEREDVSGSEASPTSDS----------HPSKLLRHCAAKLLQILAVGT 2036
            |||:|          |||.....:.:|.|.|.|.          ||:.|:......|||.|.:..
 Frog  1933 YDLKL----------TEPPPATQAMAEDSDTEDDSEGEQIDKNLHPTSLMLMSTVNLLQALCLSA 1987

  Fly  2037 GLHGAQLDKDALRGMTSMFRTII----YPKPS-MSN-ISYA---LGWLNLGFIRAISGDCPRLCL 2092
            |::...:..:..|.:..:.|.::    ..|.| .|| :.|.   ..|..|||||:|: ..|::|.
 Frog  1988 GVNAEVMQSETTRTLCGLLRMLVESGTMDKTSTQSNKLVYKEQHKSWCTLGFIRSIA-IMPQMCS 2051

  Fly  2093 ELSTPGWLSHYLSLLEQPAG-NEAGVYRQLHCLRLLQLILAQWGAEEEP-RMPALVHQLFATLGR 2155
            .||.|.|:|..:.::|.|.. :.|.:.||:..:||||.:|..|...|.. .|..||.:||:.||.
 Frog  2052 TLSMPQWISLLMKIVEGPESFSAASLQRQILAVRLLQAVLPSWDKNERSCDMKTLVEKLFSFLGS 2116

  Fly  2156 IALHCPGDASLLPTA-----EGKARVLLTASHSGSVAEELVALLRRLHTLPSWNPVINSFLAQKL 2215
            :...|..|..||..:     :.:.:..|||:||.::|||:|||||.||:|..||.:||.::..:|
 Frog  2117 LLSTCSSDIPLLRESTLRRRKARPQASLTATHSSTLAEEIVALLRTLHSLNQWNGLINKYINSQL 2181

  Fly  2216 CVAAELL-AEQSHSTAL-----DSEQVFV---LGVLGAMGGHDLRPRVGLHC----FHEGSHMVI 2267
            .....:. .::...|.|     |||...|   :.||..:||.|.|.|:|...    |.||:   :
 Frog  2182 NSVTNIFEGKRFDMTVLEDYFPDSEGPEVGSLMAVLAVIGGIDSRLRLGGQVVQDEFGEGT---V 2243

  Fly  2268 ASFTPKGRCLLAPGGVGSGVGFVKVQLPAVMP----H-LDHTVFSLSRLPMNEMLLNAWTVL--L 2325
            ...||||:..         |.|..|:...:.|    | :....|:::.||..:.:|:.|..|  |
 Frog  2244 TRITPKGKIT---------VQFHDVRTSRICPLNQLHPMPVVPFNVNNLPFTDSMLSVWAQLVNL 2299

  Fly  2326 YGPAPELRELPSS----ADGRLDLALLRAQQLQMAVLHTNGVLYRHQVALRRILKQ---RAPGSI 2383
            .|...|...|..|    ...::||..||.|||::.:|.....|..||..||:||.|   :.||.|
 Frog  2300 AGCKLEKHRLKKSMRQGLTDQVDLDRLRCQQLKLYILKAGRALLSHQDRLRQILSQPSVQEPGLI 2364

  Fly  2384 ------YASPDEPDRSDAESQQPGEQDQQLSSGSGQEPQLLIQCILLRATQASPVKACYSYMDLA 2442
                  .|||:..|.| .|..||              |.:|:|.:|..|||.|||||.:...:|.
 Frog  2365 ASDEGATASPEMVDMS-PEGPQP--------------PMILLQQLLTAATQPSPVKAIFDKQELE 2414

  Fly  2443 TAALNCIQSLATQA-HQELSEGGGVPPNGRALSSPPQPTMVHGVPVYNVARKEQKPSEQVEQKSK 2506
            .|||...|.||.:: |........:..:..| |||  .||.|..|. .|.:::|.|...|
 Frog  2415 AAALAVCQFLAVESTHPSTPLFEDICSSSEA-SSP--VTMQHIRPA-KVKKRKQSPIPPV----- 2470

  Fly  2507 WPAAATDAQLIGQIMEMGFTRRTVELALKQL---SLQAEIMPTPEQIVQWILEHPDVCANTIEED 2568
                    .::.|:|||||.|:.:|.|||.|   |..|...|..|.:|.|:|:|||:
 Frog  2471 --------PIVVQLMEMGFQRKNIEFALKSLSGASGTASSSPGVEALVGWLLDHPDI-------- 2519

  Fly  2569 TLPLASSASSHDPEADSDNECPSSNSTTSSSTSSDTVEGQPMAVSGPAPPVK-FESRKDFQTADL 2632
              .:|..:.:.....|||.|.......|.:|        .|||........: ::.|.||.:.|.
 Frog  2520 --QIAELSDAETASEDSDEEIVEEVEETEAS--------YPMANGAVVTESQTYKKRADFLSNDD 2574

  Fly  2633 YALYVRGLVRPGMTVRCCRDFEEIKQGDMGTVLIVDTEGLHDLNVQVDWRNHGSTYWVCFVHIEL 2697
            ||:|||..|:.||.|||||.:||:.:||:|.|:.:|.:||:|||||.||:..|.||||.::|:||
 Frog  2575 YAVYVRENVQVGMMVRCCRTYEEVCEGDVGKVIKLDRDGLYDLNVQCDWQEKGGTYWVRYIHVEL 2639

  Fly  2698 VEAAQTHHQPRPPPIAVGARVRLRTSSLRYGMLCPLRLGRSQGSSAIGVVS--SVRSKQLTVDFP 2760
            :....   |..|..|.:|.:||::.|     :..|.....|....::|||.  |...|.:.||||
 Frog  2640 LGFPP---QSSPSHIKIGDKVRVKAS-----VTTPKYKWGSVTHRSVGVVKAFSANGKDVIVDFP 2696

  Fly  2761 DQPAWQGHINEVELVASQPTSATLPSLGDSCSQMP------------------------------ 2795
            .|..|.|.::|:|||.|.....|.    |.|...|
 Frog  2697 QQSHWTGLLSEMELVPSIHAGVTC----DGCQMFPIHGSRFKCRVCDDFDFCDTCFKNRKHNARH 2757

  Fly  2796 -------PSD----------------------LIEDWSRCIRSLTVSSNEAAAKHLLNGSNQPWQ 2831
                   |..                      |::||||.::||||||:...|..|::||:|.||
 Frog  2758 TFGRINEPGQSPVFCGRSGKQLKQRHSGQRGMLLDDWSRIVKSLTVSSSVNQASRLIDGSDQCWQ 2822

  Fly  2832 SCSSGPCRHWIRLELHDRILVHSLTLKVSPEDHSHMPSLLEIRVGDCVDSLKEYTWIPVPAGASR 2896
            | |....:||||||:...:.||.|.:.|.|.|.|:||||:.:..|:.:::|.|...|.:......
 Frog  2823 S-SGSQGKHWIRLEIFPDVFVHRLVMTVDPADSSYMPSLVVVSGGNSLNNLIELKTININPTDLN 2886

  Fly  2897 VLLMQQVPTYYPWVEVVVKQCQNNGIQCKIHGIKFVGRRQQPDLQHILANAQFLASEY------S 2955
            |:|:.....|:.::|:.:|||:::||.||||.:..||:.:..|  ..:|...||||:.      .
 Frog  2887 VVLLTDCTEYHRYIEIAIKQCRSSGIDCKIHELNLVGQIRAED--EDMATVPFLASDNDEEDDDK 2949

  Fly  2956 AGVGP---GSTAGAGAVSTSHEEAAAAPEQDLPCTVMVWGLNDKEQLGGLKGSKVKVPTFSQTIS 3017
            |..|.   ..|||..:.:|            :...|.|||||||:|||||||||:|||:||:|:|
 Frog  2950 ASTGSFVRKKTAGLESTAT------------IRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLS 3002

  Fly  3018 RLRPIHIAGGSKSLFIVSQDGKVYACGEGTNGRLGLGVTH-NVPLPHQLPVLRQYVVKKVAVHSG 3081
            .|..:.:||||||||.|:.:||||||||.||||||||::. .||:|.|:..|..|||||||||||
 Frog  3003 ALNVVQVAGGSKSLFAVTAEGKVYACGEATNGRLGLGISSGTVPIPRQITALSNYVVKKVAVHSG 3067

  Fly  3082 GKHALALTLDGKVFSWGEGEDGKLGHGNRTTLDKPRLVEALRAKKIRDVACGSSHSAAISSQGEL 3146
            |:||.|||:||||||||||:||||||.:|...|||||:|||:.|:|||:||||||||||:|.|||
 Frog  3068 GRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAAITSSGEL 3132

  Fly  3147 YTWGLGEYGRLGHGDNTTQLKPKLVTALAGRRVVQVACGSRDAQTLALTEDGAVFSWGDGDFGKL 3211
            |||||||||||||||||||||||:|..|.|.||:|||||||||||||||::|.||||||||||||
 Frog  3133 YTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKL 3197

  Fly  3212 GRGGSEGSDTPHEIERLSGIGVVQIECGAQFSLALTRAGEVWTWGKGDYYRLGHGGDQHVRKPQP 3276
            |||||||.:.|..||||:|..|.|||||||||||||::|.|||||||||:|||||.|.||||||.
 Frog  3198 GRGGSEGCNIPQNIERLNGQAVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGTDVHVRKPQV 3262

  Fly  3277 IGGLRGRRVIHVAVGALHCLAVTDAGQVYAWGDNDHGQQGSGNTFVNKKPALVIGLDAVFVNRVA 3341
            :.||||::::||||||||||||||||||||||||||||||:|.|.||:||.||.||:...:.|||
 Frog  3263 VEGLRGKKIVHVAVGALHCLAVTDAGQVYAWGDNDHGQQGNGTTTVNRKPTLVHGLEGQKITRVA 3327

  Fly  3342 CGSSHSIAWGLPNASSDEEKRGPVPFSSTRDPLGGSSLGI---YEAETMQTLK----QEAKPLNQ 3399
            ||||||:||...:.::..... ||.|.:.||.||.|.||:   .|:....:.|    ...|| |:
 Frog  3328 CGSSHSVAWTTVDVATPSVHE-PVLFQTARDALGASYLGVPSDSESSPSSSNKISGVSSLKP-NR 3390

  Fly  3400 SSLSE-SLALETPAARQAALGHVLRAMSILQARQLIVAALTSHSKVNFKERGAVGGEEDHLIGGP 3463
            .||:: .|:::...|:|.||.|:|.|:.|:.||..:|.||...|.:                 .|
 Frog  3391 PSLAKILLSIDGSLAKQQALSHILTALQIMYARDAVVGALMPASMI-----------------AP 3438

  Fly  3464 IMGAPLQLAETIAQGGGEAPADATDAGL-----QEHSPEAAVDALTGGMSGGANTLPPLSAGPLS 3523
            :....|..|......|..:|.:..|..|     ...||....|. .|.::...:.:.|.:..|
 Frog  3439 MECPSLSTAPPSDMSGTSSPINGDDIMLAMDLEDRLSPSPWQDR-KGEVNSSEDAVTPSAVTP-- 3500

  Fly  3524 AFQSLTGSLSMSGSLSSSALPQHKHSRMSASAMSVMAATMTQQEEMLSHISHCHG-----LDDFG 3583
                     |.|.:.|...:|...    ...|.|::|.|||:.:|.:...:...|     ||:|.
 Frog  3501 ---------SASAASSRPFIPVTD----DPGAASIIAETMTKTKEDVESQNKVTGPEPQCLDEFT 3552

  Fly  3584 GLLGEPEAKSLVELLKLAVCGRCGPPSTSQTIADTLISLGAGTPAVAAMLLETCITELEDLCTSR 3648
            .||...:.:.:|:||||||..|.|... .:.::..|..:|...|.||.||||.|:|||||:.|..
 Frog  3553 SLLVPDDTRVMVDLLKLAVSNRAGEKG-KEVLSAVLSGMGTAYPQVADMLLELCVTELEDVATDS 3616

  Fly  3649 HCLGKL-PKPVMQESSHPYVDNVNVTGVVRIPGAEMLRLEFDSQCSTEKRNDPLVIMDGTGRVLA 3712
            .. |:| .:||:.||||||.|:.:.:|.|:|||||.||:|||.|||||:|:|||.||||..|:::
 Frog  3617 QS-GRLSSQPVVVESSHPYTDDTSTSGTVKIPGAEGLRVEFDRQCSTERRHDPLTIMDGANRIVS 3680

  Fly  3713 MRSGREFAHWAPEIRVLGDELRWKFSSDSSVNGWGWRFWVHAIMPAATLGESGSDRAVLSQPSMA 3777
            :|||||::.|:.|:|:.||||:|||.||.|||||||||.|:.|||||...:..|||.:||.|||.
 Frog  3681 VRSGREWSDWSSELRIPGDELKWKFISDGSVNGWGWRFTVYPIMPAAGPKDLLSDRCILSCPSMD 3745

  Fly  3778 LVMSLLDSRL-APRQPSVLLRLASALAACSQLGALTTAQRIWSLRKLHAVLLLE----------- 3830
            ||..|||.|| .....|::.|||::||||:||.||....|:|:|::|..:|..|
 Frog  3746 LVTCLLDFRLNFASNRSIVPRLAASLAACAQLSALAAGHRMWALQRLRKLLTTEFGQSININRLL 3810

  Fly  3831 -------QAPRPQDPSLSTLLQPLIPELLRQYEYEEPQVRGGIHLMHSDYFKTLAALACDMQLDA 3888
                   :|......:|:.|::.|...|.||:|||:|.||||..|:||.:||.|.|||||::||
 Frog  3811 GDGETETRAMSFSGSALAALVKGLPEALQRQFEYEDPIVRGGKQLLHSPFFKVLVALACDLELD- 3874

  Fly  3889 ALPATSSSSSSSAAPGAISSTGDVHKWAWFKRYCIAVRVAQSLIRRTELPRAFCLEVRKKFAEML 3953
            .||..:                :.||||||:|||:|.|||.:|.:||.|||.|..||.||..|::
 Frog  3875 TLPCCA----------------ETHKWAWFRRYCMASRVAVALDKRTPLPRQFLDEVAKKIRELM 3923

  Fly  3954 PSSSSNSNANPGCQSPGASMLNSTTSLSSSTVSNVSPPPGITGEQPDLHCHAHQLESTSTLLHED 4018
               :.|.|.|.|                                                  ||.
 Frog  3924 ---ADNENMNAG--------------------------------------------------HES 3935

  Fly  4019 HTLFQAPHDAQLLQWLNRRPDDWALSWGGASTIYGWGHNHRGQLGGLEGSRIKTPTPCEALSLLR 4083
            |..|:...|.||:||:|||||||.||.||:.|||||||||||||||:||:::|.|||||||:.||
 Frog  3936 HDTFKREQDEQLVQWMNRRPDDWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLR 4000

  Fly  4084 PVQLAGGEQSLFAVTPDGKLFATGYGSGGRLGVGGSDSWAIPTLLGSLQHVFVKKVAVNSGGKHC 4148
            ||||.||||:|||||.||||:|||||:|||||:||::|.:.||||.|:||||:||||||||||||
 Frog  4001 PVQLIGGEQTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHC 4065

  Fly  4149 LALTTEGEVYAWGEGEDGKLGHGNRMSYDRPKLVEHLNGMSVADIACGSAHSAAITASGHVLTWG 4213
            |||::|||||:|||.||||||||||...|||:::|.|.|..|.|||.|.||||.|||:|.:.|||
 Frog  4066 LALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGTEVVDIAAGGAHSACITAAGELYTWG 4130

  Fly  4214 KGRYGRLGHGDSEDQLRPKLVEALLGYRAIDIACGSGDAQTLCITDDDNVWSWGDGDYGKLGRGG 4278
            ||||||||||||||||:|||||||.|||.||||||||||||||:||||.||||||||||||||||
 Frog  4131 KGRYGRLGHGDSEDQLKPKLVEALQGYRVIDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGG 4195

  Fly  4279 SDGCKLPYKIESLAGLGVVKVECGSQFSVALTKSGAVYTWGKGDFHRLGHGSVDHVRRPKKVAAL 4343
            |||||:|.||:||.|:||.|||||||||||||||||||||||||:|||||||.||||||::|..|
 Frog  4196 SDGCKVPMKIDSLTGVGVTKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGL 4260

  Fly  4344 QGKKIISIATGSLHCVACSDSGEVYTWGDNDEGQLGDGTVTAIQRPRLVAALQGKHIVKVTCGSA 4408
            ||||:|:|||||||||.|::.||||||||||||||||||..||||||||||||||.|.:|.||||
 Frog  4261 QGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKINRVACGSA 4325

  Fly  4409 HTLALSTSQLSERLRPLPNPPLEYDLVRDLAPEALHARLILLHHFSELVCPCLAMLPISGDL--- 4470
            ||||.|||:.:...:.....|:||:.::::...||..||:||||.|||.|||:.|..:.|.|
 Frog  4326 HTLAWSTSKPANAGKLPSQVPMEYNHLQEIMIIALRNRLLLLHHISELFCPCIPMFDLEGRLDES 4390

  Fly  4471 ----SLG--ALKDVLVYNIKEAAFRKVIQTTMVRDKQHGPVIELNRIQVKRSRNRCNGLAGIDGM 4529
                |:|  .|:.:|:...||||||||:|.|||||:|||||:|||||||||||:: .||||.||.
 Frog  4391 GQGPSIGFDTLRGILISQGKEAAFRKVVQATMVRDRQHGPVVELNRIQVKRSRSK-GGLAGPDGT 4454

  Fly  4530 KSVFGQMVQKLPLLTQEALALPHRVWKVKFVGESVDDCGGGYSESIAEMCDELQNGSVPLLINTP 4594
            |||||||..|:...:.::|.||||||||||||||||||||||||||||||:|||||..||||.||
 Frog  4455 KSVFGQMCAKMASFSPDSLLLPHRVWKVKFVGESVDDCGGGYSESIAEMCEELQNGLTPLLIVTP 4519

  Fly  4595 NGRGEAGANRDCFLLDPTLSSVLQMNMFRFLGVLMGIAVRTGSPLSINLAEPVWRQLTGEVLRPT 4659
            |||.|:|||||||||:|...:.|.||||||||||:|||:|||||||:|||||||:||.|..|...
 Frog  4520 NGRDESGANRDCFLLNPAAKTTLHMNMFRFLGVLLGIAIRTGSPLSLNLAEPVWKQLAGMNLTIA 4584

  Fly  4660 DLTEVDRDYVAGLLCIRNMDDDPKLFTALELPFSTSSARGHEVPLSTRYTHISPRNRAEYVRLAL 4724
            ||:|||:|::.||:.||:.:...:.|.|:.|||:..||.|.::.||:::|||:..|||||||||:
 Frog  4585 DLSEVDKDFIPGLMYIRDNEATSEEFEAMILPFTVPSASGQDIQLSSKHTHITLDNRAEYVRLAI 4649

  Fly  4725 GFRLHEFDEQVKAVRDGMSKVIPVPLLSLFSAAELQAMVCGSPDIPLGLLKSVATYKGFDPSSAL 4789
            |:|||||||||.|||:||::|:||||||||:..||:.||||||||||.||||||||||.:|:::|
 Frog  4650 GYRLHEFDEQVAAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKGIEPTASL 4714

  Fly  4790 VTWFWEVMEEFTNQERSLFLRFVWGRTRLPRTIADFRGRDFVLQVLEK-NPPDHFLPESYTCFFL 4853
            :.|||:|||.|:|.||||||||||||||||||||||||||||:|||:| ||||||||||||||||
 Frog  4715 IQWFWDVMESFSNTERSLFLRFVWGRTRLPRTIADFRGRDFVIQVLDKYNPPDHFLPESYTCFFL 4779

  Fly  4854 LKMPRYSCKAVLLEKLKYAIHFCKSIDTDEYARVAM-GEPT--EATGSEDNSDLESVAS 4909
            ||:||||||.||.||||||||||||||||:|||:|: |||.  :::...||.|.:|.||
 Frog  4780 LKLPRYSCKQVLEEKLKYAIHFCKSIDTDDYARIALTGEPAADDSSDDSDNEDADSFAS 4838

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826	21/48 (44%)
		RCC1	687..737	CDD:278826	29/49 (59%)
		RCC1	740..787	CDD:278826	24/48 (50%)
		RCC1	790..841	CDD:278826	22/52 (42%)
		RCC1_2	828..857	CDD:290274	18/28 (64%)
		Cyt-b5	1290..1363	CDD:278597	19/76 (25%)
		MIB_HERC2	1928..1987	CDD:284184	44/58 (76%)
		UBA_HERC2	2515..2559	CDD:270585	20/46 (43%)
		Cul7	2624..2699	CDD:288381	41/74 (55%)
		APC10-HERC2	2762..2932	CDD:176485	67/228 (29%)
		RCC1	3037..3088	CDD:278826	35/51 (69%)
		RCC1	3091..3140	CDD:278826	37/48 (77%)
		RCC1	3144..3194	CDD:278826	43/49 (88%)
		RCC1	3197..3246	CDD:278826	37/48 (77%)
		RCC1	3250..3298	CDD:278826	36/47 (77%)
		RCC1	3302..3350	CDD:278826	34/47 (72%)
		RCC1_2	4136..4166	CDD:290274	24/29 (83%)
		RCC1	4154..4203	CDD:278826	33/48 (69%)
		RCC1	4206..4257	CDD:278826	43/50 (86%)
		RCC1	4260..4309	CDD:278826	41/48 (85%)
		RCC1	4312..4360	CDD:278826	39/47 (83%)
		RCC1	4364..4413	CDD:278826	41/48 (85%)
		HECTc	4509..4880	CDD:238033	269/371 (73%)
		HECTc	4553..4878	CDD:214523	240/325 (74%)
herc2	XP_012813154.2	ATS1	<501..794	CDD:227511	130/298 (44%)
		Cyt-b5	1219..1291	CDD:395121	19/75 (25%)
		MIB_HERC2	1879..1939	CDD:399589	45/69 (65%)
		UBA_HERC2	2471..2518	CDD:270585	20/46 (43%)
		Cul7	2566..2643	CDD:402903	41/76 (54%)
		SH3_15	2651..2708	CDD:408152	19/61 (31%)
		ZZ_HERC2	2718..2762	CDD:239084	4/47 (9%)
		APC10-HERC2	2777..2922	CDD:176485	54/145 (37%)
		ATS1	2968..3334	CDD:227511	273/377 (72%)
		ATS1	4037..4342	CDD:227511	238/304 (78%)
		HECTc	4435..4806	CDD:238033	269/371 (73%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	480	1.000	Domainoid score	I415
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3430
Inparanoid	1	1.050	3483	1.000	Inparanoid score	I12
OMA	1	1.010	-	-		QHG50139
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	1	1.000	-	-		FOG0007465
OrthoInspector	1	1.000	-	-		oto104152
Panther	1	1.100	-	-	LDO	PTHR22870
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4599
SonicParanoid	1	1.000	-	-		X6340
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	13.110