DRSC/TRiP Functional Genomics Resources

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Protein Alignment HERC2 and nek9

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:XP_021323186.1 Gene:nek9 / 100334361 -ID:- Length:921 Species:Danio rerio


Alignment Length:596 Identity:148/596 - (24%)
Similarity:235/596 - (39%) Gaps:144/596 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly  4117 GGSDSWAIPTLLGSLQHVFVKKVAVNSGGKHCLALTTEGEVYAW-----GEGEDGKLGHGNRMSY 4176
            |||          |.|||.       :|..|...:|.|.|:|.|     |....|:||||::.||
Zfish   356 GGS----------SAQHVC-------AGETHFAVVTVEKELYTWASVQGGAKMVGQLGHGDQASY 403

  Fly  4177 DRPKLVEHLNGMSVADIACGSAHSAAITASGHVLTWGKGRYGRLGHGDSEDQLRPKLVEALL--- 4238
            .:|:.||.|.|.::..::.|:..:|.:|....:..:|...||.:|   .|::|..:::|.:|   
Zfish   404 RQPRRVERLQGKAIRQVSXGADFTACVTDEDQIYMFGSDYYGCVG---VENELGMEVLEPVLLEF 465

  Fly  4239 -GYRAI-DIACGSGDAQTLCITDDDNVWSWGDGDYGKLGRGGSDGCKLPYKIESLAGLGVVKVEC 4301
             ..||: .::|  ||...|.:|....:::||.|::|:||....|....|.::|...|..:..|.|
Zfish   466 FTERAVRQVSC--GDNHVLALTQSRELYAWGCGEHGRLGLDCEDDFSSPMQVEVPQGAVIDSVYC 528

  Fly  4302 GSQFSVALTKSGAVYTWGKGDFHRL---------------GHGSVDHVRRPKKVAALQGKKIISI 4351
            ||..:..||:||.|...|..:|::|               |:..:.:......|..|...||..:
Zfish   529 GSDGTFFLTESGKVLACGNNEFNKLGLNQGITGIKNHPGEGYQGIPYTTTLTLVKLLSRFKIQFL 593

  Fly  4352 ATGSLHCVACSDSGEVYTWGDNDEGQLGDGTVTAIQRPR----LVAALQGKHIVKVTCGSAHTLA 4412
            |.|..|..|..:.|.:.|:|.|..||||   |...::.:    ||....||.:.||:||...|:|
Zfish   594 APGKTHTAAIDERGRLMTFGCNKFGQLG---VKDFKKHQGVQILVGPFGGKIVTKVSCGDGFTIA 655

  Fly  4413 LSTSQLSERLRPLPNPPLEYDLVRDLAPEALHARLILL--HHFSELVCPCLAMLPISG------D 4469
            .:..          |....:.       .|.:.||.:.  ..|...|||.|.. ||.|      |
Zfish   656 ATED----------NQIFAWG-------NAGNGRLGMPADKGFGSEVCPALPR-PIFGSLHHVPD 702

  Fly  4470 LSLGALKDVLVYNIKEAAFRKVIQTTMVRDKQHG----------PVIELNRIQVKRSRNRCNGLA 4524
            ||......:|:       ..||:.:..:|....|          ..::|.......|..|...|.
Zfish   703 LSCRGWHTILI-------MEKVLNSKTIRSNSSGLSIGSGQCSTSSVDLETASATDSELREGMLG 760

  Fly  4525 GIDGMKSVFGQMVQKLPLLTQEALA--------LPHRVWKVKFV------GESVDDCGGGYSESI 4575
            |.  :::|......:.||.:.::..        |...:...:::      .||::.....|:||.
Zfish   761 GT--VEAVMDDRGLETPLFSMDSKTNESSCPSWLRKELQDAEYIPMPDDSRESMEPLTSSYTESA 823

  Fly  4576 A---EMCDELQNGSVPLLINTP-------NG----RGE---AGAN------RDCF--------LL 4609
            .   |..|:|:..:...::.|.       ||    |||   .|||      |:..        ||
Zfish   824 TLPYEELDQLKAAAGKSMMKTACVDYERMNGVETSRGEQSCCGANVQLEQLRETVERQEGQIQLL 888

  Fly  4610 DPTLSSVLQMN 4620
            ...:|..||.|
Zfish   889 QKQVSDQLQEN 899

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826
RCC1 3091..3140 CDD:278826
RCC1 3144..3194 CDD:278826
RCC1 3197..3246 CDD:278826
RCC1 3250..3298 CDD:278826
RCC1 3302..3350 CDD:278826
RCC1_2 4136..4166 CDD:290274 8/34 (24%)
RCC1 4154..4203 CDD:278826 19/53 (36%)
RCC1 4206..4257 CDD:278826 14/55 (25%)
RCC1 4260..4309 CDD:278826 14/48 (29%)
RCC1 4312..4360 CDD:278826 14/62 (23%)
RCC1 4364..4413 CDD:278826 18/52 (35%)
HECTc 4509..4880 CDD:238033 32/157 (20%)
HECTc 4553..4878 CDD:214523 24/105 (23%)
nek9XP_021323186.1 STKc_Nek9 40..297 CDD:270860
RCC1 <347..657 CDD:332518 95/325 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1062377at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.010

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