DRSC/TRiP Functional Genomics Resources

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Protein Alignment HERC2 and hecw2b

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:XP_003197660.3 Gene:hecw2b / 100331355 ZFINID:ZDB-GENE-101001-3 Length:1472 Species:Danio rerio


Alignment Length:1974 Identity:365/1974 - (18%)
Similarity:606/1974 - (30%) Gaps:722/1974 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly  3108 GNRTTLDKPRLVEALRAKKIRDVACGSSHSAAISSQGELYTWGLGEYGRLGHGDNTTQLK----- 3167
            |..||..:..||...|:..:| ......:..::|:||     |.|..|..|.......|:     
Zfish     4 GTTTTAREHLLVVRRRSPHMR-YTLSPENLRSLSAQG-----GSGGGGSRGGAPEPMGLQRANSD 62

  Fly  3168 PKLVTALAGRRVVQVACGSRDAQTLALTE------DGAVFSWGDGDFGKLGRGGSEGSDTPHEIE 3226
            ..|||:           .||.:.|.:..:      ...|.||                |...|::
Zfish    63 TDLVTS-----------DSRSSLTASTYQFTLGRGQNLVISW----------------DIKEEVD 100

  Fly  3227 RLSGIGVVQIE--CGAQF------SLALTRAGE-VWTWGKGDY---------YRLGHGGDQHVRK 3273
            ....||:..|:  |.|..      .:..|:.|: ||....|.|         ::..||....:|.
Zfish   101 ATDWIGLYHIDETCPANVWDSKNRGVNGTQRGQIVWRLEPGPYFMEPETKICFKYYHGVSGALRA 165

  Fly  3274 PQPIGGLRGRRVIHVAVGALHCLAVTD-AGQVYAWGDNDHGQQG-SGNTFVNKKPALVIGLDAVF 3336
            ..|...::...|...|.|.:...:||: ..::.::..:|...|| ....|.|..|.|.:.:....
Zfish   166 TTPCITVKNPGVTVGAEGQVDGQSVTEHCRKLVSFTLSDIRAQGLKKGMFFNPDPYLKMSIQPGK 230

  Fly  3337 VNRVACGSSHSIAWGLPNASSDEEKRGPVPFSSTRDPLGGSSLGIYEAETMQTLKQEAKPLNQSS 3401
            .|            |.|..|...::|.....|:|.:|:.......:.|.....|:.|.|      
Zfish   231 RN------------GFPTFSHHGQERRTSIISNTTNPVWHGEKYTFVALMTDVLEIEVK------ 277

  Fly  3402 LSESLALETPAARQAALGHVLRAMSILQAR-----QLIVAAL-----TSH--SKVNFKERGAVGG 3454
              :..|...|..:: .||.::..:..|..|     |.:...|     |.|  .:::|:......|
Zfish   278 --DKFAKSRPIIKR-FLGQLIIPVQRLLERHTAGDQHVSYTLCRRLPTEHVSGQLHFRVEITFNG 339

  Fly  3455 EEDHLIGGPIMGAPLQLAETIAQGGGEAPADATDAGLQEHSPEAAVDALTGGMSGGANTLPPLS- 3518
            .||.:  |.::||      :...|...:|:|..|                        .|.|:| 
Zfish   340 HEDAM--GSLLGA------SAMNGDPGSPSDDED------------------------VLQPVSR 372

  Fly  3519 --AGPLSAFQSLTGSLSMSGSLSSSALPQHKHSRMSASAMSVMAATMTQQEEML----------- 3570
              .||     |.|||   .|||...|....:             ..|..:|:.|           
Zfish   373 MVRGP-----SPTGS---EGSLHGDAFRPDE-------------CMMDPEEDRLLRDGAPDLAEG 416

  Fly  3571 --SHISHCHGLDDFGGLLGEPEAKSLVELLKLAVCGRCGPPSTSQTIADTLISLGAGTPAVAA-- 3631
              :|......|:|:...:..|:                 ||...        .|||.:|.:.:  
Zfish   417 APAHTHRQSSLNDYLDAIEAPK-----------------PPGDR--------PLGASSPKLRSSF 456

  Fly  3632 -------MLLETCITELEDLCTSRH--CLGKLPKPVMQESSHPYVDNVNVTGVVRIPGAEMLRLE 3687
                   .:|.....|.|:...||.  ....:|:|....||.      ...|.|.:...|.|..|
Zfish   457 PTDTRLNAMLHIDSDEDEEGHASRDTALTNGMPRPEGHASSE------RGKGEVHVKNRERLESE 515

  Fly  3688 FDSQCSTEKRNDPLVIMDGTGRVLAMRSGREFAHWAPEIRVLGDELRWKFSSDSSVNGWGWRFWV 3752
            ..|. :|:......|...||.:                                |.||.|     
Zfish   516 AASS-ATDTEATASVSSSGTTK--------------------------------SQNGGG----- 542

  Fly  3753 HAIMPAATLGESGSDRAVLS-----------QPSMAL-----VMSLLDSRL--APRQPSVLLRLA 3799
                     .|.|.:.|.:|           ||::.:     ......||.  :...|:|....|
Zfish   543 ---------AEGGQEGAAISGGLTQSISSFQQPALRIQDEEGAAPQASSRTEGSSEAPAVSEASA 598

  Fly  3800 SALAACSQLGALTTA------------------QRIWSLRK----------LHAVLLLEQAPRPQ 3836
            ||:...:::|..|..                  :.||..|:          ..|:.|..:..|..
Zfish   599 SAIYTVNEVGGATATNQPERMNSSEMTNQEEEDEEIWQRRRSLQASGNESQAEAMELGNEVRRTA 663

  Fly  3837 DPSLSTLL--------------QPL--IP----ELLRQYEYEEP-----QVRGGIH--LMHSDYF 3874
            |.:.:.|:              ||:  :|    ::.|....:||     :.|...|  :.:.|:.
Zfish   664 DEAQAALITDGETGACAQVNGHQPMRSLPSVRHDISRYQRVDEPLPPNWEARIDSHGRIFYVDHV 728

  Fly  3875 KTLAALACDMQLDAALPATSSSSSSSAAPGAISSTGDVHKWAWF-KRYCIAVRVAQSLIR----- 3933
            ..              ..|....::..||..:..:..:.:.... :||       ||:.|     
Zfish   729 NR--------------TTTWQRPTAPPAPQVLQRSNSIQQMEQLNRRY-------QSIRRTITNE 772

  Fly  3934 RTELPRAFCLEVRKKFAEMLPSSSSNSN---------ANPGCQSPGASMLNSTTSLSSSTVSNVS 3989
            |||          ::.|||.|...:.|:         ...|...|.:|....|..|.|.:...::
Zfish   773 RTE----------EQAAEMPPDDLTTSDLLHHSIPEYRRDGVVGPASSRSRLTLLLQSPSAKFLT 827

  Fly  3990 PPPGITGEQPDLHCH--AHQLESTSTLL--------HEDHTLFQAPHDAQLLQWLNR-------R 4037
            .|...|    .||.:  |:::.:::|.|        .:.|...:..|:..|:.:||.       .
Zfish   828 SPDFFT----VLHSNPSAYRMFTSNTCLKHMISKVRRDAHHFERYQHNRDLVAFLNMFANKQLDL 888

  Fly  4038 PDDWALSWGGASTIYGWGHNHRGQLGGLEGSRIKTPTPCEALSLLRPVQLAGGEQSLFAVTPDGK 4102
            |..|.:.           |:|.|:...::.:       |.|.:.:.|      ...|.:..|.  
Zfish   889 PRGWEMK-----------HDHTGKPFFVDHN-------CRATTFIDP------RLPLQSARPS-- 927

  Fly  4103 LFATGYGSGGRLGVGGSDSWAIPTLLGSLQHVFVKKVAVNSGGKHCLALTTEGEVYAWGEGEDGK 4167
                                   :||...||:..::       .|     :.|||     |:|.:
Zfish   928 -----------------------SLLAHRQHLSRQR-------SH-----SAGEV-----GDDPR 952

  Fly  4168 LGHGNRMSYDRPKLVEHLNGMSVADIACGSAHSAAITA---SGHVLTWGKGRYGRLGHGDSEDQL 4229
              |.......||......|.....|:. ..|::..|.|   ..::....:.|...|....|   |
Zfish   953 --HAGPAVLPRPSNTFTANRNQCQDLV-PVAYNEKIVAFLRQPNIFDILQERQPELIRNHS---L 1011

  Fly  4230 RPKLVEALLGYRAIDIACGSGDAQTLCITD--DDNVWSWGDGDYGKLGRGGSDGCKLPYKIESLA 4292
            |.| |:.:....|..:|..|.||..:.:..  ::.|.|:                 :|.      
Zfish  1012 REK-VQFIRNEGASGLARLSSDADLVILLSLFEEEVMSY-----------------VPP------ 1052

  Fly  4293 GLGVVKVECGSQFSVALTKSGAVYTWGKGDFHRLGHGSVDHVRRPKKVAALQGKKIISIATGSLH 4357
                                           |.|.|.|                          :
Zfish  1053 -------------------------------HALLHPS--------------------------Y 1060

  Fly  4358 CVACSDSGEVYTWGDNDEGQLGDGTVTAIQRPRLVAALQGKHIVKVTCGSAHTLALSTSQLSERL 4422
            |                            |.||               ||    .:|:.|     
Zfish  1061 C----------------------------QSPR---------------GS----PVSSPQ----- 1073

  Fly  4423 RPLPNPPLEYDLVRDLAPEALHARLILLHHFSELVCPCLAMLPISGDLSLGALKDVLVYNIKEAA 4487
                |.|         ..:..:||               |..|...|.              ||.
Zfish  1074 ----NSP---------GTQRANAR---------------APAPYKRDF--------------EAK 1096

  Fly  4488 FRKVIQTTMVRDKQHGPVIELNRIQVKRSRNRCNGLAGIDGMKSVFGQMVQKLPLLTQEALALPH 4552
            .|...:....:....||    .::::...|:..        ::..|.|      ::......|..
Zfish  1097 LRNFYRKLETKGYGQGP----GKVKLIIRRDHL--------LEDAFNQ------IMCYSRKDLQR 1143

  Fly  4553 RVWKVKFVGESVDDCGGGYSESIAEMCDELQNGSVPLLINTPNGRGEAGANRDCFLLDPTLSSVL 4617
            ....|.||||...|..|...|....:..|        |.|...|..|..|| |.:.:..:..|..
Zfish  1144 SKLYVSFVGEEGLDYSGPSREFFFLVSRE--------LFNPYYGLFEYSAN-DTYTVQISPMSAF 1199

  Fly  4618 QMN---MFRFLGVLMGIAVRTGSPLSINLAEPVWRQLTGEVLR-PTDLTE---VDRDYVAGLLCI 4675
            ..|   .|||.|.::|:|:.....|......|.::.|    || |.||::   :|.::...|..:
Zfish  1200 VDNHHEWFRFSGRILGLALIHQYLLDAFFTRPFYKGL----LRIPCDLSDLEYLDEEFHQSLQWM 1260

  Fly  4676 RNMDDDPKL---FTALELPFSTSSAR-----GHEVPLSTRYTHISPRNRAEYVRLALGFRLHE-F 4731
            ::.|.:..|   ||..|..|...:.|     |..:|       :|.:|:.||:...:.:|:.. .
Zfish  1261 KDNDIEDMLDLTFTVNEEVFGQITERELKPGGANIP-------VSEKNKKEYIERMVKWRIERGV 1318

  Fly  4732 DEQVKAVRDGMSKVIPVPLLSLFSAAELQAMVCGSPDIPLGLLKSVATYK-GFDPSSALVTWFWE 4795
            .:|.:::..|..:|:...|:|:|.|.||:.::.|:.:|.||..::...|: |:..:..::.|||.
Zfish  1319 VQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLGDWRNNTEYRGGYHDNHIVIRWFWA 1383

  Fly  4796 VMEEFTNQERSLFLRFVWGRTRLP-RTIADFRGRDFVLQVLEKNPPDHF----------LPESYT 4849
            .:|.|.|::|...|:||.|.:.:| ...|..||         .|.|..|          ||.::|
Zfish  1384 AVERFNNEQRLRLLQFVTGTSSIPYEGFASLRG---------SNGPRRFCVEKWGKITSLPRAHT 1439

  Fly  4850 CFFLLKMPRYSCKAVLLEKLKYAI 4873
            ||..|.:|.|...::|.||:..|:
Zfish  1440 CFNRLDLPPYPSFSMLYEKMLTAV 1463

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826
RCC1 3091..3140 CDD:278826 7/31 (23%)
RCC1 3144..3194 CDD:278826 12/54 (22%)
RCC1 3197..3246 CDD:278826 10/56 (18%)
RCC1 3250..3298 CDD:278826 12/57 (21%)
RCC1 3302..3350 CDD:278826 8/48 (17%)
RCC1_2 4136..4166 CDD:290274 5/29 (17%)
RCC1 4154..4203 CDD:278826 11/48 (23%)
RCC1 4206..4257 CDD:278826 12/50 (24%)
RCC1 4260..4309 CDD:278826 3/48 (6%)
RCC1 4312..4360 CDD:278826 5/47 (11%)
RCC1 4364..4413 CDD:278826 5/48 (10%)
HECTc 4509..4880 CDD:238033 97/393 (25%)
HECTc 4553..4878 CDD:214523 93/349 (27%)
hecw2bXP_003197660.3 HECW_N 58..177 CDD:318711 26/145 (18%)
C2_NEDL1-like 198..334 CDD:176073 30/156 (19%)
LGT <491..633 CDD:320995 32/194 (16%)
WW 708..737 CDD:306827 4/42 (10%)
WW 887..919 CDD:197736 8/55 (15%)
HECTc 1117..1470 CDD:238033 97/390 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.000

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