DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HERC2 and hecw2a

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:XP_009302976.1 Gene:hecw2a / 100150269 ZFINID:ZDB-GENE-090311-22 Length:1475 Species:Danio rerio


Alignment Length:2096 Identity:389/2096 - (18%)
Similarity:625/2096 - (29%) Gaps:800/2096 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly  2933 GRRQQPDLQHILA--NAQFLASEYSAGVGPGSTAGAGAVSTSHEEAAAAPEQDLPCTVMVWGLND 2995
            |||:.|:::|.|:  |.:.||..     |....||.|.:..:                     :|
Zfish    16 GRRRSPNVRHTLSPENLRSLAER-----GGAEQAGVGLLRAN---------------------SD 54

  Fly  2996 KEQLGGLKGSKVKVPTFSQTISRLRPIHIAGGSK---------SLFIVSQ--DGKVYAC-GEGTN 3048
            .:.:.....|.:...|...|:.|.:.:.|:...|         .|:.:.:  ...|:.| ..|.|
Zfish    55 TDLVSSQGRSSLTASTLEFTLCRGQNLVISWDIKEEVDATDWIGLYHIDETCPSNVWDCKNRGVN 119

  Fly  3049 G--------RLGLGVTHNVPLPHQLPVLRQYVVKKVAVHSGGKHALALTLDGKVFSWGEGEDGKL 3105
            |        ||.:|       |:.|....:...|.....||...|....:               
Zfish   120 GTQCGQIVWRLEVG-------PYFLESETRICFKYYHGVSGALRATTPCI--------------- 162

  Fly  3106 GHGNRTTLDKPRLVEALRAKKIRDVACGSSHSAAISSQGELYTWGLGEYGRLGHGDNTTQLKPKL 3170
                  |:..||                    |::..|||              |...:....||
Zfish   163 ------TVKNPR--------------------ASVDGQGE--------------GQQASDSSRKL 187

  Fly  3171 VT-ALAGRRVVQVACGSRDAQTLALTEDGAVFSWGDGDFGKLGRGGSEGSDTP----HEIERLSG 3230
            |: .|:..|.|.:             :.|..|:  ...:.|:.....:.|..|    |..||.||
Zfish   188 VSFTLSDIRAVGL-------------KKGMFFN--PDPYLKMSIHPGKRSCFPTFSHHGQERRSG 237

  Fly  3231 IGVVQIECGAQFSLALTRAGEVWTWGKGDYYRLGHGGDQHV-----------------RKPQPIG 3278
            |             .......||           | |::|.                 .|.:|| 
Zfish   238 I-------------TTNTTNPVW-----------H-GEKHTFVALMTDVLVIEVKDKFAKSRPI- 276

  Fly  3279 GLRGRRVIHVAVGALHCLAVTDAGQVYAWGD------------NDH--GQQGSGNTFVNKKPALV 3329
                   |...:|.|: :.|....:.::.|:            .||  ||...      |.....
Zfish   277 -------IKRFLGQLN-IPVQLLLERHSTGNQSLSFSLCRRLPTDHVSGQMHF------KVDVTS 327

  Fly  3330 IGLDAVFVNRVACGSSHSIAWGLPNASSDEEKRGPVPFSSTRDPLGGSSLG-------------- 3380
            :|.|.|....:...::.:.|.|.|  |.|||...|:|.||. .|...:|||              
Zfish   328 MGPDDVSPETILGAAALNGAPGTP--SDDEELPHPLPISSA-GPSPTASLGSNRNGEGSSIPSPD 389

  Fly  3381 --IYEAETMQTLKQEA---KPLNQSSLSESL-ALETP-AARQAALGHVLRAMSILQARQLIVAAL 3438
              ||..    ||..||   ..|.|.|.||.| |:|.| ......||         .|...:.::.
Zfish   390 TEIYGG----TLDDEAPSSPDLLQGSFSEQLDAIEAPKGPGDRPLG---------AASPKLRSSF 441

  Fly  3439 TSHSKVNFKERGAVGGEEDHLIGGPIMGAPLQLAETIAQGGGEAPADAT-----DAGLQEHSPEA 3498
            .:|::::.........:||.   .....|.|.....|.:.....|..|.     |.|::|.|.||
Zfish   442 PTHTRLSAMLHIDSDEDEDR---SAATEATLSTFNGIPRSYQTPPKAAARGAVFDGGIEEPSEEA 503

  Fly  3499 AVDALTGGMSGGANTLPPLSAGPLSAFQSLTGSLSMSGSLSSSALPQHKHSRMSASAMSVMAATM 3563
            .:::....::.|....|.....|                  ||..|:.:           .|:.|
Zfish   504 GLESEVETLNAGEEVPPEPEVVP------------------SSVAPEVE-----------TASLM 539

  Fly  3564 TQQEEMLSHISHCHGLDDFGGLLGEPEAKSLVELLKLAVCGRCGPPSTSQTI---ADTLISLGA- 3624
            .:|||....:....  ::..||....|..:.|::..:|.....||.|.||..   |:..|..|. 
Zfish   540 ERQEEQGREVEVEE--EEEEGLARSEELATEVDISSMASDCCPGPASASQEAEQGAEAAIDPGGE 602

  Fly  3625 -------GTPAVAAMLLETCITELEDLCTSRHCLGKLPKPVMQESSHPYVDNVNVTGVVRIPGAE 3682
                   .|..||....||.:|...:        .:.|||....:.....::|....:.|     
Zfish   603 DLSDDPPTTYEVAETAEETHLTNEPE--------REAPKPEPPTNEEEECEDVTEDTMSR----- 654

  Fly  3683 MLRLEFDSQCSTEKRNDPLVIMDGTGRVLAMRSGREFAHWAPEIRVLGDELRWKFSSDSSVNGWG 3747
              |...::.....:.::..:|..|.|.  ::.|.........|:.|            ..|||  
Zfish   655 --RWSLEATAGVSQEDEDELIPSGDGE--SVDSETFVTETESELGV------------PQVNG-- 701

  Fly  3748 WRFWVHAIMPAATLGESGSDRAVLSQPSMALVMSLLDSRLAPRQPSVLLRLAS--ALAACSQLGA 3810
                               |:.|.|.||:...:........|..|:...|:.|  .:.....:..
Zfish   702 -------------------DQRVNSLPSVRQDIHRYQRVDEPLPPNWEARIDSHGRIFFVDHVNR 747

  Fly  3811 LTTAQRIWSLRKLHAVLLLEQAPRPQD-PSLSTLLQPLIPELLRQYEYEEPQVRGGIHLMHSDYF 3874
            .||.||...            .|.||. ...|::||  :.:|.|:|:    .:|           
Zfish   748 TTTWQRPTG------------PPAPQGLTRSSSILQ--MEQLNRRYQ----SIR----------- 783

  Fly  3875 KTLAALACDMQLDAALPATSSSSSSSAAPGAISSTGDVHKWAWFKRYCIAVRVAQSLIRRTELPR 3939
            :|:               ||..|.........:...||              :|||:        
Zfish   784 RTM---------------TSERSEEPRVEDPPADETDV--------------LAQSI-------- 811

  Fly  3940 AFCLEVRKKFAEMLPSSSSNSNANPGCQSPGASMLNSTTSLSSSTVSNVSPPPGITGEQPD---- 4000
               .|.|:.  .::..|||.|......|||||..|:|                      ||    
Zfish   812 ---SEYRRD--GIIGQSSSRSRLALLLQSPGAKFLSS----------------------PDFFSV 849

  Fly  4001 LHCH--AHQLESTSTLLHEDHTLFQAPHDAQ----------LLQWLN-------RRPDDWALSWG 4046
            ||.:  |:::.:::|.|  .|.:.:...|||          |:.:||       ..|..|.:.  
Zfish   850 LHSNPSAYRMFTSNTCL--KHMISKVRRDAQHFERYQHNRDLVNFLNLFSNKQLELPRGWEMK-- 910

  Fly  4047 GASTIYGWGHNHRGQLGGLEGSRIKTPTPCEALSLLRPVQLAGGEQSLFAVTPDGKLFATGYGSG 4111
                     |:|.|:...::.:       |.|.:.:.|                           
Zfish   911 ---------HDHTGKAFFVDHN-------CRATTFIDP--------------------------- 932

  Fly  4112 GRLGVGGSDSWAIPTLLGSLQHVFVKKVAVNSGGKHCLALTTEGEVYAWGEGEDGKLGHGNRMSY 4176
             ||.:..|.|                                           .|.|.|...:|.
Zfish   933 -RLPLQNSRS-------------------------------------------SGLLAHRQHLSR 953

  Fly  4177 DRPKLVEHLNGMSVADIACGSAHSAAITASGHVLTWGKGRYGRLGHGDSEDQLRPKLVEALLGYR 4241
            .|                   :|||     |.|             ||......|.:        
Zfish   954 QR-------------------SHSA-----GEV-------------GDDSRSPSPPV-------- 973

  Fly  4242 AIDIACGSGDAQTLCITDDDNVWSWGDGDYGKLGRGG--SDGCKLPYKIESLAGLGVVKVECGSQ 4304
                                         .|:..|..  .|...:.|..:.:|.|          
Zfish   974 -----------------------------QGRSSRNSQYQDLVPVAYNDKIVAFL---------- 999

  Fly  4305 FSVALTKSGAVYTWGKGDFHRLGHGSVDHVRRPKKVAALQGKKIISIATGSLHCVACSDSGEVYT 4369
                                          |:|.....||.::...:...||.        |...
Zfish  1000 ------------------------------RQPNIFEILQERQPELVRNHSLR--------EKVQ 1026

  Fly  4370 WGDNDEGQLGDGTVTAIQRPRLVAALQGKHIVKVTCGSAHTLALSTSQLSERLRPLPNPPLEYDL 4434
            :..| ||..|                    :.:::..:...:.||.              .|.::
Zfish  1027 FIRN-EGATG--------------------LTRLSSDADLVMLLSL--------------FEEEV 1056

  Fly  4435 VRDLAPEALHARLILLH---HFSELVCP------CLAMLPISGDLSLGALKDVLVYNIKEAAFRK 4490
            :..:.|.||     ||.   |.|....|      ..|..|...|.              ||..|.
Zfish  1057 MSYVPPNAL-----LLSSYCHASPQSSPGTPRANARAPAPYKRDF--------------EAKLRN 1102

  Fly  4491 VIQTTMVRDKQHGPVIELNRIQVKRSRNRCNGLAGIDGMKSVFGQMVQKLPLLTQEALALPHRVW 4555
            ..:....:....||    .::::...|:..        ::..|.|      ::......|.....
Zfish  1103 FYRKMETKGYGQGP----GKVKLIIRRDHL--------LEDAFNQ------IMCYSRKDLQRSRL 1149

  Fly  4556 KVKFVGESVDDCGGGYSESIAEMCDELQNGSVPLLINTPNGRGEAGANRDCFLLDPTLSSVLQMN 4620
            .|.||||...|..|...|....:..|        |.|...|..|..|| |.:.:..:..|....|
Zfish  1150 YVSFVGEEGLDYSGPSREFFFLVSRE--------LFNPYYGLFEYSAN-DTYTVQISPMSAFVDN 1205

  Fly  4621 ---MFRFLGVLMGIAVRTGSPLSINLAEPVWRQLTGEVLR-PTDLTE---VDRDYVAGLLCIRNM 4678
               .|||.|.::|:|:.....|......|.::.|    || |.||::   :|.::...|..:::.
Zfish  1206 HHEWFRFSGRILGLALIHQYLLDAFFTRPFYKGL----LRIPCDLSDLEFLDEEFHQSLQWMKDN 1266

  Fly  4679 DDDPKL---FTALELPFSTSSARGHEVPLSTRYTHISPRNRAEYVRLALGFRLHE-FDEQVKAVR 4739
            |.:..|   ||..|..|...:.|  |:........:|.:|:.||:...:.:|:.. ..:|.:::.
Zfish  1267 DIEDMLDLTFTVNEEVFGQITER--ELKPGGSGIAVSDKNKKEYIERMVKWRIERGVAQQTESLV 1329

  Fly  4740 DGMSKVIPVPLLSLFSAAELQAMVCGSPDIPLGLLKSVATYK-GFDPSSALVTWFWEVMEEFTNQ 4803
            .|..:|:.|.|:|:|.|.||:.::.|:.:|.|...::...|: |:..:..::.|||..:|.|.|:
Zfish  1330 RGFYEVVDVRLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNE 1394

  Fly  4804 ERSLFLRFVWGRTRLP-RTIADFRGRDFVLQVLEKNPPDHF----------LPESYTCFFLLKMP 4857
            :|...|:||.|.:.:| ...|..||         .|.|..|          ||.::|||..|.:|
Zfish  1395 QRLRLLQFVTGTSSIPYEGFASLRG---------SNGPRRFCVEKWGKVTSLPRAHTCFNRLDLP 1450

  Fly  4858 RYSCKAVLLEKLKYAI 4873
            .|...::|.||:..|:
Zfish  1451 PYPSFSMLYEKMVTAV 1466

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826 14/59 (24%)
RCC1 3091..3140 CDD:278826 4/48 (8%)
RCC1 3144..3194 CDD:278826 9/50 (18%)
RCC1 3197..3246 CDD:278826 11/52 (21%)
RCC1 3250..3298 CDD:278826 11/64 (17%)
RCC1 3302..3350 CDD:278826 9/61 (15%)
RCC1_2 4136..4166 CDD:290274 0/29 (0%)
RCC1 4154..4203 CDD:278826 8/48 (17%)
RCC1 4206..4257 CDD:278826 5/50 (10%)
RCC1 4260..4309 CDD:278826 6/50 (12%)
RCC1 4312..4360 CDD:278826 6/47 (13%)
RCC1 4364..4413 CDD:278826 5/48 (10%)
HECTc 4509..4880 CDD:238033 96/388 (25%)
HECTc 4553..4878 CDD:214523 92/344 (27%)
hecw2aXP_009302976.1 HECW_N 50..169 CDD:318711 25/187 (13%)
C2_NEDL1-like 188..323 CDD:176073 32/189 (17%)
WW 724..756 CDD:197736 8/31 (26%)
WW 903..934 CDD:197736 8/76 (11%)
HECTc 1120..1473 CDD:238033 96/385 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.900

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