Protein Alignment HERC2 and herc5.4

DIOPT Version :9

• Sequence 1: NP_608388.2
• Gene: HERC2 / 33035
• FlyBaseID: FBgn0031107
• Length: 4912
• Species: Drosophila melanogaster
• Sequence 2: XP_005160166.1
• Gene: herc5.4 / 100148091
• ZFINID: ZDB-GENE-090311-7
• Length: 995
• Species: Danio rerio
• Alignment Length: 941
• Identity: 220/941 - (23%)
• Similarity: 377/941 - (40%)
• Gaps: 198/941 - (21%)

  Fly  4075 PCEALSLLRPVQLAGGEQSLFAVTPDGKLFATGYGSGGRLGV----GGSDSWAIPTLLGSLQHVF 4135
            |.::|...:.:|:|.|:|...|::.||:||..|..:.|:||:    .|:.|   |..|.||..:.
Zfish   108 PLKSLENRQVIQIACGDQHSMALSNDGQLFVWGENTHGQLGLRKEQAGTQS---PQHLQSLCEIP 169

  Fly  4136 VKKVAVNSGGKHCLALTTEGEVYAWGEGEDGKLGHGNRMSYDRPKLVEHLNGMSVADIACGSAHS 4200
            |.:  :::||.|...|:..|.|:.||....|:||.|:......|.:|:.|.|.....|:||..|:
Zfish   170 VAQ--ISAGGNHSFVLSLSGVVFGWGSNSAGQLGLGDTKDRFVPTIVKSLCGKKTVSISCGGEHT 232

  Fly  4201 AAITASGHVLTWGKGRYGRLGHGDSEDQLRPKLVEALLGYRAIDIACGSGDAQTLCITDDDN-VW 4264
            |.::..|.|.|:|.|.:|:|||...:|:..|:|:..|.|.:...:.||.  ..||...:... ::
Zfish   233 ATLSKGGTVFTFGSGGFGQLGHNSLKDEHHPRLIAELWGSKVSQVTCGR--HHTLVFEESSKLIY 295

  Fly  4265 SWGDGDYGKLGRGGSDGCKLP-----------YKIESL--------------------------- 4291
            |:|.|..|:||.|......:|           :.:|.|
Zfish   296 SFGCGMQGQLGNGEQVKQSVPLPVLLPTECTEFTMEKLITGEHHSFALFFKNPGNESEKPKSGSN 360

  Fly  4292 AGL------------------GVVKVECGSQFSVALTKSGAVYTWGKGDFHRLGHGSVDHVRRPK 4338
            .|:                  ..||.|..:.||.|.:.:|:.....:.:.::.   ||:|.....
Zfish   361 GGILTLNDRMIDRWVSESDPWPTVKNEINTVFSSAASLNGSFLKTSRDEHYQT---SVEHCGLDF 422

  Fly  4339 KVAALQGKKIISIATGSLHCVACSDSGEVYTWGDNDEGQLGDGTVTAI---------------QR 4388
            .:......|:.:..:.....|.......:.:...|..|      |.|:               ||
Zfish   423 DLVKTSFAKLFASKSLISEVVKVVQQTLLPSLNPNPTG------VEALRLYLLLPELINGLKKQR 481

  Fly  4389 PRLVAALQGKHIVKVTCGSAHTLALSTSQLS----ERLRPLPNPPLEYDLVRDLAPEALHARLIL 4449
            .:|:.||..| |:::...:...|.:..|:|.    |||..|.:.. ..||:..:..|..|.....
Zfish   482 TKLIEALASK-ILELNSAARKVLEMYWSRLPDDWFERLIKLFHKE-STDLIDQICDETDHQSTRH 544

  Fly  4450 LHHFSELVCPCLAMLPISGDLS--------LGALKDVL----------------------VYNIK 4484
            |.:..|:: .....:..|.|::        :..|.|:|                      :..::
Zfish   545 LKNILEIL-QMAYQISCSTDITHHDFIIHKINDLLDLLQTITADLLRMELYMQINEDFHDMVKLE 608

  Fly  4485 EAAFRKV---IQTTMVRD---KQHGPVIELNRIQVKRSRNRCNGLAGIDGMKSVFGQMV------ 4537
            |..||.|   ::.....|   ||.    ..|.:|.:..||..| ||    |.:.|..::
Zfish   609 EYYFRTVKILVKFPFASDFITKQR----MFNLLQEECFRNVPN-LA----MGNSFSNLLHINRES 664

  Fly  4538 ---QKLPLLTQEALALPHRVWKVKFVGESVDDCGGGYSESIAEMCDELQNGSVPLLINTPNGRGE 4599
               ..|..|.|...:..|.: :|.|:||...|..|..:|..:             ||:      :
Zfish   665 VLTDTLQYLRQNTHSFMHPL-QVAFIGEDGIDMRGLSAEFFS-------------LIS------K 709

  Fly  4600 AGANRDCFLLDPTLSSVLQMN--------MFRFLGVLMGIAVRTGSPLSINLAEPVWRQLTGEVL 4656
            :....|..:|:...||::..|        .|.:|||:.|:|:.....::|:....::::|..:..
Zfish   710 SFIEWDKKILEVHESSLVWFNPHHTRGNKNFYYLGVICGMALYNRHHINIDFPLALFKKLLQQKP 774

  Fly  4657 RPTDLTEVDRDYVAGLLCIRNM--DDDPKLFTALELPFSTSSARGHEVPLSTRYTHISPRNRAEY 4719
            ...||.|:.......|   :|:  :|:.::.....|.|   :.:|.|:..:.....::..||.:|
Zfish   775 SLDDLEELSPVEARSL---KNLLEEDEEEVVNLQHLDF---TCKGQELVPNGSQIQVNKVNRQKY 833

  Fly  4720 VRLALGFRLHEFDEQVKAVRD----GMSKVIPVPLLSLFSAAELQAMVCGSPDIPLGLLKSVATY 4780
            |.|.:..   ||::.||...:    |.||..|:...::|...|||.::.|||......|:..|:|
Zfish   834 VDLYVDL---EFNKSVKTQFEQFTRGFSKGCPLDAWTMFHPEELQELLHGSPQYNWKELQQSASY 895

  Fly  4781 KGFDPSSALVTWFWEVMEEFTNQERSLFLRFVWGRTRLPRTIADFRGRDFVLQVLEKNPPDHFLP 4845
            :|...|..|:..||.|..|.:.:.:..||.|::|..|:|  ......|...:...:...||..||
Zfish   896 EGCSASDELIKNFWTVFFELSEENKKKFLMFLYGTERVP--AGGLSKRALKISQTDCPDPDDHLP 958

  Fly  4846 ESYTCFFLLKMPRYSCKAVLLEKLKYAIHFC 4876
            |:.|||..|.:|:||....|.:||.:||:.|
Zfish   959 EAQTCFERLVLPKYSDINTLHDKLIHAINSC 989

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826
		RCC1	687..737	CDD:278826
		RCC1	740..787	CDD:278826
		RCC1	790..841	CDD:278826
		RCC1_2	828..857	CDD:290274
		Cyt-b5	1290..1363	CDD:278597
		MIB_HERC2	1928..1987	CDD:284184
		UBA_HERC2	2515..2559	CDD:270585
		Cul7	2624..2699	CDD:288381
		APC10-HERC2	2762..2932	CDD:176485
		RCC1	3037..3088	CDD:278826
		RCC1	3091..3140	CDD:278826
		RCC1	3144..3194	CDD:278826
		RCC1	3197..3246	CDD:278826
		RCC1	3250..3298	CDD:278826
		RCC1	3302..3350	CDD:278826
		RCC1_2	4136..4166	CDD:290274	9/29 (31%)
		RCC1	4154..4203	CDD:278826	17/48 (35%)
		RCC1	4206..4257	CDD:278826	18/50 (36%)
		RCC1	4260..4309	CDD:278826	16/105 (15%)
		RCC1	4312..4360	CDD:278826	5/47 (11%)
		RCC1	4364..4413	CDD:278826	12/63 (19%)
		HECTc	4509..4880	CDD:238033	100/391 (26%)
		HECTc	4553..4878	CDD:214523	87/338 (26%)
herc5.4	XP_005160166.1	RCC1_2	117..146	CDD:290274	10/28 (36%)
		RCC1	133..183	CDD:278826	18/54 (33%)
		RCC1	186..235	CDD:278826	17/48 (35%)
		RCC1	239..286	CDD:278826	17/48 (35%)
		RCC1	294..343	CDD:278826	10/48 (21%)
		HECTc	658..993	CDD:294058	91/363 (25%)
		HECTc	682..992	CDD:214523	88/339 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820