DRSC/TRiP Functional Genomics Resources

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Protein Alignment HERC2 and herc5.3

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:XP_021330683.1 Gene:herc5.3 / 100073325 ZFINID:ZDB-GENE-070615-14 Length:1002 Species:Danio rerio


Alignment Length:969 Identity:227/969 - (23%)
Similarity:377/969 - (38%) Gaps:253/969 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly  4075 PCEALSLLRPVQLAGGEQSLFAVTPDGKLFATGYGSGGRLGV----GGSDSWAIPTLLGSLQHVF 4135
            |.:.|...:.:|:|.|:|...|:|.||:||..|..:.|:||:    .|:.|   |..|.||..:.
Zfish   114 PLKGLENRQVIQIACGDQHSMALTNDGQLFVWGENALGQLGLRKEQAGTQS---PQHLQSLCGIP 175

  Fly  4136 VKKVAVNSGGKHCLALTTEGEVYAWGEGEDGKLGHGNRMSYDRPKLVEHLNGMSVADIACGSAHS 4200
            |.:  :::||.|...|:..|.|:.||....|:||.|:......|.:|:.|:|.....|:||..|:
Zfish   176 VAQ--ISAGGNHSFVLSLSGVVFGWGSNSAGQLGLGDTTDRFIPTIVKSLSGKKTVSISCGGEHT 238

  Fly  4201 AAITASGHVLTWGKGRYGRLGHGDSEDQLRPKLVEALLGYRAIDIACGSGDAQTLCITDDDN-VW 4264
            |.::..|.|.|:|.|.:|:|||...:|:..|:||..|.|.:...:.||.  ..||...|..| ::
Zfish   239 ATLSKGGTVFTFGSGGFGQLGHNSLKDEHHPRLVAELWGSKVSQVTCGR--HHTLVFEDSSNQIY 301

  Fly  4265 SWGDGDYGKLGRGGSDGCKLPYKIESLAGLGVVKVEC----------GSQFSVAL---------- 4309
            |:|.|..|:||.|......:|..:       ::..||          |...|.||          
Zfish   302 SFGCGMQGQLGNGEQVKQSVPLPV-------LLPTECTEFTMEKLIAGENHSFALFFKSPGNESE 359

  Fly  4310 -TKSGAVYTWGKGDFHRLGHGSVDHVRRPKKVAALQGKKIISIATGSLHCVACSDSGEVYTWGDN 4373
             .|||:     .|....|....:|     :.|:.......|.....::...|.|.:|.......:
Zfish   360 KPKSGS-----NGGILTLNDRIID-----RWVSESDPWPTIKNEINTVFSSAASLNGSFLKTSRD 414

  Fly  4374 DEGQLGDGTVTAIQRPRLVAALQGKHIVKVTCG--------SAHTLALSTSQLSERLRPL----- 4425
            :..|      |:::|                ||        |...|:.|.|.:||.::.:     
Zfish   415 EHYQ------TSVER----------------CGLDFDLVKTSFAKLSTSKSLISEVVKVVQQTLL 457

  Fly  4426 ----PNPPLEYDL-VRDLAPEALH------ARLILLHHFSEL-VCPCL--------AMLP----- 4465
                |||..|..| :..|.||.::      .:||....|..| :||..        :.||     
Zfish   458 PSLNPNPTGEEALRLYLLLPELINGLKKQRTKLIEALAFKILELCPAARKVLEMYWSRLPDDWFE 522

  Fly  4466 ------------ISGDLSLGALKDVLVYNIKEAAFRKVIQ-------TTMVRDKQHGPVI-ELNR 4510
                        :...:|.|...|....::|.  |.:::|       :|.:.:  |..:| |:|.
Zfish   523 ALIKLFHKESAELIKQISRGETDDQSTRHLKN--FLEILQMAYQICCSTNITN--HDFIIPEVND 583

  Fly  4511 IQVKRSRNRCNGLAGIDGMKSVFGQMVQKLPL---------------LTQEALALPHRVWKVKFV 4560
            :           |..:|...:....|..:||:               .|.|.|.      |..||
Zfish   584 L-----------LETLDATSAEVLWMASRLPINEELHNRMKLEDYYFKTAEILV------KFPFV 631

  Fly  4561 GESV----------DDCGGGYSESIAEMCDEL---QNGSVPLLINTPN----------------- 4595
            .:.:          :.|       |..:.|.|   .||:: |.||..:                 
Zfish   632 SDFLTKKSMFILLQEQC-------IRSLLDLLVVHLNGNL-LHINRESVLTDTLQYLRPFTYSFM 688

  Fly  4596 --------GRGE----------------AGANRDCFLLDPTLSSVLQMNM--------FRFLGVL 4628
                    |..|                :....|..:|:...||::..|.        |.:|||:
Zfish   689 HPLQVAFIGEDEIDEKVISAEFFSLISKSFIEWDKKILEVHESSLVWFNPHHTQDHRDFYYLGVI 753

  Fly  4629 MGIAVRTGSPLSINLAEPVWRQLTGEVLRPTDLTEVDRDYVAGLLCIRNM--DDDPKLFTALELP 4691
            .|:|:.....::|:....::::|..:.....||.|:.......|   :|:  :|:.::.....|.
Zfish   754 CGMALYNRHHINIDFPLALFKKLLQQKPSLDDLEELSPVEARSL---KNLLEEDEEEVVDLQHLD 815

  Fly  4692 FSTSSARGHEVPLSTRYTHISPRNRAEYVRLALGFRLHEFDEQVKA----VRDGMSKVIPVPLLS 4752
            |   :.:|.|:..:.....::..||.:||.|.:.|   .|::.||.    ..:|.|:..|:...:
Zfish   816 F---TCKGQELVPNGSQIQVNKVNRQKYVDLYVDF---VFNKSVKTQFEQFTEGFSEGCPLDAWT 874

  Fly  4753 LFSAAELQAMVCGSPDIPLGLLKSVATYKGFDPSSALVTWFWEVMEEFTNQERSLFLRFVWGRTR 4817
            :|...|||.::.|||......|:..|:|:|...|..|:..||.|..|.:.:.:..||.|::|..|
Zfish   875 MFHPEELQELLHGSPQYNWNELQQSASYEGCSASDELIKNFWTVFFELSEENKKKFLMFLYGTER 939

  Fly  4818 LPRTIADFRGRDFVLQVLEKNPPDHFLPESYTCFFLLKMPRYSCKAVLLEKLKYAIHFC 4876
            :|  ...|..|...:...:...||..|||:.|||..|.:|:||....|.:||.:|::.|
Zfish   940 VP--AGGFSKRALKISQTDCPDPDDHLPEAQTCFERLVLPKYSDINTLRDKLIHAVNSC 996

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826
RCC1 3091..3140 CDD:278826
RCC1 3144..3194 CDD:278826
RCC1 3197..3246 CDD:278826
RCC1 3250..3298 CDD:278826
RCC1 3302..3350 CDD:278826
RCC1_2 4136..4166 CDD:290274 9/29 (31%)
RCC1 4154..4203 CDD:278826 17/48 (35%)
RCC1 4206..4257 CDD:278826 19/50 (38%)
RCC1 4260..4309 CDD:278826 13/59 (22%)
RCC1 4312..4360 CDD:278826 7/47 (15%)
RCC1 4364..4413 CDD:278826 8/56 (14%)
HECTc 4509..4880 CDD:238033 100/451 (22%)
HECTc 4553..4878 CDD:214523 91/392 (23%)
herc5.3XP_021330683.1 RCC1 <74..349 CDD:332518 77/248 (31%)
HECTc 665..1000 CDD:331829 82/343 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1062377at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.920

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