DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HERC2 and herc3

DIOPT Version :9

Sequence 1:	NP_608388.2	Gene:	HERC2 / 33035	FlyBaseID:	FBgn0031107	Length:	4912	Species:	Drosophila melanogaster
Sequence 2:	NP_001139096.1	Gene:	herc3 / 100003587	ZFINID:	ZDB-GENE-090313-139	Length:	1046	Species:	Danio rerio

Alignment Length:	1075	Identity:	253/1075 - (23%)
Similarity:	409/1075 - (38%)	Gaps:	297/1075 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  4054 WGHNHRGQLG-GLEGSRIKTPTPCEALSLLRPVQLAGGEQSLFAVTPDGKLFATGYGSGGRLG-- 4115
            ||.:..|||| |...:.:..|..|.........::|.|.|....:..||.::..|..|.|:||
Zfish     5 WGSSGAGQLGIGASEASVFEPRSCCVFDGRGLKEVACGNQHSLFLLHDGSVYTCGSNSCGQLGHD 69

  Fly  4116 VGGSDSWAIPTLLGSLQHVFVKKVA-VNSGGKHCLALTTEGEVYAWGEGEDGKLGHGNRMSYDR- 4178
            .|||.    |.|:|:|.   .:|:: |:.|..|.||:..:|:|:|||.|:.|:||.|......|
Zfish    70 KGGSR----PELVGALD---AQKISGVSCGQAHSLAVNEQGQVFAWGAGDGGQLGLGTAEEAVRV 127

  Fly  4179 PKLVEHLNGMSVADIACGSAHSAAITASGHVLTWGKGRYGRLGHGDSE-DQLRPKLVEALLGYRA 4242
            |:|::.|....::.:.||:.|..|::..|.:..||:...|:||.|..| ..|.|:.:::|.|...
Zfish   128 PRLIKKLCEHRISQVMCGNHHCIALSKDGQLFVWGENSSGQLGLGKGEPSTLSPQPLKSLCGIPL 192

  Fly  4243 IDIACGSGDAQTLCITDDDNVWSWGDGDYGKLGRGGSDGCKLPYKIESLAGLGVVKVECGSQFSV 4307
            ..|:.| || .:..::....|:.||....|:||........:|..|:.|....||.:.||.:.:.
Zfish   193 TQISAG-GD-HSFALSFSGAVFGWGKNSAGQLGLNDEQDRAVPCHIKFLRSQKVVYISCGEEHTA 255

  Fly  4308 ALTKSGAVYTWGKGDFHRLGHGSVDHVRRPKKVAALQGKKIISIATGSLHCVA-CSDSGEVYTWG 4371
            ||||.|.::|:|.|...:|||.|..:...|::|..|.|.::..||.|..|.:| ...:|.:|.:|
Zfish   256 ALTKEGGLFTFGNGSKGQLGHDSTRNEPLPRRVMELMGTEVSQIACGRNHTLAFVPSTGLIYAFG 320

  Fly  4372 DNDEGQLGDGTVTAIQRPRLVAALQ----------GKH--IVKVTCGSAHT-LALST-------- 4415
            .|.:||||.|...:.:.|..|:.:|          .:|  |.|:..|..|. |.|||
Zfish   321 CNTQGQLGTGIRGSAKSPVPVSNIQPLCIGNAYTRTEHCTIAKIHSGGDHNFLLLSTVEGLSCPD 385

  Fly  4416 -----------------SQLSERLRPLPN------------------------------------ 4427
                             |..|.|::...|
Zfish   386 DFRILNTTKSIALINSESLDSWRMKLHDNSDSSITNDIILLLSSTACWNASFLDQSDDGHFKTNP 450

  Fly  4428 --PPLEYDLVRDLAPEAL----HARLI--LLHHFSELVCPCLAMLP------------------- 4465
              |.::::.|| |..|.|    .|||:  :...|..|:.|.|...|
Zfish   451 KVPGIDFNAVR-LLFETLMKPAFARLLEQITKSFESLLIPQLPCSPPDVEAMRIYLILSECPAFQ 514

  Fly  4466 -------ISGDLSLGAL-----------------------------KDVLVY------------- 4481
                   ::..|::..|                             |.::|:
Zfish   515 DSKNYITLTIPLAMAILRLDANPSKVLDNWWSLMDCTVFTRLVEMYKSIVVFLLTGGKALLMPVF 579

  Fly  4482 --NIKEAAFRKVIQTTMVRDKQHGPVIELNR-----------IQ-------------------VK 4514
              :...||.|.:.:...|..|.|.  :|.|.           ||                   |:
Zfish   580 LESYTSAALRLLEKLHKVNLKAHR--VEYNHFYIPDIATLVDIQEDYLKWFLRKADIKMRYPPVQ 642

  Fly  4515 RSRNRC------NGLA---------------GIDG--MKSVFGQMVQKLPLLTQEALALPH---- 4552
            .|...|      |..|               .:.|  :.:|| .::...|||.:....:.|
Zfish   643 GSVTLCAYPFILNAQAKTTVLQTDAELQMQMAVSGANLHNVF-MLLTMEPLLARNPFLVLHVRRN 706

  Fly  4553 -------------------RVWKVKFVGESVDDCGGGYSESIAEMCDELQNGSVPL--LINTPNG 4596
                               :..||.|.||...|.||...|....:..||.|   |:  :....:.
Zfish   707 HLVSDALRELTIYNDVDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELMN---PIYGMFTQYSE 768

  Fly  4597 RGEAGANRDCFLLDPTLSSVLQMNMFRFLGVLMGIAVRTGSPLSINLAEPVWRQLTGEV------ 4655
            ......:..||         ::.|.|..:|::.|:|:...:.:.::....::::|. |:
Zfish   769 SNLLWFSDKCF---------VEHNWFHLIGIICGLAIYNSTVVDLHFPLVLYKKLL-EISPTLDD 823

  Fly  4656 ---LRPTD------LTEVDRDYVAGLLCIRNMDDDPKLFTALELPFSTSSARGHEVPLSTRYTHI 4711
               |.||:      |.|.:.| |....|:.        |......:..:..:  |:....:...:
Zfish   824 LKELSPTEGRSLQQLLEFEGD-VEETFCLN--------FAITREYYGITEVK--ELVQGGKTIAV 877

  Fly  4712 SPRNRAEYVRLALGFRLHE-FDEQVKAVRDGMSKVIPVPLLSLFSAAELQAMVCGSPDIPLGLLK 4775
            ...||.|:|:..|.:...: ..||..|...|..||....:||||..:||.|||.|:.:.....::
Zfish   878 DKTNRKEFVQAYLQYVFSDAVQEQYSAFSSGFLKVCGGEILSLFQPSELMAMVVGNNNYNWEEME 942

  Fly  4776 SVATYKG-FDPSSALVTWFWEVMEEFTNQERSLFLRFVWGRTRLP-RTIADFRGRDFVLQVLEKN 4838
            ..|:||| |..:...|..||||..||:.:::..||.|:.|..|:| ..:|..|   .|:|  ...
Zfish   943 KNASYKGEFSATHPTVKMFWEVFHEFSLEKKKQFLLFLTGSDRIPIHGMASLR---IVIQ--STA 1002

  Fly  4839 PPDHFLPESYTCFFLLKMPRYSCKAVLLEKLKYAI 4873
            ..:|:||.::||:.:|.||.|..|..|.::|..|:
Zfish  1003 AEEHYLPVAHTCYNMLDMPCYQTKETLRQRLTQAV 1037

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826
		RCC1	687..737	CDD:278826
		RCC1	740..787	CDD:278826
		RCC1	790..841	CDD:278826
		RCC1_2	828..857	CDD:290274
		Cyt-b5	1290..1363	CDD:278597
		MIB_HERC2	1928..1987	CDD:284184
		UBA_HERC2	2515..2559	CDD:270585
		Cul7	2624..2699	CDD:288381
		APC10-HERC2	2762..2932	CDD:176485
		RCC1	3037..3088	CDD:278826
		RCC1	3091..3140	CDD:278826
		RCC1	3144..3194	CDD:278826
		RCC1	3197..3246	CDD:278826
		RCC1	3250..3298	CDD:278826
		RCC1	3302..3350	CDD:278826
		RCC1_2	4136..4166	CDD:290274	12/30 (40%)
		RCC1	4154..4203	CDD:278826	17/49 (35%)
		RCC1	4206..4257	CDD:278826	16/51 (31%)
		RCC1	4260..4309	CDD:278826	13/48 (27%)
		RCC1	4312..4360	CDD:278826	16/47 (34%)
		RCC1	4364..4413	CDD:278826	18/61 (30%)
		HECTc	4509..4880	CDD:238033	103/461 (22%)
		HECTc	4553..4878	CDD:214523	88/341 (26%)
herc3	NP_001139096.1	RCC1	4..49	CDD:278826	12/43 (28%)
		RCC1_2	37..65	CDD:290274	7/27 (26%)
		RCC1	52..99	CDD:278826	19/53 (36%)
		RCC1	103..152	CDD:278826	17/48 (35%)
		RCC1	155..205	CDD:278826	16/51 (31%)
		RCC1	208..257	CDD:278826	13/48 (27%)
		RCC1	260..308	CDD:278826	16/47 (34%)
		RCC1	314..374	CDD:278826	17/59 (29%)
		HECTc	699..1044	CDD:238033	89/368 (24%)
		HECTc	723..1043	CDD:214523	88/344 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820