DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syx16 and Stx17

DIOPT Version :9

Sequence 1:	NP_523420.1	Gene:	Syx16 / 33034	FlyBaseID:	FBgn0031106	Length:	352	Species:	Drosophila melanogaster
Sequence 2:	NP_663775.1	Gene:	Stx17 / 252853	RGDID:	708499	Length:	301	Species:	Rattus norvegicus

Alignment Length:	319	Identity:	63/319 - (19%)
Similarity:	104/319 - (32%)	Gaps:	117/319 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 SDAERLLKHSVREAEEGLELQDDYGTPPAWLDKFEEAQYTMSKIKPKLDELGSLHARHLLRPAFD 94
            :|.|||.||.:.                  ::|::..     :|..|      ||..|:
  Rat    27 TDLERLKKHQIN------------------IEKYQRC-----RIWDK------LHEEHI------ 56

  Fly    95 DQRDDECDIEVLSQIVSKLITSTHRHIQCVRSSIGVGSKMEQ-CLTVNAVHCALLQ-----LQEL 153
                                 :..|.:|.:||:|   .:||: ||.|:.....||:     ::|.
  Rat    57 ---------------------NAGRTVQQLRSNI---REMEKLCLKVHKDDLILLKRMIDPMKEA 97

  Fly   154 TVKFRASQNAYLLQLNSREERSQKYFDDGGGAGAGDVFTNVELGEQSAENFVDSFDNFLQPPAEG 218
            .    |:..|..|||:.....                    ||.:|     |.:.:..|||....
  Rat    98 A----AAATAEFLQLHLESVE--------------------ELKKQ-----VKNEEALLQPSLTR 133

  Fly   219 KSGNGYLFEDDEQAIDD-HFQRPPASRMTQQQLLLFEE--ENTRVAQHREQEVTKIVKSIYDLND 280
            .:           .||. |.....|:..:..|:....|  .:...|:..|    .:...:.:|:.
  Rat   134 ST-----------TIDGVHTGEAEAASQSLTQIYALPEIPRDQNAAESWE----TLEADLIELSH 183

  Fly   281 IFKDLGHMVQEQGTVLDRIDYNVEQTQTRVSEGLRQLHKAEMYQRKNRKMCVILVLAAV 339
            :..|:..:|..|...:|.|..:|......|.||.:.|.||..|     |:..:.|..||
  Rat   184 LVTDMSLLVNSQQEKIDSIADHVNSAAVNVEEGTKNLQKAAKY-----KLAALPVAGAV 237

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syx16	NP_523420.1	SNARE_syntaxin16	261..319	CDD:277198	13/57 (23%)
Stx17	NP_663775.1	SNARE_syntaxin17	161..222	CDD:277199	13/64 (20%)
		Necessary and sufficient for localization to autophagosome. /evidence=ECO:0000250\|UniProtKB:P56962	228..274		3/10 (30%)
		Required for interaction with COPB1, TMED9 and TMED10. /evidence=ECO:0000269\|PubMed:21545355	273..301
		Endoplasmic reticulum retention signal. /evidence=ECO:0000255	298..301
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5325
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900