DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(1)G0004 and PNO1

DIOPT Version :9

Sequence 1:	NP_608387.1	Gene:	l(1)G0004 / 33033	FlyBaseID:	FBgn0027334	Length:	240	Species:	Drosophila melanogaster
Sequence 2:	NP_064528.1	Gene:	PNO1 / 56902	HGNCID:	32790	Length:	252	Species:	Homo sapiens

Alignment Length:	254	Identity:	143/254 - (56%)
Similarity:	184/254 - (72%)	Gaps:	22/254 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEAENIRAD------AFEPAKRATKR-----GASGGGQQDVEMQVDEATGIEGQVLGSSRASAPP 54
            ||.::.||:      ..:..:||.||     .|:|.|.....|..:||.       .:.|...||
Human     5 METQSARAEEGFTQVTRKGGRRAKKRQAEQLSAAGEGGDAGRMDTEEAR-------PAKRPVFPP 62

  Fly    55 KA----KRARSELRKVSVPPHRYSSLKEHWMKIFTPVVEHMKLQIRFNMKARQVELRVGPETPDI 115
            ..    ...:.|.||:.||.:||:.|||:|||||||:|||:.||||||:|:|.||:|...||.|:
Human    63 LCGDGLLSGKEETRKIPVPANRYTPLKENWMKIFTPIVEHLGLQIRFNLKSRNVEIRTCKETKDV 127

  Fly   116 ANLQRGADFVRAFLCGFEVDDALALLRLEDLFVESFEIKDVKTLRGDHQSRAIGRLAGKGGRTKF 180
            :.|.:.||||:||:.||:|:|||||:||:|||:|||||.|||.|:|||.||||||:|||||:|||
Human   128 SALTKAADFVKAFILGFQVEDALALIRLDDLFLESFEITDVKPLKGDHLSRAIGRIAGKGGKTKF 192

  Fly   181 TIENVTKTRIVLADSKIHILGSYQNIQLARRAVCNLILGSPPSKVYGNLRAVASRLSER 239
            ||||||:|||||||.|:|||||:|||::||.|:||||||:||||||||:||||||.::|
Human   193 TIENVTRTRIVLADVKVHILGSFQNIKMARTAICNLILGNPPSKVYGNIRAVASRSADR 251

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(1)G0004	NP_608387.1	Krr1	61..239	CDD:224019	125/177 (71%)
l(1)G0004	NP_608387.1	KH	165..217	CDD:197652	41/51 (80%)
PNO1	NP_064528.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..71		17/72 (24%)
		KH-I_PNO1_rpt1	73..152	CDD:411819	47/78 (60%)
		KH-I_PNO1_rpt2	154..249	CDD:411820	76/94 (81%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147120
Domainoid	1	1.000	268	1.000	Domainoid score	I1865
eggNOG	1	0.900	-	-		E1_COG1094
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6961
Inparanoid	1	1.050	269	1.000	Inparanoid score	I3029
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53604
OrthoDB	1	1.010	-	-		D1269649at2759
OrthoFinder	1	1.000	-	-		FOG0005076
OrthoInspector	1	1.000	-	-		oto89536
orthoMCL	1	0.900	-	-		OOG6_101323
Panther	1	1.100	-	-	LDO	PTHR12826
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R943
SonicParanoid	1	1.000	-	-		X3599
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800