DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HSPA1A and Hsp70Ab

DIOPT Version :9

Sequence 1:	NP_005336.3	Gene:	HSPA1A / 3303	HGNCID:	5232	Length:	641	Species:	Homo sapiens
Sequence 2:	NP_524798.2	Gene:	Hsp70Ab / 44920	FlyBaseID:	FBgn0013276	Length:	642	Species:	Drosophila melanogaster

Alignment Length:	648	Identity:	486/648 - (75%)
Similarity:	558/648 - (86%)	Gaps:	20/648 - (3%)

- Green bases have known domain annotations that are detailed below.

Human     6 AIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDA 70
            |||||||||||||||:|||||||||||||||||||||||||:||||||.||||||:||:||||||
  Fly     3 AIGIDLGTTYSCVGVYQHGKVEIIANDQGNRTTPSYVAFTDSERLIGDPAKNQVAMNPRNTVFDA 67

Human    71 KRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYL 135
            |||||||:.||.:..|||||||:|::||.|||:.|.||||:|.|.||||||||||||||.|||||
  Fly    68 KRLIGRKYDDPKIAEDMKHWPFKVVSDGGKPKIGVEYKGESKRFAPEEISSMVLTKMKETAEAYL 132

Human   136 GYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDL 200
            |..:|:|||||||||||||||||||||.|||||||||||||||||:|||||:..|||||||||||
  Fly   133 GESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDKNLKGERNVLIFDL 197

Human   201 GGGTFDVSILTIDDG-IFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLR 264
            |||||||||||||:| :|||::|||||||||||||||||.|..:|||||:|||:..|.||:||||
  Fly   198 GGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVTHLADEFKRKYKKDLRSNPRALRRLR 262

Human   265 TACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKA 329
            ||.|||||||||||:|::|||:||||.||||.::||||||||:||||:||:||||||.|||:||.
  Fly   263 TAAERAKRTLSSSTEATIEIDALFEGQDFYTKVSRARFEELCADLFRNTLQPVEKALNDAKMDKG 327

Human   330 QIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLL 394
            ||||:|||||||||||||.||||||:|::||.|||||||||||||||||||.||:|..:||:||:
  Fly   328 QIHDIVLVGGSTRIPKVQSLLQDFFHGKNLNLSINPDEAVAYGAAVQAAILSGDQSGKIQDVLLV 392

Human   395 DVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRF 459
            ||||||||:||||||||.||:||..||.|||:.|:||:||||||.|||||||||||||||.||.|
  Fly   393 DVAPLSLGIETAGGVMTKLIERNCRIPCKQTKTFSTYADNQPGVSIQVYEGERAMTKDNNALGTF 457

Human   460 ELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEK 524
            :|||||||||||||||||||:||||||||:|.:.|||||..|||.|||||||:.||:|||.||||
  Fly   458 DLSGIPPAPRGVPQIEVTFDLDANGILNVSAKEMSTGKAKNITIKNDKGRLSQAEIDRMVNEAEK 522

Human   525 YKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEK 589
            |..|||..|:|::::||||||.||:|.||| :...||:.||||..|||||.:.|.|||:||.|||
  Fly   523 YADEDEKHRQRITSRNALESYVFNVKQAVE-QAPAGKLDEADKNSVLDKCNDTIRWLDSNTTAEK 586

Human   590 DEFEHKRKELEQVCNPIISGLYQ-----GAGGPG------PGGFGAQGPKGGSGSGPTIEEVD 641
            :||:||.:||.:.|:||::.::|     ||||||      .||||..       ||||:||||
  Fly   587 EEFDHKLEELTRHCSPIMTKMHQQGAGAGAGGPGANCGQQAGGFGGY-------SGPTVEEVD 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HSPA1A	NP_005336.3	PTZ00009	1..611	CDD:240227	467/605 (77%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250\|UniProtKB:P11142	2..386		311/380 (82%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250\|UniProtKB:P11142	394..509		91/114 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	614..641		15/32 (47%)
Hsp70Ab	NP_524798.2	PTZ00009	2..642	CDD:240227	484/646 (75%)
Hsp70Ab	NP_524798.2	HSPA1-2_6-8-like_NBD	3..379	CDD:212675	308/375 (82%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H74294
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53894
OrthoDB	1	1.010	-	-		D180577at33208
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	1	1.100	-	-	O	PTHR19375
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.830