DRSC/TRiP Functional Genomics Resources

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Protein Alignment HSPA1A and Hsc70-2

DIOPT Version :9

Sequence 1:NP_005336.3 Gene:HSPA1A / 3303 HGNCID:5232 Length:641 Species:Homo sapiens
Sequence 2:NP_524339.1 Gene:Hsc70-2 / 41609 FlyBaseID:FBgn0001217 Length:633 Species:Drosophila melanogaster


Alignment Length:642 Identity:469/642 - (73%)
Similarity:534/642 - (83%) Gaps:11/642 - (1%)


- Green bases have known domain annotations that are detailed below.


Human     1 MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQN 65
            |.|..|||||||||||||||:|:.||||||||||||||||||||.:|||||||.||||||:|.:|
  Fly     1 MGKIPAIGIDLGTTYSCVGVWQNSKVEIIANDQGNRTTPSYVAFNETERLIGDPAKNQVAMNAKN 65

Human    66 TVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEI 130
            |||||||||||||.|..:|.|:|.|||:|||:..|||::|.:|||.|.|.||||||||||||:||
  Fly    66 TVFDAKRLIGRKFDDKKIQEDLKLWPFKVINEKGKPKIEVEFKGERKRFAPEEISSMVLTKMREI 130

Human   131 AEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNV 195
            ||.|||..|.:||:||||||||||||||||||.|||||||||||||||||:|||||:..||||||
  Fly   131 AEVYLGGKVKDAVVTVPAYFNDSQRQATKDAGSIAGLNVLRIINEPTAAALAYGLDKNLKGERNV 195

Human   196 LIFDLGGGTFDVSILTIDDG-IFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRA 259
            |||||||||||||:|:||:| :|||||||||||||||||||||||||.||||||||.||..|.||
  Fly   196 LIFDLGGGTFDVSVLSIDEGSLFEVKATAGDTHLGGEDFDNRLVNHFAEEFKRKHKSDIKGNARA 260

Human   260 VRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDA 324
            :||||||||||||||||||:||||||:|.||||||:.|:|||||||..||||||::|||:||.||
  Fly   261 LRRLRTACERAKRTLSSSTEASLEIDALHEGIDFYSKISRARFEELNMDLFRSTMQPVERALSDA 325

Human   325 KLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQ 389
            |:||..|||:|||||||||||:||||||.|.|:.||.|||||||||||||||||||.|..|..:|
  Fly   326 KMDKKAIHDVVLVGGSTRIPKIQKLLQDLFGGKQLNLSINPDEAVAYGAAVQAAILTGVGSSQIQ 390

Human   390 DLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNN 454
            ||||:||||||||:||||||||.|::||:.||.||.||||||||||..|.|||||||||||||||
  Fly   391 DLLLVDVAPLSLGIETAGGVMTNLVERNARIPCKQQQIFTTYSDNQNAVTIQVYEGERAMTKDNN 455

Human   455 LLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMV 519
            |||.|.|:||||||||||||||.||::|:|||||.|.|.||||:.||||:||||||||.||:||:
  Fly   456 LLGTFNLTGIPPAPRGVPQIEVAFDLNADGILNVNAKDNSTGKSEKITISNDKGRLSKAEIDRML 520

Human   520 QEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDAN 584
            .||||||.||:.|||||.:||.||:|.:..:.|| |:...|.:||.::.||.|||....||||.|
  Fly   521 SEAEKYKVEDDRQRERVQSKNNLEAYIYACRQAV-DDAPSGVLSETERSKVRDKCSSEASWLDKN 584

Human   585 TLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD 641
            :||||:|||...||.:::|.||:|.::.|..|..         ..|.||.||:||||
  Fly   585 SLAEKEEFESHLKECQRICTPIMSKIHGGKKGKS---------SMGKGSHPTVEEVD 632

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HSPA1ANP_005336.3 PTZ00009 1..611 CDD:240227 458/610 (75%)
Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142 2..386 306/384 (80%)
Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142 394..509 89/114 (78%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 614..641 8/26 (31%)
Hsc70-2NP_524339.1 PTZ00009 1..632 CDD:240227 467/640 (73%)
HSPA1-2_6-8-like_NBD 6..382 CDD:212675 303/375 (81%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0443
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H74294
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53894
OrthoDB 1 1.010 - - D180577at33208
OrthoFinder 1 1.000 - - FOG0000049
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100083
Panther 1 1.100 - - O PTHR19375
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
87.830

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