Protein Alignment CG1504 and LGI1

DIOPT Version :10

• Sequence 1: NP_608382.2
• Gene: CG1504 / 33028
• FlyBaseID: FBgn0031100
• Length: 425
• Species: Drosophila melanogaster
• Sequence 2: NP_005088.1
• Gene: LGI1 / 9211
• HGNCID: 6572
• Length: 557
• Species: Homo sapiens
• Alignment Length: 348
• Identity: 78/348 - (22%)
• Similarity: 131/348 - (37%)
• Gaps: 81/348 - (23%)

  Fly    12 LSVVVCLWNS-QQTETSK----SCPAECICLSQTQVLCNTGGLEQIPLRQLPATVENLALTKNNF 71
            ::..:||.:: ..||..|    .|||.|.| ::...||...  ..|| |.:|..|.:|:..::.|
Human    19 IAYFLCLLSALLLTEGKKPAKPKCPAVCTC-TKDNALCENA--RSIP-RTVPPDVISLSFVRSGF 79

  Fly    72 PIIKPDSFAGLRALKKLSLDGNNITRIKQFAFRGLPRLKELSIQYTPLQMVAQFAFAGLQNLSTI 136
            ..|...||....:|:.|....|:...|...||.|||.|:.|.|:...::.:::..|.||::|..:
Human    80 TEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHL 144

  Fly   137 LLSHNQIQRIEGNAFAGTSNIKLILLTNNPLIRIDSSAFSSLTNVGHL------ILPSG------ 189
            .|::|.:|.:..:.|.|..::..:.|..|. ...|......:..:||.      |...|
Human   145 SLANNNLQTLPKDIFKGLDSLTNVDLRGNS-FNCDCKLKWLVEWLGHTNATVEDIYCEGPPEYKK 208

  Fly   190 --IRSIEQDAF-----------------FGMDTVGLLKLAYMDLKEVAPF--------------T 221
              |.|:....|                 ..:||...|...|:.:.:  ||              |
Human   209 RKINSLSSKDFDCIITEFAKSQDLPYQSLSIDTFSYLNDEYVVIAQ--PFTGKCIFLEWDHVEKT 271

  Fly   222 FRGLSNVLLLT-------LQESDLGVICADAFTGLTQVETLQILNNKIDSIEELNFTSTAAIKHL 279
            ||...|:...:       :.|:.|.||.|..|.| :.:.......||...|:::
Human   272 FRNYDNITGTSTVVCKPIVIETQLYVIVAQLFGG-SHIYKRDSFANKFIKIQDI----------- 324

  Fly   280 KFFGNHVLETPDPNSIIVDGVEH 302
                 .:|:...||.|....:|:
Human   325 -----EILKIRKPNDIETFKIEN 342

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1504	NP_608382.2	leucine-rich repeat	61..84	CDD:275380	6/22 (27%)
		LRR_5	73..200	CDD:463839	34/157 (22%)
		leucine-rich repeat	85..108	CDD:275380	8/22 (36%)
		leucine-rich repeat	109..132	CDD:275380	6/22 (27%)
		leucine-rich repeat	133..156	CDD:275380	6/22 (27%)
		leucine-rich repeat	157..180	CDD:275380	3/22 (14%)
		leucine-rich repeat	181..203	CDD:275380	7/52 (13%)
		leucine-rich repeat	204..227	CDD:275380	7/36 (19%)
		leucine-rich repeat	228..251	CDD:275380	7/29 (24%)
		leucine-rich repeat	252..275	CDD:275380	3/22 (14%)
LGI1	NP_005088.1	leucine-rich repeat	71..92	CDD:275378	5/20 (25%)
		LRR_8	91..151	CDD:404697	18/59 (31%)
		LRR 1	92..113		6/20 (30%)
		leucine-rich repeat	93..116	CDD:275378	8/22 (36%)
		LRR 2	116..137		4/20 (20%)
		leucine-rich repeat	117..140	CDD:275378	6/22 (27%)
		LRR 3	140..161		5/20 (25%)
		leucine-rich repeat	141..164	CDD:275378	6/22 (27%)
		PCC	146..>221	CDD:188093	15/75 (20%)
		leucine-rich repeat	165..177	CDD:275378	2/12 (17%)
		EAR 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075	225..267		6/43 (14%)
		EPTP	225..265	CDD:461033	6/41 (15%)
		EAR 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075	271..313		11/42 (26%)
		EPTP	272..310	CDD:461033	10/38 (26%)
		EAR 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075	317..364		7/42 (17%)
		EPTP	317..362	CDD:461033	7/42 (17%)
		EAR 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075	366..415
		EPTP	366..413	CDD:461033
		EAR 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075	419..462
		EPTP	420..460	CDD:461033
		EAR 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075	464..506
		EPTP	465..504	CDD:461033
		EAR 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075	510..552
		EPTP	510..550	CDD:461033