DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1504 and mxra5b

DIOPT Version :9

Sequence 1:	NP_001259742.1	Gene:	CG1504 / 33028	FlyBaseID:	FBgn0031100	Length:	425	Species:	Drosophila melanogaster
Sequence 2:	XP_017213354.1	Gene:	mxra5b / 795448	ZFINID:	ZDB-GENE-081104-119	Length:	2548	Species:	Danio rerio

Alignment Length:	444	Identity:	108/444 - (24%)
Similarity:	159/444 - (35%)	Gaps:	148/444 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MCNSWLVLIIAL-SVVVCLWNSQQTETSKSCPAECICLSQTQVLCNTGGLEQIPLRQLPATVENL 64
            |.:|||.|::.| |..:|         |..||.:|.|.:..:|.|....|..:| ..:...|:.:
Zfish     1 MGSSWLFLLVLLVSFGLC---------SGVCPRQCACSAPAEVHCTFRALLAVP-AGISKQVQRI 55

  Fly    65 ALTKNNFPIIKPDSFAGLRALKKLSLDGNNITRIKQFAFRGLPRLKELSIQYTPLQMVAQFAFAG 129
            ....|....|...||:|||.|:.|.:.|||:.:|...||:.|..|:.|.:.|..|.::....|:|
Zfish    56 NFGFNTISQITDASFSGLRKLELLMMHGNNVQKIPDGAFQDLVSLQVLKMSYNKLTVITDRTFSG 120

  Fly   130 LQNLSTILLSHNQIQRIEGNAFAGTSNIKLILLTNNPLIRIDSSAFSSLTNVGHLILPSGIRSIE 194
            |..:..:.|.||.|..|...||.|.::::|:.|..|.|.::....||:.         |.:|..
Zfish   121 LTGIIRLHLDHNHISSIHPQAFLGLTSLRLLHLEANRLQQLHPHTFSTF---------SVLRRF- 175

  Fly   195 QDAFFGMDTVGLLKLAYMDLKEVAPFTFRGLSNVLLLTLQESDLGVICADAFTGLTQVETLQILN 259
                    .|..||..:             :|:.||.||..|.|        ....|:|||.:..
Zfish   176 --------PVSTLKHLH-------------ISDNLLQTLSRSVL--------ENTPQLETLLLTG 211

  Fly   260 NK--------------------IDSIEELNFTS------TAAIKHLKFFGNHVLETPDPNSIIVD 298
            |.                    :...::..|||      .|:.||||               ..|
Zfish   212 NPWSCDCRMRWLQDWSARHPGVMKCKKDRTFTSGQLCPLCASPKHLK---------------AAD 261

  Fly   299 GVEHLQLVSNHFPCGCHIHTLLDGPLAEGAHNLTDFLQKNYCISPLEVNGRVMSE------LDID 357
            .::..|||.:             ||               ..|||    ||.:||      |.||
Zfish   262 MLDLKQLVCS-------------GP---------------SIISP----GRNISEEDTSELLPID 294

  Fly   358 SI----GRCSDQL-----TKGNLGSSAASLALGINSMLLIAVASCAEWRHVRLL 402
            .|    |..|..|     ||.:|          |..:|....::...|.|.:.|
Zfish   295 RIKPAFGNVSFTLSDEHGTKVDL----------ICQILQPQDSTTISWNHTKSL 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1504	NP_001259742.1	leucine-rich repeat	61..84	CDD:275380	7/22 (32%)
		LRR_5	73..200	CDD:404228	38/126 (30%)
		leucine-rich repeat	85..108	CDD:275380	9/22 (41%)
		leucine-rich repeat	109..132	CDD:275380	7/22 (32%)
		leucine-rich repeat	133..156	CDD:275380	8/22 (36%)
		leucine-rich repeat	157..180	CDD:275380	6/22 (27%)
		leucine-rich repeat	181..203	CDD:275380	2/21 (10%)
		leucine-rich repeat	204..227	CDD:275380	3/22 (14%)
		leucine-rich repeat	228..251	CDD:275380	6/22 (27%)
		leucine-rich repeat	252..275	CDD:275380	7/48 (15%)
mxra5b	XP_017213354.1	leucine-rich repeat	33..51	CDD:275380	4/18 (22%)
		LRR_8	50..110	CDD:290566	20/59 (34%)
		leucine-rich repeat	52..75	CDD:275380	7/22 (32%)
		leucine-rich repeat	76..99	CDD:275380	9/22 (41%)
		LRR_8	99..158	CDD:290566	18/58 (31%)
		leucine-rich repeat	100..123	CDD:275380	7/22 (32%)
		leucine-rich repeat	124..147	CDD:275380	8/22 (36%)
		LRR_8	146..213	CDD:290566	22/105 (21%)
		leucine-rich repeat	148..179	CDD:275380	9/48 (19%)
		leucine-rich repeat	180..203	CDD:275380	9/43 (21%)
		LRRCT	212..>258	CDD:214507	7/45 (16%)
		IG	472..552	CDD:214652
		Ig	477..538	CDD:143165
		IG	567..649	CDD:214652
		Ig	573..639	CDD:299845
		IG_like	1583..1666	CDD:214653
		Ig	1592..1656	CDD:299845
		I-set	1671..1763	CDD:254352
		Ig	1686..1763	CDD:299845
		IG	1776..1860	CDD:214652
		Ig	1783..1860	CDD:299845
		I-set	1875..1959	CDD:254352
		IGc2	1882..1949	CDD:197706
		IG	1979..2062	CDD:214652
		Ig	1979..2053	CDD:299845
		I-set	2075..2156	CDD:254352
		Ig	2082..2146	CDD:299845
		IG	2175..2255	CDD:214652
		Ig	2180..2255	CDD:299845
		IG_like	2271..2351	CDD:214653
		IGc2	2276..2343	CDD:197706
		IG	2372..2438	CDD:214652
		Ig	2377..2438	CDD:143165
		IG	2462..2547	CDD:214652
		Ig	2471..2544	CDD:143165
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000