DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1504 and LRRC4

DIOPT Version :9

Sequence 1:	NP_001259742.1	Gene:	CG1504 / 33028	FlyBaseID:	FBgn0031100	Length:	425	Species:	Drosophila melanogaster
Sequence 2:	NP_071426.1	Gene:	LRRC4 / 64101	HGNCID:	15586	Length:	653	Species:	Homo sapiens

Alignment Length:	366	Identity:	93/366 - (25%)
Similarity:	156/366 - (42%)	Gaps:	88/366 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 KSCPAECICLSQ-TQVLCNTGGLEQIPLRQLPATVENLALTKNNFPIIKPDSFAGLRALKKLSLD 91
            ::||:.|.|.:| ::|:|...||.::| :.:|:....|.|.:||..:|:.|:|..|..|:.|.|.
Human    44 QNCPSVCSCSNQFSKVVCTRRGLSEVP-QGIPSNTRYLNLMENNIQMIQADTFRHLHHLEVLQLG 107

  Fly    92 GNNITRIKQFAFRGLPRLKELSIQYTPLQMVAQFAFAGLQNLSTILLSHNQIQRIEGNAFAGTSN 156
            .|:|.:|:..||.                        ||.:|:|:.|..|.:..|...||...|.
Human   108 RNSIRQIEVGAFN------------------------GLASLNTLELFDNWLTVIPSGAFEYLSK 148

  Fly   157 IKLILLTNNPLIRIDSSAFSSLTNVGHLILP--SGIRSIEQDAFFGMDTVGLLKLAYMDLK---- 215
            ::.:.|.|||:..|.|.||:.:.::..|.|.  ..:..|.:.||.|:..:..|.|...::|
Human   149 LRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIKDMPN 213

  Fly   216 ------------------EVAPFTFRGLSNVLLLTLQESDLGVICADAFTGLTQVETLQILNNKI 262
                              |:.|.:|.|||::..|.:..|.:.:|..:||.||..:..|.:.:|.:
Human   214 LTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNL 278

  Fly   263 DSIEELNFTSTAAIKHLKFFGNHVLETPDPNSIIVDGVEHLQLVSNHFPCGCHIHTLLDGPLAEG 327
            .|:....||                    |...:|:    |.|..|.:.|.|.|..|
Human   279 SSLPHDLFT--------------------PLRYLVE----LHLHHNPWNCDCDILWL-------- 311

  Fly   328 AHNLTDFLQKN-----YCISPLEVNGRVMSELDIDSIGRCS 363
            |..|.:::..|     .|.:|:.:.||.:.|:|..|. :||
Human   312 AWWLREYIPTNSTCCGRCHAPMHMRGRYLVEVDQASF-QCS 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1504	NP_001259742.1	leucine-rich repeat	61..84	CDD:275380	8/22 (36%)
		LRR_5	73..200	CDD:404228	35/128 (27%)
		leucine-rich repeat	85..108	CDD:275380	8/22 (36%)
		leucine-rich repeat	109..132	CDD:275380	2/22 (9%)
		leucine-rich repeat	133..156	CDD:275380	7/22 (32%)
		leucine-rich repeat	157..180	CDD:275380	8/22 (36%)
		leucine-rich repeat	181..203	CDD:275380	6/23 (26%)
		leucine-rich repeat	204..227	CDD:275380	8/44 (18%)
		leucine-rich repeat	228..251	CDD:275380	7/22 (32%)
		leucine-rich repeat	252..275	CDD:275380	5/22 (23%)
LRRC4	NP_071426.1	LRRNT	46..79	CDD:214470	11/33 (33%)
		LRR	<74..291	CDD:227223	63/260 (24%)
		LRR 1	76..97		7/20 (35%)
		leucine-rich repeat	77..100	CDD:275380	8/22 (36%)
		LRR 2	100..121		8/44 (18%)
		leucine-rich repeat	101..124	CDD:275380	10/46 (22%)
		LRR 3	124..145		7/20 (35%)
		leucine-rich repeat	125..148	CDD:275380	7/22 (32%)
		LRR 4	148..169		8/20 (40%)
		leucine-rich repeat	149..172	CDD:275380	8/22 (36%)
		LRR 5	172..194		5/21 (24%)
		leucine-rich repeat	173..197	CDD:275380	6/23 (26%)
		LRR 6	197..218		3/20 (15%)
		leucine-rich repeat	198..219	CDD:275380	3/20 (15%)
		LRR 7	219..240		3/20 (15%)
		leucine-rich repeat	220..243	CDD:275380	5/22 (23%)
		LRR 8	243..264		5/20 (25%)
		leucine-rich repeat	244..267	CDD:275380	7/22 (32%)
		LRR 9	267..288		5/40 (13%)
		leucine-rich repeat	268..289	CDD:275380	5/40 (13%)
		LRRCT	300..351	CDD:214507	15/59 (25%)
		IG	359..441	CDD:214652
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D180608at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920