DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1504 and islr2

DIOPT Version :9

Sequence 1:	NP_001259742.1	Gene:	CG1504 / 33028	FlyBaseID:	FBgn0031100	Length:	425	Species:	Drosophila melanogaster
Sequence 2:	NP_001013541.1	Gene:	islr2 / 541396	ZFINID:	ZDB-GENE-050320-95	Length:	712	Species:	Danio rerio

Alignment Length:	324	Identity:	59/324 - (18%)
Similarity:	112/324 - (34%)	Gaps:	124/324 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MCNSWLVLIIALSVVVCLWNSQQTETSKSCPAECICLSQTQ---VLCNTGGLEQIPLRQLPATVE 62
            |...:|:||...:.::        ..:..||.:|.|..:..   |.|....|.::|: .||:...
Zfish     1 MATKYLMLIALGTALI--------GNAHCCPKQCACSDKYNHQFVDCAYKDLVEVPV-GLPSNAS 56

  Fly    63 NLALTKNNFPIIKPDSFAGLRALKKLSLDGNNITRIKQFAFRGLPRLKELSIQYTPLQMVAQFAF 127
            .|:|:.|...::|..:|.             |:|::
Zfish    57 TLSLSANKIKVLKSKTFV-------------NVTQV----------------------------- 79

  Fly   128 AGLQNLSTILLSHNQIQRIEGNAFAGTSNIKLILLTNNPLIRIDSSAFSSLTNVGHLILPSGIRS 192
                  :::.|:||:|..:|.:..|....:|.:.::||.::..   .:..|.|:|.|
Zfish    80 ------TSLWLAHNEIITVERDTLAPLIQLKNLDISNNKIVHF---PWEDLANLGAL-------- 127

  Fly   193 IEQDAFFGMDTVGLLKLAYMDLKEVAPFTFRGLSNVLLLTLQESDLGVICADAFTGLTQVETLQI 257
                                                .||.:..:::..|..:||:.|..:.:::|
Zfish   128 ------------------------------------QLLKMNNNEMVSIPKNAFSNLKDLRSIRI 156

  Fly   258 LNNKIDSIEELNFTSTAAIKHLKFFGN-----------------HVLETPDPNSIIVDGVEHLQ 304
            .|||..:|.:..|.|.||:.||:.|.|                 ..:..|:.|:|..|...||:
Zfish   157 NNNKFTTIVQGTFDSLAAMSHLQIFHNPFICSCNLEWLRDWILKSSISIPEQNNIACDAPSHLK 220

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1504	NP_001259742.1	leucine-rich repeat	61..84	CDD:275380	5/22 (23%)
		LRR_5	73..200	CDD:404228	17/126 (13%)
		leucine-rich repeat	85..108	CDD:275380	2/22 (9%)
		leucine-rich repeat	109..132	CDD:275380	0/22 (0%)
		leucine-rich repeat	133..156	CDD:275380	6/22 (27%)
		leucine-rich repeat	157..180	CDD:275380	4/22 (18%)
		leucine-rich repeat	181..203	CDD:275380	2/21 (10%)
		leucine-rich repeat	204..227	CDD:275380	0/22 (0%)
		leucine-rich repeat	228..251	CDD:275380	6/22 (27%)
		leucine-rich repeat	252..275	CDD:275380	7/22 (32%)
islr2	NP_001013541.1	leucine-rich repeat	35..53	CDD:275380	5/18 (28%)
		LRR_RI	<47..>184	CDD:238064	41/232 (18%)
		LRR_8	53..113	CDD:290566	16/107 (15%)
		leucine-rich repeat	57..78	CDD:275380	6/33 (18%)
		leucine-rich repeat	79..102	CDD:275380	6/57 (11%)
		LRR_8	102..161	CDD:290566	16/105 (15%)
		leucine-rich repeat	103..126	CDD:275380	5/25 (20%)
		leucine-rich repeat	127..150	CDD:275380	7/66 (11%)
		leucine-rich repeat	151..174	CDD:275380	7/22 (32%)
		LRRCT	183..>221	CDD:214507	7/38 (18%)
		IG_like	252..345	CDD:214653
		Ig	256..345	CDD:299845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282791at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010