DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1504 and Lrrc4b

DIOPT Version :9

Sequence 1:	NP_001259742.1	Gene:	CG1504 / 33028	FlyBaseID:	FBgn0031100	Length:	425	Species:	Drosophila melanogaster
Sequence 2:	NP_937893.1	Gene:	Lrrc4b / 272381	MGIID:	3027390	Length:	709	Species:	Mus musculus

Alignment Length:	330	Identity:	88/330 - (26%)
Similarity:	152/330 - (46%)	Gaps:	33/330 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 SCPAECICLSQ-TQVLCNTGGLEQIPLRQLPATVENLALTKNNFPIIKPDSFAGLRALKKLSLDG 92
            ||||.|.|.:| ::|:|....|.::| ..:|.....|.|.:|:..:|:.|:|..||.|:.|.|..
Mouse    58 SCPAACSCSNQASRVICTRRELAEVP-ASIPVNTRYLNLQENSIQVIRTDTFKHLRHLEILQLSK 121

  Fly    93 NNITRIKQFAFRGLPRLKELSIQYTPLQMVAQFAFAGLQNLSTILLSHNQIQRIEGNAFAGTSNI 157
            |.:.:|:..||.|||                        :|:|:.|..|::..:...||...|.:
Mouse   122 NLVRKIEVGAFNGLP------------------------SLNTLELFDNRLTTVPTQAFEYLSKL 162

  Fly   158 KLILLTNNPLIRIDSSAFSSLTNVGHLILP--SGIRSIEQDAFFGMDTVGLLKLAYMDLKEVAPF 220
            :.:.|.|||:..|.|.||:.:.::..|.|.  ..:..|.:.||.|:..:..|.|...:||::...
Mouse   163 RELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNLKDIPNL 227

  Fly   221 TFRGLSNVLLLTLQESDLGVICADAFTGLTQVETLQILNNKIDSIEELNFTSTAAIKHLKFFGNH 285
            |  .|..:..|.|..:.|.:|...:|.|||.:..|.:::.::.:||...|....:::.|....|:
Mouse   228 T--ALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHNN 290

  Fly   286 VLETPDPNSIIVDGVEHLQLVSNHFPCGCHIHTLLDGPLAEGAHNLTDFLQKNYCISPLEVNGRV 350
            ::..|......:..:|.:.|..|.:.|.|.: ..|...|.|...:.|....:  |.:|..:.||.
Mouse   291 LMSLPHDLFTPLHRLERVHLNHNPWHCNCDV-LWLSWWLKETVPSNTTCCAR--CHAPAGLKGRY 352

  Fly   351 MSELD 355
            :.|||
Mouse   353 IGELD 357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1504	NP_001259742.1	leucine-rich repeat	61..84	CDD:275380	7/22 (32%)
		LRR_5	73..200	CDD:404228	35/128 (27%)
		leucine-rich repeat	85..108	CDD:275380	9/22 (41%)
		leucine-rich repeat	109..132	CDD:275380	0/22 (0%)
		leucine-rich repeat	133..156	CDD:275380	6/22 (27%)
		leucine-rich repeat	157..180	CDD:275380	8/22 (36%)
		leucine-rich repeat	181..203	CDD:275380	6/23 (26%)
		leucine-rich repeat	204..227	CDD:275380	6/22 (27%)
		leucine-rich repeat	228..251	CDD:275380	7/22 (32%)
		leucine-rich repeat	252..275	CDD:275380	4/22 (18%)
Lrrc4b	NP_937893.1	LRRNT	59..92	CDD:214470	11/33 (33%)
		LRR	<89..299	CDD:227223	60/235 (26%)
		LRR 1	89..110		6/20 (30%)
		leucine-rich repeat	90..113	CDD:275380	7/22 (32%)
		LRR 2	113..134		7/20 (35%)
		leucine-rich repeat	114..137	CDD:275380	10/46 (22%)
		LRR 3	137..158		6/20 (30%)
		leucine-rich repeat	138..161	CDD:275380	6/22 (27%)
		LRR 4	161..182		8/20 (40%)
		leucine-rich repeat	162..185	CDD:275380	8/22 (36%)
		LRR 5	185..207		5/21 (24%)
		leucine-rich repeat	186..210	CDD:275380	6/23 (26%)
		LRR 6	210..231		5/22 (23%)
		leucine-rich repeat	211..232	CDD:275380	6/22 (27%)
		LRR 7	232..253		5/20 (25%)
		leucine-rich repeat	233..256	CDD:275380	7/22 (32%)
		LRR 8	256..277		4/20 (20%)
		leucine-rich repeat	257..280	CDD:275380	4/22 (18%)
		LRR 9	280..301		3/20 (15%)
		leucine-rich repeat	281..302	CDD:275380	3/20 (15%)
		LRRCT	313..363	CDD:214507	14/48 (29%)
		I-set	366..455	CDD:400151
		Ig strand A	366..369	CDD:409353
		Ig strand A'	373..376	CDD:409353
		Ig strand B	382..389	CDD:409353
		Ig strand C	395..400	CDD:409353
		Ig strand C'	403..405	CDD:409353
		Ig strand D	414..418	CDD:409353
		Ig strand E	421..425	CDD:409353
		Ig strand F	435..442	CDD:409353
		Ig strand G	445..455	CDD:409353
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	496..552
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D180608at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920