DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1504 and lron-12

DIOPT Version :9

Sequence 1:	NP_001259742.1	Gene:	CG1504 / 33028	FlyBaseID:	FBgn0031100	Length:	425	Species:	Drosophila melanogaster
Sequence 2:	NP_001366666.1	Gene:	lron-12 / 190700	WormBaseID:	WBGene00013542	Length:	398	Species:	Caenorhabditis elegans

Alignment Length:	317	Identity:	74/317 - (23%)
Similarity:	147/317 - (46%)	Gaps:	19/317 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 SCPAECIC-LSQTQVLCNTGGLEQIPLRQLPATVENLALTKNNFPIIKPDSFAGLRALKKLSLDG 92
            :||..|.| ..:.||.|....:..:|.| ||:..|:|.:..::...|:.:||..:..|.::..:.
Worm    33 TCPMGCQCDEDKQQVTCEGQQVVTLPDR-LPSGYESLVIRNSSVRTIEKNSFRKMEKLMQIEFEN 96

  Fly    93 N-NITRIKQFAFRGLPRLKELSIQYTP-LQMVAQFAFAGLQNLS--TILLSHNQIQRIEGNAFAG 153
            | |:..|::.||:||.:::.:.....| |..:.:.||:|:||..  .|:.....|.||:|:.|..
Worm    97 NPNLGTIEKLAFKGLKKIRLIKFTTCPGLTELQKNAFSGIQNQMGLKIIFEKTPIHRIDGHTFRN 161

  Fly   154 TSNIKLILLTNNPLIRIDSSAFSSLTNVGHLILPSGIRSIEQDAFFGMDTVGLLKLAYMDLKEVA 218
            ..||:.:.::...| .:....|:::..:..|.: ||:..||.:.|.......::....... ::.
Worm   162 AQNIRELTISGEEL-ALSRHCFANINQLDFLTV-SGVVLIEPEIFTNSTRFHVVHFKNSQF-DIP 223

  Fly   219 PFTFRGLSNVLLLTLQESDLGVICADAFTGLTQVETLQILNNKIDSIEELNFTSTAAIKHLKFFG 283
            |.||..||:...|.::.|.:..|..|||:|||.::.:::...::.:|....|.:...:..||...
Worm   224 PSTFSTLSHTSHLLIEHSKVPSIAPDAFSGLTTIQVIELHACQLGTISARAFANVENLGELKILR 288

  Fly   284 NHVLETPDPNSIIVDGVEHLQLVSNHFPCGCHIHTLLDGPLAEGAHNLTDFLQKNYC 340
            |.:.:.....||:...:: .::..|...|.|.:..:      .....::|.   |:|
Worm   289 NTIGDLDTSESIMSRALK-TRIEENTLECSCGMKWM------TSVEEMSDI---NFC 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1504	NP_001259742.1	leucine-rich repeat	61..84	CDD:275380	5/22 (23%)
		LRR_5	73..200	CDD:404228	34/130 (26%)
		leucine-rich repeat	85..108	CDD:275380	8/23 (35%)
		leucine-rich repeat	109..132	CDD:275380	5/23 (22%)
		leucine-rich repeat	133..156	CDD:275380	6/24 (25%)
		leucine-rich repeat	157..180	CDD:275380	3/22 (14%)
		leucine-rich repeat	181..203	CDD:275380	6/21 (29%)
		leucine-rich repeat	204..227	CDD:275380	4/22 (18%)
		leucine-rich repeat	228..251	CDD:275380	8/22 (36%)
		leucine-rich repeat	252..275	CDD:275380	2/22 (9%)
lron-12	NP_001366666.1	leucine-rich repeat	45..67	CDD:275380	7/22 (32%)
		LRR_5	66..184	CDD:404228	30/118 (25%)
		leucine-rich repeat	68..88	CDD:275380	4/19 (21%)
		leucine-rich repeat	89..113	CDD:275380	8/23 (35%)
		leucine-rich repeat	114..138	CDD:275380	5/23 (22%)
		leucine-rich repeat	139..164	CDD:275380	6/24 (25%)
		leucine-rich repeat	165..187	CDD:275380	3/22 (14%)
		leucine-rich repeat	188..209	CDD:275380	6/21 (29%)
		leucine-rich repeat	210..232	CDD:275380	4/22 (18%)
		LRR_8	<221..267	CDD:404697	14/45 (31%)
		leucine-rich repeat	233..256	CDD:275380	8/22 (36%)
		leucine-rich repeat	257..277	CDD:275380	2/19 (11%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	91	1.000	Inparanoid score	I3671
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28818
OrthoDB	1	1.010	-	-		D180608at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto18302
orthoMCL	1	0.900	-	-		OOG6_112733
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.840