Protein Alignment CG1504 and CPN2

DIOPT Version :10

• Sequence 1: NP_608382.2
• Gene: CG1504 / 33028
• FlyBaseID: FBgn0031100
• Length: 425
• Species: Drosophila melanogaster
• Sequence 2: NP_001073982.3
• Gene: CPN2 / 1370
• HGNCID: 2313
• Length: 545
• Species: Homo sapiens
• Alignment Length: 474
• Identity: 100/474 - (21%)
• Similarity: 177/474 - (37%)
• Gaps: 130/474 - (27%)

  Fly     4 SWLVLIIALSVVVCLWNS--QQTETSKSCPAECICLSQTQVLCNTGGLEQIPLRQLPATVENLAL 66
            :||           ||.|  .....::.||..|.|..| :|.|:...|..:|| .:|...:|:..
Human     5 AWL-----------LWTSLLLLARPAQPCPMGCDCFVQ-EVFCSDEELATVPL-DIPPYTKNIIF 56

  Fly    67 TKNNFPII------------------------KPDSFAGLRALKKLSLDGNNITRIKQFAFRGLP 107
            .:.:|..:                        :||:|.||..|:.|.:.|::...:....|..|.
Human    57 VETSFTTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLT 121

  Fly   108 RLKELSIQYTPLQMVAQFAFAGLQNLSTILLSHNQIQRIEGNAFAGTSNIKLILLTNNPLIRIDS 172
            .|.:|::.:..|:.:.:..|..|..|.::.|..||:|.:....|...:::|.:.|..|.|.::..
Human   122 SLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPE 186

  Fly   173 SAFSSLTNVGHLILPSGIRSIEQDAFFGMDTVGLLKLAYMD---LKEVAP--FT----------- 221
            ..|..||::..|.|.:...|......||  .:|.|:..::|   :.|:.|  |:
Human   187 ELFHPLTSLQTLKLSNNALSGLPQGVFG--KLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQ 249

  Fly   222 -----------FRGLSNVLLLTLQESDLGVICADAFTGLTQVETLQILNNKIDSIEELNFT---- 271
                       |..|.|:..|:||.:.|.|:.|..|.....:..|.:.:|:::::.|..|.
Human   250 RNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSN 314

  Fly   272 ------STAAIKHLK-------------FFGNHVLETPDPNSIIVDGVEHLQLVS---------- 307
                  |..||.||.             :.|::.|....|  .:...:..|:|:|
Human   315 LRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHP--ALFQNLSKLELLSLSKNQLTTLP 377

  Fly   308 -----------------NHFPCGCHIHTLLDGPLAEGAHNLTDFLQ--KNYCISPLEVNGRVMSE 353
                             |.:.|.||:..|.:     .....||.|.  :.||..|..:.|:|:..
Human   378 EGIFDTNYNLFNLALHGNPWQCDCHLAYLFN-----WLQQYTDRLLNIQTYCAGPAYLKGQVVPA 437

  Fly   354 LDIDSIGRCSDQLTKGNLG 372
            |:...: .|  .:|:.:||
Human   438 LNEKQL-VC--PVTRDHLG 453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1504	NP_608382.2	leucine-rich repeat	61..84	CDD:275380	7/46 (15%)
		LRR_5	73..200	CDD:463839	31/150 (21%)
		leucine-rich repeat	85..108	CDD:275380	5/22 (23%)
		leucine-rich repeat	109..132	CDD:275380	5/22 (23%)
		leucine-rich repeat	133..156	CDD:275380	6/22 (27%)
		leucine-rich repeat	157..180	CDD:275380	6/22 (27%)
		leucine-rich repeat	181..203	CDD:275380	5/21 (24%)
		leucine-rich repeat	204..227	CDD:275380	8/49 (16%)
		leucine-rich repeat	228..251	CDD:275380	7/22 (32%)
		leucine-rich repeat	252..275	CDD:275380	5/32 (16%)
CPN2	NP_001073982.3	LRRNT	21..53	CDD:214470	11/33 (33%)
		leucine-rich repeat	30..53	CDD:275380	7/24 (29%)
		leucine-rich repeat	75..98	CDD:275380	5/22 (23%)
		LRR	95..419	CDD:443914	69/332 (21%)
		LRR 1	98..119		4/20 (20%)
		leucine-rich repeat	99..122	CDD:275380	5/22 (23%)
		LRR 2	122..143		4/20 (20%)
		leucine-rich repeat	123..146	CDD:275380	5/22 (23%)
		LRR 3	146..167		6/20 (30%)
		leucine-rich repeat	147..170	CDD:275380	6/22 (27%)
		LRR 4	170..191		5/20 (25%)
		leucine-rich repeat	171..194	CDD:275380	6/22 (27%)
		LRR 5	194..215		5/22 (23%)
		leucine-rich repeat	195..218	CDD:275380	5/24 (21%)
		LRR 6	218..239		5/20 (25%)
		leucine-rich repeat	219..242	CDD:275380	5/22 (23%)
		LRR 7	242..263		1/20 (5%)
		leucine-rich repeat	243..266	CDD:275380	2/22 (9%)
		LRR 8	266..287		8/20 (40%)
		leucine-rich repeat	267..290	CDD:275380	7/22 (32%)
		LRR 9	290..311		4/20 (20%)
		leucine-rich repeat	291..314	CDD:275380	4/22 (18%)
		LRR 10	314..335		5/20 (25%)
		leucine-rich repeat	315..338	CDD:275380	5/22 (23%)
		LRR 11	338..359		3/22 (14%)
		leucine-rich repeat	339..359	CDD:275380	3/21 (14%)
		LRR 12	362..383		3/20 (15%)
		leucine-rich repeat	363..382	CDD:275380	3/18 (17%)
		leucine-rich repeat	387..399	CDD:275378	1/11 (9%)
		LRRCT	395..446	CDD:214507	15/58 (26%)