Protein Alignment CG1504 and lgr5

DIOPT Version :10

• Sequence 1: NP_608382.2
• Gene: CG1504 / 33028
• FlyBaseID: FBgn0031100
• Length: 425
• Species: Drosophila melanogaster
• Sequence 2: XP_002940219.2
• Gene: lgr5 / 100486389
• XenbaseID: XB-GENE-994091
• Length: 902
• Species: Xenopus tropicalis
• Alignment Length: 327
• Identity: 84/327 - (25%)
• Similarity: 141/327 - (43%)
• Gaps: 58/327 - (17%)

  Fly    28 KSCPAECICLSQ---TQVLCNTGGLEQIPLRQLPATVENLALTKNNFPIIKPDSFAGLRALKKLS 89
            :|||..|.|..:   .:|.|:...|..:| |.|......|.|:.||...:..:....|..|::|.
 Frog    30 RSCPTPCECEQEGMLVRVDCSDRALTSLP-RNLSIFTSYLDLSMNNITNLPSNVMHNLHFLEELR 93

  Fly    90 LDGNNITRIKQFAFRGLPRLKELSIQYTPLQMVAQFAFAGLQNLSTILLSHNQIQRIEGNAFAGT 154
            |.||::|.|.:.||.||..||.|.:|...|:.|...|...|::|.::.|..|.|..:..::|.|.
 Frog    94 LAGNDLTYIPKGAFAGLGSLKVLMLQNNLLRQVPSEALHNLRSLQSLRLDANHISYVPPSSFNGL 158

  Fly   155 SNIKLILLTNNPLIRIDSSAFSSLTNVGHLILPSGIRSIEQDAFFGMDTVGLLKLAYMDLKEVAP 219
            .:::.:.|.:|.|..|...|..||:                       .:..:.||...:..:..
 Frog   159 FSLRHLWLDDNSLTEIPVRALESLS-----------------------ALQAMTLALNKIHHIPD 200

  Fly   220 FTFRGLSNVLLLTLQESDLGVICADAFTGLTQVETLQILNNKIDSIEELNFTSTAAIKHLK---- 280
            :.||.||::::|.|..:.:..:....|.||..:|||.:..|.:|..       .||||.||
 Frog   201 YAFRNLSSLVVLHLHNNRIYSLGKKCFDGLHSLETLDLNYNNLDEF-------PAAIKTLKNLKE 258

  Fly   281 --FFGNHVLETPD------PNSIIV----DGVEHL-QLVSNHFPCGCHIHTLLDGPLAEGAHNLT 332
              |..|::...|:      |:.|.:    :.::|: :....|.|   .:.||    :..||..:|
 Frog   259 LGFHSNNIKSIPEQAFIGNPSLITIHFYDNPIQHVGRSAFQHLP---ELRTL----ILNGASQIT 316

  Fly   333 DF 334
            :|
 Frog   317 EF 318

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1504	NP_608382.2	leucine-rich repeat	61..84	CDD:275380	5/22 (23%)
		LRR_5	73..200	CDD:463839	33/126 (26%)
		leucine-rich repeat	85..108	CDD:275380	11/22 (50%)
		leucine-rich repeat	109..132	CDD:275380	8/22 (36%)
		leucine-rich repeat	133..156	CDD:275380	6/22 (27%)
		leucine-rich repeat	157..180	CDD:275380	7/22 (32%)
		leucine-rich repeat	181..203	CDD:275380	0/21 (0%)
		leucine-rich repeat	204..227	CDD:275380	5/22 (23%)
		leucine-rich repeat	228..251	CDD:275380	5/22 (23%)
		leucine-rich repeat	252..275	CDD:275380	5/22 (23%)
lgr5	XP_002940219.2	LRRNT	32..>61	CDD:214470	9/29 (31%)
		leucine-rich repeat	65..88	CDD:275380	5/22 (23%)
		LRR	89..459	CDD:443914	68/267 (25%)
		leucine-rich repeat	89..112	CDD:275380	11/22 (50%)
		leucine-rich repeat	113..136	CDD:275380	8/22 (36%)
		leucine-rich repeat	137..160	CDD:275380	6/22 (27%)
		leucine-rich repeat	161..184	CDD:275380	7/45 (16%)
		leucine-rich repeat	185..208	CDD:275380	5/22 (23%)
		leucine-rich repeat	209..232	CDD:275380	5/22 (23%)
		leucine-rich repeat	233..255	CDD:275380	10/28 (36%)
		leucine-rich repeat	256..279	CDD:275380	3/22 (14%)
		leucine-rich repeat	280..301	CDD:275380	2/20 (10%)
		leucine-rich repeat	327..350	CDD:275378
		leucine-rich repeat	351..372	CDD:275378
		leucine-rich repeat	373..396	CDD:275378
		leucine-rich repeat	397..420	CDD:275378
		leucine-rich repeat	421..433	CDD:275378
		7tm_GPCRs	554..827	CDD:475119
		TM helix 1	556..580	CDD:410628
		TM helix 2	589..610	CDD:410628
		TM helix 3	634..656	CDD:410628
		TM helix 4	679..695	CDD:410628
		TM helix 5	719..742	CDD:410628
		TM helix 6	761..783	CDD:410628
		TM helix 7	795..820	CDD:410628