DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1504 and lrrc4c

DIOPT Version :9

Sequence 1:	NP_001259742.1	Gene:	CG1504 / 33028	FlyBaseID:	FBgn0031100	Length:	425	Species:	Drosophila melanogaster
Sequence 2:	XP_002938986.1	Gene:	lrrc4c / 100188921	XenbaseID:	XB-GENE-5772259	Length:	639	Species:	Xenopus tropicalis

Alignment Length:	398	Identity:	107/398 - (26%)
Similarity:	166/398 - (41%)	Gaps:	80/398 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LVLIIALSVVVCLWNSQQTETSKSCPAECICLSQ-TQVLCNTGGLEQIPLRQLPATVENLALTKN 69
            ::|.:.|.||..|..:|      :||:.|.|.:| ::|:|....|.::| ..:......|.|.:|
Frog    29 VLLALQLLVVAGLVRAQ------TCPSVCSCSNQFSKVICTRRNLREVP-DGISTNTRQLNLHEN 86

  Fly    70 NFPIIKPDSFAGLRALKKLSLDGNNITRIKQFAFRGLPRLKELSIQYTPLQMVAQFAFAGLQNLS 134
            ...|||.|||..||.|:.|.|..|:|..|            |:.            ||.||.||:
Frog    87 QIQIIKVDSFKHLRHLEVLQLSRNHIRTI------------EIG------------AFNGLANLN 127

  Fly   135 TILLSHNQIQRIEGNAFAGTSNIKLILLTNNPLIRIDSSAFSSLTNVGHLIL--PSGIRSIEQDA 197
            |:.|..|::..|...||...|.:|.:.|.|||:..|.|.||:.:.::..|.|  ...:..|.:.|
Frog   128 TLELFDNRLTTIPNGAFEYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGEMKRLSYISEGA 192

  Fly   198 FFGMDTVGLLKLAYMDLKEVAPFTFRGLSNVLLLTLQESD-----LGVICADAFTGLTQVETLQI 257
            |.|:..:..|.|...:|:::...|       .|:.|.|.|     |.|:...:|.|||.::.|.|
Frog   193 FEGLSNLKYLNLGMCNLRDIPNLT-------PLVKLDELDLSGNHLSVLRPGSFQGLTHLQKLWI 250

  Fly   258 LNNKIDSIEELNFTSTAAIKHLKFFGNHVLETPDPNSIIVDGVEHLQLVSNHFPCGCHI------ 316
            ::::|..||...|....::..|....|::...|......:..::.:||..|.:.|.|.|
Frog   251 MHSQIQVIERNAFDDLQSLVELNLAHNNLTLLPHDLFTPLHNLQRIQLHHNPWNCNCDILWLSWW 315

  Fly   317 --HTLLDG----------PLAEGAHNLTDFLQKNY--CISP--------LEVNGRVMSELDIDSI 359
              ..:..|          |..:|.|...  |..||  |.:|        |.|...:.:||..
Frog   316 LKEIVTTGSTCCARCSTPPSLKGTHIAE--LDHNYFTCYAPVIVEPPADLNVTEGMAAELKC--- 375

  Fly   360 GRCSDQLT 367
             |.|..||
Frog   376 -RASTSLT 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1504	NP_001259742.1	leucine-rich repeat	61..84	CDD:275380	10/22 (45%)
		LRR_5	73..200	CDD:404228	42/128 (33%)
		leucine-rich repeat	85..108	CDD:275380	6/22 (27%)
		leucine-rich repeat	109..132	CDD:275380	5/22 (23%)
		leucine-rich repeat	133..156	CDD:275380	7/22 (32%)
		leucine-rich repeat	157..180	CDD:275380	9/22 (41%)
		leucine-rich repeat	181..203	CDD:275380	6/23 (26%)
		leucine-rich repeat	204..227	CDD:275380	4/22 (18%)
		leucine-rich repeat	228..251	CDD:275380	9/27 (33%)
		leucine-rich repeat	252..275	CDD:275380	6/22 (27%)
lrrc4c	XP_002938986.1	LRRNT	47..78	CDD:214470	9/31 (29%)
		LRR	<77..302	CDD:227223	71/255 (28%)
		leucine-rich repeat	78..101	CDD:275380	10/22 (45%)
		leucine-rich repeat	102..125	CDD:275380	11/46 (24%)
		leucine-rich repeat	126..149	CDD:275380	7/22 (32%)
		leucine-rich repeat	150..173	CDD:275380	9/22 (41%)
		leucine-rich repeat	174..198	CDD:275380	6/23 (26%)
		leucine-rich repeat	199..220	CDD:275380	5/27 (19%)
		leucine-rich repeat	221..244	CDD:275380	8/22 (36%)
		leucine-rich repeat	245..268	CDD:275380	6/22 (27%)
		leucine-rich repeat	269..290	CDD:275380	3/20 (15%)
		LRRCT	301..351	CDD:214507	11/51 (22%)
		Ig	354..443	CDD:416386	9/33 (27%)
		Ig strand A	354..357	CDD:409353	1/2 (50%)
		Ig strand A'	361..364	CDD:409353	0/2 (0%)
		Ig strand B	370..377	CDD:409353	2/10 (20%)
		Ig strand C	383..388	CDD:409353	107/398 (27%)
		Ig strand C'	391..393	CDD:409353
		Ig strand D	402..406	CDD:409353
		Ig strand E	409..413	CDD:409353
		Ig strand F	423..430	CDD:409353
		Ig strand G	433..443	CDD:409353
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D180608at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920