DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab10 and RAB28

DIOPT Version :9

Sequence 1:	NP_523419.1	Gene:	Rab10 / 33025	FlyBaseID:	FBgn0015789	Length:	204	Species:	Drosophila melanogaster
Sequence 2:	NP_001017979.1	Gene:	RAB28 / 9364	HGNCID:	9768	Length:	221	Species:	Homo sapiens

Alignment Length:	214	Identity:	66/214 - (30%)
Similarity:	106/214 - (49%)	Gaps:	12/214 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KKTYDLLFKLLLIGDSGVGKTCILFRFSDDAFTSTFISTIGIDFKIKTVELRGK-KIKLQIWDTA 66
            :::.|...|::::||...|||.:...|:.:.|...:..|||:||.::.:.|.|. .:.|||||..
Human     6 EESQDRQLKIVVLGDGASGKTSLTTCFAQETFGKQYKQTIGLDFFLRRITLPGNLNVTLQIWDIG 70

  Fly    67 GQERFHTITTSYYRGAMGIMLVYDITNEKSFENIVKW---LRNIDEHANEDVEKMILGNKCDMTD 128
            ||.....:...|..||.|::|||||||.:||||:..|   ::.:.|.:.......::|||.|:..
Human    71 GQTIGGKMLDKYIYGAQGVLLVYDITNYQSFENLEDWYTVVKKVSEESETQPLVALVGNKIDLEH 135

  Fly   129 KRVVNKERGEAIAREHGIRFMETSAKSNINIERAFCELAEAILDKTSGRESAENQERVI---IDR 190
            .|.:..|:.....:|:|......|||:..::...|.::|..||.....:...|..:||:   |..
Human   136 MRTIKPEKHLRFCQENGFSSHFVSAKTGDSVFLCFQKVAAEILGIKLNKAEIEQSQRVVKADIVN 200

  Fly   191 RNQEKA-----PGYSKCCA 204
            .|||..     |..|..||
Human   201 YNQEPMSRTVNPPRSSMCA 219

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab10	NP_523419.1	Rab8_Rab10_Rab13_like	7..173	CDD:206659	55/169 (33%)
RAB28	NP_001017979.1	Rab28	13..221	CDD:206694	65/207 (31%)
RAB28	NP_001017979.1	Effector region. /evidence=ECO:0000250	41..49		3/7 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0078
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810