Protein Alignment Rab10 and RAB28

DIOPT Version :10

• Sequence 1: NP_523419.1
• Gene: Rab10 / 33025
• FlyBaseID: FBgn0015789
• Length: 204
• Species: Drosophila melanogaster
• Sequence 2: NP_001017979.1
• Gene: RAB28 / 9364
• HGNCID: 9768
• Length: 221
• Species: Homo sapiens
• Alignment Length: 214
• Identity: 66/214 - (30%)
• Similarity: 106/214 - (49%)
• Gaps: 12/214 - (5%)

  Fly     3 KKTYDLLFKLLLIGDSGVGKTCILFRFSDDAFTSTFISTIGIDFKIKTVELRGK-KIKLQIWDTA 66
            :::.|...|::::||...|||.:...|:.:.|...:..|||:||.::.:.|.|. .:.|||||..
Human     6 EESQDRQLKIVVLGDGASGKTSLTTCFAQETFGKQYKQTIGLDFFLRRITLPGNLNVTLQIWDIG 70

  Fly    67 GQERFHTITTSYYRGAMGIMLVYDITNEKSFENIVKW---LRNIDEHANEDVEKMILGNKCDMTD 128
            ||.....:...|..||.|::|||||||.:||||:..|   ::.:.|.:.......::|||.|:..
Human    71 GQTIGGKMLDKYIYGAQGVLLVYDITNYQSFENLEDWYTVVKKVSEESETQPLVALVGNKIDLEH 135

  Fly   129 KRVVNKERGEAIAREHGIRFMETSAKSNINIERAFCELAEAILDKTSGRESAENQERVI---IDR 190
            .|.:..|:.....:|:|......|||:..::...|.::|..||.....:...|..:||:   |..
Human   136 MRTIKPEKHLRFCQENGFSSHFVSAKTGDSVFLCFQKVAAEILGIKLNKAEIEQSQRVVKADIVN 200

  Fly   191 RNQEKA-----PGYSKCCA 204
            .|||..     |..|..||
Human   201 YNQEPMSRTVNPPRSSMCA 219

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab10	NP_523419.1	Rab8_Rab10_Rab13_like	7..173	CDD:206659	55/169 (33%)
RAB28	NP_001017979.1	Rab28	13..221	CDD:206694	65/207 (31%)
		Switch I. /evidence=ECO:0000255|PROSITE-ProRule:PRU00753, ECO:0000269|PubMed:19026641, ECO:0007744|PDB:3E5H	35..49		4/13 (31%)
		Switch II. /evidence=ECO:0000255|PROSITE-ProRule:PRU00753, ECO:0000269|PubMed:19026641, ECO:0007744|PDB:3E5H	68..85		4/16 (25%)