DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rab10 and RASEF

DIOPT Version :9

Sequence 1:	NP_523419.1	Gene:	Rab10 / 33025	FlyBaseID:	FBgn0015789	Length:	204	Species:	Drosophila melanogaster
Sequence 2:	NP_689786.2	Gene:	RASEF / 158158	HGNCID:	26464	Length:	740	Species:	Homo sapiens

Alignment Length:	200	Identity:	76/200 - (38%)
Similarity:	119/200 - (59%)	Gaps:	9/200 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 FKLLLIGDSGVGKTCILFRFSDDAFTSTFISTIGIDFKIKTVELRGKKIKLQIWDTAGQERFHTI 74
            :|::|.||:.|||:..|.|...:.|.....:|:|:||::||:.:.|::..||:|||||||||.:|
Human   542 YKIVLAGDAAVGKSSFLMRLCKNEFRENISATLGVDFQMKTLIVDGERTVLQLWDTAGQERFRSI 606

  Fly    75 TTSYYRGAMGIMLVYDITNEKSFENIVKWLRNIDEHANEDVEKMILGNKCDMTDKRVVNKER--- 136
            ..||:|.|.|::|:||:|.||||.||.:|:..|::.|:|.|..|::|||.|:.|......::
Human   607 AKSYFRKADGVLLLYDVTCEKSFLNIREWVDMIEDAAHETVPIMLVGNKADIRDTAATEGQKCVP 671

  Fly   137 ---GEAIAREHGIRFMETSAKSNINIERAFCELAEAILDKTSGRESAENQERVIIDRRNQEKAPG 198
               ||.:|..:|..|.|||||...||..|...||..:..:|   :..:::....:...|.:|:|.
Human   672 GHFGEKLAMTYGALFCETSAKDGSNIVEAVLHLAREVKKRT---DKDDSRSITNLTGTNSKKSPQ 733

  Fly   199 YSKCC 203
            ...||
Human   734 MKNCC 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab10	NP_523419.1	Rab8_Rab10_Rab13_like	7..173	CDD:206659	70/168 (42%)
RASEF	NP_689786.2	EFh	12..71	CDD:238008
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	82..110
		SMC_N	<174..>351	CDD:330553
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	376..403
		Rab	542..706	CDD:206640	69/163 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	713..740		4/25 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0078
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900