DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab10 and RAB40A

DIOPT Version :9

Sequence 1:	NP_523419.1	Gene:	Rab10 / 33025	FlyBaseID:	FBgn0015789	Length:	204	Species:	Drosophila melanogaster
Sequence 2:	NP_543155.2	Gene:	RAB40A / 142684	HGNCID:	18283	Length:	277	Species:	Homo sapiens

Alignment Length:	168	Identity:	76/168 - (45%)
Similarity:	106/168 - (63%)	Gaps:	1/168 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KTYDLLFKLLLIGDSGVGKTCILFRFSDDAFTSTFISTIGIDFKIKTVELRGKKIKLQIWDTAGQ 68
            :.||.|.|.||:||..|||:.||....|.|..|.:....|||:|..|:.|.|:::||::|||:||
Human     9 QAYDFLLKFLLVGDRDVGKSEILESLQDGAAESPYSHLGGIDYKTTTILLDGQRVKLKLWDTSGQ 73

  Fly    69 ERFHTITTSYYRGAMGIMLVYDITNEKSFENIVKWLRNIDEHANEDVEKMILGNKCDMTDKRVVN 133
            .||.||..||.|||.|::|||||.|..|||.:.:|::.|:||| ..|.|:::||:..:..||.|.
Human    74 GRFCTIFRSYSRGAQGVILVYDIANRWSFEGMDRWIKKIEEHA-PGVPKILVGNRLHLAFKRQVP 137

  Fly   134 KERGEAIAREHGIRFMETSAKSNINIERAFCELAEAIL 171
            :|:.:|.|...|:.|.|.|...|.||..:|.|||..:|
Human   138 REQAQAYAERLGVTFFEVSPLCNFNIIESFTELARIVL 175

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab10	NP_523419.1	Rab8_Rab10_Rab13_like	7..173	CDD:206659	75/165 (45%)
RAB40A	NP_543155.2	P-loop_NTPase	9..277	CDD:328724	76/168 (45%)
RAB40A	NP_543155.2	SOCS_Rab40	187..228	CDD:239711
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910