DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17068 and KBTBD4

DIOPT Version :9

Sequence 1:	NP_608379.1	Gene:	CG17068 / 33024	FlyBaseID:	FBgn0031098	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	NP_001305645.1	Gene:	KBTBD4 / 55709	HGNCID:	23761	Length:	567	Species:	Homo sapiens

Alignment Length:	255	Identity:	53/255 - (20%)
Similarity:	99/255 - (38%)	Gaps:	24/255 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 KDRG----------QYLLHSEKWADCRFLVGSSPTQRLIAGHKLLLAMASPVFERMFYGNLPDKT 67
            |||.          :..|..|.:||....|.....|.    |:|:|:..|..|..||..||.:..
Human    71 KDRSHSGRVAQGIMKLCLEEELFADVTISVEGREFQL----HRLVLSAQSCFFRSMFTSNLKEAH 131

  Fly    68 D-PIVIPDVQPEAFEAMLEYIYTDRITIGSFDKACELCYVAKKYMLPHVVTRCTHFLWADLSPKN 131
            : .||:.||....|:.:::|||...:.:.: ::..|:..|:..|.|..:...|:.||...:...|
Human   132 NRVIVLQDVSESVFQLLVDYIYHGTVKLRA-EELQEIYEVSDMYQLTSLFEECSRFLARTVQVGN 195

  Fly   132 ACRAYEFAKLFDEPRLMQSSMDLIAANTREVLSDPSFLDIEVSTLMAILDQNRLNIDSELDLFNC 196
            ..:....|....:|.|..::......:..::.:...||.:....|..|:........:..:....
Human   196 CLQVMWLADRHSDPELYTAAKHCAKTHLAQLQNTEEFLHLPHRLLTDIISDGVPCSQNPTEAIEA 260

  Fly   197 LLKFASERGILNESGQEETASGGQVLTKESPDNAAGHVLVEEIKMEPDVAAMVQHMHQDD 256
            .:.|       |:..:|..|...:...||..:|...:::.:|......:|..: |..:||
Human   261 WINF-------NKEEREAFAESLRTSLKEIGENVHIYLIGKESSRTHSLAVSL-HCAEDD 312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17068	NP_608379.1	BTB	19..123	CDD:279045	28/104 (27%)
		BTB	27..127	CDD:197585	27/100 (27%)
		BACK	136..>199	CDD:197943	7/62 (11%)
KBTBD4	NP_001305645.1	BTB	88..187	CDD:279045	28/103 (27%)
		BTB	95..189	CDD:197585	27/98 (28%)
		BACK_like	191..249	CDD:269806	8/57 (14%)
		Kelch_2	327..363	CDD:284956
		KELCH repeat	328..363	CDD:276965
		KELCH repeat	367..414	CDD:276965
		mutarot_permut	403..>560	CDD:274642
		KELCH repeat	417..463	CDD:276965
		KELCH repeat	471..516	CDD:276965
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143716
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840