DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17068 and btbd8

DIOPT Version :9

Sequence 1:	NP_608379.1	Gene:	CG17068 / 33024	FlyBaseID:	FBgn0031098	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	XP_002662476.3	Gene:	btbd8 / 550304	ZFINID:	ZDB-GENE-050411-113	Length:	1573	Species:	Danio rerio

Alignment Length:	794	Identity:	150/794 - (18%)
Similarity:	232/794 - (29%)	Gaps:	271/794 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 GLTELKDRGQYLLHSEKWADCRFL------VGSSPTQRL-----IAGHKLLLAMASPVFERMFYG 61
            ||..|||..:.:|..:.   |||.      |..|..:.|     |..|.|.|:....|.|. |..
Zfish   246 GLEGLKDVAEMVLTRDY---CRFFPKPVDGVQRSILECLAITHSIGLHDLYLSCVRWVAEH-FVK 306

  Fly    62 NLPDKTDPIVIPDVQPEAFEAMLEYIYTDRIT---------IGSFDK----------ACELCYVA 107
            ...::...::.|::|.:....:.:.:....:.         |||..:          |.||....
Zfish   307 CWSERNFALLPPELQRDCLNTVTKNMTIQSVVSVLCGSEQLIGSLPEVKWAKQVLSLASELQEEC 371

  Fly   108 KKYMLPHV--VTRCTHFLWADLSPKNACRAYEFAKLFDEPRLM-------------QSSMDLIAA 157
            .:.::.|:  ||....|  .||.     |..||.:   :|.||             ::..||..|
Zfish   372 LQMVVKHLPQVTHTAAF--HDLR-----RREEFTR---DPTLMRKVCIAVREGVTVENCCDLFTA 426

  Fly   158 NTREVLSDPSFLDIEVSTLMAILDQNRLNIDSELDLFN---CLLK-------------------- 199
            ..| :..||:.:|:..:      ||..   ..||..|.   |||:
Zfish   427 VNR-LSGDPTEVDVITN------DQAS---QEELKPFRRELCLLRTRLWTFLLQSFFAVKHTQGW 481

  Fly   200 -------------FASERGILNESGQEETASGGQVLTK---------ESPD------------NA 230
                         .|.::|.....|::...|..|..||         :||.            :.
Zfish   482 ESLQPRHREKILAAALDKGDCRRLGKKPVLSSSQKPTKCLSGTSSPCDSPTRRPVKVSQGPRASP 546

  Fly   231 AGHVLVEEIKMEPDVAAMVQH---------------------MHQDDEADSFE--------TDAG 266
            |..|......|:.|......|                     .|...:|.:..        |..|
Zfish   547 ARSVAAASGTMKSDALGPTAHSGKTKASNNTSLKSKNDKVKPTHMPAKAKTTSTVKPVLNGTTGG 611

  Fly   267 MASTSSAAAAAAAAPTA----------ASPPLDVASGSDDLVIIDSDASADAAANMINIMDAQRT 321
            ....:|..:.|..:||.          .:.|...|:|||       .::|.|....:     |:.
Zfish   612 TPQENSTTSGARGSPTGKTALDRKPNPGARPKSSAAGSD-------LSAAHAKGGKV-----QKN 664

  Fly   322 ILDGAMLRQAVKKIRFL---TMTPQQFAEGP----------ARSKLLQQHEALSILIKISSPSLN 373
            .:.|..|.|........   :.:|......|          .||||  |.:|.:....:|.|:
Zfish   665 TMSGKDLTQETASNALSNSGSTSPDNSTGSPRNNGHCTPTGLRSKL--QAKAATTKSPLSKPA-- 725

  Fly   374 DCHMPEGFCVSRSTRNFYESGHRHAQRELSSSYR---TGAAPSGVCFPGPGPAVRSGGPSGGGMM 435
              ..||....|..|..             ||..:   |..|.||.      ||.|| .|...|.:
Zfish   726 --QKPEIEKTSSPTNK-------------SSKAKPTTTSRAVSGT------PASRS-DPKIKGTV 768

  Fly   436 MGIAPRFGSVGTGFGFAGE---------ELVIRPPEPV---------------GVPPDAAPAPAP 476
            .|::....|...|...:..         |..|..|..:               .....:...||.
Zfish   769 SGLSDNQASSRLGSTLSSSKPALPRKEVEKDISKPSTIKKTTKAISESRSSVKASTSSSKQTPAA 833

  Fly   477 LRCFGEGYESGAPVPAPANDDDGGDRGAPAPAGGAAAGGA--GSAAGNSHNDMVRA--------- 530
            ....|..:::...:||.::....|....|.|||....|.|  .|.:...|:|:.:|
Zfish   834 SAKTGPKHKAPETLPAKSSVKPSGVVKNPTPAGSKKTGTAVKDSVSSPKHSDLKKATQQLNTISI 898

  Fly   531 ----------YCM-----RSLTRQFDFRNTSVTDAGVTFQVDTNIWILGVQVPTRVLCGELMTSA 580
                      .||     .|:..|....|.:|.|....  |..:|.....||.......:.::..
Zfish   899 EGKTGSKDDTSCMGGSEVSSVLEQHTLVNPAVPDQPEV--VSKSIPATSTQVNNMDKNSDPVSKL 961

  Fly   581 GFTERYTEVLYAHI 594
            ..||..|:.:..|:
Zfish   962 SSTEMKTQSVIPHL 975

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17068	NP_608379.1	BTB	19..123	CDD:279045	25/135 (19%)
		BTB	27..127	CDD:197585	25/131 (19%)
		BACK	136..>199	CDD:197943	19/78 (24%)
btbd8	XP_002662476.3	BTB	33..114	CDD:295341
		BTB	154..258	CDD:279045	5/11 (45%)
		BTB	165..255	CDD:197585	5/8 (63%)
		BACK	280..>326	CDD:197943	10/46 (22%)
		SPOP_C_like	357..411	CDD:269810	15/63 (24%)
		Herpes_U47	<542..1000	CDD:283192	87/474 (18%)
		DUF4596	1531..1573	CDD:292007
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576653
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930