DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17068 and ABTB2

DIOPT Version :9

Sequence 1:	NP_608379.1	Gene:	CG17068 / 33024	FlyBaseID:	FBgn0031098	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	NP_665803.2	Gene:	ABTB2 / 25841	HGNCID:	23842	Length:	1025	Species:	Homo sapiens

Alignment Length:	181	Identity:	45/181 - (24%)
Similarity:	80/181 - (44%)	Gaps:	18/181 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 YLLHSEKWADCRFLVGSSPTQRLIAGHKLLLAMASPVFERMFYGNLP---DKTDPIVIPDVQPEA 79
            :.|::::.:|..|||..    :|...||:||..||..|:.:......   |.:..|.|.|::...
Human   837 HFLNNKEMSDVTFLVEG----KLFYAHKVLLVTASNRFKTLMTNKSEQDGDSSKTIEISDMKYHI 897

  Fly    80 FEAMLEYIY---TDRITIGSFDKACELCYVAKKYMLPHVVTRCTHFLWADLSPKNACRAYEFAKL 141
            |:.|::|:|   |:.:.|.:.| ..||...|..:.|..:...|.......||.::|...|::||:
Human   898 FQMMMQYLYYGGTESMEIPTTD-ILELLSAASLFQLDALQRHCEILCSQTLSMESAVNTYKYAKI 961

  Fly   142 FDEPRLMQSSMDLIAANTREVLSDPSFLDI------EVSTLMAILD-QNRL 185
            .:.|.|..........:.:.:|...:|..:      :|..|..:.| ||.|
Human   962 HNAPELALFCEGFFLKHMKALLEQDAFRQLIYGRSSKVQGLDPLQDLQNTL 1012

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17068	NP_608379.1	BTB	19..123	CDD:279045	29/109 (27%)
		BTB	27..127	CDD:197585	28/105 (27%)
		BACK	136..>199	CDD:197943	13/57 (23%)
ABTB2	NP_665803.2	H2A	194..>242	CDD:305064
		Ank_4	<498..542	CDD:290365
		ANK	516..670	CDD:238125
		ANK 1	521..550
		ANK repeat	524..565	CDD:293786
		Ank_2	526..633	CDD:289560
		ANK repeat	567..604	CDD:293786
		ANK 2	567..596
		ANK 3	606..635
		ANK repeat	606..631	CDD:293786
		ANK repeat	649..679	CDD:293786
		ANK 4	649..678
		BTB	837..940	CDD:279045	28/107 (26%)
		BTB	846..947	CDD:197585	28/105 (27%)
		SPOP_C_like	947..>991	CDD:269810	10/43 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143711
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930