DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17068 and BTBD9

DIOPT Version :9

Sequence 1:	NP_608379.1	Gene:	CG17068 / 33024	FlyBaseID:	FBgn0031098	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	NP_001092742.1	Gene:	BTBD9 / 114781	HGNCID:	21228	Length:	612	Species:	Homo sapiens

Alignment Length:	498	Identity:	103/498 - (20%)
Similarity:	183/498 - (36%)	Gaps:	149/498 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LLHSEKWADCRFLVGSSPTQRLIAGHKLLLAMASPVFERMFYGNLPDKTDPIVIP--DVQPEAFE 81
            ||..|::.|..|:|    .::....|:::||.....|..:.||.:.:......||  |...|||.
Human    29 LLIGEEYGDVTFVV----EKKRFPAHRVILAARCQYFRALLYGGMRESQPEAEIPLQDTTAEAFT 89

  Fly    82 AMLEYIYTDRITIGSFDKACELCY--VAKKYMLPHVVTRCTHFLWADLSPKNACRAYEFAKLFDE 144
            .:|:||||.|.|:....:...|.:  :|.||..|.:....:.:|...|:.:|.|..::.|.|:..
Human    90 MLLKYIYTGRATLTDEKEEVLLDFLSLAHKYGFPELEDSTSEYLCTILNIQNVCMTFDVASLYSL 154

  Fly   145 PRLMQSSMDLIAANTREVLSDPSFLDIEVSTLMAILDQNRLNIDS----ELDLFNCLLKFASERG 205
            |:|.......:..|.:||||...||.:..:.|:.|:.:     ||    |.|:|..||.:.....
Human   155 PKLTCMCCMFMDRNAQEVLSSEGFLSLSKTALLNIVLR-----DSFAAPEKDIFLALLNWCKHNS 214

  Fly   206 --------------------ILNESGQEETASGGQVL-----TKESPD---NAAGHVLVEEIKME 242
                                :||........|...:|     ..||.|   |..|.::.||
Human   215 KENHAEIMQAVRLPLMSLTELLNVVRPSGLLSPDAILDAIKVRSESRDMDLNYRGMLIPEE---- 275

  Fly   243 PDVAAM----------VQHMHQDDEADSFETDAGMASTSSAAAAAAAAPTAASPPLD-------- 289
             ::|.|          ::....|.:..:::.|.|.                :..|:|
Human   276 -NIATMKYGAQVVKGELKSALLDGDTQNYDLDHGF----------------SRHPIDDDCRSGIE 323

  Fly   290 VASGSDDLV----IIDSDASADAAANMINI----MDAQRTILDGAMLRQAVKKIRFLTMTPQQFA 346
            :..|...::    |:..|..:.:.:..|.:    :|..|.|.....|.::.:|:.|
Human   324 IKLGQPSIINHIRILLWDRDSRSYSYFIEVSMDELDWVRVIDHSQYLCRSWQKLYF--------- 379

  Fly   347 EGPAR----SKLLQQHEALSILIKI-----------------------SSPSLNDC-HMPEGFCV 383
              |||    .:::..|..::.:..|                       :..::.|| .:.||  |
Human   380 --PARVCRYIRIVGTHNTVNKIFHIVAFECMFTNKTFTLEKGLIVPMENVATIADCASVIEG--V 440

  Fly   384 SRS--------TRNF-YESGHRHAQR-------ELSSSYRTGA 410
            |||        |:|: ::||:...|.       :|:..|..|:
Human   441 SRSRNALLNGDTKNYDWDSGYTCHQLGSGAIVVQLAQPYMIGS 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17068	NP_608379.1	BTB	19..123	CDD:279045	30/107 (28%)
		BTB	27..127	CDD:197585	28/103 (27%)
		BACK	136..>199	CDD:197943	19/66 (29%)
BTBD9	NP_001092742.1	BTB_POZ_BTBD9	14..133	CDD:349596	30/107 (28%)
		BACK_BTBD9	137..235	CDD:350518	23/102 (23%)
		F5_F8_type_C	292..405	CDD:366285	20/139 (14%)
		F5_F8_type_C	445..546	CDD:366285	8/39 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	560..612
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143720
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840