DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sdk1 and DIP-delta

DIOPT Version :9

Sequence 1:	NP_808547.3	Gene:	Sdk1 / 330222	MGIID:	2444413	Length:	2193	Species:	Mus musculus
Sequence 2:	NP_001097508.2	Gene:	DIP-delta / 5740816	FlyBaseID:	FBgn0085420	Length:	469	Species:	Drosophila melanogaster

Alignment Length:	476	Identity:	102/476 - (21%)
Similarity:	169/476 - (35%)	Gaps:	104/476 - (21%)

- Green bases have known domain annotations that are detailed below.

Mouse   364 IIEPPYFTAEPESRILGEVEETMDIPCRAMGVPLPTLQWYKDA--------------VPLSKLQN 414
            :::.|.| |:|...:...|....::||     .:..|..||.|              ..:|::
  Fly    40 MMDEPRF-AQPIPNVTVAVGRDANLPC-----VVEHLGGYKVAWIHIDRQMILTIHRHVISRI-- 96

Mouse   415 PRYKVLPSGG---LHIQKLSPEDSGIFQCFASNEGGEVQTHT------YLDVTNIAPA----FTQ 466
            |||.:..:..   ||:.:...:|.|.:.|       :|.|:.      ||.|  :.|.    ...
  Fly    97 PRYSITYTDNTWLLHVNQAHQDDRGYYMC-------QVNTNPMISQVGYLQV--VVPPNILDIES 152

Mouse   467 RPVDTTVTDGMTAVLRCEVSGAPKPAITWKR--GNHILASGSVRIPRFMLLESGGLRIAPVFIQD 529
            .|....|.:.....:.|...|.|.|.|.|:|  |..|......::   ::.::..|.:..|...:
  Fly   153 TPSSVAVRENQNINMTCRADGFPAPKIIWRREDGEEIAVEKKKKV---LVYDADVLPLTKVSRNE 214

Mouse   530 AGNYTCYAAN-TEASVNASAMLTV------WNRTSIVHPPEDRVVIKGTTATLCCGATHDPRTSL 587
            .|.|.|.|.| ...||:...:|.|      |....:|..|      .||..|:.|.....|:..:
  Fly   215 MGAYLCIATNGVPPSVSKRIILDVEFSPMIWVPNQLVGAP------SGTDVTIDCHTEAHPKAII 273

Mouse   588 RYVWKKDNVVITASSSSRIVVEKDG-----SLVISQTWSGDIGDYTCEIISEGGSDSRTARLEVI 647
              .|..::|::..|...:....::.     .|.|.....||.|:|.|  ||:.........:.|.
  Fly   274 --YWVYNSVMVLPSKKYKTDYTENSYRAHMKLTIRNLQYGDFGNYRC--ISKNSLGETEGSIRVY 334

Mouse   648 ELPHPPQNLLASLSPARSHSVTLSWVRPFDGNSPVLYYIVQVSENNSPWKVHLSNVGPEMTGVTV 712
            |:|.|.       :|  |..||.:.|...:.|      |:..|.|::. |...::||..|.
  Fly   335 EIPLPS-------TP--SKQVTHTTVESRENN------IIPSSRNDTT-KSLQTDVGYAMK---- 379

Mouse   713 SGLTPARTYQFRVCAVNQVGKGQYSTETSRLMLPEEPPSAPPKNIVASGRTNQSIMV------QW 771
            :.|.|...........:.......|.:||.|      |.....|.::|..:..|:.:      ..
  Fly   380 NDLYPGSASSSSSGGSSSAASSSSSMQTSAL------PGGVAGNSLSSMGSKGSLAIGKSTFYTE 438

Mouse   772 QPPPETEHNGVLRGYILRYRL 792
            :||.|...:.| .|.:|...|
  Fly   439 RPPNEYAASSV-AGLLLHRAL 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sdk1	NP_808547.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..56
		Ig_2	94..169	CDD:290606
		IG_like	100..169	CDD:214653
		IG_like	183..263	CDD:214653
		Ig	197..247	CDD:299845
		IG_like	281..357	CDD:214653
		IGc2	294..347	CDD:197706
		I-set	368..457	CDD:254352	24/111 (22%)
		Ig	388..454	CDD:143165	17/88 (19%)
		I-set	462..552	CDD:254352	22/96 (23%)
		Ig	476..552	CDD:299845	19/78 (24%)
		I-set	557..646	CDD:254352	19/93 (20%)
		Ig	562..646	CDD:299845	18/88 (20%)
		FN3	650..741	CDD:238020	18/90 (20%)
		fn3	753..839	CDD:278470	10/46 (22%)
		FN3	854..949	CDD:238020
		FN3	954..1036	CDD:238020
		FN3	1052..1148	CDD:238020
		FN3	1158..1253	CDD:238020
		FN3	1261..1349	CDD:238020
		FN3	1360..1453	CDD:238020
		FN3	1459..1554	CDD:238020
		FN3	1562..1676	CDD:238020
		FN3	1686..1779	CDD:238020
		FN3	1784..1865	CDD:238020
		FN3	1885..1978	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2057..2080
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:Q6V4S5	2187..2193
DIP-delta	NP_001097508.2	IG	51..143	CDD:214652	21/107 (20%)
		Ig	145..238	CDD:416386	21/95 (22%)
		Ig strand A	145..149	CDD:409353	0/3 (0%)
		Ig strand A'	154..159	CDD:409353	1/4 (25%)
		Ig strand B	165..172	CDD:409353	1/6 (17%)
		Ig strand C	178..183	CDD:409353	2/4 (50%)
		Ig strand C'	185..187	CDD:409353	0/1 (0%)
		Ig strand D	195..199	CDD:409353	0/6 (0%)
		Ig strand E	203..209	CDD:409353	1/5 (20%)
		Ig strand F	216..223	CDD:409353	3/6 (50%)
		Ig strand G	230..238	CDD:409353	2/7 (29%)
		Ig	242..333	CDD:416386	20/100 (20%)
		Ig strand A'	250..253	CDD:409353	1/2 (50%)
		Ig strand B	259..266	CDD:409353	2/6 (33%)
		Ig strand C	272..277	CDD:409353	1/6 (17%)
		Ig strand C'	281..283	CDD:409353	0/1 (0%)
		Ig strand D	289..293	CDD:409353	0/3 (0%)
		Ig strand E	295..305	CDD:409353	1/9 (11%)
		Ig strand F	314..322	CDD:409353	5/9 (56%)
		Ig strand G	325..334	CDD:409353	0/8 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810