DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sdk1 and Dscam2

DIOPT Version :9

Sequence 1:	NP_808547.3	Gene:	Sdk1 / 330222	MGIID:	2444413	Length:	2193	Species:	Mus musculus
Sequence 2:	NP_001261500.1	Gene:	Dscam2 / 38788	FlyBaseID:	FBgn0265296	Length:	2101	Species:	Drosophila melanogaster

Alignment Length:	1698	Identity:	414/1698 - (24%)
Similarity:	665/1698 - (39%)	Gaps:	377/1698 - (22%)

- Green bases have known domain annotations that are detailed below.

Mouse    47 TPGPGAGRRAAKLRPGRGWWALLLLQLHLLRALAQDDVAPYFKTE--PGLPQIHLEGN---RLVL 106
            |.|...|..:|:||.                     .||...:.|  |.:..:|:.|.   |.::
  Fly   311 TAGNVGGEASAELRL---------------------TVATPIQVEISPNVLSVHMGGTAEFRCLV 354

Mouse   107 TCLAEGSWPLEFK---WIRNDSELTTYSS-EYKYIIPSLQKLDAGFYRCVVRNRMGALLQRKSEI 167
            |  :.|| |:..:   |.::..:|.:... |...::|.:.:.:.|.|:||||...|...|..:|:
  Fly   355 T--SNGS-PVGMQNILWYKDGRQLPSSGRVEDTLVVPRVSRENRGMYQCVVRRPEGDTFQATAEL 416

Mouse   168 QV-----AYMGNFMDTDQRKTVSQGHAALLNLLPIVSC-----PQPQVTWFREGHKIIPSSRIA- 221
            |:     ..:.:|::    :|:..|.|..|      .|     |.||::|..:|..:..:.|..
  Fly   417 QLGDAPPVLLYSFIE----QTLQPGPAVSL------KCSAAGNPTPQISWTLDGFPLPSNGRFMI 471

Mouse   222 ---ITLENQLV----ILATTASDAGAYYVQAVNEKNGENKTSPFIHLSVARDTGTHEAMAPIIVV 279
               ||:...::    |......|.|.|...|      ||:.....|.:.....|     .|.|.:
  Fly   472 GQYITVHGDVISHVNISHVMVEDGGEYACIA------ENRAGRVQHAARLNIYG-----LPYIRL 525

Mouse   280 APGNRSVVAGSSET-TLECIANARPVEELSVHWKRNGVRLTSGLHSYGR---RLTITNPT--SAD 338
            .|   .|.|.|.|| .|:|.....|:||  :||:|.|..|...:....:   .||| :|.  ::|
  Fly   526 IP---KVTAVSGETLNLKCPVAGYPIEE--IHWERGGRELPDDIRQRVQPDGSLTI-SPVQKNSD 584

Mouse   339 TGMYVCEATLRGSTFEPARARAFLSIIEPPYFTAEPESRILGEVEETMDIPCRAMGVPLP-TLQW 402
            :|:|.|.|  |......||....:::|.||..:....:.:...:.:...:.|..:...|| |:.|
  Fly   585 SGVYTCWA--RNKQGHSARRSGEVTVIVPPKLSPFQTNILQLNMGDRASLTCSVVKGDLPLTINW 647

Mouse   403 YKDAVPLSKLQNPRYKVLP--SGGLHIQKLSPEDSGIFQCFASNEGGEVQTHTYLDVTNIAPAFT 465
            .||..|:...|:...|.:.  :..|.|:.|..:.:|.:.|...|...||:....| :.|:.|.:.
  Fly   648 RKDGRPIDPTQHMSVKQVDQYNSILVIENLGSDHTGNYSCVVRNSAAEVENSQAL-LVNVPPRWI 711

Mouse   466 QRPVDTTVTDGMTAVLRCEVSGAPKPAITWKRGNHILASGS-------VR-IPRFMLLESGGLRI 522
            ..|||..|......:|.|:..|.|.|:|.||:     |:||       || .|...||.:|.|.:
  Fly   712 VEPVDANVERNRHIMLHCQAQGVPTPSIVWKK-----ATGSKSGEYEEVRERPFTKLLGNGSLLL 771

Mouse   523 APVFIQDAGNYTCYAAN---------TEASVNASAMLTVWNRTSIVHPPEDRVVIKGTTATLCCG 578
            ..|.....|.|.|.|.|         .:..||:|...:..:|:.:|.        ||.||.|.|.
  Fly   772 QHVKEDREGFYLCQANNGIGTGIGKVIQLKVNSSPYFSSTSRSVMVK--------KGDTALLQCA 828

Mouse   579 ATHDPRTSLRYVWKKDNV-VITASSSSRIVVEKDGS-------LVISQTWSGDIGDYTCEIISEG 635
            .:.|  ..:..||.:... .:..|::.:|.|:::.:       |.|....:.|.|.|.|...:..
  Fly   829 VSGD--KPINIVWMRSGKNTLNPSTNYKISVKQEATPDGVSAELQIRTVDATDSGPYFCRASNLY 891

Mouse   636 GSDSRTARLEVIELPHPPQNLLASLSPARSHSVTLSWVRPFDGNSPVLYYIVQVSENN------- 693
            |:|.:..:|:|.|.|.||..|.|::..:|  ||.:.|.....|...|..|||:..|.:
  Fly   892 GNDQQLVQLQVQEPPLPPSVLEAAMISSR--SVNIKWQPKTLGTGDVTKYIVEFREADHSLPPAL 954

Mouse   694 --SPWKVHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNQVGKGQYSTETSRLMLPEEP--PSAPP 754
              ..|: .:....|......:..|.||..|.|||.|....|:   |..:..|::..||  |:.||
  Fly   955 FVDQWQ-QIEVKDPPHFNAMIENLKPATRYAFRVIAEGSAGR---SAPSQELIVRTEPQRPAGPP 1015

Mouse   755 KNIVASGRTNQSIMVQWQPP-PETEHNGVLRGYILRYRLA----------GLPGEHQQRNISSPE 808
            .::.|...::..:::.|..| ||..| |.::||.:.|:|:          .:.|:....|
  Fly  1016 LSLSARPLSSTELLISWVAPLPELRH-GDIQGYNVGYKLSSSGNTAYNFTSVSGDGDGGN----- 1074

Mouse   809 VNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQAEAVNSTTVHFLWN 873
             ...|::.|..:.:|.:.|.|:|..|.|..|......|::.||:.||::|:..|::|.::...|.
  Fly  1075 -GELLLSGLAKFARYTVVVQAFNQVGPGPLSEPTAAQTMEDVPSRPPEDVRCAALSSQSLQVSWQ 1138

Mouse   874 PPPQQFINGINQGYKLLAWP--------ADAPET--VTVVTIAPDFHGIHHGYITNLKKFTAYFT 928
            |||....||:.|||||:..|        .|..|:  .|.:|:.          :|.|:|:|.|..
  Fly  1139 PPPIYHTNGLLQGYKLIFEPIIDDIQPSKDEVESRKTTALTMV----------LTGLRKYTNYSI 1193

Mouse   929 SVLCFTTPGDGPPSSPQLVWTHEDKPGAVGHLSFTEILDTSLKVSWQEPLERNGIIMGYQISWEV 993
            .||..|..|||..|.|....:.||.|.|...:........||.:||..|.|.||:|..|.:...|
  Fly  1194 QVLAHTRMGDGVVSKPLFCHSEEDVPEAPADIKVVSSSSQSLYISWLPPNEPNGVITKYSLYTRV 1258

Mouse   994 Y-GR----NDSRLTHTLNSTMHEYKIQGLSSLTTYTIDVAALTAAGVGVTTSSTISSGVPPD-LP 1052
            . ||    |:.|   :|.|....|:.:||.....|...|.|.|..|.|  .||.:||.:..: :|
  Fly  1259 VNGREELNNEKR---SLPSQQAYYEAKGLHPHMEYQFWVTASTRVGEG--KSSRVSSQITTNRIP 1318

Mouse  1053 GAPSNLVISNISPRSATLQFRPGYDGKTAICRWIVEGQVGAIG-DEEEW----VTLYEEENEPDA 1112
            ..    :||...|     ..||.....|..|.        |:| .:.||    |.| .:....::
  Fly  1319 AR----IISFGGP-----VVRPWRSTVTLPCT--------AVGKPKREWFKSDVAL-RQGGLHNS 1365

Mouse  1113 QMLE-----IPNLTPYTHYRFRMRQVNIVGPSPFSQSSRVIQTL--QAPPDVAPTSLTVRTASET 1170
            |:|:     |.:|.......:..:..|.:|      :.|:..||  |.|| .||. |.|.:|:.:
  Fly  1366 QLLDSGDLIISSLQLADGGNYSCQVDNGIG------TDRLTHTLIVQVPP-TAPV-LYVTSATSS 1422

Mouse  1171 SLRLRWVPLPDSQYNGNPESVGYRVKYWRSDQPSSALAQVVSDRLERELTIEELEE---WTEYEL 1232
            |:.:.|    ...:.||....||.:.|.|::..:..:      :|.|..:..||:.   .:.|::
  Fly  1423 SILMHW----KCGFTGNAPITGYTLFYRRANGNTDEM------QLSRHASSHELKGLMCGSTYQI 1477

Mouse  1233 RMQAFNAIGAGPWSELVRGRTRESVPSAAPENVSAEAVSSTQILLTWASVPEQDQNGLILGYKVL 1297
            .:.|.|.:|..|.|.::..||:...| ..|.:.:..|.:||.:|:...|.|:   ||..|.|.||
  Fly  1478 HLSAQNKVGTSPTSTILHVRTQGQSP-GHPASTALLAPNSTSLLVRLHSWPD---NGCPLLYFVL 1538

Mouse  1298 -YCAKDLDPE-----------PRSHVVRGNHTQSALLAGLRKFVVYELQVLAFTRIGNGVPSSPL 1350
             |.|...||:           |:..:|..|         |:...:|:|::.|....|........
  Fly  1539 QYRAVTDDPDAEWVLVSNALKPQRRIVINN---------LQPSTLYQLRMEAHNVAGISQAEFNF 1594

Mouse  1351 ILERTKDDTPGPPVRLVFPEVRLTAVRIVWQPPEEPNGVILGYQIAYRLASGSPHTFTTVEVGAT 1415
            : ..|||..|.||                              :|.:|..||.    ||| :.|.
  Fly  1595 V-TLTKDGDPPPP------------------------------EIMHRGRSGQ----TTV-IFAN 1623

Mouse  1416 VRQFTATELAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTARSLRLQ 1480
            :.....|..|....:.             .:...::......:.|||   |..|:::...||..:
  Fly  1624 INLLIPTIAAVSGMFC-------------TIIMIIVCYRHMLKNAPP---LAEQSQIQKESLENR 1672

Mouse  1481 WVPGSDGASPIRYFTVQVRELPGGEWQTYSSSISHEATACAVERLRPFTSYKLRLKATNDIGDSD 1545
              ..|:.|...||:.                                 |.:|:.::..:.|.::
  Fly  1673 --ANSEAAQRERYYA---------------------------------TIHKVSMQNNDKIPET- 1701

Mouse  1546 FSAETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELESETGMS 1610
             |.:.....|.|  ..|..|::|             ||......|.||..: :|:....:|...|
  Fly  1702 -SEDISPYATFQ--LSEAGGNMS-------------QPHHGGPANTLLHSF-MYHERALAEGCSS 1749

Mouse  1611 PEPKTLKS 1618
            |.|...|:
  Fly  1750 PPPAASKN 1757

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sdk1	NP_808547.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..56		3/8 (38%)
		Ig_2	94..169	CDD:290606	20/81 (25%)
		IG_like	100..169	CDD:214653	19/75 (25%)
		IG_like	183..263	CDD:214653	21/92 (23%)
		Ig	197..247	CDD:299845	14/62 (23%)
		IG_like	281..357	CDD:214653	26/81 (32%)
		IGc2	294..347	CDD:197706	18/57 (32%)
		I-set	368..457	CDD:254352	20/91 (22%)
		Ig	388..454	CDD:143165	18/68 (26%)
		I-set	462..552	CDD:254352	32/106 (30%)
		Ig	476..552	CDD:299845	27/92 (29%)
		I-set	557..646	CDD:254352	22/96 (23%)
		Ig	562..646	CDD:299845	21/91 (23%)
		FN3	650..741	CDD:238020	27/99 (27%)
		fn3	753..839	CDD:278470	23/96 (24%)
		FN3	854..949	CDD:238020	34/104 (33%)
		FN3	954..1036	CDD:238020	27/86 (31%)
		FN3	1052..1148	CDD:238020	21/105 (20%)
		FN3	1158..1253	CDD:238020	23/97 (24%)
		FN3	1261..1349	CDD:238020	25/99 (25%)
		FN3	1360..1453	CDD:238020	13/92 (14%)
		FN3	1459..1554	CDD:238020	15/94 (16%)
		FN3	1562..1676	CDD:238020	14/57 (25%)
		FN3	1686..1779	CDD:238020
		FN3	1784..1865	CDD:238020
		FN3	1885..1978	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2057..2080
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:Q6V4S5	2187..2193
Dscam2	NP_001261500.1	Ig	51..127	CDD:299845
		Ig	138..>203	CDD:299845
		I-set	238..327	CDD:254352	6/36 (17%)
		Ig	247..327	CDD:299845	6/36 (17%)
		I-set	332..418	CDD:254352	22/88 (25%)
		IGc2	344..407	CDD:197706	16/65 (25%)
		IG_like	432..517	CDD:214653	21/96 (22%)
		IGc2	436..507	CDD:197706	19/82 (23%)
		I-set	521..610	CDD:254352	30/96 (31%)
		IGc2	533..597	CDD:197706	23/68 (34%)
		Ig	630..699	CDD:143165	18/68 (26%)
		IG_like	714..802	CDD:214653	28/92 (30%)
		Ig	725..802	CDD:299845	24/81 (30%)
		Ig	823..894	CDD:143165	16/72 (22%)
		FN3	906..1006	CDD:238020	28/105 (27%)
		FN3	1013..1111	CDD:238020	24/104 (23%)
		FN3	1119..1209	CDD:238020	33/99 (33%)
		FN3	1219..1313	CDD:238020	32/98 (33%)
		Ig	1336..1402	CDD:143165	15/80 (19%)
		FN3	1409..1498	CDD:238020	24/100 (24%)
		FN3	1515..1588	CDD:238020	23/84 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810