DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AnxB10 and ANXA8L1

DIOPT Version :9

Sequence 1:	NP_001162804.1	Gene:	AnxB10 / 33019	FlyBaseID:	FBgn0000084	Length:	321	Species:	Drosophila melanogaster
Sequence 2:	NP_001092315.2	Gene:	ANXA8L1 / 728113	HGNCID:	23334	Length:	327	Species:	Homo sapiens

Alignment Length:	313	Identity:	151/313 - (48%)
Similarity:	207/313 - (66%)	Gaps:	1/313 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 TVKDAAPFDASQDAQVLRAAMKGFGTDEQEIIDVLVGRSNQQRQTIKAVYEAEFERDLVDDLKDE 72
            |||.::.|:...||:.|..||||.||:||.|||||..|||.|||.|...::|:|.:||.:.||.|
Human    14 TVKSSSHFNPDPDAETLYKAMKGIGTNEQAIIDVLTKRSNTQRQQIAKSFKAQFGKDLTETLKSE 78

  Fly    73 LGGKFEDVIVGLMMPPVEYLCKQLHAAMAGIGTEEATLVEILCTKTNEEMAQIVAVYEERYQRPL 137
            |.||||.:||.||.||..|..|:||.||.|:||:|..::|||.::|..::.:|:..|||.|...|
Human    79 LSGKFERLIVALMYPPYRYEAKELHDAMKGLGTKEGVIIEILASRTKNQLREIMKAYEEDYGSSL 143

  Fly   138 AEQMCSETSGFFRRLLTLIVTGVRDGLDTPVDVGQAKEQAAQLYSAGEAKLGTDEEVFNRIMSHA 202
            .|.:.::|||:..|:|..::.|.||.:.:.||...|.:.|..||:|||...||||..|..|:...
Human   144 EEDIQADTSGYLERILVCLLQGSRDDVSSFVDPALALQDAQDLYAAGEKIRGTDEMKFITILCTR 208

  Fly   203 SFPQLRLVFEEYKVLSGQTIEQAIKHEMSDELHEAMMAIVECVQSPAAFFANRLYKAMNGAGTDD 267
            |...|..|||||:.::.::||.:||.|....|.|||:.:|:|.|:..::||.|||.||.||||.|
Human   209 SATHLLRVFEEYEKIANKSIEDSIKSETHGSLEEAMLTVVKCTQNLHSYFAERLYYAMKGAGTRD 273

  Fly   268 ATLIRIIVSRSEIDLETIKQEFERIYNRTLHSAVVDAETSGDYKRALTALLGS 320
            .||||.|||||||||..||..|:::|.:||.|.::: :||||||.||.:|:||
Human   274 GTLIRNIVSRSEIDLNLIKCHFKKMYGKTLSSMIME-DTSGDYKNALLSLVGS 325

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AnxB10	NP_001162804.1	Annexin	19..84	CDD:278615	37/64 (58%)
		Annexin	91..156	CDD:278615	26/64 (41%)
		Annexin	176..241	CDD:278615	28/64 (44%)
		Annexin	251..317	CDD:278615	40/65 (62%)
ANXA8L1	NP_001092315.2	Annexin 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	21..92		39/70 (56%)
		Annexin	26..90	CDD:395139	37/63 (59%)
		Annexin 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	93..164		28/70 (40%)
		Annexin	97..162	CDD:395139	26/64 (41%)
		Annexin 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	177..249		29/71 (41%)
		Annexin	181..247	CDD:395139	28/65 (43%)
		Annexin 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	253..324		41/71 (58%)
		Annexin	257..322	CDD:395139	40/65 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	81	1.000	Domainoid score	I8495
eggNOG	1	0.900	-	-		E1_KOG0819
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54302
OrthoDB	1	1.010	-	-		D500720at33208
OrthoFinder	1	1.000	-	-		FOG0000105
OrthoInspector	1	1.000	-	-		oto90446
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10502
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X76
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.930