DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AnxB10 and Anxa2

DIOPT Version :9

Sequence 1:	NP_001162804.1	Gene:	AnxB10 / 33019	FlyBaseID:	FBgn0000084	Length:	321	Species:	Drosophila melanogaster
Sequence 2:	NP_063970.1	Gene:	Anxa2 / 56611	RGDID:	621170	Length:	339	Species:	Rattus norvegicus

Alignment Length:	312	Identity:	122/312 - (39%)
Similarity:	191/312 - (61%)	Gaps:	1/312 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 TVKDAAPFDASQDAQVLRAAMKGFGTDEQEIIDVLVGRSNQQRQTIKAVYEAEFERDLVDDLKDE 72
            :||....|||.:||..:..|:|..|.||..|:::|..|||.|||.|...|:...:::|...:|..
  Rat    26 SVKPYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNAQRQDIAFAYQRRTKKELPSAMKSA 90

  Fly    73 LGGKFEDVIVGLMMPPVEYLCKQLHAAMAGIGTEEATLVEILCTKTNEEMAQIVAVYEERYQRPL 137
            |.|..|.|::||:..|.:|...:|.|:|.|:||:|.:|:||:|::||:|:.:|..||:|.|:..|
  Rat    91 LSGHLETVMLGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDL 155

  Fly   138 AEQMCSETSGFFRRLLTLIVTGVRDGLDTPVDVGQAKEQAAQLYSAGEAKLGTDEEVFNRIMSHA 202
            .:.:.|:|||.||:||..:..|.|....:.:|.....:.|.:||.||..:.|||...:..||:..
  Rat   156 EKDIISDTSGEFRKLLVALAKGKRAEDGSVIDYELIDQDARELYDAGVKRKGTDVPKWISIMTER 220

  Fly   203 SFPQLRLVFEEYKVLSGQTIEQAIKHEMSDELHEAMMAIVECVQSPAAFFANRLYKAMNGAGTDD 267
            |...|:.|||.||..|...:.::|:.|:..:|..|.:.:|:|:|:...:||:|||.:|.|.||.|
  Rat   221 SVCHLQKVFERYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRD 285

  Fly   268 ATLIRIIVSRSEIDLETIKQEFERIYNRTLHSAVVDAETSGDYKRALTALLG 319
            ..||||:|||||:|:..|:.||:|.|.::|: ..:..:|.|||::||..|.|
  Rat   286 KVLIRIMVSRSEVDMLKIRSEFKRKYGKSLY-YFIQQDTKGDYQKALLYLCG 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AnxB10	NP_001162804.1	Annexin	19..84	CDD:278615	23/64 (36%)
		Annexin	91..156	CDD:278615	29/64 (45%)
		Annexin	176..241	CDD:278615	22/64 (34%)
		Annexin	251..317	CDD:278615	32/65 (49%)
Anxa2	NP_063970.1	S100A10-binding site. /evidence=ECO:0000255	2..24
		Annexin 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	33..104		28/70 (40%)
		Annexin	37..102	CDD:395139	23/64 (36%)
		Annexin 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	105..176		30/70 (43%)
		Annexin	109..174	CDD:395139	29/64 (45%)
		Annexin 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	189..261		22/71 (31%)
		Annexin	193..259	CDD:395139	22/65 (34%)
		Annexin 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	265..336		33/71 (46%)
		Annexin	269..334	CDD:395139	32/65 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0819
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54302
OrthoDB	1	1.010	-	-		D500720at33208
OrthoFinder	1	1.000	-	-		FOG0000105
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10502
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X76
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.930