DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AnxB10 and PRNP

DIOPT Version :9

Sequence 1:	NP_001162804.1	Gene:	AnxB10 / 33019	FlyBaseID:	FBgn0000084	Length:	321	Species:	Drosophila melanogaster
Sequence 2:	NP_000302.1	Gene:	PRNP / 5621	HGNCID:	9449	Length:	253	Species:	Homo sapiens

Alignment Length:	99	Identity:	17/99 - (17%)
Similarity:	30/99 - (30%)	Gaps:	31/99 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 YEER-------------YQRPLAEQMCSETSGFFRRLLTLIVTGVRDGLDTPVDVGQAKEQAAQL 180
            ||:|             |.||:.|.  |..:.|....:.:.:                |:.....
Human   145 YEDRYYRENMHRYPNQVYYRPMDEY--SNQNNFVHDCVNITI----------------KQHTVTT 191

  Fly   181 YSAGEAKLGTDEEVFNRIMSHASFPQLRLVFEEY 214
            .:.||....||.::..|::......|.....:.|
Human   192 TTKGENFTETDVKMMERVVEQMCITQYERESQAY 225

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AnxB10	NP_001162804.1	Annexin	19..84	CDD:278615
		Annexin	91..156	CDD:278615	9/39 (23%)
		Annexin	176..241	CDD:278615	7/39 (18%)
		Annexin	251..317	CDD:278615
PRNP	NP_000302.1	Prion_bPrPp	1..28	CDD:288443
		PRP	23..240	CDD:197548	17/99 (17%)
		Interaction with GRB2, ERI3 and SYN1. /evidence=ECO:0000250\|UniProtKB:P04925	23..230		17/99 (17%)
		Interaction with ADGRG6. /evidence=ECO:0000250\|UniProtKB:P04925	23..38
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	26..108
		5 X 8 AA tandem repeats of P-H-G-G-G-W-G-Q	51..91
			51..59
			60..67
			68..75
			76..83
			84..91
		Prion	134..251	CDD:278789	17/99 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10502
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100