DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AnxB10 and anxa11b

DIOPT Version :9

Sequence 1:	NP_001162804.1	Gene:	AnxB10 / 33019	FlyBaseID:	FBgn0000084	Length:	321	Species:	Drosophila melanogaster
Sequence 2:	NP_861431.1	Gene:	anxa11b / 353365	ZFINID:	ZDB-GENE-030707-5	Length:	485	Species:	Danio rerio

Alignment Length:	325	Identity:	145/325 - (44%)
Similarity:	218/325 - (67%)	Gaps:	10/325 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PVP--------TVKDAAPFDASQDAQVLRAAMKGFGTDEQEIIDVLVGRSNQQRQTIKAVYEAEF 61
            |.|        |:||....|..:|.:|||.|||||||||..||::|..|||:||..:.|.|:..:
Zfish   162 PAPAINRGFRGTIKDFPGADPLRDVEVLRKAMKGFGTDENAIIELLGSRSNKQRVPLLAAYKTTY 226

  Fly    62 ERDLVDDLKDELGGKFEDVIVGLMMPPVEYLCKQLHAAMAGIGTEEATLVEILCTKTNEEMAQIV 126
            .:|||.|||.||.|.||::::.::..|.::...:...|::|.||:||.|:|||.:::|.|:.:|.
Zfish   227 GKDLVRDLKSELTGHFEELVLAMLKSPAQFDASECKEAISGAGTDEACLIEILSSRSNAEIKEIN 291

  Fly   127 AVYEERYQRPLAEQMCSETSGFFRRLLTLIVTGVRDGLDTPVDVGQAKEQAAQLYSAGEAKLGTD 191
            .:|:..|.:.|.:.:.::|||.|||||..:..|.||..:| ||:..||:.|.:|:||||.|:|||
Zfish   292 RIYKAEYGKSLEDAISNDTSGHFRRLLVSLCQGNRDERET-VDISMAKQDAQKLHSAGENKVGTD 355

  Fly   192 EEVFNRIMSHASFPQLRLVFEEYKVLSGQTIEQAIKHEMSDELHEAMMAIVECVQSPAAFFANRL 256
            |..||.|:...|.|.||.||:||:.:.|:.||::|..|||.:|...|:|:|:|:::..|:||.||
Zfish   356 ESQFNAILCARSKPHLRQVFQEYQQMCGRDIEKSICREMSGDLESGMVAVVKCIKNTPAYFAERL 420

  Fly   257 YKAMNGAGTDDATLIRIIVSRSEIDLETIKQEFERIYNRTLHSAVVDAETSGDYKRALTALLGSA 321
            :|||.||||.|.|||||:|||||:|:..|:||:.|::.::|::. :..:||||||:.|..|.|.:
Zfish   421 HKAMQGAGTKDRTLIRIMVSRSELDMLDIRQEYLRLFGKSLYTH-ISGDTSGDYKKLLLKLCGGS 484

Fly 322 321
Zfish 485 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AnxB10	NP_001162804.1	Annexin	19..84	CDD:278615	34/64 (53%)
		Annexin	91..156	CDD:278615	24/64 (38%)
		Annexin	176..241	CDD:278615	31/64 (48%)
		Annexin	251..317	CDD:278615	35/65 (54%)
anxa11b	NP_861431.1	WWbp	<1..70	CDD:304964
		DUF1720	7..90	CDD:285440
		Annexin	184..249	CDD:278615	34/64 (53%)
		Annexin	256..321	CDD:278615	24/64 (38%)
		Annexin	339..405	CDD:278615	31/65 (48%)
		Annexin	415..480	CDD:278615	35/65 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0819
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54302
OrthoDB	1	1.010	-	-		D500720at33208
OrthoFinder	1	1.000	-	-		FOG0000105
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X76
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.830