DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AnxB10 and ANXA5

DIOPT Version :9

Sequence 1:	NP_001162804.1	Gene:	AnxB10 / 33019	FlyBaseID:	FBgn0000084	Length:	321	Species:	Drosophila melanogaster
Sequence 2:	NP_001145.1	Gene:	ANXA5 / 308	HGNCID:	543	Length:	320	Species:	Homo sapiens

Alignment Length:	312	Identity:	145/312 - (46%)
Similarity:	197/312 - (63%)	Gaps:	2/312 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 TVKDAAPFDASQDAQVLRAAMKGFGTDEQEIIDVLVGRSNQQRQTIKAVYEAEFERDLVDDLKDE 72
            ||.|...||...||:.||.||||.||||:.|:.:|..|||.|||.|.|.::..|.|||:||||.|
Human     8 TVTDFPGFDERADAETLRKAMKGLGTDEESILTLLTSRSNAQRQEISAAFKTLFGRDLLDDLKSE 72

  Fly    73 LGGKFEDVIVGLMMPPVEYLCKQLHAAMAGIGTEEATLVEILCTKTNEEMAQIVAVYEERYQRPL 137
            |.||||.:||.||.|...|...:|..|:.|.||.|..|.||:.::|.||:..|..||||.|...|
Human    73 LTGKFEKLIVALMKPSRLYDAYELKHALKGAGTNEKVLTEIIASRTPEELRAIKQVYEEEYGSSL 137

  Fly   138 AEQMCSETSGFFRRLLTLIVTGVRDGLDTPVDVGQAKEQAAQLYSAGEAKLGTDEEVFNRIMSHA 202
            .:.:..:|||:::|:|.:::...||. |..:|..|.::.|..|:.|||.|.|||||.|..|....
Human   138 EDDVVGDTSGYYQRMLVVLLQANRDP-DAGIDEAQVEQDAQALFQAGELKWGTDEEKFITIFGTR 201

  Fly   203 SFPQLRLVFEEYKVLSGQTIEQAIKHEMSDELHEAMMAIVECVQSPAAFFANRLYKAMNGAGTDD 267
            |...||.||::|..:||..||:.|..|.|..|.:.::|:|:.::|..|:.|..||.||.||||||
Human   202 SVSHLRKVFDKYMTISGFQIEETIDRETSGNLEQLLLAVVKSIRSIPAYLAETLYYAMKGAGTDD 266

  Fly   268 ATLIRIIVSRSEIDLETIKQEFERIYNRTLHSAVVDAETSGDYKRALTALLG 319
            .||||::||||||||..|::||.:.:..:|:| ::..:||||||:||..|.|
Human   267 HTLIRVMVSRSEIDLFNIRKEFRKNFATSLYS-MIKGDTSGDYKKALLLLCG 317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AnxB10	NP_001162804.1	Annexin	19..84	CDD:278615	38/64 (59%)
		Annexin	91..156	CDD:278615	25/64 (39%)
		Annexin	176..241	CDD:278615	27/64 (42%)
		Annexin	251..317	CDD:278615	36/65 (55%)
ANXA5	NP_001145.1	Annexin 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	15..86		41/70 (59%)
		Annexin	20..84	CDD:395139	38/63 (60%)
		Annexin 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	87..158		26/70 (37%)
		Annexin	91..156	CDD:395139	25/64 (39%)
		Annexin 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	170..242		29/71 (41%)
		Annexin	174..240	CDD:395139	27/65 (42%)
		Annexin 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	246..317		39/71 (55%)
		Annexin	250..315	CDD:395139	36/65 (55%)
		[IL]-x-C-x-x-[DE] motif. /evidence=ECO:0000305\|PubMed:25417112	314..319		2/4 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0819
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3218
OMA	1	1.010	-	-		QHG54302
OrthoDB	1	1.010	-	-		D500720at33208
OrthoFinder	1	1.000	-	-		FOG0000105
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10502
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X76
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.880