DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AnxB10 and ANXA3

DIOPT Version :9

Sequence 1:	NP_001162804.1	Gene:	AnxB10 / 33019	FlyBaseID:	FBgn0000084	Length:	321	Species:	Drosophila melanogaster
Sequence 2:	NP_005130.1	Gene:	ANXA3 / 306	HGNCID:	541	Length:	323	Species:	Homo sapiens

Alignment Length:	312	Identity:	139/312 - (44%)
Similarity:	199/312 - (63%)	Gaps:	2/312 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 TVKDAAPFDASQDAQVLRAAMKGFGTDEQEIIDVLVGRSNQQRQTIKAVYEAEFERDLVDDLKDE 72
            ||:|...|..|.||:.::.|::|.||||:.:|.:|..|||.|||.|...|:|.:.::|.||||.:
Human    11 TVRDYPDFSPSVDAEAIQKAIRGIGTDEKMLISILTERSNAQRQLIVKEYQAAYGKELKDDLKGD 75

  Fly    73 LGGKFEDVIVGLMMPPVEYLCKQLHAAMAGIGTEEATLVEILCTKTNEEMAQIVAVYEERYQRPL 137
            |.|.||.::|.|:.||..:..|||..:|.|.||.|..|:|||.|:|:.:|..|...|...|::.|
Human    76 LSGHFEHLMVALVTPPAVFDAKQLKKSMKGAGTNEDALIEILTTRTSRQMKDISQAYYTVYKKSL 140

  Fly   138 AEQMCSETSGFFRRLLTLIVTGVRDGLDTPVDVGQAKEQAAQLYSAGEAKLGTDEEVFNRIMSHA 202
            .:.:.|||||.||:.|..:..|.||. ...||...||:.|..||.|||.:.||||:.|..|:...
Human   141 GDDISSETSGDFRKALLTLADGRRDE-SLKVDEHLAKQDAQILYKAGENRWGTDEDKFTEILCLR 204

  Fly   203 SFPQLRLVFEEYKVLSGQTIEQAIKHEMSDELHEAMMAIVECVQSPAAFFANRLYKAMNGAGTDD 267
            |||||:|.|:||:.:|.:.|..:||.|:|....:.::|||.||::..||.|.||::|:.|.|||:
Human   205 SFPQLKLTFDEYRNISQKDIVDSIKGELSGHFEDLLLAIVNCVRNTPAFLAERLHRALKGIGTDE 269

  Fly   268 ATLIRIIVSRSEIDLETIKQEFERIYNRTLHSAVVDAETSGDYKRALTALLG 319
            .||.||:||||||||..|:.||::.|..:|:|| :.::|||||:..|..:.|
Human   270 FTLNRIMVSRSEIDLLDIRTEFKKHYGYSLYSA-IKSDTSGDYEITLLKICG 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AnxB10	NP_001162804.1	Annexin	19..84	CDD:278615	29/64 (45%)
		Annexin	91..156	CDD:278615	27/64 (42%)
		Annexin	176..241	CDD:278615	27/64 (42%)
		Annexin	251..317	CDD:278615	34/65 (52%)
ANXA3	NP_005130.1	Annexin 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	18..89		32/70 (46%)
		Annexin	23..87	CDD:278615	29/63 (46%)
		Annexin 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	90..161		29/70 (41%)
		Annexin	94..159	CDD:278615	27/64 (42%)
		Annexin 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	173..245		31/71 (44%)
		Annexin	177..243	CDD:278615	27/65 (42%)
		Annexin 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	249..320		35/71 (49%)
		Annexin	255..318	CDD:278615	33/63 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0819
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54302
OrthoDB	1	1.010	-	-		D500720at33208
OrthoFinder	1	1.000	-	-		FOG0000105
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X76
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.830