DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AnxB10 and Anxa1

DIOPT Version :9

Sequence 1:	NP_001162804.1	Gene:	AnxB10 / 33019	FlyBaseID:	FBgn0000084	Length:	321	Species:	Drosophila melanogaster
Sequence 2:	NP_037036.1	Gene:	Anxa1 / 25380	RGDID:	2118	Length:	346	Species:	Rattus norvegicus

Alignment Length:	319	Identity:	134/319 - (42%)
Similarity:	189/319 - (59%)	Gaps:	4/319 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 YK--PVPTVKDAAPFDASQDAQVLRAAMKGFGTDEQEIIDVLVGRSNQQRQTIKAVYEAEFERDL 65
            ||  |...|.....|:.|.|...|..|:...|.||..|||:|..|:|.|||.|||.|..|..:.|
  Rat    28 YKGGPGSAVSPYPSFNPSSDVAALHKAIMVKGVDEATIIDILTKRTNAQRQQIKAAYLQETGKPL 92

  Fly    66 VDDLKDELGGKFEDVIVGLMMPPVEYLCKQLHAAMAGIGTEEATLVEILCTKTNEEMAQIVAVYE 130
            .:.||..|.|..|:|::.::..|.::...:|.|||.|:||:|.||:|||.|::|:::.:|..||.
  Rat    93 DETLKKALTGHLEEVVLAMLKTPAQFDADELRAAMKGLGTDEDTLIEILTTRSNQQIREITRVYR 157

  Fly   131 ERYQRPLAEQMCSETSGFFRRLLTLIVTGVRDGLDTPVDVGQAKEQAAQLYSAGEAKLGTDEEVF 195
            |..:|.||:.:.|:|||.||..|..:..|.|.. |..|:...|...|..||.|||.:.|||..||
  Rat   158 EELKRDLAKDITSDTSGDFRNALLALAKGDRCE-DMSVNQDLADTDARALYEAGERRKGTDVNVF 221

  Fly   196 NRIMSHASFPQLRLVFEEYKVLSGQTIEQAIKHEMSDELHEAMMAIVECVQSPAAFFANRLYKAM 260
            |.|::..|:|.||.||:.|:..|...:.:|:..|:..::.:.:..||:|..|..||||.:||:||
  Rat   222 NTILTTRSYPHLRKVFQNYRKYSQHDMNKALDLELKGDIEKCLTTIVKCATSTPAFFAEKLYEAM 286

  Fly   261 NGAGTDDATLIRIIVSRSEIDLETIKQEFERIYNRTLHSAVVDAETSGDYKRALTALLG 319
            .||||...|||||:|||||||:..||..:::.|...|..|::| ||.|||::.|.||.|
  Rat   287 KGAGTRHKTLIRIMVSRSEIDMNEIKVFYQKKYGIPLCQAILD-ETKGDYEKILVALCG 344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AnxB10	NP_001162804.1	Annexin	19..84	CDD:278615	27/64 (42%)
		Annexin	91..156	CDD:278615	29/64 (45%)
		Annexin	176..241	CDD:278615	23/64 (36%)
		Annexin	251..317	CDD:278615	35/65 (54%)
Anxa1	NP_037036.1	Annexin 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	42..113		29/70 (41%)
		Annexin	47..111	CDD:395139	27/63 (43%)
		Annexin 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	114..185		30/70 (43%)
		Annexin	118..183	CDD:395139	29/64 (45%)
		Annexin 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	197..269		25/71 (35%)
		Annexin	202..267	CDD:395139	23/64 (36%)
		Annexin 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	273..344		39/71 (55%)
		Annexin	277..342	CDD:395139	35/65 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0819
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54302
OrthoDB	1	1.010	-	-		D500720at33208
OrthoFinder	1	1.000	-	-		FOG0000105
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10502
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X76
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.930